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PubMed1977

[Preeclampsia].

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Blood Volume↗
PubMed1977

Hemodynamic studies in experimental toxemia of the dog.

The following experiments demonstrate that the severity of toxemia is proportional to the degree of reduction in blood flow to the pregnant uterus. Blood pressure and blood flow variations were studied in 21 nonpregnant and pregnant dogs following the placement of a progressive stricture on the abdominal aorta below the renal arteries. The immediate effect of the stricture was a mild hypertension in half of the pregnant dogs; in addition, in all the dogs, the blood flow progressively dropped in the arteries below the stricture (femoral and uterine) while it remained constant in the arteries above (ovarian and renal). In 3 of 5 pregnant dogs the delayed effect of the aortic stricture was hypertension associated with all the other signs of experimental toxemia. Removal of the aortic stricture after 10 days immediately improved the blood flow below the stricture. No noticeable preferential distribution of blood toward the pregnant uterus was noted during the constriction.

Animals↗
PubMed1977

[Polycythemia in the newborn infant (author's transl)].

Respiratory distress syndrome and cyanonis in newborns (first neonatal week) may be caused by polycythemia. During 14 months twentyone newborns with symptoms of cardiorespiratory or neurological distress caused by polycythemia on the neonatological division of our hospital were observed. The values of hemoglobin ranged between 22.7 and 28.6 g% (mean 25.65 g%), the values of hematocrit ranged between 72 and 90% (mean 81%). The central venous hematocrit measured on 14 patients ranged between 65 and 77% (mean 71%). On 20 newborns isovolemic haemodilution by 5% plasma was performed. The volume of exchange was calculated according to the formula: Sign and symptoms seemed to improve rapidly following treatment, clinically reflecting the fall in hemoglobin and hematocrit.

Exchange Transfusion, Whole Blood↗
PubMed1977

[The development of the perinatal mortality at the university department for women in Innsbruck from 1969 to 1975 (author's transl)].

In a retrospective study the development of the perinatal mortality at the University Hospital for Women in Inssbruck was reviewed. Among a total of 14,839 deliveries, 323 perinatal deaths according to the WHO definition were reviewed. The years from 1969 to 1971 prior to the introduction of intensive monitoring and the years 1972 to 1975 after the introduction of monitoring were compared. The perinatal mortality was reduced from 27.7 per 1000 in 1969 to 13.7 per 1000 in 1975. The decrease was due to intensive monitoring during labour. The Caesarean Section rate rose from 3.17% in 1969 to 8.53% in 1975. The increase was mainly due to fetal indications. Conditions which were of special obstetric interest in the context of intensive antenatal care were especially reviewed. It was surprising the preeclampsia accounted for the same number of perinatal deaths in the second portion of our review as in the first. Prematurity accounted for 60--70% of the perinatal mortality and received the focus of the efforts to reduce the perinatal mortality. The perinatal mortality of infants with a birth weight of less than 2500 grams was reduced from 224.0 per thousand in 1969 to 140.0 per thousand in 1975. This result was obtained by excellent co-operation with the pediatricians. The rate of premature deliveries remained unchanged at between 8 to 9% inspite of all efforts. The possible causes for this phenomenon are discussed. The perinatal mortality was higher in cases who had antenatal care by obstetricians and general practitioners not affiliated with the University Department. The timely referral of high risk cases to a regional perinatal centre is stressed again.

Austria↗
PubMed1977

[Vaginalcytology and late pregnancy (determination of term, fetal monitoring, correlation with hormon patterns) (author's transl)].

The "before term" pattern allows to exclude over-maturity with probability of 95--100%. The "at term" pattern lets expect spontaneous labour in next five days just so with great probability. We attribute no importance to cytology as a method of control for high risk pregnancies. At last we didn't find any correlation with statistical methods between the alterations of the cell patterns some days before delivery and values of hormons.

Female↗
PubMed1977

The etiology of preeclampsia: a hypothesis.

Recent investigations into the pathophysiology and immunobiology of preeclampsia have strongly implicated immunologic dysfunction as a central feature of this disease. A hypothesis is herein presented which unifies current research with clinical manifestations, in an attempt to clarify the etiology of this obstetric enigma.

Female↗
PubMed1977

[Investigations regarding the validity of estrogen-creatine quotients from morning urine compared with those from 24-hour urine in high risk pregnancies (author's transl)].

An automated method for determining total estrogen in 24-hour urine was reported. The "estrogen-creatinine quotient" was computed in order to make the results of collective errors as independent as possible. This numerical value also makes possible comparative studies of 24-hour urine and morning urine (6:00 a.m.) as well as of urine specimens taken every two hours between 6:00 a.m. and 6:00 p.m. A total of 1000 analyses were made in 110 pregnant women; in addition, 82 daily profiles were studied. A high correlation was found between the E/C from 24-hour urine and from morning urine. In approximately two thirds of the cases, the deviation between morning urine and 24-hour urine did not exceed 10%. In the daily profiles, however, a wide variation in the daily rhythmn of some patients could be observed. According to our results, the determination of E/C in morning urine is well suited as a screening method for quick detection of estrogen elimination, particularly in high risk pregnancies.

Circadian Rhythm↗
PubMed1979

[Comparative examinations of high-molecular maternal serum protein bodies during pregnancy--a contribution to biochemical pregnancy control (author's transl)].

The maternal Serum concentrations of beta 1 SP 1, IgM and alpha 2-macroglobulin were determined in relation to the gestation age, using the simple radial immunodiffusion method in 102 non-pathologic pregnancies and 35 pregnancies involving risk factors. To assess the clinical relevance of these determinations, we examined to what extent the changes in concentration of beta 1 SP 1 IgM and alpha 2-macroglobulin would permit a prognostically useful conclusion on the placenta function and foetal condition. All patients with lowered beta 1 SP 1-serum concentrations were examined for their antepartua CTG-evaluation, as well as the type of termination of parturition. The normal distribution for beta 1 SP 1 showed a continuous rise in serum concentration up to the 37th pregnancy week. During the last 3 weeks, beta 1 SP 1 remained almost constant. For the cases with EPH-gestosis and placenta insufficiency, a beta 1 SP 1-concentration below the normal distribution level was found in the large majority of all cases. In diabetes mellitus during gravidity, twin gravidity and MHN, the determination of beta 1 SP 1 is not of any decisive prognostic significance. The maternal serum levels of IgM showed no significant differences when comparing normal pregnancy and risk pregnancy. The serum concentration of alpha 2-macroglobulin increased in both groups of patients with increasing gestation age. Of the three examined protein bodies, we consider beta 1 SP 1 to be a good, additional parameter for the assessment of the trophoblast function.

Female↗