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PubMed1978

Failure of low dose heparin to prevent pulmonary embolism after hip surgery or above the knee amputation.

In a randomized, double-blind trial, 5,000 USP units of sodium heparin or saline were give subcutaneously at least two hours before surgery and at 12 hour intervals thereafter to patients requiring total hip replacement, surgical correction of hip fracture, or major lower extremity amputation for vascular insufficiency. Lung perfusion scans were performed before surgery and at weekly intervals during the postoperative period. Pulmonary arteriograms were requested in patients developing new perfusion defects on serial scans. Two hundred twelve patient hospitalizations were analyzed. We diagnosed acute pulmonary embolism by serial lung perfusion scans or at autopsy in 37 patients. The incidence of pulmonary embolism in 40 patients with below the knee amputation was too low to warrant conclusions. The incidence of acute pulmonary embolism in 94 patients undergoing above the knee amputation was 25% in patients receiving heparin and 27% in patients receiving saline. The incidence of acute pulmonary embolism in 78 patients undergoing hip surgery was 13% in patients receiving heparin and 12% in patients receiving saline. We conclude that the regimen used had no significant effect on the incidence of acute pulmonary embolism in patients undergoing hip surgery or above the knee amputation.

Acute Disease↗
PubMed1982

The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy.

Between May 1975 and April 1981, 43 adult patients with high-grade soft tissue sarcomas of the extremities were prospectively randomized to receive either amputation at or above the joint proximal to the tumor, including all involved muscle groups, or to receive a limb-sparing resection plus adjuvant radiation therapy. The limb-sparing resection group received wide local excision followed by 5000 rads to the entire anatomic area at risk for local spread and 6000 to 7000 rads to the tumor bed. Both randomization groups received postoperative chemotherapy with doxorubicin (maximum cumulative dose 550 mg/m2), cyclophosphamide, and high-dose methotrexate. Twenty-seven patients randomized to receive limb-sparing resection and radiotherapy, and 16 received amputation (randomization was 2:1). There were four local recurrences in the limb-sparing group and none in the amputation group (p1 = 0.06 generalized Wilcoxon test). However, there were no differences in disease-free survival rates (71% and 78% at five years; p2 = 0.75) or overall survival rates (83% and 88% at five years; p2 = 0.99) between the limb-sparing group and the amputation treatment groups. Multivariate analysis indicated that the only correlate of local recurrence was the final margin of resection. Patients with positive margins of resection had a higher likelihood of local recurrence compared with those with negative margins (p1 less than 0.0001) even when postoperative radiotherapy was used. A simultaneous prospective randomized study of postoperative chemotherapy in 65 patients with high-grade soft-tissue sarcomas of the extremities revealed a marked advantage in patients receiving chemotherapy compared with those without chemotherapy in three-year continuous disease-free (92% vs. 60%; p1 = 0.0008) and overall survival (95% vs. 74%; p1 = 0.04). Thus limb-sparing surgery, radiation therapy, and adjuvant chemotherapy appear capable of successfully treating the great majority of adult patients with soft tissue sarcomas of the extremity.

Adolescent↗
PubMed1991

Limb salvage versus traumatic amputation. A decision based on a seven-part predictive index.

In severe traumatic injuries to the lower extremity, it is often a difficult decision to attempt heroic efforts aimed at limb salvage or to amputate primarily. To answer this question, the authors performed a 5-year review of 70 limbs in 67 patients. Patients were identified as presenting with major lower extremity trauma and an associated arterial injury. Nineteen (27%) of the 70 limbs were amputated. Limb salvage was not related to the presence or absence of shock and order of repair (orthopedic or vascular). No statistical difference was noted between the time of injury to operative repair in either the amputated or limb salvage group. Limb salvage was related to warm ischemia time and the quantitative degree of arterial, nerve, bone, muscle, skin, and venous injury. A limb salvage index (LSI) was formulated based on the degree of injury to these systems. All 51 patients with an LSI score of less than 6 had successful limb salvage (p less than 0.001). All 19 patients with an LSI score of 6 or greater had amputations (p less than 0.001). Although statistics cannot replace clinical judgment, this index can be a valuable objective tool in the evaluation of the patient with a severely traumatized extremity.

Adolescent↗
PubMedDate not supplied

Comparison of quality of life of persons who have experienced amputations and persons who have had bowel resections.

