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At least 973 records · Page 54Linked to original sources
PubMed1990

[The effect of acute alcoholic intoxication on the morphofunctional properties of the peripheral blood erythrocytes].

In experiments on rabbits it has been established that the acute alcoholization causes prolonged uncompensated alterations of such physical and chemical properties of erythrocytes as the average volume, the concentration of dry substance and water, the density, the content of endoerythrocytal hemoglobin, as well as the concentration of erythrocytes and hemoglobin in blood.

Alcoholic Intoxication↗
PubMed1996

[Traffic accidents in alcoholic intoxication].

A study of group comprising all road accidents caused by drivers of private cars who were under the influence of alcohol (BAC > = 0.3 g/kg; X = 1.56 +/- 0.62 g/kg) that occurred in a defined area over the span of one calendar year (n = 625) was compared with a randomly selected control group of 718 road accidents in which the drivers had not been under the influence of alcohol. The drivers in the study group were marginally younger than the ones in the control group. However, there was no evidence of an alcohol related increase in the risk of an accident associated with younger age. The sex ratio in the study group corresponded to that, generally found amongst people driving under the influence of alcohol. In the study group there was no evidence of a restricted manner and extent of car use, based on the distances between the sites of the accidents and the offenders' homes. However, the proportion of accidents occurring out of towns was greater in the study group. Alcohol associated accidents occurred more frequently in the evenings and at night, which reflects habitual drinking patterns. Therefore these accidents occurred mainly in darkness and twilight. Surprisingly, unfavorable weather conditions such as rain or ice did not lead to an increase in accidents due to alcohol. In fact, in the study group, proportionally fewer accidents occurred on icy roads. Both injury to persons and damage to property were more severe in the study group. While no relationship between accident severity and blood alcohol concentration could be proven within the study group, the risk of death or severe injury was 3 to 4 times greater in this group than in the control group.

Accidents, Traffic↗
PubMedDate not supplied

[Influence of acute alcohol intoxication on the synthesis of RNA and proteins in the liver of rats at various times of the day].

An acute alcoholic poisoning occurring 12 hours after intragastric administration of a 40 degrees ethanol (1.5 ml/kg) produced at 9 and 21 hours an inhibitory action on the incorporation of H3-uridine in the nuclei and cytoplasm, as well as of S35-methionine in the cytoplasm of the hepatic cells in rats. An alcohol inhibition of the RNA and protein synthesis at different time of the day proved dissimilar. Intact animals demonstrated significant diurnal variations in the intensity of the isotopes incorporation in the nuclei and cytoplasm of hepatocytes which continued after the action of alcohol, with the incorporation maximum at 21 and minimum at 9 hours.

Acute Disease↗
PubMed1994

Tolerance and dependence in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats after chronic alcohol intoxication by inhalation.

In rats selected for their differences in sleep time following acute administration of ethanol (high or low alcohol sensitivity: HAS or LAS), alcohol chronic tolerance and behavioural dependence were determined. Tolerance was assessed by calculating the interval between the loss and regain of the righting reflex following an acute administration of ethanol (4 g/kg body wt), after intoxication by inhalation of ethanol vapour for 3 weeks. The importance of behavioural dependence was estimated by measuring the ethanol intake in a free-choice situation water/ethanol (10% v/v), after intoxication by inhalation for 4 weeks. The two HAS and LAS lines did not show any behavioural dependence, while they developed a significant tolerance to the hypnotic effect of ethanol, which was more marked for the LAS line.

Administration, Inhalation↗