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At least 973 records · Page 54Linked to original sources
PubMed1995

Adie's tonic pupil secondary to migraine.

A 46-year-old woman observed transient unilateral mydriasis during a classic migraine attack. One week later she experienced a similar episode after which anisocoria was persistent. Subsequent examination showed the clinical and pharmacologic features of a postganglionic parasympathetic paresis (Adie's tonic pupil). This case confirms the hypothesis that transient mydriasis accompanying migraine is due to interruption of parasympathetic innervation rather than sympathetic overactivity.

Adie Syndrome↗
PubMed1994

Time-varying properties of respiratory fluctuations in pupil diameter of human eyes.

The time varying properties have been investigated of respiratory components in fluctuations of the pupil diameter (PDF) of the human eye. PDF and instantaneous lung volume were simultaneously measured for 45 minutes under natural binocular viewing conditions. The short-term Fourier transform and the autoregressive signal modeling together with the recursive least squares algorithm have been applied for the estimation of nonstationary power spectra. Data analysis showed a bursting type non-stationarity in the appearance of the respiratory component in PDF.

Adult↗
PubMed1993

[Stages of primary pupil-block chronic angle-closure glaucoma].

In China, primary pupil-block chronic angle-closure glaucoma is a blinding eye disease of high incidence in primary glaucoma, with different clinical course and features from acute angle-closure glaucoma. Based on the conditions of the anterior chamber angle, the level of IOP, the defects in optic disc and visual field, and the mechanism of IOP elevation, this morbid entity was classified into 5 stages, i.e., the preclinical, the early, the progressive, the advanced and the absolute stages, and the clinical manifestations of each stage were described. This classification may be of referential use to ophthalmologists in clinical and research work.

Anterior Chamber↗
PubMed1993

Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma.

Topically applied demecarium bromide (0.125 and 0.25%) and echothiophate iodide (0.125 and 0.25%) solutions were evaluated in Beagles with normotensive eyes and Beagles with inherited glaucoma. In single-dose studies, the effects of intraocular pressure (IOP) and pupil size (PS) were measured in eyes before drug treatment and in drug- and nondrug-treated eyes. Both concentrations of the 2 drugs induced long-term miosis and decrease in IOP in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma. Demecarium bromide (0.125 and 0.5%) decreased IOP for 49 and 55 hours, respectively. Echothiophate iodide (0.125 and 0.5%) reduced IOP for 25 and 53 hours, respectively. The miosis associated with both concentrations of the 2 drugs generally paralleled the decreases in IOP.

Administration, Topical↗
PubMed1977

Miosis and fluctuation in the rabbit pupil: effects of morphine and naloxone.

In the unanesthetized rabbit, morphine (12-16 mg/kg i.v.) produced a miosis that was not sustained. The response to the narcotic was a pupillary constriction that became maximal within 2 minutes following i.v. administration, after which time the pupil size fluctuated appreciably. The magnitude of the fluctuation, typically as high as 40% of control diameter, was much larger than can be attributed to "noise." The fluctuations occurred within a frequency of approximately 0.5 to 2/min. The miosis and subsequent fluctuation seen with 12 and 16 mg/kg of morphine was blocked by naloxone (0.5 mg/kg i.v.), but 128 mg/kg of morphine overcame the block. Cumulative dose-response curves for morphine and for morphine after naloxone yielded the value pA2=6.8 which is in agreement with the values obtained using other effects and species. Administration of morphine after exposure to high intensity light produced less miosis than that seen under normal illumination.

Animals↗
PubMed1996

A new matrix formulation of spectacle magnification using pupil magnification. II and III: High myopia corrected with contact lenses and intraocular lenses.

In this paper we use the matrix method to calculate spectacle magnification (SM) and relative spectacle magnification (RSM) using pupil magnification for myopic eyes corrected with contact lenses (CLs), and intraocular lenses (IOLs). For myopic eyes corrected with contact lenses, the calculation is very similar to the one done for myopic eyes corrected with ophthalmic lenses (OLs) since both OLs and CLs are external correcting systems. For myopic eyes corrected with intraocular lenses, the calculation is different from the ones carried out for myopic eyes with external correcting systems. In this paper we show the differences that exist between the matrix calculations for these two correcting systems, external and internal. The magnifications are calculated for specific myopic eyes corrected with CLs and IOLs. By comparing the results obtained with three correction types, namely, OLs, CLs and IOLs, we will be able to choose the best correction system for each case.

Contact Lenses↗
PubMed1997

Correlation of the pilo-pupil ratio average, a new test for autonomic denervation, to the severity of diabetic retinopathy.

