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At least 973 records · Page 54Linked to original sources
PubMed2003

Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001.

Exposures to doses of radiation of 1-10 Gy, defined in this workshop as moderate-dose radiation, may occur during the course of radiation therapy or as the result of radiation accidents or nuclear/radiological terrorism alone or in conjunction with bioterrorism. The resulting radiation injuries would be due to a series of molecular, cellular, tissue and whole-animal processes. To address the status of research on these issues, a broad-based workshop was convened. The specific recommendations were: (1) RESEARCH: Identify the key molecular, cellular and tissue pathways that lead from the initial molecular lesions to immediate and delayed injury. The latter is a chronic progressive process for which postexposure treatment may be possible. (2) Technology: Develop high-throughput technology for studying gene, protein and other biochemical expression after radiation exposure, and cytogenetic markers of radiation exposure employing rapid and accurate techniques for analyzing multiple samples. (3) Treatment strategies: Identify additional biological targets and develop effective treatments for radiation injury. (4) Ensuring sufficient expertise: Recruit and train investigators from such fields as radiation biology, cancer biology, molecular biology, cellular biology and wound healing, and encourage collaboration on interdisciplinary research on the mechanisms and treatment of radiation injury. Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public.

Animals↗
PubMed2005

Evaluating the safety of new vaccines: summary of a workshop.

Public concerns about the safety of vaccines arise on a regular basis. In November 2000, a workshop titled "Evaluation of New Vaccines: How Much Safety Data?" was convened by US Public Health Service agencies, including the Food and Drug Administration, the National Institutes of Health, the Centers for Disease Control and Prevention, and the Health Resources and Services Administration, to discuss appropriate methods for evaluating the safety of new vaccines. Workshop presentations addressed the current standards and approaches for new vaccine evaluation and postlicensure surveillance, as well as public views about vaccine safety and alternative approaches that could be considered. The advantages and disadvantages of conducting large controlled trials before licensure or widespread use of a new vaccine were discussed. We summarize these presentations and discussions.

Child↗
PubMed1999

The Abuela Project: safe cheese workshops to reduce the incidence of Salmonella typhimurium from consumption of raw-milk fresh cheese.

OBJECTIVES: A multiagency intervention was implemented in Yakima County, Wash, to reduce the incidence of Salmonella serotype Typhimurium infections resulting from eating queso fresco (fresh cheese) made from raw milk, a traditional food in the Hispanic diet. METHODS: A pasteurized-milk queso fresco recipe with taste and texture acceptable to the Hispanic community was developed. Trained Hispanic volunteers conducted safe cheese workshops, which were attended by more than 225 persons. RESULTS: Workshop participants' acceptance of the new recipe was excellent and positive behavior changes were maintained over 6 months. CONCLUSIONS: Educational interventions in Hispanic communities can reduce the incidence of Salmonella Typhimurium associated with eating queso fresco.

Adolescent↗
PubMed1992

Improved specificity of ICA assays in the Fourth International Immunology of Diabetes Serum Exchange Workshop.

The goal of the Fourth International Workshop for Standardization of ICA Measurements was to determine the specificity of ICA assays and their ability to distinguish between control sera (n = 57) and sera from IDDM-related individuals--representing relatives of IDDM patients (n = 21), healthy individuals who later developed IDDM (n = 8), or newly diagnosed IDDM patients (n = 23). Results from 28 laboratories were analyzed. The mean specificity (percentage of control sera reported as negative) among 27 laboratories was 91%, including 6 laboratories with 100% specificity. Nevertheless, 78% of laboratories found at least one control sample > 0 JDF U. Among samples from first-degree relatives, the mean concordance was 86%, including three sera found negative (0 JDF U) by all laboratories. Among individuals who later developed diabetes, the mean concordance was 93%, with two sera found positive by 100% of laboratories. In sera from newly diagnosed IDDM patients, the mean concordance was 82%. Three sera were found positive and one serum negative by all laboratories. The JDF U of the sera considered to be positive were significantly greater than each laboratory's average for the controls. In conclusion, the results from laboratories participating in the Fourth International ICA Workshop demonstrated excellent specificity, good concordance, and an ability to separate control sera from defined, IDDM-related subjects.

Animals↗
PubMed2001

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.

