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Primary extrapulmonary small cell carcinoma involving the stomach or duodenum or both: findings on CT and barium studies.

OBJECTIVE: The purpose of this study was to evaluate the CT and radiographic features of extrapulmonary small cell carcinoma involving the stomach or duodenum or both. CONCLUSION: Although the radiologic findings of extrapulmonary small cell carcinoma involving the stomach or duodenum or both appear to be variable and nonspecific, some distinguishing features are poor contrast enhancement, bulky exophytic mass, and minimal peritumoral infiltration.

Aged↗

Gastrointestinal stromal tumors of the duodenum: CT and barium study findings.

OBJECTIVE: The purpose of this study was to describe the CT and radiographic features of gastrointestinal stromal tumors of the duodenum. CONCLUSION: Gastrointestinal stromal tumors of the duodenum appear on barium studies as extrinsically compressing or submucosal masses with or without ulceration. These tumors usually appear on contrast-enhanced CT as well-defined masses with an exoenteric growth pattern and relatively good heterogeneous enhancement.

Adult↗

Helicobacter pylori and chronic active inflammation of the duodenum and stomach in duodenal ulcer patients treated with ranitidine, misoprostol, or an acid-neutralizing agent.

Biopsy specimens from the stomach and duodenum of 45 duodenal ulcer patients treated with ranitidine, misoprostol, or an antacid were examined. During 4 weeks of treatment the duodenal ulcer healed in 31 patients. The treatment regimens showed no significant effect on the amount of Helicobacter-like structures (HLS) or the presence of active inflammation, either in the stomach or in the duodenum. All patients had chronic active antral gastritis before and after treatment. HLS were found histologically in 91.7% of all antral specimens, in 94.2% of the gastric corpus specimens, in 15.9% of the duodenal bulb specimens, and in 0.9% from the lower duodenal knee. The frequency of chronic active gastritis was clearly lower in the gastric corpus than in the antrum, whereas the occurrence of HLS was about the same. This may indicate a higher resistance of the gastric corpus mucosa to H. pylori.

Adult↗

Primary adenocarcinoma of the duodenum with choledochoduodenal fistula.

BACKGROUND: Primary adenocarcinoma of the duodenum is an uncommon clinical entity. It has been associated with a dismal prognosis because it is rare and produces no distinctive symptoms until late in its course. CASE SUMMARY: A 68-year-old man presented with a 6-month history of epigastralgia, anorexia, and progressive weight loss. Esophagogastroduodenoscopy showed a tumor mass in the deformed duodenal bulb with a fistula into the biliary tract. Upper gastrointestinal (UGI) barium studies and cholangiography confirmed a fistulous communication between the duodenum and biliary tree. CONCLUSIONS: Aggressive evaluation of minor, yet refractory, UGI symptoms and a high index of suspicion offer the best hope for early diagnosis. Esophagogastroduodenoscopy and barium UGI study are the principal methods of diagnosis of these tumors. Early diagnosis would thus prevent metastasis and complications.

Adenocarcinoma↗

Gangliocytic paraganglioma of the duodenum: report of a case with immunocytochemical and ultrastructural investigation.

A case of gangliocytic paraganglioma is reported in a 70-year-old female presenting as a polypoid tumor of the second portion of the duodenum. Immunohistochemical and ultrastructural features of the tumor indicate that gangliocytic paraganglioma of the duodenum (GPD) represents an unique tumor originating from the neuroectodermal derivative exhibiting dual phenotypic expression toward paraganglionic and epithelial (neuroendocrine) cells. These findings correlate well with the literature and it is further suggested that GPD belongs to the histopathologic spectrum of tumors derived from the neural crest. The findings offer a plausible explanation for histogenetic possibilities of the occurrence of pure epithelial tumors (i.e., carcinoid-like tumors) in the paraganglionic systems. The patient remains with no evidence of disease 4 years following a simple polypectomy.

Aged↗

[A case of Lemmel's syndrome caused by a large diverticular enterolith at the peripapillary portion of the duodenum].

A 93-year-old woman admitted because of epigastralgia. Cholelithiasis, obstructive jaundice, acute suppurative cholangitis and acute pancreatitis were diagnosed on blood chemistry and ultrasonography on admission. We performed emergency PTCD. A calculus 4 cm in diameter was detected at the papilla of Vater and marked dilatation of the common bile duct and pancreatic duct. ESWL was performed because of her age and because endoscopical operation seemed to be difficult. After lithotripsy, PTC and endoscopy demonstrated a diverticulum at the peripapillary portion of the duodenum. Based on analysis of PTC result before and after ESWL, we diagnosed this case as Lemmel's syndrome (obstructive jaundice, acute suppurative cholangitis and acute pancreatitis) caused by a large diverticular enterolith at the peripapillary portion of the duodenum. ESWL treatment of aged patient with an enterolith is safe.

Acute Disease↗

Malignant phyllode tumor metastatic to the duodenum.

