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PubMedDate not supplied

Age and sex related levels of albumin, ceruloplasmin, alpha 1 antitrypsin, alpha 1 acid glycoprotein, and transferrin.

Serum levels of albumin (alb), ceruloplasmin (Cp), alpha 1-antitrypsin (AT), alpha 1-acid glycoprotein (AGP) and transferrin (Tf) were quantitatively determined by electroimmunodiffusion in 50 normal men and 75 normal women of varying ages. Alb, Cp and Tf are carrier proteins, AT is a protease inhibitor, and AGPs are acute phase reactants, with protective functions in inflammation. Subjects were grouped as follows: 20 to 44 years, 45 to 54 (an average statistical age at menopause +/- 5 years), and over 55. Differences related to sex and age were noted. These values are to serve, however, as controls for studies of rheumatic disorders in which sex and age are significant factors in demography.

Adult↗
PubMed1994

Clinical value of fructose 1,6 bisphosphatase in monitoring renal proximal tubular injury.

The usefulness of the gluconeogenic key enzyme fructose 1,6 bisphosphatase (FBPase), which is localized exclusively in the proximal nephron segment, as a marker compound to monitor injury of the proximal nephron segment during nephrotoxic therapy, was tested in a collective model of male patients treated for testicular cancer. These patients with normal kidney function were submitted to therapy with the nephrotoxic chemotherapeutics carboplatinum and a combination of cisplatinum, etoposide, bleomycin and ifosfamide. The release of FBPase activities into the urine was monitored during the initial two treatments over a period of eight days. The urinary enzyme activities measured were compared to the excretion of the "proximal tubular injury markers" N-acetyl-beta-D-glucosaminidase (NAG) and alpha 1-microglobulin (alpha 1m). The presence of glomerular damage was determined by measurement of urinary excretion rates of albumin (ALB) and IgG. In addition, protein excretion patterns following chemotherapy were monitored. The combined administration of cisplatin, etoposide and ifosfamide resulted in a pronounced proximal tubular injury as shown by the release of FBPase into the urine. This is substantiated by simultaneously increased excretion rates for NAG and alpha 1m. Proximal tubular toxicity was found to be less severe when cisplatin was combined with etoposide and bleomycin and was nearly absent following carboplatinum monotherapy. Carboplatinum only affected glomerular function and resulted in an elevated ALB and IgG excretion. From this model investigation it can be delineated that determination of urinary FBPase activities ensures a sensitive and reliable identification of proximal nephron damage.

Acetylglucosaminidase↗
PubMed1994

[Edema-inducing properties of lacidipine, nitrendipine and nifedipine in the spontaneously hypertensive rat].

INTRODUCTION: Clinical studies suggest that lacidipine (LA) is better tolerated than other DHP, in terms of peripheral edema. We evaluated edema due to LA, nitrendipine (NT) and nifedipine (NF) in SHR. METHODS: Mean arterial pressure (MAP) was measured with an intra-femoral probe. Peripheral edema was determined (i) by the plasmatic distribution of 14C-albumin, (ii) by Evans blue extravasation. RESULTS: In bolus(ip), LA, NT and NF had non different effects on plasmatic *ALB, i.e. + 3.9 +/- 1.7 (delta % vs control at 60 min; mean +/- SEM, n = 18). Evans blue extravasation (hind paws muscle = EBM) was positively correlated to MAP reduction (EBM = 0.1 x delta MAP + 5.2; p < 0.025), without differences between the molecules. In chronical administration (9 days), at comparable MAP decreases (31 +/- 2 mmHg), there was less edema formation with LA (0.05 mg/kg/j) than with NT (0.5 mg/kg/j) or NF (1.4 mg/kg/j): the variations of *ALB were respectively (% vs control at 45 min after tracer injection; mean +/- SD): + 5% (n = 10) vs. 73% (n = 14; p < 0.01 vs LA) and + 34% (n = 10; p < 0.01 vs LA); no significant change of hematocrit or plasma volume was noted. CONCLUSION: Our results confirm, in SHR, that lacidipine induces a very moderate edema formation. This does not seem to be due to a renal effect, nor to an effect on peripheral resistances. It was only observed in chronical administration, which suggests that pharmacokinetic properties of lacidipine are involved.

Animals↗
PubMed1995

[Preliminary study on pathophysiology of liver-qi deficiency syndrome].