Several self-antigens have been reported as targets of the autoimmune response in nonobese diabetic (NOD) mice. The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in this animal model for type 1 diabetes. More than 400 serum samples from NOD (4, 8, and 12 weeks of age and at diabetes onset), BALB/c, and B6 mice were collected from six separate animal facilities, coded, and distributed to five laboratories for autoantibody measurement. Insulin autoantibodies (IAA) were measured by radiobinding assay (RBA) by four laboratories and by enzyme-linked immunosorbent assay (ELISA) in one laboratory. Using the 99th percentile of BALB/c and B6 control mice as the threshold definition of positivity, IAA by RBA were detected in NOD mice at frequencies ranging from 10 to 30% at age 4 weeks, from 26 to 56% at 8 weeks, from 42 to 56% at 12 weeks, and from 15 to 75% at diabetes onset. With ELISA, IAA signals differed significantly between control mouse strains and increased with age in both control and NOD mice, with frequencies in NOD animals being 0% at 4 weeks, 14% at 8 weeks, 19% at 12 weeks, and 42% at diabetes onset. For IAA, the ELISA results were relatively discordant with those of RBA. GAD autoantibody (GADA) and IA-2 autoantibody (IA-2A) signals obtained by RBA were low (maximum 2.5% of total) but were increased in NOD mice compared with control mice at diabetes onset (GADA 29-50%; IA-2A 36-47%). ELISA also detected GADA (42%) and IA-2A (50%) at diabetes onset, with results concordant with those of RBA. Remarkably, GADA and IA-2A frequencies varied significantly with respect to the source colony of NOD mice. Furthermore, whereas neither GADA nor IA-2A correlated with IAA, there was strong concordance between GADA and IA-2A in individual mice. Sera with increased binding to GAD and IA-2 also had increased binding to the unrelated antigen myelin oligodendrocyte glycoprotein, and binding to GAD could not be inhibited with excess unlabeled antigen, suggesting nonspecific interactions. In sum, this workshop demonstrated that IAA measured by sensitive RBA are a marker of autoimmunity in NOD mice and draw into question the true nature of GADA and IA-2A in this animal model.

Animals↗
PubMedDate not supplied

Screening in diabetes mellitus: report of the Atlanta workshop.

A Diabetes Screening Workshop was held in Atlanta, Georgia, May 15--17, 1978, which was sponsored by the Center for Disease Control, the American Diabetes Association, and the National Institute of Arthritis, Metabolism, and Digestive Diseases. The workshop formulated the following recommendations for the use of screening procedures in diabetes mellitus from a community control viewpoint: (1) screening for asymptomatic glucose intolerance should be done among pregnant women as part of a well-coordinated program to decrease perinatal morbidity and mortality; (2) screening programs to detect asymptomatic glucose intolerance per se are not recommended as health services in nonpregnant populations; (3) screening for diabetes or its complications for research purposes should be done only as part of well-designed studies focusing on identification of predictive factors, implementation and effectiveness of preventive and therapeutic measures, descriptive epidemiology in selected populations, dynamic and economic factors of the medical care system related to case detection and management, and the nature and effects of screening processes; (4) information and education programs for health care providers, parents, and the general public should be implemented to bring about increased awareness of the clinical signs and symptoms of diabetes; and (5) all persons known to have diabetes should be evaluated regularly for the detection and management of the common chronic complications of the disease.

Congresses as Topic↗
PubMed1991

A behavioral workshop for training immediate supervisors: the key to neck and back injuries?

This study investigated the short-term effects of a workshop for 22 immediate supervisors designed to reduce musculoskeletal pain injuries. One group of supervisors received training on how to deal with musculoskeletal injuries, while the control group of 14 received no training. 36 male immediate supervisors and 171 male employees within the Swedish railroad system completed questionnaires before and after the intervention. The trained supervisors' ratings showed that they enjoyed the workshop and believed that it improved their skills. Moreover, trained supervisors significantly more often than the controls showed target behaviors and attitudes compatible with course content. Finally, employees of the trained supervisors reported significantly more often than the control group that their supervisor used target behaviors. It is concluded that an educational program for immediate supervisors is viable and may lead to changes in attitude and behavior. Teaching supervisors to work with employees is a rich field for future investigation; the long-term effects of such programs need to be studied.

