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PubMedDate not supplied

Teleplot: a computing system for objective analysis of fetal heart rate recordings.

In human pregnancies, fetal heart rate recordings are useful both in predicting and in preventing imminent fetal death. Although an objective numerical measurement of such recordings is preferable to visual analysis, few obstetric centres have the computer expertise to implement this. Here we describe the principles of a technique whereby the fetal heart rate versus time trace may be transferred into computer memory for further processing in a numerical and objective fashion. The methodology is valid howsoever the fetal heart rate is detected.

Computers↗
PubMed2005

A distributed computing system for multivariate time series analyses of multichannel neurophysiological data.

We present a client-server application for the distributed multivariate analysis of time series using standard PCs. We here concentrate on analyses of multichannel EEG/MEG data, but our method can easily be adapted to other time series. Due to the rapid development of new analysis techniques, the focus in the design of our application was not only on computational performance, but also on high flexibility and expandability of both the client and the server programs. For this purpose, the communication between the server and the clients as well as the building of the computational tasks has been realized via the Extensible Markup Language (XML). Running our newly developed method in an asynchronous distributed environment with random availability of remote and heterogeneous resources, we tested the system's performance for a number of different univariate and bivariate analysis techniques. Results indicate that for most of the currently available analysis techniques, calculations can be performed in real time, which, in principle, allows on-line analyses at relatively low cost.

Algorithms↗
PubMed1995

Influence of codon usage and translational initiation codon context in the AcNPV-based expression system: computer analysis using homologous and heterologous genes.

Codon usage by all the known gene sequences from Autographa californica nuclear polyhedrosis virus (AcNPV) was compared with that of firefly luciferase (luc) and the beta subunit of human chorionic gonadotropin (beta hCG) expressed to contrasting levels in the baculovirus system. The highly expressed luc gene showed a codon usage similar to AcNPV genes, as reflected by a very low D-squared statistic value (0.78) and a similar G/C usage (45%) at wobble positions. However, the underexpressed beta hCG gene displayed a high D-squared value (7.3) and G/C usage (82.5%) at the wobble base position. Alignment of the 20 nucleotides around the initiation codon of 23 AcNPV genes identified a novel consensus translation initiation sequence aag/ta/tat/aa/cAAaATGaa/ct/ag/aAan, which was quite different from the Kozak consensus sequence (GCC)GCCA/GCCATGG. An extension of these analyses to a sample of other heterologous genes overexpressed and underexpressed in BEVS suggested similar trends. These theoretical analyses have important implications for heterologous gene expression in this system.

Animals↗
PubMed2005

Touch-screen computer systems in the rheumatology clinic offer a reliable and user-friendly means of collecting quality-of-life and outcome data from patients with rheumatoid arthritis.

OBJECTIVES: To investigate the feasibility of collecting rheumatoid arthritis (RA) patient self-administered outcome data using touch-screen computers in a routine out-patient clinic. METHODS: Forty patients with RA completed the touch-screen and paper Rheumatoid Arthritis Quality of Life Questionnaire (RAQol) in the clinic and rated ease of use and preference. Forty-five others completed the Stanford Health Assessment Questionnaire (HAQ) and visual analogue scales (VASs) for pain, fatigue and global arthritis activity on touch screen and paper and a joint assessment on touch screen. They rated ease of use and willingness to complete the assessment again. Joints were independently assessed, and completion times and technical problems recorded. RESULTS: No technical problems were encountered. The touch-screen RAQol took no longer to complete, was preferred by 64% (33% had no preference) and was rated significantly higher for ease of use (two-tailed P=0.003, n=40) even by computer naïve patients (two-tailed P=0.031, n=24). Intraclass correlation coefficients between methods were high for RAQol (0.986) and tender joint counts (0.918), and as high for the pain, fatigue and global activity (0.855, 0.741, 0.881) as for test-retest of the paper versions (0.865, 0.746, 0.863). Ninety-eight per cent rated the touch screen very/quite easy for HAQ and VAS, and 90% for joint assessment. Ninety-six per cent stated a willingness to complete the touch-screen assessment in clinic again. CONCLUSIONS: Touch-screen questionnaires in the clinic can produce comparable results to paper, eliminate the need for data entry and afford immediate access to results. It is an acceptable, and in many cases a preferable, option to paper, regardless of age and previous experience of computers.

Adult↗
PubMedDate not supplied

Practical use of a free-text computer system in pathology.

Free-text is a natural and effective means of communication of clinically valuable information in subjects such as morbid anatomy. Due to recent developments in hardware and software, it is becoming possible for a greater number of pathologists and others to consider the computer as a possible means of storing, retrieving and analysing findings which have been expressed in words. This paper describes some experiments which have been carried out in this area; these suggest that computer-held free-text can yield useful and hitherto unavailable information, but that coded input may be required for some applications.

Brain Neoplasms↗
PubMed1981

[Experience in developing and using telemetric computer systems in cardiology].

A system of automated analysis of ECG consisting of subsystems of analysis of monitored ECG and subsystems of automated analysis of ECG in 12 leads is described. Both subsystems are united by the base data for preserving the results of analysis of monitoring and machine electrocardiographic data. The results of the use of the above systems for monitoring observations and mass examinations are presented.

Computers↗