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At least 973 records · Page 54Linked to original sources
PubMed1988

Prevention of heterotopic ossification by nonsteroid antiinflammatory drugs after total hip arthroplasty.

The effect of three weeks of postoperative treatment with indomethacin or ibuprofen on the development of periarticular heterotopic ossification (PHO) after bilateral total hip arthroplasty (THA) was investigated. Widespread PHO did not occur in 31 patients who had been treated with indomethacin or ibuprofen after both operations. Thirty-eight patients had been treated after one but not the other THA. Widespread PHO occurred in 14 of 38 untreated THA, but was not found after THA on the treated side. These findings are indicative of an inhibitory effect of nonsteroid antiinflammatory drugs on the development of PHO, since the development of severe heterotopic ossification is strongly correlated between the two sides after bilateral THA.

Aged↗
PubMed1985

Calcification and ossification in the arytenoid cartilage: incidence and patterns.

Calcification or ossification occurs early and commonly in the arytenoid cartilage. It may be difficult to detect, but there are only eight patterns that specifically identify ossification and calcification. Each arytenoid independently ossifies or calcifies. The cervical spine examination can specifically identify the patterns found at autopsy.

Adolescent↗
PubMed1977

[The ossification of the ear cartilage in Addison's disease].

Stiffening and tenderness of the helix of the ear, with radiologically demonstrable calcific deposits, has been reported in various conditions such as frostbite, and also in Addison's disease. To a total of 14 clinical observations with only 4 well documented cases, a first autopsy report of the disorder in a case of tuberculosus Addison's disease is added. It is shown that the elastic cartilage of the pinna, of the epiglottis and of the trachea undergoes ossification without preceding dystrophic or metastatic calcification. The ossification has been observed only in males with longstanding Addison's disease treated exclusively with mineralocorticoids over a long period. The possible pathogenetic mechanisms are discussed. An important factor seems to be the long-standing glucocorticoid deficiency.

Addison Disease↗
PubMed1977

Heterotopic ossification mimicking acute arthritis after neurologic catastrophes.

Three patients developed periarticular heterotopic new bone formation during the first two months after a CNS disorder. In each patient warmth, swelling, and tenderness around one or two joints initially resembled severe arthritis. Diagnosis was aided by roentgenograms of the involved areas that showed the ossification. While no treatment has been clearly demonstrated to interrupt the ossification and resultant contracture, a course of cautious physical therapy and antiinflammatory medication is probably indicated.

Adult↗
PubMed1977

[The antero-posterior diameter of the cervical spinal canal in the ossification of the posterior longitudinal ligament (author's transl)].

1. The antero-posterior diameter (APD-Fig. 1A) of the cervical spinal canals in 38 cases of symptomatic ossification of the posterior longitudinal ligament (OPLL) and 29 cases of asymptomatic OPLL was measured for each vertebra, and the thecoperiosteal diameter (TPD-Fig. 1B) of the cervical spinal canals in the same cases was measured. 2. The APD in the cases of symptomatic OPLL was found to be significantly smaller than those of asymptomatic OPLL. 3. The TPD in symptomatic OPLL was also found to be more significantly smaller than those of asymptomatic OPLL. Measurements of 9 mm or less were considered liable to be associated with cord compression. 4. The growing rate of the ossification was calculated in 13 cases of symptomatic OPLL which we have followed up radiologically for more than 2 years. The growing rate varied considerably from case to case. The average growing rate per one year was 4.07 mm in axial length and 0.67 mm in thickness on antero- posterior direction. 5. The incidence of OPLL was examined.

Adolescent↗
PubMed1978

[Soft-tissue ossification following stable osteosyntheses using bone meal].

Ectopic ossifications occassionally occur after stable osteosyntheses. The literature and our own observations indicate that osseous bore-chips probably favour these ossifications, especially after intermedullary nailing. Experiments determined the weight of osseous bore-chips which occur in intermedullary nailing of femur and in plate osteosynthesis of radius and ulna. Conclusions drawn from these findings should be considered when performing osteosynthesis.

Bone Plates↗
PubMed1979

[Ossifications of soft parts after operative treatment of luxation fractures of the ankle joint (author's transl)].

Operative treatment of luxation fractures of the ankle joint has caused a drop in poor late results, to one-quarter of the total number of patients compared with about one-half with the conservative procedure. Part of the unsatisfactory results is caused by ossifications in region of the interosseous membrane and tibiofibular syndesmoses. The incidence of such ossifications within a closed series of 200 own operatively treated cases was examined and pathogenetic factors were discussed. Further improvement of the treatment results of ankle joint fractures appears possible via subtle operation technique and omission of routine application of fixation screws for safeguarding lesions of the syndesmoses.