OBJECTIVE: To evaluate the association between the degree of diabetic retinopathy and autonomic neuropathy, and to test whether ocular parasympathetic denervation is correlated to the degree of diabetic retinopathy. DESIGN: Cross-sectional pilot study. SETTING: The tertiary ophthalmic centre for the Atlantic provinces in Halifax. PATIENTS: Twelve randomly selected patients (six women and six men with a mean age of 36.6 years) with insulin-dependent diabetes mellitus who had diabetic retinopathy. OUTCOME MEASURES: Degree of diabetic retinopathy, hemoglobin Alc level, orthostatic change in systolic and diastolic blood pressure and in serum catecholamine levels, degree of pupillary supersensitivity to 0.125% pilocarpine (pilo-pupil ratio average [PPRA]). RESULTS: The degree of diabetic retinopathy was significantly correlated with the duration of diabetes (p = 0.035), the hemoglobin Alc level (p = 0.004), the orthostatic change in diastolic blood pressure (p = 0.022) and the PPRA (p = 0.0007). CONCLUSIONS: The degree of diabetic retinopathy was significantly correlated with autonomic neuropathy and with the PPRA. Given these results, further study is indicated to determine whether autonomic neuropathy is a predictor of the severity of diabetic retinopathy.

Adult↗
PubMed1997

Disparity between keratometry-style readings and corneal power within the pupil after refractive surgery for myopia.

PURPOSE: Because keratometry readings may no accurately reflect the refractive changes after keratorefractive surgery for myopia, better methods for the assessment of corneal curvature in the postsurgical cornea are needed. METHODS: We developed a procedure to calculate the average central power (ACP) of the cornea within the entrance pupil from videokeratography. Videokeratograph-derived keratometry-style readings (average K; K) and calculated ACPs, as well as the differences between the two values, were compared in four groups: normal corneas (n = 30), corneas with regular astigmatism (n = 30); post-radial keratotomy corneas (RK, n = 85), and post-excimer laser photorefractive keratectomy corneas (PRK, n = 63). Intraocular lens (IOL) powers calculated by using K or ACP in the Sanders-Retzlaff-Kraff formula were compared. RESULTS: In the groups with normal corneas or regular astigmatism, none of the eyes showed a difference between K and ACP > 0.25 D. However, six (7%) of the RK eyes and 16 (25%) of the PRK eyes had differences > 0.55 D; in these eyes, the disparity between IOL powers calculated by using K and IOL powers calculated by using ACP was > 0.5 D. CONCLUSION: These results suggest that basing the calculation of IOL powers on keratometry readings in patients who have undergone RK. PRK, or possibly other refractive procedures may result in a residual refractive error in some eyes. In particular, patients undergoing surgery involving a small optical zone or large attempted correction or both, as well as those with low postoperative keratometry readings, may be at risk for this problem if IOL placement becomes necessary in later years.

Cornea↗
PubMed1997

[A case of Sjögren syndrome associated with multiple mononeuritis and dysautonomia including bilateral tonic pupils].

Sjögren syndrome (SjS) is a glandular disease characterized by dry eyes and dry mouth. Extraglandular manifestations in SjS are also common, and peripheral nerve involvement has been reported in 10-20% of cases. We report a case of Sjögren syndrome with bilateral tonic pupils, dysautonomia, and multiple mononeuritis. The fact that sural nerve sections, in addition to marked loss of myelinated and unmyelinated fibers, showed an increased number of infiltrating macrophages without lymphocytes and aberrant expression of HLA-DR (class II) antigen in Schwann cells was an especially interesting finding. No evidence of active vasculitis was detected. The patient was treated with corticosteroids and her condition gradually improved, as confirmed by thermography. Our findings suggested the presence of specific immunological abnormalities simultaneously involving the ciliary ganglia, autonomic ganglia, and dorsal root ganglia in this peculiar form of SjS.

Autonomic Nervous System Diseases↗
PubMed1978

Transaqueous diffusion of acetylcholine to denervated iris sphincter muscle: a mechanism for the tonic pupil syndrome (Adie syndrome).

The accepted hypothesis for the pathophysiology of tonic pupil syndrome (Adie syndrome) was reexamined in light of recent developments concerning denervation supersensitivity of cholinergically innervated smooth muscle. Kinetic analysis suggests that enzymatic hydrolysis is unimportant relative to convective diffusion in the turnover of acetylcholine in the aqueous humor. We postulate that the greater response to near stimuli than to light stimuli and the delay in iris sphincter contraction and relaxation can be explained by release of acetylcholine from the neuromuscular junction of the ciliary muscle followed by transaqueous diffusion to receptor sites on denervated, supersensitive iris sphincter muscle.

Acetylcholine↗
PubMed1999

The effectiveness of peer support systems in challenging school bullying: the perspectives and experiences of teachers and pupils.

This large-scale questionnaire survey (n=2313) has sought teachers' and pupils' perceptions and experiences of peer support systems in challenging bullying in U.K. (mainly English) secondary schools and colleges (n=51). In general, these systems have been found to be effective in reducing the negative effects of bullying for victims. Collectively, the respondents also perceive many important benefits to users of these systems, to peer supporters and to the school as a whole, including helping to create a socio-emotional climate of "care". The respondents also perceive problems with these systems and, importantly, how they have been overcome and might be further improved.

Adolescent↗
PubMed2001

Mental health services in schools: the challenge of locating a psychotherapy service for troubled adolescent pupils in mainstream and special schools.

