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Effect of bromocriptine in patients with apomorphine-responsive erectile impotence: an open study.

An open pilot study was undertaken to investigate the therapeutic effect of the dopaminergic agent, bromocriptine (BC), in impotent patients who developed an erectile response to the dopamine receptor agonist, apomorphine. Eight out of 17 patients reported improvement in ability to obtain an erection; five of these 8 subjects were able to achieve penetration. The optimum dose of BC was 2.5 - 11.25 mg/day. A double-blind placebo-controlled study is merited.

Adult↗

[Impotence. Behavior therapy with substitute partner].

Some emotional reactions underlying sexual impotence are pointed out. Avoidance phobic behavior in the light of an expected failure is assumed. In order to suppress anxiety, and get a new training in sexual behavior, a therapeutic technique based on learning and conditioning principles is proposed. Under relaxation, previously designed imaginary exercises are presented to patients. Following imaginary sessions, the same exercises are repeated in vivo with a substitute partner, should patient lack partner, or his partner be unwilling to cooperate with treatment. Steps of exercises are described. Out of 8, 7 patients achieved a total improvement. The last patient involved gave up treatment.

Adult↗

Sexual impotence: studies of the hypothalamic-pituitary-thyroid axis and the effect of oral thyrotropin-releasing factor.

Thyrotropin-releasing factor was given orally to 12 impotent patients in a dose of 43 mg daily for 4 weeks in a double-blind crossover technique and compared with placebo. TRF showed no beneficial effect over placebo. In these patients, thyroid function and the hypothalamic-pituitary-thyroid axis were examined by measuring T3, T4, and TSH before and after the TRF test. There were no pathological findings for patients included in this study.

Adult↗

[Diagnostic and therapeutic aspects of impotence secondary to radical cystectomy and prostatectomy].

The authors report on their experience about diagnosis and therapies concerning cases of impotentia erigendi on account of urological operations in the small pelvis in order to extirpate tumours (radical prostatectomy, total cystectomy). The oncological effectiveness of the nerve-sparing technique is pointed out. The therapeutic diagnostic level is shown for this type of iatrogenic impotence and the various therapeutic possibilities are pointed out in relation to the wishes of the patient and to his life expectancies.

Combined Modality Therapy↗

Vacuum therapy in the treatment of erectal impotence.

The authors were the first in Hungary to use vacuum-induced erection in the treatment of erectal dysfunction. Negative pressure was induced by OSBON ERECAID SYSTEM. Erectal impotence was successfully treated with this non-invasive and complications-free method in patients with diabetes and psychic problems. The method was applied first for ameliorating sexual complaints due to virile climacteric and--based on the results--its application is recommended.

Adult↗

[Surgery for venocavernous impotence: what indications and techniques in 24 cases?].

The efficiency and even the usefulness of the venous reconstructive surgery are presently debated. 24 carefully selected cases of venocavernous impotence (VCI) have been operated on using: a. an extensive venous ligation, b. a pericavernoplasty, c. a cavernoplasty. After a median follow-up of 15 months, the erectile post-operative rigidity has been sufficient in only 8 cases (33%) spontaneously. In 7 cases (29%), a sufficient rigidity has been obtained only after intracavernous injection of drugs. No improvement has been noted in 9 cases (38%). The best results have been noted for VCI by rigidity obtention anomaly, without severe arterial or tissue lesions, or associated to La Peyronie's disease. The association venous ligation+pericavernoplasty+cavernoplasty, whatever the techniques appears hydraulically as an efficient solution for some selected VCI. In spite of the imprecisions of both definition and diagnostic criteria of VCI, a reduced number, still difficult to recognize, may be cured by venous surgery. Thus, the lack of reliability of this surgery seems to result more from an insufficiency of both its indications and its techniques than to a real usefulness.

Adult↗

Self intra-cavernous injections as a successful treatment in pure neurogenic impotence.

The aim of our research is to investigate the success of the vasoactive intracavernous therapy in subjects suffering impotence only on a neurological basis. We have submitted 50 subjects to a multisciplinary study including P.B.P.I., intracavernous minitest plus V.S.S., M.M.P.I., B.C.R. latency, duration, aspect and an hormonal screening (SH, LH, PRL, F. TEST, 17 BE2). The patients, or their partners, were instructed in the technique of self intracavernous injection (S.I.C.I.) of vasoactive drugs. Papaverine alone was given to 37 patients in a mean dose of 20.8 +/- 11.7 mg. Other 13 patients were treated with papaverine plus phentolamine in order to obtain a full erection. Comprehensive results of the treatment were judged at 80% effective: only 10 patients discontinued self injection treatment, unable to perform this technique properly.

Adult↗

[First consultation of impotent patient].

This paper defines the main goals of the first consultation of an impotent patient, and describes the practical procedure. First of all, the first consultation must include a thorough history-taking which will make it possible in many cases to have a fairly objective idea of the degree of organic involvement. The most important questions are about the possible occurrence of regular rigid erections in situations that are neither coital nor sexual. Their occurrence rules out any organic involvement almost with certainty, and allows abstaining from additional examinations, or keeping them within minimum limits. Their absence is compatible with an organic involvement, but is not specific for this, and leads to further exploration. The first consultation is also the occasion of a first human contact, and its quality will often influence the prognosis. Besides being sufficient to cure some patients, this first contact is a major condition for the compliance with the therapeutic advice that will be given later on.