Phyllode tumor (PT) is extremely rare tumor of the breast. Distant metastasis occurs in 10%-20% of patients with malignant phyllode tumor. The most common sites of metastases are the lungs and bones. Although theoretically any organ may have metastasis, an isolated duodenum metastasis has not been documented as yet in the English-language literature. We report herein a case with a isolated duodenal metastasis from PT of breast in a 31 year-old-woman who underwent right mastectomy 4 years before because of the recurrent malignant PT. She presented to our hospital with massive upper gastrointestinal bleeding. Clinical evaluation revealed a huge mass originated from duodenum. Urgent laparotomy and pancreaticoduodenectomy were carried out in order to remove the bleeding duodenal mass. The pathologic examination of the resected specimen showed a malignant spindle cell tumor consistent with metastatic malignant PT. Our case of gastrointestinal bleeding due to an isolated duodenal metastasis as a result of hematogenous spread from malignant phyllode tumor of breast is unique in the English literature and pancreaticoduodenectomy is a curative treatment for patients with isolated duodenal involvement.

Adult↗

Effect of devazepide reversed antagonism of CCK-8 against morphine on electrical and mechanical activities of rat duodenum in vitro.

AIM:To study the antagonism of cholecystokinin octapeptide (CCK-8) against the effect of morphine and its mechanism.METHODS:The method of simultaneously recording the electrical and mechanical activities of rat duodenum in vitro was adopted.RESULTS:Acetylcholine (ACh) could increase the amplitude and the number of the spike potential (SPA and SPN of rat duodenum in vitro, followed by the increase of the duodenal contraction amplitudes (CA), showing a positive correlation. Morphine, on the contrary, inhibited the potentiation of ACh, showing a negative correlation. CCK-8 could antagonize the effects of morphine, i.e. th SPA and SPN were increased again, followed by the increase of CA. On the basis of the above, CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.CONCLUSION:CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro.Furthermore, it was inferred that the antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.

Journal Article↗

A case of primary T-cell lymphoma of the duodenum.

Primary malignant lymphoma located in the duodenum is a rarity. A case of primary lymphoma of the duodenum in a 27-year-old man, in which the 2 discrete masses of duodenal bulb and the second portion with pancreatic head invasion was found, is reported here. Immunohistochemical evaluation of the present case showed that lymphoma cells expressed the T-cell markers MT1 and UCHL1. Treatment consisted of pancreaticoduodenectomy followed by antineoplastic chemotherapy.

Adult↗

Benign pancreatic tumor treated with duodenum-preserving resection of the head of the pancreas. Case report.

Cystic neoplasms of the pancreas constitute about 9% of all cystic lesions of the pancreas and less than 1% of all pancreatic neoplasms. Authors report the case of a 70 year-old woman with microcystic cystadenoma. Computed tomography (CT) scan of the abdomen diagnosed a 5 cm multilocular septated cyst, with calcifications in the context, localized in the head-uncinate process of the pancreas. The mass was well separated by a sharp cleavage plane with portal vein and superior mesenteric vessels. An endoscopic retrograde cholangiopancreatography (ERCP) showed cephalic symmetrical stenosis (diameter: 3 mm) of the main pancreatic duct (MPD), mildly dilated in the remaining tract (diameter: 6 mm). An intra-operative biopsy of the cystic wall had been performed. Therefore, it was decided to proceed with a duodenum-preserving resection of the head of the pancreas (DPPHR), including stenosis tract of the MPD in the surgical specimen. The reconstructive procedure consisted, by i.v. jejunal loop transposition, of a side-to-side pancreatico-jejunostomy, including in the anastomosis both corpocaudal stump and the resection cavity of the pancreatic head, and an end-to-side Roux-en-Y jejuno-jejunostomy. With respect to long-lasting pain relief and preservation of the endocrine and exocrine functions of the pancreas, duodenum-preserving resection of the head of the pancreas is a highly effective surgical procedure with low early and late morbidity and mortality due to limited surgical resections. This technique, introduced into surgical practice in 1972 by Beger, is indicated in patients with chronic pancreatitis with an inflammatory mass in the head of the pancreas. The authors conclude that this procedure can also be performed in cases of pancreatic benign tumors, such as microcystic cystadenoma. Advantages of this technique make DPPHR an attractive alternative to pylorus-preserving pancreatico-duodenectomy (PPPD).

Aged↗

[Recurrent acute hemorrhage in the duodenum as a symptom of Bouveret's syndrome].

The authors demonstrate on the case-history of a 51-year-old patient the rare cause of repeated haemorrhage into the digestive tract calling for emergency surgery. On operation they found as the cause a solitary biliary concrement which penetrated into the duodenum and caused haemorrhage of its wall. The disease was described in 1896 by Bouveret as a syndrome of duodenal obturation by a large gallstone. In the described case the whole concrement did not yet penetrate into the duodenum to cause its obturation but it produced repeated haemorrhage which could not be treated by conservative methods.

