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PubMed1989

Retrospective evaluation of piperacillin use in a university hospital.

A retrospective review was conducted to evaluate the appropriateness of empiric and definitive piperacillin use and to determine if less expensive, more appropriate antibiotics could have been used. The criteria were approved by the chief of infectious diseases and the drug utilization review committee at this institution. One hundred courses of piperacillin use in adult patients were reviewed. Therapy was categorized as appropriate in 78 of the 100 courses: 21 were appropriate empiric, 32 were appropriate empiric changed to definitive due to culture and sensitivity reports, and 25 were appropriate definitive. Reasons for this high percentage of appropriate use include: 1) 40% of the infections involved Pseudomonas aeruginosa; 2) 18% of the organisms that were sensitive to piperacillin were resistant to ticarcillin and mezlocillin; and 3) 64% of the courses of therapy involved critically ill patients with diagnoses such as neutropenia secondary to cancer chemotherapy, burns, sepsis, and hospital-acquired pneumonia. Although only 19.7% of the 11,845 grams of piperacillin used were categorized as inappropriate, the cost is relatively high (annualized to $19,648) and cost savings could be realized if piperacillin use were monitored more closely.

Adolescent↗
PubMed1981

Inconsistency in level of care assignment decisions in skilled nursing facilities.

In Arizona, a non-Medicaid state, we investigated the extent to which unregulated level of care assignments in Skilled Nursing Facilities consistently reflect level and nature of patient impairment. Using Multiple Discriminant Analysis (MDA) to develop optimal prediction functions, approximately 70 per cent of patients could be correctly classified. Factors identified by MDA as discriminating among patients at different levels of care are an Activities of Daily Living (ADL) impairment factor, and a factor defined by confusion, transitory contact with the social environment, and propensity to wander. Results are compared with those of studies using MDA to replicate Multidisciplinary Review Team (MRT) or other expert level of care assignments intended to develop patient classification functions for clinical use. MRT assignments appear to reflect patient impairment characteristics only slightly better than do unregulated institutional assignments, suggesting that such utilization review efforts may result in minimal net gains in appropriateness of placement.

Arizona↗
PubMed1995

Economic tools for the pathologist.

Whether or not it is generally accepted by medical care personnel within the hospital or the laboratory, the laboratory is a business within a hospital. If the laboratory is free-standing, with a corporate ownership, then a laboratory is a business by itself. Even if it is a part of a nonprofit organization (more than two thirds of American hospitals are nonprofit), a laboratory must be able to generate more gains (profits, assets, contribution margin) than losses (liabilities, costs). With the growing volume and complexity of laboratory tests in the United States, the onerous surge of regulatory restrictions, decreasing capital, decreasing physician's reimbursement, increasing salary and operating costs, it is now time for the pathologist to add new tools to his/her customary "tools of the trade," such as surgical knives, microtomes, analyzers, and microscopes. These new tools are the economic tools of cost analysis, productivity analysis, ratio analysis, utilization review, and capital asset analysis. The pathologist of the future must not only provide patient care diagnostic expertise, but must also be a successful manager of human, fiscal, and operational resources to survive in an economic environment that demands knowledge of the principles of successful laboratory management. In addition to a general review of economic and financial "tools," this article describes techniques that have been developed during the past several years by the Laboratory Fiscal Management Committee of the College of American Pathologists that analyze, condense, and interpret general macro-indicators of laboratory cost and operational functions. These indicators are generic and can be quickly understood and utilized by every pathologist practicing in a private, commercial, or public laboratory setting.

Humans↗
PubMed2001

A cost--utility analysis comparing second-line chemotherapy schemes in patients with metastatic breast cancer.

