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Mantoux and contact positivity in tuberculosis.

OBJECTIVE: To study the role of Mantoux and contact history in various forms of Childhood tuberculosis. METHODS: 605 children registered with TB clinic of Institute of Child Health and Hospital for Children, Chennai over a 5 year period from January 2000 to October 2005 with various forms of tuberculosis were recruited in the study. Clinical examination findings, basic investigations, chest skiagrams, computerized tomography (CT) wherever warranted, sputum or gastric aspirates for AFB smear, histopathology wherever possible were analyzed. RESULTS: The study showed that Mantoux positivity in various forms of tuberculosis studied is 34.7%. The positivity of Mantoux was highest in lymph node tuberculosis (53%) and the lowest with CNS tuberculosis (21.2%). Among the other forms, Mantoux positivity was 36.4% in TB abdomen, 44.4% in Skeletal TB, 30.3% in pulmonary tuberculosis. The contact positivity was 30.4% in the sample studied. CONCLUSION: The study also reflects that the extra pulmonary forms of tuberculosis seems to be more common in the pediatric population which constituted 79.8% of the cases included in the study.

Child↗

[Lymphotropic chemotherapy of patients with tuberculosis of the lymph nodes, skin and abdominal organs].

Experience gained as a result of indirect endolymphatic chemotherapy of patients with tuberculosis of the skin, peripheral and mesenteric lymph nodes is presented. The above treatment is tolerated well by the patients and causes no local or general complications. The clinical effect is achieved 1-3 months earlier than with a traditional therapy which provides a significant drop in the inpatient period and the drug load. Incidence of exacerbations also becomes less. It is worthwhile to include lymphotropic chemotherapy into a complex of therapeutic measures both at the beginning of the treatment and in a torpid course of the disease.

Adult↗

Bronchoesophageal fistulae secondary to tuberculosis.

An elderly patient with a bronchoesophageal fistula secondary to tuberculosis and a 3-month history of cough and dysphagia worsening with deglutition was admitted to hospital. Radiological examination and CT of the thorax revealed mediastinal adenopathy. Bronchoscopy, esophagoscopy and esophagraphy confirmed the presence of a bronchoesophageal fistula. Histological examination of the esophagus and bronchial biopsy specimens revealed nonnecrotic granulomas, and the acid-fast bacilli tested positive for Mycobacterium tuberculosis in respiratory secretions. Antituberculous treatment was started after diagnosis of intrathoracic lymph node tuberculosis with bronchoesophageal fistulization. A month and a half after initiating treatment, paroxistic coughing during deglutition persisted. An esophagoscopy was performed, and the orifice was closed with a fibrin tissue. After 9 months of treatment, the patient was asymptomatic and in good health.

Aged↗

[Lymph node and cutaneous tuberculosis revealed by a pyloroduodenal stenosis: a case report].

Lymphadenitis is the most frequent form of extrapulmonary tuberculosis. In immunocompetent patients, its clinical presentation is usually superficial, less frequently intra-abdominal located, and exceptionnally symptomatic. We report a case of scrofuloderma characterized by the lymph nodes extent of spread which led to a pyloro-duodenal stenosis. An 18 years old immunocompetend man is admitted in the internal medicine department, presenting a pyloroduodenal stenosis syndrome, fever, weight loss, and ulcerated axillary and cervical lymph nodes. The upper gastrointestinal endoscopy and ultrasound examination reveal the extrinsic duodenal compression by large numerous lymph node. A biopsy confirms the tuberculosis disease for which no other localisation was detected. Despite of the diagnostic and therapeutic delay, which explains the expanse and depth of the lesions, the antituberculosis therapy was effective on the digestive symptom and cleared all the cutaneous manifestations.

Abdominal Pain↗

[The lymph node perforation in tuberculosis and its consequences for the course of pulmonary tuberculosis].

After a historic review of the ever changing views concerning the pathogenesis of tuberculosis, a special possibility of extension is closely examined, that is the lymph node perforation into the bronchial system. In the past decades, the importance of this has been commensurately over -- as well as under -- evaluated. Our own examinations are based upon the experience gained by over 20.000 bronchoscopies in the past 25 years. According to the formulations of these examinations, carried out in 3 different groups, the following correlations were determined: The first series, registered during the years 1949-1952, included tuberculosis patients alone. In these series, 5.5% of the bronchoscopically proven changes were of tubercular lymph node perforation. The second series, published in 1961, included the compiling of 350 bronchoscopies performed on 350 cases of tuberculosis in the old age. In these series 11.4% of apparent lymph node perforations were observed. The third series contained 6021 bronchoscopies which were performed during 1970-1975. In this series, the tuberculosis presents only a small percentage of pulmonary diseases. In these cases, 2,9% were revealed as florid or healed lymph node invasions. This percentage would indicate that in cases of tuberculosis, lymph node invasion into the bronchial system means a minimal incidence. However, these figures, which are only based upon bronchoscopically determined findings must be considered, from an anatomical point of view, as the lowest occurrence border. Upon the basis of individual cases, different clinical pictures have been described, whereby these lymph node perforations can be clinically manifested. Consequently, it is this obturation with symptomatic foreign bodies, the atelectasis, which can falsely be diagnosed as a malignant bronchial closure, and also spread and aspiration even as is observed in the pneumonias. Additionally, because of interlobular lymphogenic propagation a similar symptom may be produced. Finally, as a last significant clinical manifestation, bleeding must be mentioned. Such bleeding is caused primarily when a caseous lymph node simultaneously perforates into the bronchial system and into a neighboring blood vessel. Over the past 25 years the clear up of the findings, due to constant improvements in bronchoscopy, have culminated in a method, the importance of which must be necessarily emphasized. This method should be universally utilized as routine examination in pulmonary departments and its neglecting should only be justified in specifically indicated cases.

Aged↗