In Part 1, the case is presented for school-based mental health services in terms of the low utilization of community-based clinics and the high dropout rate among young adolescents attending clinics in the community. The advantages and potential pitfalls of school-based services are also assessed. In Part 2, the paper discusses the lessons learned from delivering psychotherapy services in mainstream and special schools to tackle the mental health problems presented by troubled pupils. The author describes the schools and discusses the expectations among teachers of the psychotherapist and psychologist. The role of the psychotherapist and psychologist in the schools is outlined. The types of treatment approach, the setting for treatment, method of referral, parental consent, and links with the wider network of adolescent mental health services and evaluation of outcome are considered. Finally, the author discusses the tensions that can arise between the psychotherapist and psychologist and school staff and ways of overcoming them.

Adolescent↗
PubMed1993

Level dependent signal flow in the light pupil reflex. III. Phase velocity in high gain instability oscillations.

The pupil can be excited to sustained oscillations under high gain feedback conditions. The period of these oscillations (cycle time) is reduced by increased average light level by an amount commensurate with reductions in phase lag reported in the companion paper (Myers et al. 1991b). A mathematical model of this phenomenon is used to unify and clarify experimental data presented here and in the literature.

Cybernetics↗
PubMed1986

Eye movement research with schizophrenic patients and normal controls using corneal reflection-pupil center measurement.

The eye movements of 20 partially remitted outpatient schizophrenics (ICD 9), for the most part receiving neuroleptic maintenance medication, and 20 normal controls were recorded using corneal reflection-pupil center measurement. Performance was investigated on the basis of widely varied measurement parameters during a fixation task and a visual search task (list of letters). Psychopathological data were additionally recorded for the group of patients by means of self and observer ratings, current social adjustment, and neuroleptic dosage. The schizophrenic patients showed the tendency to perform more poorly than the normal controls in the eye movement parameters recorded, and there was marked variation in performance within the group of schizophrenic patients. In particular, various abnormalities in fixation performance were connected differentially with individual psychopathological syndromes and neuroleptic dosage. Connections between fixation performance and search performance were found only within the group of patients. They are interpreted as an indicator of disturbed interhemispheric coordination in schizophrenics. Based upon specific pupillary findings one concludes that the processing load imposed on the attentional system by the search task is different for various schizophrenic subgroups.

Adult↗
PubMed1993

Road traffic noise around schools: a risk for pupil's performance?

Noise levels around educational centres can negatively affect the performance of both teachers and pupils. Two public schools in Valencia, Spain, were selected for study. One of these schools was exposed to excessively high road traffic noise levels while the other was located in a relatively quiet area. The socioeconomic level of those attending the schools was very similar. A set of external and internal noise measurements were carried out, along with two different attention tests among the children. Test results were consistently better (both for tests and for children from different classrooms in each school) in the quiet school. Exposure to high traffic noise levels in the noisy school over the whole school year is a plausible determinant of these results.

Attention↗
PubMed1979

[Disturbances of the pupil reflex associated with lesions of the upper visual pathway (author's transl)].

In six patients with ischemic lesions of the visual pathways above the lateral geniculate body, the pupil light reflex was investigated under perimetric conditions. The size of the lesions--in four cases caused by lateralized cerebral infarction, in two cases by complicated migraine attacks--was certified by neurological examination and by angiography or computerized tomography respectively. The recordings were done with a portable pupillograph measuring the infrared light reflected from the iris. A Tübinger perimeter served as stimulator. All patients except one, whose visual fields recovered quickly and completely, showed parallel tracings concerning the sensory and the pupillographic profiles, in the older lesions as well as in the recent ones.

Adult↗
PubMed1988

A psychometric study of positive and negative nominations and the pupil evaluation inventory.

Two peer evaluation measures, the Pupil Evaluation Inventory (PEI) and positive and negative nominations were compared in a sample of 260 children in grades 1 to 5. Stabilities of the measures were assessed over a 4-month period. In the total sample, PEI factors and negative nominations were more stable than positive nominations, and PEI Aggression and Withdrawal scores were more stable than negative nominations. PEI Aggression and Withdrawal scores were more stable in grades 3 and 5 than in grade 1, and the Likability factor was more stable in grades 2 to 5 than in grade 1. Negative nominations were most strongly correlated with the PEI Aggression factor, and positive nominations were more strongly correlated with Likability than with Aggression. Implications for the use of these nomination measures are discussed.

Aggression↗
PubMed1976

The Pupil Evaluation Inventory. A sociometric technique for assessing children's social behavior.

The Pupil Evaluation Inventory was developed to assess peer ratings of the behavior of male and female children in grades one through nine. Three homogeneous and stable factors emerged from a factor analyss: Aggression, Withdrawal and Likeability. High interrater agreement between male and female raters, stability of factorial structure, high internal consistency, and moderate concurrent validity were found across sex and grade levels. Test-retest reliability was high for a separate sample of third and sixth graders. There was a tendency for higher internal consistency and teacher-peer correlations for the Aggression factor.

Adolescent↗