The authors advocate a program for diagnosing Liver-Qi Deficiency Syndrome (LQDS) based on the TCM theory and clinical practice. Through investigation, LQDS was found to be widely existed as latent period or as external manifestation, which occupied 18.85% in Qi Deficiency Syndrome. The subjects were divided into four groups including normal group, Spleen-Qi Deficiency Syndrome (SQDS) group, LQDS with Liver diseases (LD) and LQDS with non-Liver diseases (NLD) group. In order to explore the essence, the simultaneous determinations were done on lactate dehydrogenase (LDH) and its isoenzyme, dopamine beta-hydroxylase (D beta H), trace element Zn and Cu, and other serological indexes such as GPT, TP, Alb, A/G, etc. The results were, the content of LDH and trace element Zn in both LQDS-NLD and SQDS were significantly lower than that of normal group. D beta H reflecting sympathetic nerve function in LQDS-NLD was significantly higher than that of both normal and SQDS group; comparing LQDS-LD and LQDS-NLD group, the content of GPT, LDH, LDH5 and trace element Cu in former was significantly higher than that of the latter, but the content of TP, Alb, A/G, D beta H and Zn in former was remarkably lower than that of the latter. In order to avoid confusion, in studying this syndrome, one should distinguish LD and NLD.

Adult↗
PubMedDate not supplied

[Changes in liver protein synthesis in the preterm newborn infant of a pre-eclamptic mother and/or with intrauterine growth retardation].

To verify in the preterm newborn the hypothesis, recently proposed by some authors, of an hepatosynthetic deficiency, blood fibrinogen (FIB), prothrombin time (PT) and albumin (ALB) levels at birth were studied in 44 neonates, selected to obtain 4 groups of the same number and gestational age, different only for the presence of intrauterine growth retard and preeclampsia during pregnancy. In the newborns born of preeclamptic pregnancies, FIB, PT and ALB blood levels at birth resulted lower, but not significantly, than in those born of normal pregnancies; in SGA newborns the values (except for albumin) resulted significantly lower than in AGA newborns (FIB = 168 +/- 63 mg/dl vs 223 +/- 55 mg/dl; p < 0.01; PT = 51 +/- 15% vs 71 +/- 19%; p < 0.001). Besides, PT values resulted significantly lower (p < 0.01), in presence of normal pregnancy, in SGA than in AGA newborns, while FIB values resulted significantly lower (p < 0.01), in presence of preeclampsia, in SGA than in AGA newborns. It seems that, in preterm newborn, the intrauterine growth retard, rather than preeclampsia, would condition lower blood levels of the examined seric proteins. These results could be explained by hypothesizing, in the SGA preterm newborn, 3 possible etiopathogenetic mechanisms: 1) increased turnover of hepatosynthetized seric proteins, such as albumin; 2) deficiency of liver enzymes involved in proteic synthesis, already demonstrated for some coagulation factors; 3) diminished amino acidic substratum, necessary for proteic hepatosynthesis, caused by poor amino acidic passage through placenta, possible in presence of intrauterine growth retard. This would probably be the most important mechanism in causing low levels of the examined seric proteins.

Adult↗
PubMed1994

Effect of albendazole on the larvae and eggs of Necator americanus in golden hamster.

When golden hamsters infected with adult Necator americanus were treated ig with albendazole(Alb) 75 or 150 mg/kg, the efficacy rates were 83.8% and 100%, respectively. Three days before treatment, the mean numbers of larvae recorded from the incubation of feces from 2 treated groups were 29,716 +/- 3,299 and 28,256 +/- 118 per gram of feces, while in the control group, it was 8,828 +/- 2,659. Within 3 days after treatment, no larva was detected in the 2 treated groups, but in the control group the mean larva number was 9,066 +/- 7,416. Furthermore, in 2 treated groups none or only a few degenerated eggs could be found using saturated saline solution method. when infected golden hamsters were treated ig with Alb at a single dose of 150 or 300 mg/kg on day 3, 7 or 14 after infection with the third stage larvae, the egg positive rates in the feces were 0-9.1%, while the worm reduction rates were 96.8-100%.

Albendazole↗
PubMed1994

[Effects of long-term application of bunazosin hydrochloride eye drops on the aqueous flow rate and blood-aqueous barrier permiability in rabbit eyes].

