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[Economic losses in pheasant breeding evoked with endoparasites].

Parasitical invasions constitute a serious veterinary-economic problem in pheasant breeding. The studies were carried out between 1995-1997 in a big breeding centre situated in the Middle Pomerania region, where the basic flock amounted to 1000-1200 bird individuals. The aim of the study was to determine a condition of the pheasants' affliction with nematodes, reasons for the invasion and possibilities of a decrease in the losses thus brought about. In the subsequent years, the flock affliction reached the following proportions: 40% in 1995, 42% in 1996, and 68% in 1997. Between 1995 and 1996, the findings revealed eggs of the nematode Capillaria sp (C. anatis and C. phasianina) in their faeces, with less frequent cases of Trichostrongylus tenuis, Heterakis isolonche and Syngamus trachea. Between 1995-1996 40% deaths in the afflicted flock were brought about by Syngamus trachea whilst in 1997 syngamosis resulted in 80% deaths among the afflicted birds. To determine reasons for the confirmed nematode invasion in the studied period during which all the requirements were fulfilled in the pheasant breeding, conclusions were drawn on the basis of the study. Also, preventive measures were suggested to stop any further appearance of syngamosis or losses due to other endoparasites, as those in 1997.

Animal Husbandry↗

[Detection of serum fucosidase activity].

A procedure has been developed for simultaneous determination of the activity of a-L-fucosidase (EC 3.2.1.5 1) and the beta-D-fucosidase activity caused by beta-D-galactosidase (EC 3.2.1.23, Form IV) in serum. The paper presents data on changes in the above serum enzymatic activities in an experiment, in children with recurrent laryngotracheitis and in pregnant females with gestosis and placental insufficiency.

Acute Disease↗

[Serological studies of the role of the respiratory syncytial virus in acute respiratory diseases in children].

The presence of the syncytial respiratory virus was determined by CF in 281 children admitted with acute respiratory diseases between 15 Sept. 1971 and 30 Dec. 1973, using the Long antigen prepared in the "St. Nicolau" Institute of Virology, Bucharest. In 38 children (13.5%) a serologic diagnosis of infection with the syncytial virus was established; in the other cases of respiratory infection of different etiology, antibodies to the syncytial virus were found in low but constant titers in both serum samples. The presence of these antibodies in a high proportion of the children points to the wide circulation of the syncytial virus in the infantile population, with all its clinico-epidemiologic implications.

Acute Disease↗

[Experience in the complex vaccination of birds against pseudoplague, infectious laryngotracheitis and diphtheria pox].

The immunity was studied as conferred by the simultaneous vaccination against Newcastle disease (strain La Sota), infectious laryngotracheitis (strain "TsNIIP"), and fowl pox (strain FK), applied at different sites. The vaccine against Newcastle disease was diluted at 1 : 10 and was applied nasally through instilling one drop in each orifice. When it was mixed with a vaccine against infectious laryngotracheitis at a ratio of 1 : 1 it was applied via the cloaca or nasally, orally, muscularly or through the ocular sinus. The vaccine against fowl pox was applied at the same time at dilution of 1 : 50 through the wing web. The effectiveness of the immunity conferred was checked through challenge infection, haemagglutination inhibition reactions, and virus-neutralization in chick embryos. It is stated that the resulting stress accompanying every vaccination was not stronger with the combination used than that in other cases. This was also an advantage over the alternative of administering the vaccines alone. The immunity against the three diseases, obtained at the simultaneous application of the vaccines, did not differ from that resulting from administering the vaccines alone. This, XXX indisputably, points to the fact that the method is equally useful from an epizootiologic and an economic standpoint.

Animals↗

[Some respiratory viruses in the etiology of acute upper respiratory infections].

The viral etiology of acute respiratory diseases, determined in 107 children admitted to hospital during the 1966-1969 period, was confirmed in 36% of the cases by isolation of the viral agent and in 59% by serologic reactions. Parainfluenza viruses, especially of type 1 and 3, were encountered more often in the etiology of acute or obstructive laryngitis, and the syncytial respiratory virus in tracheobronchitis.

Adenoviridae Infections↗

[Results of serologic surveys of children with acute stenosing laryngotracheobronchitis].

The materials of serologic surveys of 269 children with acute stenosing laryngotracheobronchitis hospitalized in Children's Infectious Hospital No. 3, Leningrad, are presented. Acute stenosing laryngotracheobronchitis developed most frequently against the background of low titres of antibody to viruses of the respiratory group. Severe cases of the disease were caused by influenza A2 virus, milder cases by influenza B, parainfluenza, respiratory syncytial and adenoviruses.

