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At least 991 records · Page 55Linked to original sources
PubMed1986

Influence of complex charge and size on the uptake of 99mTc-diphosphonates in osteogenic tissue.

The biodistributions of six chromatographically pure 99mTc-HEDP complexes have been determined in soft tissues, normal bone and osteogenic lesions (induced with a Walker 256 tumor) in Fisher 344 rats. The physical properties of each 99mTc-HEDP complex including anionic charge, partial molar volume, molecular weight and spectral characteristics are known; thus allowing structure-activity relationships to be drawn. The results indicate that the smallest, low charged, mononuclear 99mTc-HEDP complexes have the greatest uptake in bone lesions, and the highest lesion to muscle and lesion to normal bone ratios.

Animals↗
PubMed1988

Autoradiographic localization of technetium-99 methylene diphosphonate in growth sites of young mice.

Conflicting reports about the localization of 99mTc-MDP in bone and cartilage are found in the literature. Possible binding sites include hydroxyapatite and non-osteoid matrix such as immature collagen. The present study used autoradiographs of demineralized and non-demineralized growth sites in young mice to demonstrate localization of 99Tc-MDP, and consequently 99mTc-MDP, in mineralizing cartilage and bone. Uptake of the isotope was seen in mineralizing bone and cartilage, associated with the mineral in contrast to the organic phase. The results indicate that bone seeking radiopharmaceutical uptake (BSRU) may detect alterations in the rate of mineralized phase in growth sites and thus has the potential to disclose skeletal growth disorders.

Animals↗
PubMed1988

Nuclear medicine studies of aging--II. Femoral vessel uptake of 99mTc-diphosphonates vs age.

Bone images obtained after use of 99mTc-MDP were examined for activity presumed to be present in the femoral vessels. The criteria for this extraosseous uptake were: present on anterior views of the thighs, located medial to the femurs, extended outward and downward, approximately linear and continuous, and present on both thighs. Each image was graded as zero (not visible), one plus (barely detectable) and two plus (readily visualized). Using the mean age of each grouping (20-29 years depicted as age 25), the percent positive were noted to closely correlate with age. The earliest positive detected was in a 24 year old male; by age 80 years and greater, over 93% of the cases showed 1+ or 2+ activity. In addition, the average score increased linearly with age. These findings were correlated with literature data on femoral artery diameter and stiffness, and with information on aortic calcification.

Adult↗
PubMed2000

[Uptake of 99mTc-diphosphonates due to brain infarction].

The case of a patient who came to the Nuclear Medicine Department for a bone scintigraphy to rule out bone metastasis because of a lung neoplasm is presented. Some days before, the patient had suffered a right brain infarction. 99mTc-MDP uptake could be seen in the infarction area. Different mechanisms of 99mTc phosphates deposition in tissues other than bones are reviewed in this article.

Aged↗