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At least 973 records · Page 54Linked to original sources
PubMed2002

4alpha-Phorbol negates the inhibitory effects of phorbol-12-myristate-13-acetate on human cilia and alters the phosphorylation of PKC.

In medium 199, ciliary beat frequency (CBF) in human nasal epithelium declines to 60% of baseline by 2 h and 1 nM phorbol-12-myristate-13-acetate (PMA) doubles the rate of decline by activating protein kinase C (PKC). We find that a reported negative control for PMA, 4alpha-phorbol (1 pM-1 nM)+/-1 nM PMA, not only maintains CBF at baseline, but arrests a pre-existing PMA-induced decline in CBF and alters the profile of multiple phosphorylated PKC species. Thus, 4alpha-phorbol not only potently prevents PMA from inhibiting CBF but also has potent effects on the phosphorylation of PKC.

Blotting, Western↗
PubMed1989

Properties of an excitable dynein model for bend propagation in cilia and flagella.

Murase & Shimizu (1986, J. theor. Biol. 119, 409) introduced an excitable dynein-microtubule system based on a three-state mechanochemical cycle of dynein to demonstrate bend propagation in the absence of a curvature control mechanism. To examine the essential behavior of this class of models in a viscous fluid, we have represented the force generated by the complex dynein mechanochemistry by a formal model consisting of "force" and "activation" functions vs. sliding distance. Since the model has excitable properties with threshold phenomena and hysteresis switching between two opposed subsystems, it closely resembles the more realistic dynein kinetic scheme in its overall properties but is specified by fewer parameters. This model displays both bend initiation and bend propagation when the filaments at the basal end are either fixed or free to slide. A passive region is necessary at one end of the axoneme in order to obtain stable wave propagation; bends propagate towards the end with the passive region. Stable bend propagation is highly sensitive to small perturbations in external force distribution.

Adenosine Triphosphatases↗