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Results for “developmental disorders”

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At least 955 records · Page 53Linked to original sources
PubMed1981

[New findings on the importance of the histocompatibility Y antigen for sex differentiation and its role in the origin of developmental disorders of the reproductive organs].

In the differentiation of the male reproductive organs the histocompatibility antigen Y plays an important role, which is formed under physiological conditions under the influence of a gene of the Y-chromosome in the most cell types of male mammals and occurs in the cell membranes. The H-Y is delivered by Sertoli's cells and furthers the development of the testicles. These cells moreover deliver testosterone-binding protein and an inhibiting factor for the development of Müller's ducts. For the effectiveness of testosterone the equipment of the in their function testosterone-depending cell types with androgen-receptor protein is necessary, the formation of which is conditioned by a gene lying on the X-chromosome. For the maturation and preservation of the viability of the oocytes two functioning X-chromosomes are necessary. Several disturbances of the development of the reproductive organs as well as the trans-sexuality are demonstrated taking into consideration recent realizations.

Disorders of Sex Development↗
PubMedDate not supplied

[Sigetin treatment of the developmental disorders induced in rabbit prenatal ontogeny by curtailment of the uteroplacental blood circulation].

About 40 per cent of the uterine preplacental vessels were ligated in rabbits on the 11th or 18th days of gestation. Some of the female rabbits operated upon were given 5 mg of intravenous sigetin twice a day till the end of pregnancy. Investigation of the progeny development, the ability of learning at an age of about 6 months, in particular, showed a somewhat better development and ability of learning in the offsprings of female rabbits receiving sigetin.

Animals↗
PubMed1980

[Diagnosis of combined developmental disorders of the large intestine and urinary tract in children].

The authors call attention to the importance of directed clinical examination of the urinary secretion system in children with an abnormal development of the large intestine and anorectal zone. In 23.9% of cases the malformations of the large intestine were associated with anomalies in the development or organs of urinary excretion. The symptoms of associated abnormalities in the anorectal zone and urine excretion ducts are described. A scheme for the examination of such patients is proposed.

Abnormalities, Multiple↗
PubMed1995

[The dynamics of developmental disorders of the brain in fetuses obtained from mothers consuming alcohol during pregnancy (14- to 15-week-old fetuses)].

By histological method cerebral development was studied in 3 fetus obtained after 14, 14 and 15 weeks to gestation in the mothers abusing alcohol. The excessive plication, invagination and adhesions of the brain wall, porencephalia, abnormal hyperplasia and heterotopia of cells, as well as agenesis of plexus choroideus were detected. These finding were compared with the disturbances in 5- to 12-week-old embryos which had been earlier discovered by authors. It was noted their resemblance, which means the stability of the structural brain changes during ontogenesis.

Abnormalities, Drug-Induced↗
PubMed1994

[Prenatal developmental disorders of brain structures in schizophrenic psychoses].

In recent years neuroimaging techniques have revealed various cerebral and structural variances in patients with schizophrenic psychoses. The best established findings are the enlargement of the lateral ventricles and discrete structural deficits in temporobasal structures of the cortex. Neuropathological investigations have detected subcortical as well as cortical variances. Subcortically, the volume of the striatum and the globus pallidus have been found to be enlarged in schizophrenics. Among the cortical deviations, the cytoarchitectonic disturbances of the rostral entorhinal region have been well documented and are especially important. According to neuropathological criteria, they are derived from disturbances of prenatal cell migration within the central nervous system. Due to its close anatomical and functional connection with the hippocampal formation and its being the assembly point of all sensory cortical areas, disturbances of this area could seriously impede the processing and filtering of information within the limbic system. The other hitherto reported structural anomalies, such as the disturbance to the radial order of hippocampal neurons, and the abnormal structures in the frontobasal orbital regions and the rostroventral insula, could be connected to the disturbances of migration within the entorhinal region; the former could be secondary, but still prenatal developments. Well documented are the architectonic changes in the rostral cingulate gyrus which is itself connected with the entorhinal region via the Papez circuit. These findings are supported and supplemented by the results of epidemiological studies which indicate a disturbance of brain development during the second trimenon of the prenatal period. Viral infections (Influenza A2) of mothers during this critical period appear to play an especially important role.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1995

[Rett syndrome a developmental disorder. Presentation of a variant with preserved speech].

Rett's syndrome is a disorder of neuropsychological development of unknown aetiology. All those described as having all the classical traits of the syndrome are girls. Typically apparently normal development in the first year of life is followed by loss of acquired hand skills and speech, together with deceleration in the growth of the head and development of characteristic hand washing movements, hyperventilation and mental retardation. The disorder is the most common cause of progressive mental retardation in girls. Parents experience health workers who have not heard about this disorder. The article describes a four year-old girl with some preserved speech and an ability to sing. This is an atypical trait in a variant of Rett's syndrome. The importance of cooperation between different professions and medical specialties is underlined. Early diagnosis and start of intervention may delay loss of function. Controlled clinical trials, both medical and psychological, are needed.

Cephalometry↗
PubMed1993

Developmental disorders of the lymphatic system.

Approximately 67% of human conceptuses die prenatally. Of these, a significant number involve a disorder of the lymphatic system. A small number of live-born children also exhibit congenital lymphatic malformations, including an estimated 60% of patients with Turner syndrome. These observations have prompted a search for the genetic and dysmorphologic basis and the different patterns of congenital lymphedema and associated anomalies. In this article, we attempt to summarize available pertinent information on congenital disorders of the lymphatic system and to propose a conceptual overview of lymphatic development.

Adult↗
PubMed1995

[Borderline developmental disorders in children--on theory and treatment].

The author characterizes so called "borderline-children" on the basis of 190 case-studies referring to the results of a survey of some 100 child therapists and 40 child psychiatrists. "Borderline-children" show severe psycho-social strain and traumatic experiences and can be characterized by discrepant development, narcissistic pathology, aggressively and impulsiveness, clinging relationships as well as contact problems with children of the same age. The therapy aims at helping children to continue their development at a level appropriate to their age. Due to anxieties and hectic acting out, the therapy has to set distinct boundaries from the very beginning. Regression has to be curbed, archaic fantasies are to be copied with at a metaphorical level by play therapy and not interpreted by the therapist so that dissociated conscious matter is bridged. Usually the social environment has to be integrated into the treatment. In some cases. residential treatment and pharmacotherapy are necessary.

Adolescent↗