Accidents, Occupational↗
PubMedDate not supplied

Ideas for training teachers and search analysts using on-line services, arising from the training working group of the MEDLINE Workshop, 1979.

The types of organization offering training courses in on-line information retrieval techniques are grouped into four broad classes: system suppliers and data-base owners, library schools, independent organizations and individuals within organizations. The form of courses offered by the suppliers of the National Library of Medicine's (NLM) data-bases in Europe and Australia, discussed at the MEDLINE Workshop held in Paris in June 1979, are described. NLM already has a large programme of continuing education for search analysts, but not very much has been attempted in Europe as yet, because the services are still comparatively new. The training needed for teachers of on-line services was briefly discussed at the MEDLINE Workshop. This training includes a knowledge of computerized techniques, details of the actual system and software, public speaking, the design of courses and lectures, and the design of documentation and aids. After being trained initially, a teacher also has to keep up-to-date with changes made by the suppliers as well as developments in teaching. Seminars are proposed as a means of achieving this.

Humans↗
PubMedDate not supplied

Report of workshop on traffic, health, and infrastructure planning.

Recent air pollutant measurement data document unique aspects of the air pollution mixture near roadways, and an expanding body of epidemiological data suggests increased risks for exacerbation of asthma and other respiratory diseases, premature mortality, and certain cancers and birth outcomes from air pollution exposures in populations residing in relatively close proximity to roadways. The Workshop on Traffic, Health, and Infrastructure Planning, held in February 2004, was convened to provide a forum for interdisciplinary discussion of motor vehicle emissions, exposures and potential health effects related to proximity to motor vehicle traffic. This report summarizes the workshop discussions and findings regarding the current science on this issue, identifies planning and policy issues related to localized motor vehicle emissions and health concerns, and provides recommendations for future research and policy directions.

Air Pollution↗
PubMedDate not supplied

Report on the UICC workshops on breast cancer screening in premenopausal women in developed countries. Union Internationale Contre le Cancer.

At the recent UICC Meeting on Breast Cancer Screening in Premenopausal Women, three workshops were held to address issues concerning the evaluation of the efficacy of screening, current strategies in research and practice, and future directions in breast cancer control. The authors report on the results of these workshops, including a proposal for a multinational clinical study of breast cancer screening in premenopausal women.

Adult↗
PubMed1998

Measles control in Australia. Report of the Measles Control in Australia Workshop, 5 November 1997.

The proceedings of the Measles Control in Australia Workshop held on 5 November 1998 are presented in this report. Prompted by the possibility of a global elimination campaign in the near future the Workshop considered the factors involved in elimination of measles from Australia. Epidemiology, surveillance, laboratory diagnosis methods, mathematical modelling, and the cost and logistics were all addressed. Mass vaccination for all 2-18 year olds, and a routine 2-dose regimen with scheduled doses at 12 months and school entry were recommended. Intensified surveillance, based on a sensitive case definition and laboratory confirmation (measles specific IgM) of suspected cases was identified as a crucial component of the campaign. The continuation of high vaccination coverage for each of the two doses would be essential to maintain elimination once established.

Adolescent↗
PubMed2002

Data archiving for animal cognition research: report of an NIMH workshop.

In July 2001, the National Institute of Mental Health sponsored a workshop titled "Data Archiving for Animal Cognition Research." Participants included scientists as well as experts in archiving, publishing, policy, and law. As is described in this report, the workshop resulted in a set of conclusions and recommendations concerning (A) the impact of data archiving on research, (B) how to incorporate data archiving into research practice, (C) contents of data archives, (D) technical and archival standards, and (E) organizational, financing, and policy issues. The animal cognition research community is encouraged to begin now to establish archives, deposit data and related materials, and make use of archived materials in new scientific projects.

Animals↗
PubMed2003

Training family caregivers of patients with dementia. A structured workshop approach.

The Minnesota Family Workshop consisted of seven weekly 2-hour sessions that provided education, family support, and skills training to primary family caregivers of patients with dementia, and other accompanying family members. The interdisciplinary faculty used a general stress and coping model to design the caregiver education program. To increase family involvement, the Minnesota Family Workshop required at least one other family member accompany the primary caregiver to the sessions. In addition, a concurrent adapted activity group was offered for the patients with dementia. This 14-hour curriculum with specific weekly objectives and activities detailed in this article was successful in reducing burden among caregivers of patients with dementia.