Acute Disease↗

Fatal generalized feline viral rhinotracheitis in a young adult cat.

A 7-month-old cat died following a 17-day illness. Necropsy findings included sharply demarcated lingual ulcers and multifocal necrotic hepatitis. Intranuclear inclusions were found in the lesions, and a herpesvirus was recovered from specimens of liver and tongue. The virus was identified by neutralization with specific antiserum as feline rhinotracheitis virus.

Animals↗

Severe acute laryngotracheitis in Christchurch 1980-90.

A review of children admitted to Christchurch Hospital with acute laryngotracheitis over a 10 year and nine month period revealed that 894 admissions occurred for this condition. Forty-four (4.9%) were admitted to the intensive care unit of the hospital, of whom 12 (1.3% of all laryngotracheitis admissions) required endotracheal intubation. The mean time of intubation was 170 hours (range 24-432). There were no deaths, although seven children who were intubated had serious complications, of which perforation of a gastric ulcer was the most important. In our group of patients intubation is a rare event, and the need for aggressive treatment with dexamethasone at the time of admission to the general ward is questioned.

Airway Obstruction↗

DNA activates human polymorphonuclear leukocytes--a new importance of DNA presented in the inflammatory tracheobronchial secretion.

DNA from calf thymus (1 to 10 micrograms/ml) was shown to stimulate the release of myeloperoxidase (MPO) and low amounts of H2O2 (about 1.5 nmoles/10(6) cells) from human polymorphonuclear leukocytes (PMNL). PMNL during 60 min incubation with DNA (10 micrograms/ml) and with DNA and cytochalasin B (4.8 micrograms/ml) released 14.4 +/- 3.4 and 25.5 +/- 4.8% (n = 7) of the total MPO cell activity, respectively. Higher DNA concentrations (0.25 to 1mg/ml) were chemotactic for PMNL as assayed under agarose method. At DNA concentration 1mg/ml the chemotactic index reached 1.5 +/- 0.2 and was approximate to value 1.7 +/- 0.2 (n = 7) obtained with zymosan-activated serum. However, the introduction of DNA to the mouse pleural cavity caused insignificant increase in the number of PMNL and lymphocytes recovered from the cavity at 3 h after injection, comparing it to material obtained from buffer-treated animals. The yield of DNA preparation from purulent sputum (about 10 micrograms/ml) indicates that DNA concentrations which activate PMNL in vitro occur in the inflammatory tracheobronchial secretion. The DNA from sputum electrophoresed on the 0.6% agarose gel reveal pattern which could be the result of nucleosomal DNA degradation. These results suggest that DNA released from nuclear debris in the place of inflammation, especially in the lower respiratory tract could secondarily modulate its course by PMNL activation. This novel role of DNA may be important for pulmonary pathology since lungs are susceptible to proteolytic and oxidant mediated injury.

Animals↗

Airway mucosal blood flow: response to autonomic and inflammatory stimuli.

A major portion of airway blood flow is distributed to the subepithelial tissue space and is strategically located to influence both epithelial and airway smooth muscle functions. To assess the magnitude and responsiveness of blood flow through the subepithelial microvasculature, we measured tracheal mucosal blood flow with a soluble gas method in intact sheep. We found responses of tracheal mucosal blood flow to pharmacological stimuli alpha- and beta- (adrenoceptor agonists) and inflammatory stimuli (antigen and histamine), and demonstrated that alterations in mucosal blood flow influence the magnitude and duration of allergic airway smooth muscle contraction in the trachea. Mucosal blood flow, which under certain circumstances is regulated independently of total airway blood flow, could play a critical role in the manifestations of and recovery from airway disease.

Adrenergic alpha-Agonists↗

Necrotizing tracheobronchitis: complication of mechanical ventilation in an adult.

A 51-year-old woman had localized interstitial pneumonia that rapidly progressed to involve all lung fields. After 9 days of conventional mechanical ventilation, pneumothorax developed in the presence of an obstruction of the right main bronchus. Bronchoscopy and endobronchial biopsies revealed NTB involving the tracheobronchial tree distal to the tip of the endotracheal tube, with complete obstruction of the right main bronchus by hard, eschar-like material. Tracheal mucosa proximal to the tip of the endotracheal tube was normal. Subsequent bronchoscopy, 20 days later, showed marked resolution of NTB. Though a frequent complication of mechanical ventilation in the neonate, NTB as a complication of conventional mechanical ventilation has not previously been recognized in an adult. Necrotizing tracheobronchitis should be suspected in adults who have had mechanical ventilation and who are experiencing ventilatory difficulties, after routine problems have been treated or excluded.

Bronchitis↗