We investigated the effects of long-term instillation of bunazosin hydrochloride--alpha 1 specific adrenergic antagonist--on the aqueous humor dynamics and blood-aqueous barrier in rabbit eyes. We examined intraocular pressure, aqueous flow rate, and blood-aqueous barrier permiability for albumin after four weeks application of 0.05% bunazosin. The effect of bunazosin on blood-aqueous barrier destruction by laser iridophotocoagulation was also examined. During four weeks, bunazosin reduced the intraocular pressure by 1.7 +/- 0.6 mmHg (mean +/- SEM). Continuous application of bunazosin had no significant influence on aqueous flow rate and fluorescein isothiocyanate-labeled rabbit albumin (FITC-Alb) concentration in the anterior chamber. Bunazosin had no effect on the rise of the FITC-Alb concentration after iris photocoagulation, but the intraocular pressure in bunazosin treated eyes was significantly lower than in control eyes one hour after photocoagulation.

Adrenergic alpha-Antagonists↗
PubMed1994

Oxidant exposure stimulates cultured coronary artery endothelial cells to release 15-HETE: differential effects on PGI2 and 15-HETE synthesis.

Oxidant stress to the endothelium is an important component of inflammatory processes involved in the pathogenesis of ischemic/reperfusion injury. The effects of acute oxidant exposure on cultured bovine coronary artery endothelial cell (BCA) functions including arachidonic acid metabolism, permeability, tissue factor expression, and viability were assessed after exposure of cells to the hydrogen peroxide-generating system of glucose-glucose oxidase (GO). GO markedly stimulated the synthesis of the arachidonic acid metabolites 15-hydroxyeicosatetraenoic acid (15-HETE) and prostacyclin (PGI2). Both sublethal and lethal concentrations of GO increased 15-HETE release from BCAs by as much as 15-fold. In contrast to 15-HETE, enhanced PGI2 synthesis occurred at concentrations of GO that did not injure the BCA monolayers, whereas lethal doses of GO had no stimulatory effect on PGI2 production. Moreover, the sublytic oxidant-induced stimulation of PGI2 synthesis in BCAs (50-fold) was significantly greater than that induced by other mediators or that observed in parallel studies with human umbilical vein endothelial cells. In vitro endothelial cell barrier function was determined by measuring iodine 125-labeled albumin clearance across confluent cell monolayers. GO increased cellular permeability in a concentration-dependent manner, although statistically significant increases were only observed at the highest (i.e., lethal) concentrations (C(alb) = 0.840 +/- 0.16 with 1.0 U/ml GO vs C(alb) = 0.24 +/- 0.02 in control cells). Finally, oxidant exposure did not induce BCA tissue factor activity at any concentration examined. These results suggest that oxidant exposure, as might occur during ischemic reperfusion, could affect subsequent coronary vascular responses by releasing the arachidonate metabolite 15-HETE, which can cause vasoconstriction as well as attract and activate leukocytes. In addition, oxidants may also modulate vascular reactivity by altering the release of the potent vasodilator and neutrophil modulator PGI2 as lower levels of oxidant generation stimulate its synthesis, whereas higher levels suppress PGI2 release. Thus the degree of oxidant stress may profoundly affect the endothelial synthesis and release of 15-HETE and PGI2, compounds with antagonist effects on vascular tone and neutrophil activation. Consequently the balance between oxidant-induced production of these mediators by the coronary endothelium may significantly affect the pathophysiology of myocardial ischemia and reperfusion injury.

Animals↗
PubMed1994

[Studies on serum protein fractions of patients with uterine cervical cancer undergoing radiotherapy: relationship between changes in serum protein fractions and prognosis].

