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[Effect of phosphemide on the glycogen content in the organs of white rats].

Tests on albino rats brought evidence that the antineoplastic drug phosphemide, administered to the animals in doses of 10 mg/kg daily for 7 days reduces the glycogen content in the liver on the 5th day of investigation. In the heart, skeletal muscles, kidneys and spleen no changes in the glycogen were noted. Phosphemide produced morphological changes in the spleen and kidneys.

Animals↗
PubMed1972

Chemosterilization of Culex pipiens fatigans Wiedemann by exposure of aquatic stages. 3. Induction of dominant lethal mutations in the F 1 generation by certain aziridines, phosphoramides, and s-triazines.

In insects it is known that the chemosterilant treatment induces dominant lethal mutations which bring about embryonic death. The possibility of delayed expression of the chemosterilant-induced dominant lethals in F(1) progeny of the tropical house mosquito, Culex pipiens fatigans Wiedemann has been investigated. The chemosterilants employed were 8 aziridinyl compounds, 3 phosphoramides, and 4 s-triazines. In general, all the chemosterilants tested were found to cause different degrees of mortality at different life stages of the F(1) progeny. In this respect the aziridinyl compounds were more effective than the phosphoramides and s-triazines. This effect of the chemosterilants may be useful in the sterile-male technique.

Animals↗
PubMed1979

[Effect of the alkylating agent dipin on the induced proliferation of hepatocytes. I. The kinetics of the cell population].

The alkylating drug dipin was injected to mice 2 hours before a partial hepatectomy. Liver regeneration was characterized by a decrease of the intensity of 3H-thymidine label, an increase of the labeled cell index, absence of mitoses, constant number of binuclear cells. The analysis of these data has shown that dipin causes a sharp (more than by 2 times) increase of the S-period and prolonged (up to 6--20 days) blocking of cells in the G2-period. No phenomenon of unbalanced growth was recorded. No changes in duration of prereplicative period, or in the volume of proliferative pool were recorded. The increase of mitotic cycle periods resulted in the cell population synchronization: by the end of the second ay more than a half of hepatocytes were in S-period, by the end of the third day about 80% of cells passed to G2-period.

Alkylating Agents↗
PubMed1979

[Effect of the alkylating agent, dipin, on induced hepatocyte proliferation. II. An increase in the DNA synthesis period].

The alkylating drug dipin was injected to mice 2 hours before a partial hepatectomy. The duration of DNA synthesis of proliferating hepatocytes was determined by means of cytophotometry of DNA mass in the nuclei, labeled with 3H-thymidine 30 hours after the operation. The DNA mass was doubled simultaneously in diploid and tetraploid nuclei within 18-26 hours. The DNA in labeled nuclei of the control mice was doubled in 8 hours. The kinetics of 3H-thymidine incorporation at different stages of S-period was similar in alkylated and normal cells.

Alkylating Agents↗
PubMed1979

Potentiation of anticancer effect of carboquone in vivo by glucose pretreatment.

Anticancer effect of carboquone was notably potentiated in tumor-bearing mice when they were pretreated with 5% glucose solution in the system of blood flow-interrupting hyperthermic chemotherapy. It was further found by quantitative analysis that the potentiation was much greater than increase in the general toxicity of the drug by administration of glucose. Mitomycin-C, on the other hand, revealed no such marked effect though it is considerably similar to carboquone in chemical structure.

Animals↗