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Results for “Dermatofibrosarcoma”

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PubMed2002

[Repair of skin defect after resection of cutaneous malignant tumor].

OBJECTIVE: To investigate the clinical effects of repairing skin defect after resection of cutaneous malignant tumors. METHODS: From 1984 to 2001, cutaneous malignant tumors of 38 patients were resected and diagnosed pathologically. There were 12 cutaneous squamous cancer, 14 carinal cutaneous fibrosarcomas, 2 in situ cancers, 1 wart like cancer, 4 eczematoid cancers, and 5 deteriorative chronic ulcers. The biggest skin defect was 14 cm x 20 cm in size. Skin defects were repaired with flaps, myocutaneous flaps, free skin grafts and suturations. There were 4 gastronomies flaps, 6 latissimus flaps, 2 tensor fascia lata myocutaneous flaps, 1 transverse recuts abdominis myocutaneous flap, 5 plantaris medialis flaps, 3 random flaps, 12 free skin grafts and 5 suturings. RESULTS: All the operations succeed. Among 21 cases followed up for 3 to 12 years, 19 healed and 2 relapsed, but the 2 patients healed after second operation. CONCLUSION: Thorough resection of tumor is the key to eradicate malignant tumor. The method to repair skin defect after resection should be chosen according to the patients individually.

Adult↗
PubMedDate not supplied

[Epidemiological features of tumors of the skin and mucosal membranes in the department of dermatology at the Yalgado Ouedraogo National Hospital, Ouagadougou, Burkina Faso].

We conducted a retrospective study of the files of all patients seen from 1 January 1992 through 31 December 1996 with tumors of the skin and mucosal membranes at the Yalgado Ouédraogo National Hospital in order to determine the epidemiologic features of this disease. The records revealed 988 patients presented 1024 tumors, which could be classified into 33 categories. Most of the patients (60.6%) were in the age bracket of 20 to 39 years. Nearly all cases (988 or 96.5%) were benign skin tumors, mainly of infectious origin, especially viral (51.7%). We observed a substantial number of sexually transmissible infections, such as condylomata. We also found 36 cases (3.5%) of malignant tumors, including 29 cases of Kaposi sarcoma, five skin carcinoma (13.8%), three spinocellular and two basocellular; we also noted two borderline malignant tumors: a dermatofibrosar-coma protuberans and a nodular hidradenoma. The elevated prevalence of condyloma (151 cases) may explain the predominance of the 20-39 year age group, which is the most sexually active. Our series also confirmed the relative rarity (3.5%) of cutaneous cancers among African blacks. The predominance of Kaposi sarcoma may be explained by the high prevalence of HIV infection in our country.

Adolescent↗
PubMed2003

[Detection of COL1A1/PDGFB fusion transcripts in dermatofibroscoma protuberans by revers transcriptase-polymerase chain reaction using paraffin-embedded tissues].

OBJECTIVE: To detect the COL1A1/PDGFB fusion transcripts and discuss its clinicopathological significance in dermatofibroscoma protuberans. METHODS: Formalin fixed, paraffin-embedded tumor specimens from 12 patients with DFSP were reviewed by light microscope and the expression of COL1A1/PDGFB mRNA resulting from the reciprocal translocation t(17;22) (q22;q13.1) was detected by one-step revers transcriptase-polymerase chain reaction. The following tumor specimens were included as controls: 2 fibrosarcoma, 2 malignant fibrous histocytoma, 3 leiomyosarcoma, 1 dermarofibroma and 1 nerve shealth tumor. RESULTS: The COL1A1/PDGFB fusion transcripts were detected in 8 (67%) of 12 samples from patients with DFSP. Nucleotide sequence analysis using the PCR products confirmed that different regions of the COL1A1 gene, respectively, were fused with of PDGFB gene. No COL1A1/PDGFB fusion transcripts were detected in the control tumors. CONCLUSION: Detection of specific COL1A1/PDGFB fusion transcripts in DFSP will help to diagnose the nature of DFSP and research the mechanism of its molecular histogenesis.

Adolescent↗
PubMed2004

[The analysis of different treatment methods for 184 cases of soft tissue sarcoma].

OBJECTIVE: To study the proper way of using combined postoperative chemo-radiotherapy and prognostic factors of soft tissue sarcoma. METHODS: The clinical data of 184 patients were retrospectively reviewed. These patients were devided into surgery group (S, 94 patients), surgery plus postoperative radiotherapy group (S + R, 62 patients) and surgery plus chemotherapy group (S + C, 28 patients). RESULTS: The 5-year survival rates of S, S + R and S + C groups were 39.4%, 48.4% and 28.6%, respectively. Combined multitherapy was the key to improve survival rate and life quality. Clinical stage, pathological type and therapeutic method were also important prognostic factors for the long term survival. CONCLUSION: Surgery plus postoperative radiotherapy can improve the 5-year survival rate of soft tissue sarcoma.

Adolescent↗
PubMed2005

[Prognostic factors and treatment of 74 patients with dermatofibro-sarcoma protuberans].