The levels of 23 protein components of the sera of 84 patients with uterine cervical cancer undergoing radiotherapy were determined by a single radial immunodiffusion method, before radiation therapy, after whole pelvic irradiation, and after intracavitary irradiation using a remote after roading system (RALS). We examined the correlations between changes in serum protein fractions and the prognosis of the patients. The patients with uterine cervical cancer were treated with combined external irradiation of 60Co gamma-rays or 10 MV X-rays, and RALS therapy. The levels of the same protein components were also measured in 21 normal adult women as a control. All patients were observed between 4 years and 8 years after radiation therapy. In the pretreatment sera obtained from patients with uterine cervical cancer, the concentrations of prealbumin (Prealb), alpha 2HS glycoprotein (alpha 2 HS), alpha 2-plasmin inhibitor (alpha 2PI), transferrin (Tf), plasminogen (Pmg), albumin (Alb), IgM and hemopexin (Hx) were significantly lower than those normal controls. However the serum concentrations of: alpha 1-antichymotrypsin (alpha 1 X), haptoglobin (Hp), C9, fibrinogen (Fib), ceruloplasmin (Cp), alpha 1-acid glycoprotein (alpha 1AG), alpha 1-antitrypsin (alpha 1AT) and C4 were elevated. At the completion of whole pelvic irradiation and RALS therapy, the Hp, C4, and Fib levels were significantly lower than those before radiation therapy, whereas Prealb, alpha 2HS and alpha 2PI were elevated. In patients who had lived between 4 years and 8 years after radiation therapy, the Cp, alpha 1 AG, Hp and C9 levels measured before radiation therapy were reduced significantly, while Tf was elevated compared with patients who died within 4 years. In those who had lived more than 4 years, the alpha 1 AT, Hp, alpha 1X, Cp and C9 levels measured after whole pelvic irradiation were reduced significantly; while the C4 level was elevated. In cases of uterine cervical cancer followed for a period of 4 to 8 years after radiation therapy, multiple regression analysis was used to determine whether increased concentrations of serum protein fractions were associated with good prognosis for the original disease. Tf, Pmg, and alpha 1AT before radiation therapy were positively correlated with survival, whereas AT III, Cp, C1Inh, IgA, alpha 1 AG and C9 showed negative correlations. After whole pelvic irradiation,Pmg, C4 Prealb, Alb,alpha 2M and Hp were found to be positively associated with survival, whereas Tf, alpha 2PI, AT III, alpha 1 AT,C1Inh, C9 and IgA were negative factors.

Adult↗
PubMed1994

[Evaluation of liver function in carbon tetrachloride-damaged rabbits by dynamic SPECT: comparison of 99mTc-GSA and 99mTc-Sn colloid].

Technetium-99m-DTPA-galactosyl human serum albumin (99mTc-GSA) is a new ligand that binds specifically to asialoglycoprotein receptors in hepatocytes. We performed liver dynamic SPECT using 99mTc-GSA and 99mTc-Sn colloid in nine normal control rabbits and 17 chronically CCI4-damaged rabbits (total 29 examinations), and also performed liver function tests (ICGR15, Alb, etc). Using the obtained dynamic SPECT data, we analyzed the liver kinetics of 99mTc-Sn colloid using a one-compartment model (hepatic blood flow [K]) and 99mTc-GSA using a two-compartment model (hepatic blood flow and receptor binding [K1], catabolism [K2]). As the CCl4-treated period increased, K1 decreased most significantly. K1 showed the most significant statistical correlation with the results of liver function tests, ICGR15 (p < 0.0001), Alb, PT, HP, Bil and GPT. Further, only K1 showed a correlation with the hepatic fibrosis of the HAI score. From the present results, liver dynamic SPECT using 99mTc-GSA may be said to provide a novel method for the evaluation of hepatic functional reserve.

Animals↗
PubMed1994

The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domain.

HNF1 and C/EBP alpha are transcription factors that bind to and trans-activate the human albumin gene proximal promoter. Various 5' deletions of the human albumin promoter were coupled to a luciferase reporter gene (alb-luc constructs) and co-electroporated with HNF1 and/or C/EBP alpha expression vectors into HeLa cells. Luciferase activities from co-electroporation of the HNF1 and C/EBP alpha expression vectors with the alb-luc constructs were approximately 10-fold greater than the sum of the activities achieved with HNF1 and C/EBP alpha alone. Analysis of COOH-terminal or internal deletions of the HNF1 expression vector revealed that the domain important for collaborative interaction with C/EBP alpha could be localized to a 157 amino acid region not previously described. This domain is proline and glutamine-rich and is highly homologous (66%) to a portion of vHNF1, an evolutionarily related gene first identified in dedifferentiated hepatoma cells. A construct linking the negatively charged activation domain of herpes simplex virus protein VP16 to the DNA-binding domain of HNF1 showed that it could also synergize with C/EBP alpha to trans-activate the human albumin gene promoter. Our studies delineate a domain in HNF1 important for synergistic activation with C/EBP alpha.

Albumins↗
PubMed1993

Urinary calcium and renal function in the Japanese female population.