Comparing the quality of life of persons who have experienced amputations and persons who have had bowel resections illustrates the impact of chronic disease upon all aspects of a patient's life. Because the purpose of nursing research is to bring about knowledge to better direct patient care, understanding the impact of chronic illness contributes to an improvement in the quality of life of these patients. By appreciating the patient's perspective concerning the illness, the nurse can better educate the patient in all aspects of the disease process. Based on Jean Watson's Theory of Human Caring, this study acknowledged the need for evidence-based nursing practice to care for the well-being of the patient in a holistic manner. Our hypothesis was adult patients after Crohn disease-related bowel resection experience a better quality of life than do adult patients with peripheral vascular disease related amputation. This descriptive comparative study had a sample of patients with Crohn disease and resection (n = 28) and patients with peripheral vascular amputation (n = 16). The instrument used to measure quality of life was the RAND-36 Item Health Survey 1.0. Results revealed significant differences between the patients with bowel resection and those with peripheral vascular amputation with regard to physical functioning, general health, and role limitations related to physical health. No significant differences existed between the two groups in terms of energy/fatigue, emotional well-being, social functioning, role limitations related to emotional problems, and pain. Results from the data may indicate that the incorporation of more education regarding social, emotional, physiological, and psychological aspects of postoperative life may be of importance to evidence based nursing practice. This addition may also lead to better adjustment to postoperative life for patients and improve overall quality of life.

Activities of Daily Living↗
PubMed2001

Structural and functional cortical abnormalities after upper limb amputation during childhood.

Functional reorganization has been well documented in the human adult brain after amputation of the arm. To assess the effects of amputation on the developing brain, we investigated six patients with upper limb amputation in early childhood and one with right dysmelia. Transcranial magnetic stimulation indicated contralateral cortical disinhibition and enlargement of the excitable area of the stump. FMRI data corroborated these plastic changes and also showed an ipsilateral functional reorganization. In the T1-weighted MRI, we found structural deformities of the contralateral and ipsilateral central sulcus in three patients and a contralateral atrophic parietal lobule in two patients. Therefore, arm amputation in childhood affects functional organization as well as anatomical structure in both hemispheres.

Adolescent↗
PubMed1988

Occlusive vascular disease of lower limbs: diagnosis, amputation surgery and rehabilitation. A review of the Burke experience.

This review is concerned with the epidemiology of lower limb amputations, frequency and results of limbsaving procedures and the contemporary management of dysvascular amputees. National data showed no decline in the number and rates of amputations from 1981-1985, but the frequency of bypass surgery increased indicating that the problem of peripheral arterial occlusive disease is far from being resolved. Femoral/popliteal bypasses are performed twice as often as aorto/ileac procedures but failure rates are high. Based on observations of 238 amputees we noted that femoral/popliteal bypasses had the highest failure rate, particularly when performed as a last limbsaving effort. A laudable trend of preserving the knee was noted but poor stump conditions were the most important factors influencing the length of hospital stay (average 51 days). The amputee rehabilitation process is discussed along with a description of contemporary prosthetic technology. The cost effectiveness of state of the art devices for the older dysvascular amputee is questioned. The cost of amputation and rehabilitation is enormous, especially when preceded by unsuccessful arterial reconstruction. The loss of a leg is, of course, a major disaster for every individual and therefore limbsaving efforts and amputation techniques must be refined and the rehabilitation effort optimized.

Activities of Daily Living↗
PubMed1999

Prosthetic options for below knee amputations after osteomyelitis and nonunion of the tibia.

Below the knee amputation after trauma is an appropriate option for many patients with recalcitrant infection and nonunion of the tibia. Patients who have had transtibial amputations have lower energy expenditure, heart rate, and oxygen cost when ambulating with their prostheses than when using a three-point gait with crutches without their artificial limb. Innovative prosthetists have improved each of the five essential components of the limb amputated below the knee: socket, insert, shaft and pylon, foot and ankle assembly, and suspension system. Prosthetists are integral members of the patient's healthcare team. Their recommendations and direct patient care are essential to optimizing the functional ability of patients who have had amputations.

Amputation, Surgical↗
PubMed1998

Body image and patients with amputations: does the prosthesis maintain the balance?

This paper attempts to establish whether dissatisfaction with the artificial limb and/or body image relate to achieved mobility following lower limb amputation in established limb wearers. Patients attending limb fitting clinics (n = 107, 62% male, mean time from amputation 13.9 years; range 1-54) participated. The measures were a specially designed Attitude to Artificial Limbs Questionnaire, a Body Image Questionnaire adapted from an eating disorders instrument including reference to body shape, the Hospital Anxiety and Depression Scale and the Harold Wood Stanmore Mobility Scale. The rehabilitation physician rated prosthetic suitability on a Numerical Rating Scale. The results showed patients were moderately satisfied with their artificial limb, had little experience of body image disruption or distress and there was no overall relationship between these variables and mobility. However, those with a more negative body image were more anxious and in younger patients who sustained more traumatic than vascular amputations, the correlation between body image and mobility was significant, anxiety was higher and physician satisfaction with the prosthesis was lower. It is concluded that body image disruption, anxiety and depression are not common in established limb wearers except in young people with traumatic amputations.

Adult↗
PubMed2003

Return to work after lower limb amputation.

