Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Reinforcement Schedule”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 955 records · Page 53Linked to original sources
PubMed1984

Clozapine blocks disruptive and discriminative stimulus effects of quipazine.

Clozapine was tested in two serotonin-dependent behavioral measures. One group of rats was trained to discriminate the serotonin agonist, quipazine, from saline in a two-lever operant choice task. Pretreatment with clozapine completely blocked the discrimination of quipazine. Another group of rats was trained to bar press for milk on a variable interval schedule of reinforcement. Quipazine decreased the response rate in these animals and pretreatment with clozapine completely reversed this effect. Thus, clozapine acted as a serotonin antagonist in both measures of serotonin function.

Animals↗
PubMed1990

The discriminative stimulus properties of cocaine: effects of BAY K 8644 and nimodipine.

Calcium channel blockers appear to reduce the cardiac toxicity of cocaine and some stimulant-induced behaviors. The present experiment was designed to test whether the internal state induced by cocaine is altered by the calcium antagonist nimodipine. Substitution tests with the calcium agonist BAY K 8644 were also conducted in rats (N = 8) trained to discriminate cocaine (10 mg/kg) from saline in a two-lever, water-reinforced drug discrimination paradigm. Cocaine (0.625-10 mg/kg) produced a dose-related increase in drug-lever responding while BAY K 8644 (0.25-2 mg/kg) and nimodipine (0.2-0.8 mg/kg) engendered primarily saline responding. In combination with cocaine (2.5-10 mg/kg), nimodipine shifted the cocaine dose-response curve to the right at doses of 0.2 and 0.4 mg/kg; this attenuation did not increase with higher doses of nimodipine (0.8 and 1.6 mg/kg). The present results suggest that nimodipine may partially block the discriminative stimulus properties of cocaine, however, this reduction is neither robust nor dose-related. Thus, nimodipine might be expected to only marginally alter the subjective cocaine state in humans.

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethy↗
PubMed1977

Certain select variables as predictors of goal achievement in speech therapy.

A previous factor-analytic investigation indicated that 18 variables, structured within interpersonal and technical skill dimensions, contribute most significantly to supervisor's evaluations of student clinicians engaged in speech therapy. The present study was designed to extend that investigation by determining the relative contribution of the variables to the clinicians' accomplishment of the goals of the therapy session. Using the previously collected data, 17 of the resultant variables were regressed in stepwise fashion against the clinicians' accomplishment of the session's goals. The regression solution yielded a three-variable prediction system, which accounted for approximately two-thirds of the criterion variance. All three variables were related to clinicians' technical skills. The "schedule of reinforcement" variable was the single most valid predictor and accounted for half of the criterion variance. The other two technical skill variables were "implements carryover procedures in therapy" and "changes therapeutic procedure to meet client needs." Implications for inclusion of these variables in interactive and microtherapy methodologies of clinical training are discussed.

Achievement↗