The Japanese have not reached the recommended daily allowance (RDA) for calcium (Ca, 600 mg/day), they are a Ca-deficient population. To determine factors influencing urinary Ca (U-Ca) in the Ca-deficient female population, age, body mass index (BMI), drinking habits, smoking habits and Ca intake were surveyed, and urinary albumin (U-Alb) and retinol binding protein (U-RBP) as renal function tests were analyzed in 210 Japanese females aged 24-76 years. The mean Ca intake for the subjects was 542.8 mg/day, which was less than the RDA for Ca. A significant positive correlation was found between U-RBP and U-Ca, but neither age, BMI, drinking habits, smoking habits, Ca intake nor U-Alb would affect U-Ca in the subjects. In a Ca-deficient status, a proximal tubular dysfunction may be a significant factor increasing Ca loss in urine, and may be a risk factor for osteoporosis.

Adult↗
PubMed1993

Quantification of adequacy of peritoneal dialysis.

Nineteen patients treated by continuous ambulatory peritoneal dialysis (CAPD) were studied according to clinical outcome parameters: insomnia, asthenia, pruritus, arterial hypertension, anorexia, nausea and/or vomiting, anemia, and rate of hospitalization. Using clinical scores, three groups were defined: poor clinical outcome (P), intermediate (I), and good (G). The quantity of treatment by PD was evaluated monthly with urea kinetic tests (weekly Kt/V, weekly urea clearance/1.73 m2 of body surface area (BSA), index of dialysis by Teehan), and with the weekly creatinine clearance/1.73 m2 of BSA. The metabolic index was analyzed: normalized protein catabolic rate (NPCR), serum albumin (Alb) and prealbumin, and reabsorption of glucose. There was good correlation between clinical scores and quantity of dialysis. The Alb was lower in group P. Group G was differentiated from group I and from group P by quantification tests and NPCR, with lower levels as follows: weekly Kt/V = 2.06, urea clearance 70 L/week/1.73 m2, index of dialysis = 0.87, and creatinine clearance = 60 L/week/1.73 m2. We conclude that the qualitative clinical approach is not sufficient to predict deleterious signs, and the quantitative approach is predictive of the good clinical outcome and good nutritional status. We think that levels proposed to now are insufficient, and we suggest the following: weekly urea clearance > 70 L, weekly Kt/V > 2, weekly creatinine clearance > 60 L, and index of dialysis > 0.85.

Adult↗
PubMed1993

[Natural killer cell activity in severely handicapped children: correlation with malnutrition and frequent infections].

We studied natural killer cell (NK) activity in 20 severely handicapped children and investigated the relationship between NK activity and malnutrition. We divided our patients into two groups with regard to frequency of infections: high frequency group (group 1) and low frequency group (group 2). NK activity in group 1 was low in comparison with group 2. Calorie intake and Rohrer's index were lower in group 1. Serum albumin (Alb) and iron (Fe) in group 1 were also lower than those in group 2, and serum zinc (Zn) and hemoglobin (Hb) were slightly lower in group 1. NK activity was positively correlated with calorie intake, Alb, Zn and Hb. Six patients with low NK activity were given supplementary diet; two patients were given protein-enriched diet; three patients were given protein-enriched diet and zinc sulfate; one patient was given increased diet. NK activity rose in 4 patients. These results indicated that the depression of NK activity was associated with frequent infections and correlated with nutritional conditions of the severely handicapped children.

Adolescent↗
PubMed1993

[Permanent hemispheric pain syndrome due to traumatic cortico-subcortical lesions in the left hemisphere].

Pain due to cortical-subcortical lesions may be paroxystic or permanent. The latter may be strictly similar to that derived from the selective involvement of the thalamic ventroposterior nucleus. We report a 21 year-old right handed patient who in a cranial-encephalic injury had a counter-stroke lesion of the left parietal-temporal-frontal region, demonstrated by magnetic resonance imaging (MRI), and who remained in coma for 2 weeks. At 6 weeks the patients began to have continuous burning algias in the right hemisome with hyperpathy, allodynia, etc., with exacerbations. Treatment attempted to elevate the levels of brain serotonin was followed by partial improvement. Likewise, the patient presented certain aphasic disturbances and showed different coordination synkinesis, etc., of the right side. The somato-sensitive evoked potentials (PE) were normal. A review of the literature is undertaken emphasizing the rarity with which algic pictures by cortical-subcortical lesions appear in lesions of the dominant hemisphere. Special emphasis is made in the concept of "deafferentation", particularly developed during the last decade (Albe-Fessard, Tasker, Leijon, Boivie). Following the suggestions of Albe-Fessard, the possibility of a central algogenic mechanism by "retrograde" deafferentation (interference in the thalamic-cortical loops) of the median thalamus (unspecific nuclei or of diffuse projection) as a consequence of the cortical-subcortical lesion (of an outstanding form, probably of the parietal operculum) is suggested.