A cost-utility analysis has been performed comparing taxanes, vinorelbine and standard therapy for metastatic breast cancer considering clinical efficacy, quality-adjusted-life-years (QALYs) and costs. A decision model has been built. Clinical efficacy data were collected by literature review. Utility data and cost data were collected from previous studies and Dutch wholesale prices. Except for the MV standard therapy, VM has the lowest C/E ratio of $17,114/QALY, followed by paclitaxel ($30,270/QALY) and docetaxel ($49,739/QALY). VM yields the highest number of QALYs (0.47), compared to paclitaxel (0.35), docetaxel (0.34) and MV (0.29). Compared to the MV standard therapy, the incremental C/E of VM is $23,046/QALY, which is the lowest of all alternatives. We conclude that compared to paclitaxel, docetaxel and MV standard chemotherapy, VM is the most cost-effective second-line chemotherapy for metastatic breast cancer patients. There is a considerable variation in utility scores, depending on the methods or the data sources used. The C/E ratios were influenced most strongly by drug prices, utility and efficacy (in descending order of importance).

Adult↗
PubMed1981

Preselecting literature for routine delivery to physicians in a community hospital-based patient care related reading program.

Health sciences librarians have been actively responding to the changing information needs of users by extending services which involve the selection of literature in response to specific requests from health care personnel. A further development is Patient Care Related Reading (PCRR), a hospital-based program of continuing medical education in which the librarian actively participates in the preselection, packaging, and routine delivery of literature for use by physicians caring for patients with certain clinical disorders. Criteria for selection of literature packet topics were developed jointly by librarians and physicians at their own hospitals. Librarians compiled bibliographic material, reviewed articles, and prepared preliminary packets. Physicians reviewed these packets and made suggestions for each article. Librarians then prepared final packets following reviewers' recommendations and distributed them as a routine procedure to all physicians caring for patients with a diagnosis corresponding to prepared topics. Librarians were notified of patients with PCRR clinical problems by admitting office personnel, floor nurses, nursing supervisors, utilization review, and Professional Standards Review Organization personnel as a part of their usual activities. Packets are used by physicians to add to their fund of knowledge, and for review and teaching purposes. PCRR has provided increased visibility of the library and its many services. Recognition of the librarian's role in the program reinforces the concept of the community hospital library as a service-oriented entity, and helps to establish the library as an active partner in the development and implementation of hospital-based continuing education programs.

Hospitals, Community↗
PubMed1989

Strategies to improve antibiotic use.

The desideratum of "appropriate" antibiotic therapy include efficacy, safety, and low cost. Strategies for achieving these goals include education, control of the hospital formulary, written justification forms and automatic stop orders, ongoing utilization review, restriction, required consultation, control of laboratory susceptibility testing, and limitation of contact time between physicians and pharmaceutical representatives. Because traditional education methods have had limited impact on "appropriate" antibiotic use, the potential of the newer strategies must be explored. Most published studies emanate from teaching hospitals, leaving the applicability of the findings to community hospitals largely unsettled. At each hospital, it should be determined which combination of strategies will strike the best balance between effectiveness and palatability. Computer technology continues to hold promise as a way to provide instantaneous, nonthreatening feedback to prescribing physicians.

Anti-Bacterial Agents↗
PubMedDate not supplied

Corporate involvement in medical costs containment.

This is a discussion of the cost-saving measures designed by American corporations to reduce expenditures on employees' health care. These measures include utilization review, cost sharing, alternative delivery systems, outpatient treatment, self-insurance, preventive care programs, and business coalitions. The author concludes that although some cost-containment measures lower corporate expenditures on health, they may be detrimental to the quality of care. At the same time, measures that have clearly beneficial effects on both quality and cost-efficiency are not fully utilized. The study is based on an analysis of available literature on the subject.

Cost Control↗
PubMed1984

Strengthening the formulary system by implementing a drug usage guidelines program.