OBJECTIVE: To analyze treatment and prognostic factors of 74 patients with dermatofibro-sarcoma protuberans (DFSP). METHODS: From August 1990 to November 1999, 74 patients with DFSP confirmed pathologically were treated. There were 52 males and 22 females with a median age of 37 years (range 4 to 80 years) on diagnosis. Seventeen patients were treated by extensive excision and 2 by limited excision. Fifty-two patients had surgical resection alone (S), and 22 postoperative radiotherapy (S + R) of 50-70 Gy. The multivariate parameters were analyzed using Cox model. Kaplan-Meier and Log-Rank test were used to evaluate the results of the recurrence-free survival. RESULTS: The rate of recurrence was 28.4% for all patients. The 5-year recurrence-free survival rate (RFSR) was 66.6% and the 10-year RFSR was 52.5%. The 5-year and 10-year in the S group were 58.4% and 41.2%, compared with 90.0% and 83.3% in the S + R group (P < 0.05). The 5-year and 10-year RFSR in the pathologically positive margin group were 57.5% and 41.4% respectively, compared with the 75.0% and 56.6% in the pathologically negative group (P < 0.05). Multivariate analysis suggested radiotherapy and negative pathological margins were favorable prognostic factors. CONCLUSION: Post-operation radiotherapy and pathological margin are the independent prognostic factors.

Adolescent↗
PubMed2005

Bednar tumor.

Explore the source record for details and available documents.

Dermatofibrosarcoma↗
PubMed1994

Nuclear morphometry of soft tissue tumors of fibrous origin.

In this study we investigated the diagnostic significance of a set of different morphometric nuclear parameters in the differential diagnosis of soft tissue tumors. Nuclear area, the standard deviation of the nuclear area, the shape factor and other parameters such as Feret's Diameter and Martin's Radii were assessed using a computer assisted image analyzer system. A statistically significant difference (p < 0.01) between benign and malignant tumors and tumor-like lesions could be confirmed for the nuclear area and the standard deviation of the nuclear area, with the significance level being lower (p = 0.5) for the latter parameter. The shape factor also discriminated between the examined groups. Reclassification of the assessed histological diagnosis was performed by linear discriminant analysis using all possible combinations of the different nuclear parameters. This procedure disclosed an increasing rate of correctly reclassified cases with rising number of parameters applied. We conclude that the assessment of nuclear parameters may be helpful in the correct diagnosis and differential diagnosis of soft tissue tumors and tumor-like lesions of fibrous origin.

Cell Nucleus↗
PubMed1996

Giant cell fibroblastoma: a case report.

A one-year-old girl with a giant cell fibroblastoma (GCF) of the skin in the left arm is described. The tumor presented as a small, asymptomatic, subcutaneous mass that enlarged relatively slowly. GCF is a rare mesenchymal tumor occurring predominantly in young children. Its unique histopathological feature can lead to a misdiagnosis as sarcoma very easily. We review briefly the clinical and pathological information of 68 documented cases in the literature and discuss the pathogenesis of this peculiar neoplasm.

Dermatofibrosarcoma↗
PubMed1996

Caudal trapezius composite island flap for extensive shoulder defects.

The trapezius composite flap was first described by Demergasso in 1979 (2). The caudal trapezius island flap was described by Mathes and Nahai (4), in head and neck cancer reconstruction. Baek and Biller (1) described the descending branch of the transverse cervical artery, as a dominant blood supply. It is an useful flap for the reconstruction of defects around shoulder, neck and cheek regions. The anatomy of the trapezius muscle, its blood supply, vascular territories and its function is described in brief. Use of this flap in the reconstruction of compound extensive tissue defects in shoulder region of our patient is presented.

Adult↗
PubMed1996

[Primary orbital tumors in children].

We present the incidence, diagnosis and clinical picture of the primary orbital tumors in children. They were treated in ENT Clinic CM UJ in Kraków between 1981-1990 years. Discovered was preponderance of primary non malignant tumors. The most frequently encountered tumors were dermatomas, angiomas and among the malignant tumors-rhabdomyosarcoma.

Child↗
PubMed1996

Renaut bodies. Benign disease process mimicking neurotropic tumor infiltration.

BACKGROUND: Mohs micrographic surgery maximizes the potential for complete tumor removal with normal tissue preservation through the histologic examination of all tissue margins. One component of the histologic examination is the evaluation of excised nerves for the presence of tumor infiltration. During such an evaluation, a subperineurial structure was noted. OBSERVATION: Further investigation displayed a discrete, loosely textured, cell-sparse, whorled, subperineurial structure that invaginated into the peripheral nerve. Inflammation was absent and the nuclei were monomorphous. These findings are those seen with Renaut bodies. CONCLUSIONS: Renaut bodies are found at sites of nerve compression. Mechanical factors are thought to play a major role in pathogenesis. Cells comprising the Renaut body are fibroblasts of perineurial origin with the extracellular matrix comprised of collagen fibrils, basal lamina material, and oxytalan filaments. Renaut bodies are important insofar as the surgeon must recognize that they are benign. Histologic characteristics that differentiate Renaut bodies from malignant neurotropic infiltration are: (a) a cell-sparse mass, (b) absence of nuclear atypia, (c) less than expected inflammatory infiltrate, and (d) well-defined borders.

Actin Cytoskeleton↗