Adult↗
PubMed1996

[The evaluation of therapeutic effect on partial splenic embolization (PSE) for liver cirrhosis patients].

Partial splenic embolization (PSE) was performed on fifty cases with liver cirrhosis underwent no therapy. We evaluated changes of platelet count, ICGR15, GPT and Child-Pugh score which were significantly recovered by PSE. About liver cirrhosis before PSE, K.ICG, GPT, Alb, platelet count and splenic volume were selected as total characteristic factors by principal component analysis. We showed predicting formulas after PSE by multiple regression analysis between five factors selected by principal component analysis and platelet count, HPT, PT, Alb, ICGR15, K.ICG, GOT, GPT and Child-Pugh score after PSE. In conclusion, it is suggested that PSE is useful for recovering of platelet count and liver function. We made it possible to estimate therapeutic effect by predicting formulas before PSE.

Aged↗
PubMed1996

Prevalence of hyperlipidemia in a cohort of CAPD patients. Italian Cooperative Peritoneal Dialysis Study Group (ICPDSG).

An association between hyperlipidemia and cardiovascular disease is well described in the literature. We conducted an observational study in order to evaluate the lipid profile, the prevalence of hyperlipidemia and its relationship with age, sex, duration of CAPD, peritoneal glucose load (PGL), serum albumin (ALB), serum glucose (GLU), and BMI in a large cohort of uremics undergoing long-term treatment with CAPD. 457 nondiabetic patients (245 males, 212 females; mean age 63.8 +/- 11.9 years; mean duration of CAPD: 41.8 +/- 26.9 months) treated during 1992 in 25 centers participating in the Italian Cooperative Peritoneal Dialysis Study Group (ICPDSG) were studied. The serum lipid parameters evaluated were triglycerides (TG), total cholesterol (CHO), HDL-cholesterol (HDL). Indications given in the New England Journal of Medicine, SI Unit Conversion Guide, 1992, were adopted for normal ranges. In the whole population the evaluation of lipid parameters showed: TG 227.4 +/- 123.3 mg/dl, CHO 232.8 +/- 56.0 mg/dl, HDL 40.7 +/- 12.0 mg/dl. No differences were found between the two sexes with regard to age, BMI, duration of CAPD, distribution of renal diseases, TG, ALB, and GLU; whereas CHO and HDL were significantly lower in males than in females (CHO: 222.2 +/- 53.5 vs. 245.0 +/- 56.5 mg/dl, p < 0.001; HDL: 39.3 +/- 11.4 vs. 42.6 +/- 12.6 mg/dl, p < 0.05). The prevalence of hypercholesterolemia was significantly lower in males than in females (19.7 vs. 35.4%; p < 0.001). The multiple regression analysis indicated that TG were directly correlated to PGL (p < 0.05), and HDL was inversely correlated with TG (p < 0.001). The coexistence of the two variables (TG and HDL) may increase the risk of cardiovascular events. Further strategies should therefore be developed to select and manage CAPD patients to reduce the incidence of hyperlipidemia.

Blood Glucose↗
PubMed1996

[Microproteinuria and circadian rhythm of blood pressure in patients with arterial hypertension].

Microproteinuria is a recognized sign of early nephropathy in the course of arterial hypertension. There is few data concerning the excretion of proteins other than albumin in this group of patients. The aim of the study was to examine circadian rhythm of alfa-l-microglobulin (AlMG), albumin (ALB), immunoglobulin G (IgG) excretion and N-acetyl-beta-glukosaminidase (beta NAG)-activity, then to compare the results with the results of 24 hour ambulatory monitoring of arterial blood pressure in patients with arterial hypertension. The study comprised 28 patients. The control group included 27 healthy volunteers. Albumin concentration was determined by Beckman ICS2 nephelometer, using Beckman and Dako reagents. Blood pressure and ECG were monitored by analysis with ABP-system (AMP-USA). In patients with arterial hypertension significantly higher levels of ALB, AlMG, IgG and increased beta NAG activity were observed in morning urine samples. Despite hypotensive treatment blood pressure values were slightly, though significantly higher than in the control group. Among patients in the study circadian BP rhythm was disturbed. The results obtained suggest that in this group of patients subclinical nephropathy develops involving renal glomeruli and proximal tubules--probably resulting from vascular and humoral disorders, with accompanied hypertension.

Acetylglucosaminidase↗