Acute Disease↗

Eosinophilic infiltration of duodenum and pancreatic head: report of a case studied arteriographically.

A case of tumorlike eosinophilic infiltration of the duodenum and pancreas is reported. Arteriography and hypotonic duodenography indicated a large lesion involving both the pancreatic head and the second portion of the duodenum without encasement or obstruction of the intrinsic vasculature. This is the first reported use of angiography in this condition. The combination of findings described should suggest a benign infiltrative process.

Adult↗

[The factors of cell immunity in patients with peptic ulcer of duodenum].

20 patients with peptic ulcer disease of duodenum were studied. We found that metabolic activity of neutrophils in peripheral blood and in mucosa is the same in patients with complicated peptic ulcer. The absorption activity of tissue neutrophils is higher than in blood. During operation we observed an increase of neutrophils' activity both in blood and mucosa. On the 6th day after operation the response of neutrophils recovered. In patients who undergo conservative treatment for peptic ulcer of duodenum the activity of neutrophils decreased significantly. This emphasizes that immunocorrection treatment is indicated to all patients that receive conservative treatment for peptic ulcer.

Adult↗

Leiomyosarcoma of the duodenum. A successful reoperation after recurrency.

Leiomyosarcomas of the duodenum are rare tumours. Approximately 160 cases have been reported so far. Pain, bleeding and duodenal obstruction causing vomiting and weight loss are the leading symptoms. The mass may be palpable. If resected, prognosis is favorable in a majority of cases, much better then in carcinomas of the duodenum. Patients have to be followed up as eventual recurrencies are frequently suitable for resection. We present a 62 years old male who was submitted to cephalic duodenopancreatectomy for duodenal leiomyosarcoma (reported earlier) who developed recurrency 6 years after original surgery and in whom a successful reoperation was performed. Two years after second surgery the patient stayed disease free.

Duodenal Neoplasms↗

[Treatment of adenocarcinoma of the duodenum: presentation of 4 clinical cases and review of the literature].

The Authors comment on the difficulty of diagnosing and treating duodenal tumours. The most appropriate indications and extent of resection of these neoplasms are discussed. The Authors report 4 cases of primitive adenocarcinoma of the duodenum treated by pancreaticoduodenectomy (2 cases), segmental resection (1 case) and palliative surgery (1 case) for the presence of omental and lymph-node metastases. Survival was 18 and 14 months in the patients who underwent pancreaticoduodenectomy and 9 months for the patient receiving palliative treatment; the patient who underwent segmental resection is still alive and healthy after 12 months. The Authors point out that adenocarcinoma of the duodenum is an uncommon neoplasm and stress the difficulty encountered in establishing an accurate diagnosis and appropriate surgical management. Better results can be obtained only with an early diagnosis. Chemotherapy and radiotherapy do not significantly improve survival.

Adenocarcinoma↗

[Indolent primary gastric adult T-cell leukemia/lymphoma with recurrent lesions limited to the stomach and duodenum].

A 75-year-old man visited our hospital complaining of heartburn in November 1997. Gastroscopical examination revealed ulcerous protruding extended from the gastric antrum to body and a flat, elevated lesion in the greater curvature of the stomach. Biopsy specimens revealed a CD4-positive malignant lymphoma. The serum anti-human T-lymphotrophic virus type I (HTLV-I) antibody test was positive. He was diagnosed as having primary gastric adult T-cell leukemia/lymphoma (ATLL; acute type). Complete remission was achieved with chemotherapy. In December 1998, the patient experienced a relapse. The lesions were limited to the region between the upper gastric body and the fornix and disappeared with radiation therapy. A second relapse was detected in the gastric greater curvature and descending portion of the duodenum in May 1999 but spontaneously disappeared in 5 months. The third relapse in May 2000 was systemic. Monoclonal integration of the HTLV-I provirus was observed in DNA extracted from ascitic lymphocytes. Chemotherapy was resumed, but the response was poor. The patient subsequently died of respiratory failure as a result of pneumonia. Although gastrointestinal involvement is frequent in ATLL, this appears to be a rare case of an idolent clinical course with lesions limited to the stomach and duodenum for 30 months.

Aged↗

[Delayed diagnosis of congenital membranous stenosis of the duodenum (author's transl)].

A 12 year old boy with Down's syndrome is described who had a congenital membranous duodenal stenosis. Although the boy had been vomiting from birth and normal feeding was impossible, the diagnosis was made only at the age of 6 years when radiographs were taken because he had swallowed foreign bodies. The malformation was not suspected and no treatment undertaken. Because vomiting increased he was admitted at the age of 12 years to a department for surgical pediatrics. At operation stenosis of the duodenum was confirmed, some coins were removed which had settled proximal to it, the membrane was excised and the duodenum, plit longitudinally, sutured transversely. The postoperative course was smooth and now the boy is very fit.

Child↗