Ankle Injuries↗
PubMed1984

Hyperostosis of the clavicle and ossification of the costoclavicular ligament in association with ankylosing spondylitis.

A patient with ossification of the ligaments of the entire vertebral column has shoulder difficulties due to ossification of the right costoclavicular ligament. The speculation is that the sclerotic changes in the clavicle were caused by the same inflammatory process that has involved the ligaments of the vertebral column and of the sacroiliac joints. In some cases reported in the literature, although not in ours, vascular structures in the costoclavicular space were involved, resulting in venous obstruction or phlebitis. The patient's therapy currently consists of rehabilitation exercises. Nonsteroidal antiinflammatory medication was prescribed in the past without any marked benefit.

Aged↗
PubMed1984

Ossification of the posterior longitudinal ligament of the spine.

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a newly recognized entity. As the incidence of this disease was exceptionally high in Japan, the Japanese Ministry of Public Health and Welfare instituted a special commission for the investigation of this perplexing disease; since 1975 this committee has performed an intensive study of 2100 patients with OPLL in Japan. An epidemiologic study was conducted by this group in Japan and in eastern Asiatic countries. Symptoms and disabilities caused by the disease were described. Roentgenographic findings were classified as continuous, segmental, mixed, or localized. OPLL at the thoracic and lumbar levels combined with ossification of the yellow ligament was described, and the risk of spinal cord damage as well as the importance of tomography and computerized tomographic scanning were stressed. No conclusions were reached concerning etiology, but common findings included a generalized hyperostotic tendency, a tendency for abnormal glucose metabolism, and low enteral calcium absorption. A relatively high hereditary occurrence was noted. Conservative and surgical treatment methods were described, with particular reference to spinal canal-widening operations.

Aged↗
PubMed1984

Heterotopic ossification and HLA antigens.

Thirty patients with neurogenic (nontraumatic) heterotopic ossification following spinal cord injury in 20 and head injury in 10, were comprehensively screened for HLA antigens. The frequencies of 68 HLA-A, -B and -C antigens were examined. The HLA-A2 locus was present in 18 patients (60%) as compared to the phenotypically adjusted normal of 48.4% and was not statistically significant at the 0.05 level. No statistically significant increased frequency of the HLS-B18 or HLA-B27 antigens was detected. A positive correlation does not exist between the HLA antigen system and patient susceptibility to heterotopic ossification following head injury or spinal cord injury.

Adult↗
PubMed1980

Periarticular heterotopic ossification in head-injured adults. Incidence and location.

The records of 496 adult patients who sustained severe injuries to the head were reviewed retrospectively in order to reveal the incidence and location of heterotopic ossification. All traumatized joints were excluded from the study. Clinically significant heterotopic bone causing pain and a decrease in the range of motion of the adjacent joint was identified in 100 joints in fifty-seven patients (11 per cent). All fifty-seven patients had some residual spasticity, although the spasticity was not always present about the involved joint. Twenty-seven patients had monoarticular involvement while thirty patients had involvement of more than one joint. Forty-four hips, twenty-seven shoulders, twenty-six elbows, and three knees had heterotopic ossification. Complete ankylosis (16 per cent of all joints) developed in eight elbows, six hips, and two shoulders.

Adolescent↗
PubMed1981

[Roentgenological measurement of the cervical vertebral bodies in ossification of the posterior longitudinal ligament (OPLL) and cervical spondylosis (CS) (author's transl)].

