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At least 973 records · Page 54Linked to original sources
PubMed2002

Recent development on computer aided tissue engineering--a review.

The utilization of computer-aided technologies in tissue engineering has evolved in the development of a new field of computer-aided tissue engineering (CATE). This article reviews recent development and application of enabling computer technology, imaging technology, computer-aided design and computer-aided manufacturing (CAD and CAM), and rapid prototyping (RP) technology in tissue engineering, particularly, in computer-aided tissue anatomical modeling, three-dimensional (3-D) anatomy visualization and 3-D reconstruction, CAD-based anatomical modeling, computer-aided tissue classification, computer-aided tissue implantation and prototype modeling assisted surgical planning and reconstruction.

Animals↗
PubMed1995

Prevention of mandibular fractures by using constructional design principles. I. Computer simulation of human mandibular strength after segmental resections.

A study was carried out on mechanical stress at the resection site in mandibles undergoing segmental resections. A computer simulation model was used to study particularly the effect of various radii of the posterior resection corners and the effect of elimination of muscle action. It was found that an enlarged radius of the resection corner in conjunction with coronoid process resection on the ipsilateral side offers the best condition to prevent fracture of the mandible.

Biomechanical Phenomena↗
PubMed1999

Computer-Aided Reaction Design. Development of a New Facile Procedure to Synthesize 2-Mercapto-3-alkoxycarboxylate on the Basis of ab Initio Molecular Orbital Calculations.

This paper describes a new facial procedure to substitute a tosyloxy group in 2-(tosyloxy)alkanoate with SH(-) to yield 2-mercaptoalkanoate on the basis of ab initio MO calculations. Combination of substrate and solvent effects can control both reactivity and selectivity of reaction for 2-(tosyloxy)-3-alkoxycarboxylic acid which gave 2-mercapto-3-alkoxycarboxylic acid in good yield while its ethyl ester gave alpha,beta-unsaturated carboxylate ester as a main product. The difference of carboxylate moiety in the substrate causes remarkable change in reactivity and selectivity. To clarify origin of the difference, ab initio MO calculations in the gas phase and in DMF have been carried out. The solvent effect was considered at RHF/6-31+G with the IPCM-SCRF model. It was confirmed that the substrate with an ester fragment prefers the E1cB to the S(N)2 mechanism. In the transition state of the S(N)2 mechanism with a carboxylate ion fragment, the nucleophile SH(-) locates far from the reaction center due to the electrostatic repulsion between the COO(-) fragment and SH(-). This repulsion causes high activation barrier in the gas phase while polar solvent can reduce the barrier height. Therefore, reaction conditions can control reactivity of carboxylic acid. On the basis of analysis of the MO calculations, subsequent experiments were designed for a new dianion system to synthesize 2-pyrimidinylthio carboxylic acid from 2-tosyloxy carboxylate. We succeeded in developing a new facile method that the two reactions for thioether carried out in a one-pot procedure in excellent yield.

Journal Article↗
PubMed1992

Respirator performance rating table for mask design.

The ultimate goal for respirator mask designers is computer-aided design. Mask design, however, is a very complex operation, with many different interrelationships. Current knowledge does not allow significant incorporation of physiological information into mask design. Rather, physiological information is usually gathered during mask evaluation, after the design process has been completed. The Performance Rating Table (PRT) is a beginning step to formulating physiological knowledge in a way that can be useful for design. The PRT organizes physiological knowledge to assign performance data to various mask and level of work causes. Best estimates of tabled values were obtained from the literature.

Body Temperature Regulation↗
PubMed2001

A cognitive approach for designing a computer-based learning tool in dentistry: ODONTOS application.

This work emphasises a cognitive approach to build ODONTOS, a computer-based education system in dentistry. It aims at providing for both instructors and students without any particular knowledge in computer programming; a tool dedicated to dental disease learning. For instructors, it implements for knowledge construction e.g. creating and proposing clinical cases according to student learning style, using multimedia technology. For students it is a tool, which privileges their learning style in order to solve uniform and inflexible learning problem. World Wide Web (WWW) technology has allowed us to offer flexible learning program without any pressure of time and place to student. 13 instructors and 84 students tested the ODONTOS prototype via Internet and answered to the questions related to their habit regarding learning style for the students and knowledge construction for the instructors. Although video data have emerged as an important learning support for the students (82 out of 84), their use in knowledge construction still remains unusual comparative with the use of text and picture (10 out of 13 instructors). It appears that, the integration of video data should be more used by instructors (2 out of 13) while textual data are overwhelmingly used in knowledge construction (13 out of 13). We introduce ODONTOS, and discuss the concrete contributions of this work.

Cognition↗
PubMed1989

Evaluation of a phenytoin dosage regimen design and adjustment computer program.

A computer program for phenytoin (PHT) dosing was developed containing seven different menus: two for drug-naive patients, one using an empirical equation, the other using means for Vmax and Km; two for patients in whom either one or two dose rates and steady-state concentrations are available; two for patients with hypoalbuminemia, and uremia, respectively; and one menu that optimizes Vmax and Km from available steady-state concentrations. The program accepts or converts PHT and sodium PHT, and makes blood level correction for the concomitant administration of 25 different drugs. The evaluation of the program was done by retrospective analysis using data from three study pools: group I involved 47 patients from the University Hospital, group II relied upon 29 patient data supplied from a collaborative Veterans Administration study, and group III involved 26 patients from the Children's Hospital. Predictions were made and compared with found data to be within a range of +/- 15, 20, or 25%. For study group III, many individual blood samples were less than 8 micrograms ml-1; hence, saturation kinetics may not have been involved. It is suspected that saturation kinetics in infants may begin at higher levels. Compliance seems to still be a major problem in PHT monitoring and dosage regimen adjustment. Accepting the data as they are, using one or two dose rates with the corresponding blood concentrations resulted overall in 73-86% achieving blood levels within +/- 25% of the predicted value.

Adolescent↗