Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Autobiography”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 973 records · Page 54Linked to original sources
PubMedDate not supplied

The chemistry and immunochemistry of blood group A, B, H, and Lewis antigens: past, present and future.

This article traces reseach on the chemistry and immunochemistry of blood group A, B, H, and Lewis antigens from early work on the identification of soluble sources of these antigens, through the elucidation of the structures of the carbohydrate epitopes responsible for these specificities, to recent work on exploring their possible use as cancer vaccines. The various approaches used in the isolation of oligosaccharides from mucins for use in structural studies are discussed, as are recent efforts in the chemical systhesis of blood group-active oligosaccharides.

ABO Blood-Group System↗
PubMedDate not supplied

So what do your sugars do?

Up to about fifteen years ago the above question was quite often asked of glycoconjugates enthusiasts. It was always a silly question, the answer being 'How many doings do you want to hear about?' Since then our understanding of the structures, biosynthesis and varied functions of the glycoconjugates has developed incredibly and come to have a major impact on much of present-day biological and medical research.

Animals↗
PubMedDate not supplied

Hyaluronan, a common thread.

Hyaluronan, nature's simplest, but still exceptionally versatile glycosaminoglycan, is currently the focus of attention across a wide front of research; from cell biology, morphogenesis, matrix organization, pathobiology to tissue engineering. This macromolecule has entangled me in a number of puzzling and challenging projects over the past 3 decades. These entertaining encounters are outlined in this retrospective.

Animals↗
PubMed2002

The trauma of profound childhood loss: a personal and professional perspective.

Profound loss in childhood as a precipitant for symptoms of posttraumatic stress disorder has been a largely neglected subject. There is now some literature to suggest that severe loss and the absence of care may be as predictive of psychological distress in children as events that are more frequently studied, such as exposure to natural disasters and physical or sexual abuse. This paper combines the author's personal experience as an orphaned child who was placed in foster care with a discussion of this emerging literature to examine the relationship between childhood loss and trauma symptoms. An awareness of the traumatic nature of severe losses in childhood could help caregivers and mental health professionals deal more effectively with such children.

Adolescent↗
PubMed2002

Autobiographical memory specificity, intrusive memory, and general memory skills in Dutch-Indonesian survivors of the World War II era.

A lack of specific autobiographical memory may result from exposure to psychological trauma, intrusive memories of adverse events, and/or a general memory deficit. This study explored the role of these variables in 25 patients with various psychiatric diagnoses and 15 healthy controls. All participants had been exposed to war atrocities during their childhood in Indonesia. Patients produced significantly less specific memories than did controls. In addition, rather than performance on general neuropsychological memory tests, the frequent occurrence of intrusive memories and the avoidance of reminders of trauma predicted less autobiographical memory specificity. These results replicate and extend earlier findings on intrusive and nonspecific autobiographical memory in depressed samples to a group of people who experienced war atrocities in childhood.

Adaptation, Psychological↗
PubMedDate not supplied

Nobel Lecture. Yeast and cancer.

The discovery of genes that control cell division in yeast, and their relation to cancer, is reviewed.

Cell Cycle Proteins↗
PubMed1998

Twenty five years of the "psychosine hypothesis": a personal perspective of its history and present status.

Twenty five years ago in 1972, a hypothesis was introduced to explain the pathogenetic mechanism underlying the unusual cellular and biochemical characteristics of globoid cell leukodystrophy (Krabbe disease). It postulated that galactosylsphingosine (psychosine), which cannot be degraded due to the underlying genetic defect, is responsible for the very rapid loss of the oligodendrocytes and the consequent paradoxical analytical finding, the lack of accumulation of the primary substrate, galactosylceramide, in patients' brain. It took nearly ten years before the actual accumulation of psychosine was demonstrated in human Krabbe patients and also in the brain of twitcher mice, an equivalent murine mutant. Meanwhile this "psychosine hypothesis" has been extended to Gaucher disease and then to a more general hypothesis encompassing all sphingolipidoses that the "lyso-derivatives" of the primary sphingolipid substrates of the defective enzymes in respective disorders play a key role in their pathogenesis. Some of these extensions not only remain speculative without conclusive factual evidence but may eventually turn out to be an overstretching. This article attempts, from my personal perspective, at tracing historical development of the "psychosine hypothesis" and examining its current status and possible future directions.

Animals↗
PubMed1998

A history of proteolipids: a personal memoir.

This review is a personal memoir of the history of proteolipids and is limited to aspects of the field with which the author has been involved in one way or another. The discovery of proteolipids was a serendipitous observation made in the course of the study of sulfatides. Initial focus was on the chemical characterization of brain proteolipids, their behavior under different conditions and their identification as the major protein of CNS myelin. The sequence of PLP was obtained using solid phase protein sequencing techniques. This, in turn, made possible a new era in which biochemical, cellular and molecular approaches could be applied to address new questions about PLP. Identification of genetic defects in the PLP molecule and its regulation has contributed to understanding myelin biology. Studies of the encephalitogenic activity of PLP in animal models have influenced the views of inflammatory processes in multiple sclerosis. Despite remarkable progress, much remains to be learned about the structure and function of PLP.

Animals↗
PubMed2003

Coming out in community psychology: personal narrative and disciplinary change.

Community psychology as a discipline has not focused its attention on the lives of lesbians, gay men, and bisexual (LGB) people, despite the field's potential to collaborate with this population in dealing with the many psychosocial challenges they face. Professional and personal barriers that community psychologists must confront conducting research and developing interventions with the LGB community are described. Community psychology work with LGB communities is often a "coming out" experience for LGB community psychologists, and a questioning of sexual orientation for heterosexual community psychologists. Conceptual analyses and empirical reports are presented that exemplify how community psychologist can contribute to decreasing the pervasive stigma LGB people face. The use of an ecological model, a focus on the development and evaluation of preventive interventions, and a recognition of the diversity within the LGB population are core perspectives that can direct future work by community psychologists. Issues ranging from testing ways to empower young LGB people to analyses of the impact of the sociopolitical climate on LGB lives demonstrate the rich range of contributions community psychologists can make.

Autobiographies as Topic↗
PubMed1997

Reflections.

Explore the source record for details and available documents.

History, 20th Century↗
PubMed2004

[Fake pearls... imperative day somnolence--a personal experience].

In this review, narcolepsy is described based on personal experience of the author with this disease, especially with imperative day-somnolence and cataplexy. Narcolepsy is frequently underestimated and repressed. The economical (disability) and ethical (traffic accidents) implications of the disease may be significant. Optimal treatment and changes of behaviour are important.

Accidents, Traffic↗