[Effects of isosorbide dinitrate of prolonged action on the prevention of myocardial ischemia induced by exercise: correlation with nitrate blood levels].
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Adult↗
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Results for “Isosorbide Dinitrate”
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[Isosorbide dinitrate in exercise induced angina pectoris despite use of beta-blocking treatment. Clinical and hematological effects assessed by isotope angiocardiography].
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Adult↗
[Use of isosorbide dinitrate in pearl form in the treatment of congestive heart failure. Phonomecanographic study].
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Administration, Oral↗
Management of vasospastic angina at rest with continuous infusion of isosorbide dinitrate. A double crossover study in a coronary care unit.
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Aged↗
Comparative haemodynamic and peripheral vasodilator effects of oral and chewable isosorbide dinitrate in patients with refractory congestive cardiac failure.
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Administration, Oral↗
Effects of isosorbide dinitrate and nicardipine hydrochloride on postprandial blood pressure in elderly patients with stable angina pectoris or healed myocardial infarction.
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Aged↗
Oral isosorbide dinitrate in the treatment of angina pectoris. Dose-response relationship and duration of action during acute therapy.
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Administration, Oral↗
Antianginal efficacy of oral therapy with isosorbide dinitrate capsules. Prolonged benefit shown by exercise testing in patients with ischemic heart disease.
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Administration, Oral↗
Effects of long-term oral administration of isosorbide dinitrate on the antianginal response to nitroglycerin. Absence of nitrate cross-tolerance and self-tolerance shown by exercise testing.
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Administration, Oral↗
[Disparate efficacy of isosorbide dinitrate, in sustained-release form, during acute and chronic administration (author's transl)].
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Angina Pectoris↗
The antianginal efficacy of isosorbide dinitrate: dose-response relation and long-term effects of high-dose treatment.
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Administration, Oral↗
The effect of isosorbide dinitrate on left ventricular size, wall stress and left ventricular function in chronic refractory heart failure. An echocardiographic study.
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Adult↗
[Isosorbide dinitrate spray: a comparative pharmacodynamic study with a sublingual preparation in patients with chronic cardiac insufficiency].
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Administration, Inhalation↗
[Hemodynamic and coronary effects of isosorbide dinitrate, by the intravenous route, before and after the cold test in chronic coronary insufficiency treated with a beta-blocker].
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Adrenergic beta-Antagonists↗
[Effect of isosorbide dinitrate (isoket) on central hemodynamics and myocardial contraction in patients with ischemic heart disease].
The authors studied the effect of isoket on the central hemodynamics and myocardial contractility as well as on the conditions of myocardial functioning in 38 patients aged 28-53 years and suffering from coronary heart disease. The infusion of 2 mg of isoket at a rate of 400 micrograms/min was followed by a decrease in the arterial pressure with the maximum drop seen on the seventh minute (by 26% from the baseline value), a reduction in the end-diastolic pressure by 50%, and a lengthening of the preejection period without any significant changes in either the cardiac output or the total peripheral resistance. Taken as a whole these changes justify the conclusion that the influence of dinitrate isosorbite (isoket) on the central hemodynamics is largely due to its venodilating action leading to a reduction of the pre-load which in turn improves myocardial functioning.
Adult↗
Randomized controlled trial of vaginal misoprostol versus vaginal misoprostol and isosorbide dinitrate for termination of pregnancy at 13-29 weeks.
When compared to the use of 12 hourly 200 microg vaginal misoprostol on its own, the addition of a single dose of 5 mg did not significantly increase the abortion or delivery rate in pregnancy termination at 13-29 weeks gestation. All patients were given intravenous syntocinon at 30 mU/min from the first dose of misoprostol onwards.
Abortifacient Agents, Nonsteroidal↗
[Isosorbide dinitrate and bupranolol in the therapy of coronary heart disease (author's transl)].
Sixteen patients with coronary heart disease (CHD) and three healthy volunteers were treated with a combination of a long-acting nitrite and a beta-receptor blocking agent. The drug proved effective in diminishing haemodynamic changes after physical and mental stress, respectively. The implications of these findings are discussed in the light of recent knowledge on CHD pathogenetic mechanisms.
Blood Pressure↗
Effects of high-dose lisinopril-isosorbide dinitrate on severe mitral regurgitation and heart failure remodeling.
In long-term, 1-year follow-up, uptitration of angiotensin-converting enzyme inhibitor and nitrate therapy over established doses can further improve severe functional mitral regurgitation in patients with dilated cardiomyopathy due to a reversal of heart failure-related left ventricular remodeling. With marked left ventricular enlargement, >6.8 cm end-diastolic diameter, heart failure remodeling may be irreversible and resistant to further medical intervention.
Aged↗