Ejaculation↗

Surgical treatment and prevention of vasculopathic impotence in conjunction with revascularisation of the lower extremities in Leriche's syndrome.

The results are presented of combined revascularization of the lower extremities and the penis in 29 patients with Leriche's syndrome. This was effected by placing an autogenous venous shunt between the branch of a prosthesis or the common femoral artery and one of the dorsal arteries of the penis. Preoperatively lost sexual function was restored in 6 patients, while in 16 the sexual function was maintained at the preoperative level or improved in the late postoperative period. A comparison of the results obtained with the sexual performance of patients who had undergone bifurcated aortofemoral shunting only, prompted the conclusion that this surgical procedure was effective in the prevention and treatment of vasculopathic impotence in Leriche's syndrome.

Anastomosis, Surgical↗

[Penile self-injection of a papaverine-phentolamine combination, as treatment of impotence, in patients treated with radical cystoprostatectomy].

Four patients with impotence secondary to radical cystoprostatectomy due to infiltrant vesical urothelial carcinoma, received treatment with a mixture of papaverine-phentolanin, at dosages of 18-0, 34 mg respectively. Good results were obtained in every occasion, all four cases achieving rigid erection for over an hour which allowed penetration. Currently, patients continue peneal self-injection treatment with these drugs, with no complications or therapy failure being reported.

Adolescent↗

[Male impotence. Radiologic venous evaluation].

Vascular lesions are one of the most frequent causes of organic impotence. Dysfunction of the penile veno-occlusive mechanism is studied by cavernography-cavernometry. The major criterion of venous leakage is the maintenance flow which remains less than 25 ml/min after intracavernous injection of papaverine (60 mg). In the erect state cavernography can demonstrate the abnormal venous drainage.

Erectile Dysfunction↗

[Impotence from venous leakage associated with another disease].

The exact mechanism of venous leaks remains obscure. However, we know that venous occlusion depends on two principal factors: the intrapenile arterial blood flow and the compliance of the corpora cavernosa. Since 1983, the authors have treated 23 patients presenting with mixed vasculogenic impotence. These patients, with a mean age of 57 years, were treated by arterio-arterial microanastomosis then ligation of the deep dorsal vein or by arterialization of the deep dorsal vein of the penis, using the epigastric artery as the donor artery. The results were encouraging and stable in the medium-term (mean follow-up: 24 months). 80% of patients were satisfied with their erections and their sex life.

Aged↗

[Results of the treatment of vascular-induced impotence using PTA].

PTA was employed in 19 patients with impotency caused by vascular disorders. In 16 (84%) of the patients, potency was successfully restored. PTA treatment was applied only to those patients under 50 years of age in whom moderate and limited arteriosclerotic stenoses were diagnosed via DSA. Restitution of potency was recorded after 3 days to 2 weeks after PTA application.

Angioplasty, Balloon↗

[Current diagnosis of impotence].

In recent years the true incidence of impotence due to organic diseases in comparison with psychogenic disorders could be verified. New diagnostic tools as penile Doppler ultrasonography, PBI estimation, NPT measurement, invasive SKIT's, neurophysiological methods, selective phalloarteriography, artificial erection and dynamic cavernosography are introduced and are the guide to therapeutic approach.

Adult↗

[A new method of surgical treatment of vasculogenic impotence].

The authors describe a method of surgical management of vasculogenic impotence consisting in the formation of an anastomosis of an autovenous shunt with the dorsal artery of the penis. To prevent revascularization of the cavernous bodies of the penis with the restoration of erection, the dorsal artery of the penis is divided transversely at the root of the penis, the distal end of the autovenous shunt is given the shape of a trapezium with the upper side sutured, after which the autovenous shunt is anastomosed end to end with both the distal and proximal segments of the dorsal artery of the penis at the lateral sides of the trapezium where the angles were not sutured. The method allows incompetence and thrombosis of the vascular anastomosis to be prevented, raises the efficacy of revascularization of the cavernous bodies of the penis by creating favourable hemodynamic conditions through separation of the blood flow into the distal and proximal segments of the dorsal artery of the penis, which provides retrograde supply of blood into the deep artery of the penis sufficient for adequate revascularization of the cavernous bodies.

Adult↗

[Surgical treatment and prevention of angiogenic impotence in combination with revascularization of the lower extremities in Leriche's syndrome].

The article deals with the results of combined revascularization of the lower limbs and penis in 29 patients with Leriche's syndrome. It was accomplished by creating an autovenous shunt between the blades of the prosthesis or common femoral artery with the dorsal artery of the penis. In the late-term postoperative period the initially lost sexual function was restored in 6 patients and improved or maintained on the preoperative level in 16 patients. On the basis of comparison of the results with the sexual function in patients who were treated by bifurcation aortofemoral shunting it is concluded that the suggested surgical tactics in the prevention and treatment of vasculogenic impotence in Leriche's syndrome produces a significant clinical effect.

Aorta, Abdominal↗