Morphological alterations in type II alveolar cells in essential fatty acid deficiency.
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Plasma lipoproteins, prepared from the blood of superovulated rats by precipitation with phosphotungstate/Mg2+, were similar to HDL and LDL prepared by 24 hr centrifugation. Analyses of the fatty acid compositions of the major lipid classes in HDL, LDL and ovary revealed that the esterified fatty acids of plasma were markedly shorter and more saturated than those of the ovary. Elongation of essential fatty acids by ovary may be important in disposing of carbon fragments generated by the incomplete oxidation of fatty acids during steroidogenesis. The function of HDL and/or LDL in supplying polyunsaturated fatty acids to ovary may be more important than their role in delivering cholesterol, which the ovary can make.
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The experiments were carried out to investigate the effects of prostaglandins (PGs) on the sleep pattern in the cat, and in normal and EFAD rats. The data indicate that the duration of slow wave sleep (SWS) was significantly longer in EFAD rats compared with the normal rats. However, no difference in the REM sleep was observed between the two groups. Intraventricular (i.vc. )administration of PGE1, PGE2 and PGF2alpha increased wakefulness without a significant alteration of REM sleep. PGE1 administered i.vc. did not alter the duration of SWS or REM sleep in the chronic cat, but induced ponto-geniculo-occipital (PGO) waves (spikes) which are the phasic phenomenon of REM sleep. The fact that previous administration of 5-hydroxytryptophane abolished the PGE1-induced PGO spiking, might indicate that this drug triggered the spikes mainly via the functional inhibition of the serotonergic system.
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