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[Morphofunctional changes in the thyroid gland of golden hamsters during acclimatization to a temperature of 4 degrees C].

Morphological and physiological peculiarities of the thyroid gland have been studied in the golden hamster (Cricetus auratus W.) exposed to prolonged acclimation at +4 degrees C. These heterothermal rodents, kept constantly under laboratory conditions at +18-+20 degrees, show no distinct seasonal changes in the thyroid activity. As demonstrated by morphological findings, a relatively high activity of the gland persists throughout the whole year. At a prolonged acclimation to cold (up to 3 months, +4 degrees), the thyroid activity increases both in golden hamster, and in homothermal rats. Morphological indices of the hyperactivity are as follows: hypertrophy of the gland occurring by the 20th--30th days of exposure and increasing since then; hyperplasy of the granular tissue; colloid vacuolation; strong vessel hyperemy. However, the size of cells is not increased as are likely to retain a partial activity which is evidenced by the presence of tracks. Intensification of the thyroid function is also expressed by the increase in 131(uptake and output rates as well as by the increase in the protein bound iodine content in the blood of hamsters. Changes of the thyroid gland in acclimated animals occur independently of the season and photoperiod. It is shown that the degree of adaptation to prolonged action of cold, is more pronounced in golden hamsters than in rats. It has been also demonstrated that golden hamsters tend to hibernate after a prolonged cold acclimation.

Acclimatization↗

[Effect of cold acclimatization on acid peptide hydrolase activity in lysosome enriched fractions of rat brain and liver tissue].

On the 3rd day of cold acclimation (2 degrees-4 degrees C) membrane destabilization occurs in the rat brain followed by enzyme outflow from lysosomas into citoplasm. On the 15th day the enzyme activity returned to control level, whereas on the 30th and 45th days this activity enhanced in lysosomic fraction and declined in the supraprecipitate fraction. By the moment of adaptation (the 45th day) stabilization of lysosomic membranes occurred. The membrane destabilization also took place in the liver. Stabilization of the lysosomic membranes occurred at the moment of the animals coming out of stress state.

Acclimatization↗