The development and implementation of a Drug Usage Guidelines (DUG) program in a 1,200-bed, federal teaching hospital are described. The program was designed to promote effective formulary control through established procedures for the review and evaluation of drugs submitted to the Pharmacy and Therapeutics (P & T) Committee for addition to the formulary. The procedures required the submission of the DUG and an oral presentation to the Committee prior to any final vote on the request. Anticipated potential benefits of the DUG program are to: (1) stimulate rational drug therapy, (2) provide reliable drug information to the professional staff in a usable format, (3) promote a thorough evaluation of therapeutic agents before approving for formulary inclusion, and (4) provide physician-generated guidelines for use as criteria in drug utilization review audits.

Drug Utilization↗
PubMed1983

Regulation of ribosomal RNA transcription during differentiation of Acanthamoeba castellanii: a review.

During the cellular differentiation induced by starvation of Acanthamoeba castellanii, the expression of a number of genes is regulated. Evidence is reviewed that at least one of these, the precursor ribosomal RNA transcription unit, is regulated at the level of transcription. The structure of the rRNA transcription unit and of the RNA polymerases responsible for transcription in Acanthamoeba are reviewed. Utilizing an in vitro transcription system constructed from these components, preliminary evidence has been obtained that pre-rRNA gene expression is regulated by a modification of RNA polymerase I that affects the enzyme's ability to participate efficiently in the initiation of transcription. These results are reviewed in relation to other known mechanisms of transcriptional regulation in eukaryotes.

Amoeba↗
PubMed1995

Psychotropic use among older residents of board and care facilities.

OBJECTIVE: To describe patterns of psychotropic use as well as clinically relevant and concurrent nonpsychotropic use among older residents of board and care facilities in 10 states. METHODS: Weighted use rates were based on data from a sample of 2054 residents aged 65 and older from 410 facilities in 10 states, drawn via a complex, multistage sampling design. Data, including drug name, use frequency, and PRN use, were collected on all drugs taken by the resident during a 7-day period. During face-to-face interviews with residents and/or proxies, data were also collected on resident characteristics. SUBJECTS: The majority of subjects were female, white, and widowed. Average age was 82 years. Approximately 25% had a current mental or emotional condition, and 8% had been hospitalized for a psychiatric condition during the year before admission. More than half needed help with at least one activity of daily living. Forty percent had moderate or severe cognitive impairment, and 18% had received mental health care during the previous year. ANALYSES: Weighted descriptive analyses were performed with Software for Survey Data Analysis (SUDAAN), which accounts for the complex, multistage sampling design. RESULTS: Approximately 35% of the older residents used at least one psychoactive agent, with 30% of psychotropic users receiving two to four different psychotropic medications. Use rates decline with age, for psychotropics overall and for therapeutic classes. Results revealed potentially problematic polypharmacy in relation to drug duplication within therapeutic classes, use of multiple psychotropics across classes, and concurrent nonpsychotropic use. CONCLUSIONS: Compared with community-dwelling older adults, this study revealed high psychotropic use rates among older board and care facility residents. Overall, our results suggest that serious consideration be given to the apparent need for systematic drug utilization review, a potentially useful program that is mandated in other settings.

Aged↗
PubMed2003

Update on drug-related problems in the elderly.

BACKGROUND: Although pharmacotherapy for the elderly can treat diseases and improve well-being, its benefits can be compromised by drug-related problems. OBJECTIVE: This article reviews recent publications concerning drug-related problems in the elderly, as well as articles describing the development of 3 sets of quality indicators for medication use in the elderly. METHODS: Relevant articles were identified through a search of MEDLINE (2002-March 2003) for articles on drug-related problems, inappropriate prescribing, and adverse drug events in the elderly. RESULTS: The review included 7 articles published in 2002 and 2003. A study in ambulatory elderly persons reported that approximately 5.0% of patients had > or =1 adverse drug event within the previous year. Another study found that approximately 20.0% of ambulatory elderly persons used > or =1 inappropriate drug, as defined by drug utilization review (DUR) criteria, with drug-disease interactions and duration of use being the most common drug-related problems. A third study involving elderly individuals in assisted living facilities found that 16.0% used > or =1 inappropriate drug, as defined by the Beers criteria. Another study examined whether inappropriate drug use, as defined by the Beers or DUR criteria, was associated with death or a decline in functional status; it found that only use of drugs defined as inappropriate by DUR criteria (particularly those drugs associated with drug-drug or drug-disease interactions) was associated with a decline in the ability to perform basic self-care. Three studies, 1 from the United States, 1 from the United Kingdom, and 1 from Canada, described consensus development of quality indicators for drug use in the elderly, including drugs to avoid, maximum daily dose, drug duplication, limits on duration of use, drug-drug and drug-disease interactions, need for drug monitoring, underuse of necessary drugs to treat or prevent common problems, and inappropriate drug-administration technique. CONCLUSIONS: Drug-related problems are common in elderly patients. Data from recently published studies provide guidance to practitioners and directions for future research.

