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At least 973 records · Page 54Linked to original sources
PubMed1991

[The spleno-cytotoxic test--an indicator of toxemia in oncologic patients].

Biologic integral methods for indication of blood toxicity, the migration activity of intact donor leukocytes in agar, and the splenocytotoxic test were used in radiotoxemia assessment in 62 oncologic patients with radiation reactions and in studies on the efficacy of detoxifying therapy with polyvisoline, a new blood substitute, in 25 subjects. Both the methods for studies of the blood serum toxicity were found sufficiently informative and unsophisticated, but the splenocytotoxic test proved to be more sensitive, simple, and rapid.

Cytotoxicity Tests, Immunologic↗
PubMed1990

[Endogenous toxemia in surgery].

An analysis of the mechanisms of the development of endogenous intoxication was used to consider its role in pathogenesis of most serious surgical diseases and traumas and their complications. The role of endogenous intoxication is shown in the development of multiple organ insufficiency. Methods of extracorporal hemocorrection in treatment of endogenous intoxication are substantiated. Potentialities of the present-day methods of extracorporal hemocorrection and prospects of development are discussed.

Bacterial Infections↗
PubMed1990

[Endogenous toxemia in acute disorders of cerebral circulation].

Critical conditions that develop because of hypoxia of different genesis are accompanied by endogenous intoxication induced to a considerable degree by the appearance in the blood of an excess amount of medium-sized molecules (MSM). An appreciable increase of the content of MSM was demonstrated since the very first days after the brain stroke as a result of examining 100 patients who suffered brain stroke, including 83 patients during the first week of the disease and 17 patients of the reference group with a history of acute impairment of cerebral circulation which had occurred over a month before. A reverse correlation was established between the level of endogenous intoxication and the clinical status of the patients which could be observed every day during the acute disease phase. The critical level of MSM was determined in the patients' blood plasma. In the majority of cases, the attainment of the above level resulted in a lethal outcome irrespective of the pattern of acute impairment of cerebral circulation. The data obtained make it possible to recommend using the level of MSM as one of the simple and rapid quantitative methods for assessment of the patients' status gravity and monitoring of persons with acute impairment of cerebral circulation.

Acute Disease↗
PubMed1990

[Toxemia syndrome in patients with acute intestinal obstruction].

The results of examination and treatment of 216 patients with acute intestinal obstruction of benign genesis are discussed. The values of blood plasma toxicity and the values of hemostasis determined before and after the operation were compared. Intoxication of patients was found to increase in the postoperative period. Its increase was appraised according to the duration of the disease. The causes of mortality were analysed and the risk factors of intoxication increase in the postoperative period were revealed. The authors suggest a classification of the phases of intoxication in patients with acute intestinal obstruction on the basis of the degree of intoxication and the condition of homeostasis.

Acute Disease↗
PubMed1990

[Endogenous toxemia in pancreatic necrosis of alcoholic etiology].

Operation for pancreonecrosis was carried out in 197 patients, in 52 (26.4%) of them the disease was of alcoholic etiology. The disease was marked by severe clinical manifestations with the development of respiratory, hemodynamic, and peritoneal syndromes and their complications, and by psychic disorders. The endo-intoxication structure was studied in 13 patients by mass-spectrometry proceeding from alcohol metabolism in the organism. Eleven intermediate products were identified: ethanol, acetaldehyde, normal butyraldehyde and isovaleric aldehyde, diethylamine, acetone, isopropanol, methyl isocyanide, trimethylamine, ethannitrile. It was noted that the clinical manifestations of alcoholic pancreonecrosis are included in the spectrum of ethanol pharmacological action; the content of ethanol in the blood was tenfold of the normal, that of the product of its metabolism acetaldehyde was 1.6 times the normal level. Inclusion of exogenic ethanol in metabolism leads to its distortion and accumulation of substances of different origin in the organism, among which an important role is played by acetaldehyde, normal butyraldehyde, and isovaleric aldehyde. The results of the study create proconditions for the search for a rational means for their desactivation.

Acute Disease↗
PubMed1990

[Functional state of the lungs in toxemia in peritonitis and acute intestinal obstruction].

On the basis of examination of 214 patients, it was established that the pronounced intoxication syndrome developing in peritonitis and acute ileus led to disorders in the non-respiratory pulmonary functions. This contributes to the development of arterial hypoxemia, hypocapnia and acute respiratory failure. In the complex of treatment of the patients, it is expedient to use extracorporeal desintoxication.

Acute Disease↗
PubMedDate not supplied

[Effect of kontrikal on the dynamics of proteolytic system indices in postischemic toxemia].

It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by 2.5-3 times; level of alpha 1-protease inhibitor (alpha 1-PI) decreased by 4 times and that of alpha 2-macroglobulin (alpha 2MG) by 2.5 times. At administration of contrykal (10,000 U/kg) proteolytic activity increased only by 32.5%, content of alpha 1-PI decreased only by 10-20% and level of alpha 2-MG did not differ from that in healthy animals. Activity of AST and ALT remained high, and contents of urea and residual nitrogen were near-normal.

Animals↗