Many studies of the pathogenesis of ossification of posterior longitudinal ligaments (OPLL) have been reported, and both general and local factors have been pointed out. In case a longitudinal ligament is affected by both the general and local OPLL factors for many years, the shape and size of the cervical vertebral bodies and the arrangement of the cervical spinal column might be affected. The relation between OPLL and disc degeneration, the morphology of the facet joint and the change of longitudinal ligament tension has been reported by many authors. But the relation between OPLL and the shape, size and arrangement of cervical vertebral bodies has not been reported. We selected X-ray films of the lateral view of cervical spines which had been taken at our hospital since 1975. The subjects consisted of 190 cases in Group I and 189 cases in Group II. Half of Group I had OPLL, of which 71 were males and 24 females. The other half of Group I was composed of 95 cases (CS) of cervical spondylosis of the same sex and age distribution. Group II comprised 189 cases, all males aged 49 yrs. Of them, 41 were OPLL cases, 102 CS, and 46 normal subjects. The X-ray films of Group II were taken during medical examinations. The height, antero-posterior diameter of the cervical vertebral bodies and the antero-posterior diameter of the cervical spinal canals were measured and examined for kyphosis between the two neighbouring cervical vertebral bodies, disc space narrowing and Barsony ossification. The height and antero-posterior diameter of the cervical vertebral bodies were compared among the following groups. 1) the 3 groups divided according to age (-49,50-59,60-75 yrs.), 2) segmental type with non-segmental type, 3) OPLL only at C3 and C4 with OPLL only at C5, C6, and C7. The results were as follows: The cervical vertebral bodies of OPLL were taller and wider than those of CS. Cervical vertebral bodies of the older group were shorter and wider than those of the younger groups in both OPLL and CS. THe relative height (C3 = I) of OPLL group was very close to Normal group. The cervical vertebral bodies of non-segmental type were taller but not wider than those of segmental type of OPLL group. The C3 and C4 vertebral bodies with OPLL only at C3 and C4 were taller, but not wider than those with OPLL only at C5, C6 and C7. The antero-posterior diameter of cervical spinal canal of OPLL was narrower than CS group. The above data indicate the following: 1) With advance in age, cervical vertebral bodies become lower and wider. 2) The cervical vertebral body of OPLL is taller and wider than that of CS. 3) The level of OPLL and the type of OPLL have a relation to the height of cervical vertebral body. 4) The cervical vertebral bodies which have OPLL are wider than non-OPLL. But the level and the type of OPLL have no relation with the A-P diameter of the cervical vertebral body.

Adult↗
PubMed1995

Retroviral expression in a patient who has paraarticular ossification.

Reverse transcriptase activity is reported in the mononuclear blood cells isolated from a patient in whom paraarticular ossification developed after surgery for an aneurysmal bone cyst. The enzyme was purified to apparent homogeneity by chromatography before being characterized biochemically for its template specificity and ionic requirement. The enzyme was able to transcribe poly(rA).(dT)12-18 very efficiently in the presence of Mn++ ions. Viral particles were observed in the HuT-78 cell line, cocultured with the mononuclear cells of the patient. No viral particles were observed in HuT-78 cells before the coculture. The patient was found seronegative for HIV-1, HIV-2, and HTLV-1. These results suggest that a new retrovirus infecting mononuclear blood cells may be involved in the development of ectopic ossification. This hypothesis is strengthened by the previous finding of a retrovirus in the mononuclear blood cells of a patient with benign osteopetrosis, and by the fact that HTLV-1 infected T-lymphocytes acquire the ability to secrete factors responsible for the lytic bone lesions observed in the patients. A family of human bone diseases that reflect T-cell dysfunction(s) and are caused by lymphotropic viruses may exist.

Bone Cysts, Aneurysmal↗
PubMed1995

[Metaplastic ossification in the breast--a case report].

Metaplastic calcification and ossification originating in the subcutaneous fat of the breast are rare and commonly included in the malignant tumor. We reported a 24-year-old female who developed a huge metaplastic ossification without neoplasm in her right breast. To the best of our knowledge, this is the second case in the world literature and the first case in Taiwan.

Adult↗
PubMed1995

Single dose 6 Gy prophylaxis for heterotopic ossification after total hip arthroplasty.

Forty-five patients (50 hips) at risk for heterotopic ossification after total hip arthroplasty who received a single dose of 6 Gy postoperative irradiation were compared with a historical control group of 42 patients (50 hips) with similar risk factors who did not receive radiation prophylaxis. All surgeries were done by the same surgeon using the same perioperative protocol. Radiation was delivered through anteroposterior/posteroanterior limited fields, avoiding areas of desired bony ingrowth. Of those hips that received radiation, Grade II or III heterotopic bone developed in 6% and Grade IV heterotopic bone developed in none. Of the control group, Grade II or III heterotopic bone developed in 34% of the hips and Grade IV heterotopic bone in 6%. The radiated hips had a significant net gain in abduction and adduction when compared with the nonradiated hips. No early complications were noted in association with the radiation treatment. A single dose of 6 Gy of radiation given within the first 3 postoperative days provides effective prophylaxis against heterotopic ossification developing after total hip arthroplasty in high risk patients.

Aged↗
PubMedDate not supplied

[Disseminated pulmonary ossification].

A case of disseminated nodular pulmonary ossification in 89-year-old male is presented. The patient was treated for broncho-pneumonia nad demonstrated chronic circulatory and respiratory failure. Pulmonary ossification was diagnosed at autopsy. The diagnostic problems, morphologic forms, pathogenesis are discussed and the relevant literature reviewed.

Aged↗
PubMed1994

[Heterotopic ossification and vascular compression].

Heterotopic ossification is common in patients with spinal cord or brain injury. Whereas the articular complications of heterotopic ossification have been well documented, the vascular complications are less well known. We report three cases with vascular compression and discuss the diagnosis and treatment in the light of a review of the literature.

Adult↗