Age Factors↗
PubMed2004

Tap water or normal saline for cleansing traumatic wounds?

The aim of this review was to identify whether cleansing with tap water results in higher rates of wound infection or delayed healing compared with other cleansing solutions in adults or children with acute uncomplicated traumatic soft tissue wounds. The review utilized a systematic search of key databases (Cochrane Library, Medline, Embase, Cinahl, British Nursing Index and PubMed), bibliographies, and internet resources. Three controlled trials were found which studied 1281 people. One further study reported outcomes but could not be fully examined as only an abstract was available. Based on the studies reviewed, results suggest no clinically significant increase in the risk of wound infection in wounds irrigated with tap water when compared to sterile normal saline in uncomplicated soft tissue injury. However, the available evidence lacks strength because of the relatively low power and poor quality of studies.

Adult↗
PubMed1995

Health status questionnaires.

Because they accurately and efficiently tap into important aspects of rheumatic disease status and outcome, health status questionnaires have found increasing use in the clinic, controlled clinical trials, and observational studies. This article reviews utility assessment methodologies as well as generic and disease-specific health status questionnaires relevant to rheumatology.

Health Status↗
PubMed1981

A multicenter study of ICU drug utilization.

As part of a view of hospital practice a sample of medical records of 15 intensive care units were analysed for the following items: reason for and origin of admission, age, sex, full pharmacological history, length of stay, clinical outcome, discharge diagnosis. Antibiotic therapy, steroid use for shock, problems of hemostasis, and cardiovascular drugs are areas where an active intervention appears to be specifically needed. Interhospital differences in diagnostic and general care criteria, documentation of inappropriate therapeutic practice, lack of reliable data registration gave occasion for an extensive discussion with clinicians leading to decisions on exclusion of drugs from hospital formularies, organization of information programs and of controlled clinical trials. The application of simple techniques of drug utilization review has proved a useful, inexpensive tool for creating favourable conditions for wide scale improvement of therapeutic practice.

Adolescent↗
PubMed2001

Approach to diagnosing lower extremity edema.

Edema, a sign of a localized or systemic disease process, results from a disruption in the normal physiological forces controlling extracellular fluid volume. This review utilizes an anatomical approach in discussing the various causes of edema.

Diagnosis, Differential↗
PubMed1976

Assessment of ambulatory care: application of the tracer methodology.

Utilizing a tracer method in the assessment of care was investigated in a large pediatric clinic. A set of tracers were selected and agreement was obtained concerning the relevance of care criteria by at least 80 per cent of the facility physicians. One tracer, iron-deficiency anemia, was studied using two nonphysician abstractors to review a sample of 100 patient records with hemoglobins of 11.0 gm/100 ml or less. Results were compared with an implicit review by a panel of physicians. In 52 patients, the low hemoglobin level was not recognized. Only 25 patients proceeded through the care levels of evaluation, diagnosis, treatment, and follow-up. Poor compliance was found with the approved criteria. Weighted scores of the explicit tracer method were closely related to ratings by the implicit reviewers. Utilizing tracer assessment with nonphysician abstractors demonstrated remediable deficiencies in health care services.

Ambulatory Care↗