Aged↗
PubMed1999

Workshop discusses priorities in veterinary helminthology for South Africa.

A workshop was held at Onderstepoort to set priorities in veterinary helminthology for South Africa. Representatives from 19 organisations attended. The workshop achieved 2 of the 3 aims set, namely to identify the problems within the field and to develop strategies to address these challenges. The 7 strategies proposed are: motivation, education, therapeutic, worm resistance, animal tolerance, biological control and diagnostic strategies. A follow-up session is being planned to formulate action plans for each sphere.

Animals↗
PubMed2005

Evaluation of a nurse education workshop on children's grief.

This paper provides an overview of the development and evaluation of an educational program to increase the knowledge of hospice and paediatric nurses who support grieving children and improve their attitudes toward death and bereavement. The specific target groups for the project included nurses providing care through community-based hospice services and inpatient palliative care units, as well as nurses providing inpatient and community-based care at a children's teaching hospital. Fifty-nine nurses from hospice, community and inpatient settings participated in three workshops. Results indicated that the workshop produced a sustained improvement in bereavement knowledge among the nurses and an improvement in their attitudes toward death and bereavement.

Adolescent↗
PubMed1989

A fresh start. Report of a one-day workshop on occupational asthma in the aluminium industry.

The workshop was successful from a number of viewpoints. It achieved the general goal of a greater understanding of respiratory problems in the aluminium industry. A free exchange of information and attitudes occurred. While the prevalence of asthma was not high compared with other occupational asthmas, it was noteworthy. The industry had embarked on a programme for the development of standard criteria of diagnosis and of the collection of statistics that related to the condition. Some concerns remain. It is to be hoped that further developments will be derived from the workshop, including opportunities for research and for a better understanding of the occupational-health issues and practices in the primary aluminium industry in Australasia.

Aluminum↗
PubMed1999

The future of the immunisation schedule: recommendations of a workshop.

The Ministry of Health convened a workshop in June 1998 on the future of the immunisation schedule. Your comments are invited on the recommendations of the workshop. PRINCIPLES BEHIND THE SCHEDULE: Improve on-time immunisation coverage as the priority. Reaching the last 20% will cost at least as much as the first 80% and is vital to achieve the aims of the immunisation programme (disease elimination and improved control). Obtain regular secure coverage data, derived from a tracking system that ensures children are followed up. Assess compliance with early childhood centre immunisation checks at entry and improve if necessary. Establish an expert committee to advise on the immunisation schedule and policies. Keep the schedule as simple as possible. Accept that vaccines are not generic and future schedule recommendations may be vaccine-specific. Involve providers in the process of change. PROPOSED CHANGES: Move the second dose of measles-mumps-rubella vaccine from age 11 years to around five years. Consider moving the third visit from five to four months to achieve earlier protection against pertussis. Consider adding a fifth dose of pertussis vaccine. Change to acellular pertussis vaccine, once suitable vaccines are available. Change to inactivated polio vaccine, once suitable vaccines are available. Consider omitting the fourth dose of polio vaccine. Consider introducing an adult immunisation schedule with fewer adult tetanus-diphtheria boosters.

Adult↗
PubMed1998

Health services research in breast cancer: background paper for a Canadian Breast Cancer Research Initiative workshop.

OBJECTIVE: To describe a systematic review of breast cancer health services research that was conducted to guide a Canadian Breast Cancer Research Initiative workshop. DESIGN: A literature review of major citation databases was conducted. The National Cancer Institute of Canada Framework for Cancer Control was adopted to classify articles by theme area and by type of health services research. RESULTS: The majority of the studies focused on screening for breast cancer and were descriptive studies on accessibility. Relatively few studies examined quality and outcomes of breast cancer services or interventions to improve such services. Furthermore, few health services research studies examined the areas of supportive care or palliation. CONCLUSIONS: The results help to identify the gaps in the Canadian and international research in this area. The material from the review was used as background for a workshop to support the work of the Canadian Breast Cancer Research Initiative Task Force on Health Services Research.

Breast Neoplasms↗