This study investigated the proportion of patients who returned to work following amputation and the factors that influenced a positive or negative outcome. One hundred patients of working age who had sustained unilateral lower limb amputation at least 1 year previously and who were established prosthesis users participated in the study. A specially designed questionnaire similar to a guided interview was administered by the rehabilitation physician at the patients' routine follow-ups. The questionnaire yielded a unique score dependent on whether return to work (or a different or preferred occupation) had been achieved with good or reduced productivity. All patients were eligible for mobility benefit, including schemes to purchase suitably adapted vehicles if necessary. However, no vocational rehabilitation was available. Sixty-six per cent of patients returned to employment and this was related to mobility, time since amputation and Handicap Scale scores. Age, socket comfort, level and cause of amputation, type of previous work or the presence of other medical problems did not differ between those who did and did not return to work. The Employment Questionnaire showed good correspondence with the London Handicap Scale, indicating some concurrent validity, although future development might include consideration of psychological factors, which could explain more of the reasons for continued unemployment.

Adult↗
PubMed1991

Acute management of traumatic forequarter amputations: case reports.

Traumatic forequarter amputation is a rare and very devastating injury. The arm, including the scapula, clavicle, and pectoral muscle, is torn from the body by a tremendous traction force, usually combined with a counteracting force from the body. The cases of three patients are presented. One patient was caught by the axle of a harvesting machine, resulting in a forequarter amputation of his right extremity and amputation of his left arm at the level of the upper arm. The other two patients had their arms caught in conveyer belts. All patients survived. Closure of the defect was performed acutely using a local pedicled musculocutaneous flap in one case and free vascularized musculocutaneous flaps from the amputated limbs in the two other cases.

Accidents, Occupational↗
PubMed1994

Rehabilitation after amputation following lower limb fracture.

Twenty-two patients were interviewed after lower limb amputation above the ankle joint following fractures. Their median age at the time of the injury was 44 years (range, 14-77 years), and median amputation delay was 2 months (range, 0-213 months). Of the 15 patients who were working before the injury, ten returned to gainful employment after amputation. Amputation delay did not affect the ability to return to work. Twenty patients could walk outdoors; two patients aged 69 and 71 years could not, but regularly went outdoors using a wheelchair or a three-wheeled moped. Eleven patients were more or less dependent on help from others. The study indicates that most patients have an acceptable functional result, but with increasing age the chance of a return to employment decreases, and the need for help with everyday demands increases.

Activities of Daily Living↗
PubMed1978

Freezing an extremity in preparation for amputation.

Patients requiring a major amputation for ischemia are frequently gravely ill. Physiologic amputation obtained by freezing the leg, usually with a tourniquet, will permit delay and intensive preoperative therapy. In an efficient, safe, and convenient method which we have developed and used in 46 patients, a pump circulates antifreeze solution through a specially constructed boot. The last 32 patients so treated have been analyzed as to indications and results. Advantages obtained control of sepsis, correction of diabetic coma, dialysis for chronic renal failure, improvement in congestive heart failure, and improvement in pulmonary function. Four patients had successful below-knee amputations after control of infection that had previously seemed to dictate above-knee amputation. The control of pain and odor, the resultant appreciation of the family, and the lessened demand on nursing staff offer worthwhile benefits in many of the patients, even in some in whom advanced systemic disease prevented survival.

Adult↗
PubMed1992

Vascular surgery: possible adverse effect on extent of subsequent lower limb amputation.

The influence of previous vascular surgery on the level of amputation was examined retrospectively in 345 amputations (66 bilateral) in 279 patients with peripheral vascular disease. Seventy-two patients (38% diabetic) had previous vascular surgery on 74 limbs and 207 (65% diabetic) had no history of vascular surgery on 271 limbs. In patients with previous vascular surgery, above-knee amputation was done on 55% of limbs versus 71% of limbs in patients with no previous vascular surgery (P < .05), despite a lower incidence of diabetes in the former group. We conclude that although reconstructive vascular surgery is an effective treatment for vascular insufficiency, occasionally it not only fails, but is associated with an increased incidence of above-knee amputation.

Aged↗
PubMed1995

Variation in the practice of dose reduction of chemotherapeutic agents after weight loss or amputation.

PURPOSE: Dose reduction of chemotherapeutic agents in response to weight loss or amputation is important in avoiding excessive therapy-related toxicity. Several methods of calculating this dose reduction are currently in use, including dose reduction in proportion to (a) the reduction in body surface area (BSA), (b) the amount of weight lost, and (c) no dose reduction unless toxicity is observed. Each of these methods results in the administration of a different dose, and few guidelines exist as to the preferred method. METHODS: We conducted a survey of a large group of pediatric oncologists, pediatric oncology nurses, and data managers to determine the methods of dose reduction currently in use for patients (a) with weight loss, (b) after amputation, and (c) with further weight loss after amputation. RESULTS: Responses were obtained from 237 of 294 individuals surveyed (80.6%). The most popular method was to dose reduce in proportion to the reduction in BSA in patients with weight loss alone (88%), amputees (60%), and amputees with ongoing weight loss (66%). Other methods were chosen by 7%, 31%, and 24% of participants in each of these clinical settings, respectively. CONCLUSION: The chosen methods result in a discrepancy of administered doses of up to 37%. Our results highlight the need for the standardization of practice, and the determination of the optimal method of dose reduction after weight loss or amputation.

Amputation, Surgical↗
PubMed2006

The hatchet flap for reconstruction of fingertip amputations.

BACKGROUND: Emmett has described a single triangular flap that contains a partial skin bridge on one of its sides and called it the hatchet flap. It was successfully used for defects located on various body parts. The aim of this study was to present the authors' experience and results obtained with this flap in fingertip amputations. METHODS: Nine patients who have completed their 1-year follow-up period were included in the study. Two-point discrimination and stiffness were tested, and the patients were queried about the existence of cold intolerance, hypersensitivity, numbness, and pain in the early (3 months) and late (1 year) postoperative periods. RESULTS: The amputations were located on the thumb in three patients, index finger in one patient, middle finger in three patients, and ring finger in two patients. The average defect size was 2.1 x 1.5 cm. Partial wound dehiscence was observed in one patient. The flap has provided good protective padding and aesthetic contour for the fingers. All incisions healed with inconspicuous scars. Average two-point discrimination was 6.3 mm (range, 4 to 8 mm). Cold intolerance was observed in two (22.2 percent) and paresthesia in one patient (11.1 percent). Joint stiffness was not noted. Most patients could return to their normal routine in approximately 4 to 5 weeks. CONCLUSIONS: The hatchet flap is a good alternative for transverse and lateral oblique fingertip amputations and valuable for volar oblique amputations (defects <2 cm) with more extensive flap designs. The technique is simple and safe and provides good protective padding and acceptable tactile gnosis.

Adult↗
PubMed2003

Factors affecting composite graft survival in digital tip amputations.

Distal fingertip amputations present the hand surgeon with a myriad of treatment options. Composite tissue replantation offers the patient the possibility of maintaining digital length and function. The purpose of this study was to determine the efficacy of this treatment modality and to support its use. During a 2.5-year period, 53 patients with 57 digital tip amputations distal to the distal interphalangeal (DIP) joint underwent composite tissue grafting of the tip with minimal defatting. All patients were evaluated in a prospective manner. Specific information regarding the patient and the injury were recorded. The survival rates for amputations distal to the eponychium and between the DIP joint and eponychium were 58% and 43%, respectively. Smoking was the only significant factor that had a strong, independent association with graft loss. Age older than 18 years and alcohol use appeared only initially to have an effect on graft survival because they were so closely linked with smoking. Diabetes mellitus and crush-type injuries may potentially predispose a graft to fail, but a larger sample size is needed to prove this with significance. There were no infections or serious complications, even in those grafts that failed. After reviewing the data, the authors recommend using composite tissue replantation for fingertip amputations distal to the DIP joint in nonsmokers.

Adolescent↗
PubMed2006

An alternative technique for microsurgically unreplantable fingertip amputations.

Reattachment of the amputated fingertips as composite grafts has been performed for distal levels in children, with high rates of good outcome, but the majority of the reports emphasized that this procedure had success rates only up to 50% in adults. Several techniques to enhance composite graft take in adults have been defined. In this study, a technique to enhance nonmicrosurgical replantation of amputated fingertips as composite grafts is presented.Twenty-three patients were treated with this technique, 20 of which were adults. An area of skin on the amputation margin of the stump was deepithelized, and the amputated part was defatted to reattach the piece as a cap composite graft and to increase the contact area. The patients were evaluated after the operations regarding functional and esthetic outcome. Success rates of 86.95% in total and 85% in adults were achieved, with acceptable sensibility (with a mean value of 7.26 mm for the 2-point discrimination), minimal shortening (a mean value of 6.80 mm), and satisfactory esthetic outcome using this technique.

Adolescent↗
PubMed2006

Treatment of painful neuroma of amputated phalanx with distal toe transfer: a case report.

A painful neuroma in the amputation stump of a finger can be psychologically and physically disabling. Numerous surgical procedures have been attempted to prevent and treat amputation neuromas of the finger, but the results are inconsistent. Microsurgical transfer of the distal second toe to the amputated stump of the finger can provide a pathway and target for the regenerating axons and avoid recurrence of neuromas. In this article, we present the experience of successful treatment of amputation neuromas of an index finger with microsurgical distal toe transfer.

Amputation, Traumatic↗