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At least 955 records · Page 53Linked to original sources
PubMed1998

The influence of race on the efficacy of curative radiation therapy for carcinoma of the prostate.

The purpose of this study was to examine the effect of race on the outcome of patients treated curatively with external beam irradiation for carcinoma of the prostate. The study was performed between January 1980 and December 1993 of 1,529 men with prostate cancer. Similar percentages of Caucasian men (CM) and African-American men (AAM) had localized disease (stages T1 and T2) and advanced stage disease (stage T3). There was no difference in crude survival by race (P = .13). At 5 years, crude survival by race was 75% for CM and 73% for AAM. At 10 years, the crude survivals, were 50% and 40%, respectively. Disease-specific survival rates were equivalent for AAM and CM (P = .66). The 5-year disease-specific survival was 83% for CM and 85% for AAM. At 10 years, the disease-specific survival was 65% for CM and 69% for AAM. There was no difference in disease-specific survival by race when stage-for-stage comparisons were made. Among those patients referred for curative radiation therapy, AAM and CM had a similar age, stage, and grade distribution. This study demonstrated that there was no difference in disease-specific survival between CM and AAM treated curatively with radiation for prostate cancer.

Adult↗
PubMed2025

Impact of subthreshold troponin levels and temporal trends on short term adverse cardiovascular outcomes in patients discharged from the emergency department: a RACE-IT trial substudy.

BACKGROUND: High-sensitivity cardiac troponin I assays enable early exclusion of myocardial infarction in the emergency department. However, the clinical implications of detectable troponin values below the 99th percentile upper reference limit (4-18 ng/L) remain unclear. OBJECTIVE: To assess the association between subthreshold troponin levels and 30-day outcomes in patients from the RACE-IT trial, using exact troponin values when available. METHODS: This post-hoc analysis of the RACE-IT stepped-wedge randomized controlled trial included patients with troponin ≤ 18 ng/L across nine EDs. Patients were stratified by initial troponin, peak value, absolute change, and percent change. The primary outcome was a 30-day composite of all-cause death, acute MI, percutaneous coronary intervention, and coronary artery bypass grafting. Logistic regression analysis after adjusting for age, sex, race, and coronary artery disease was performed. RESULTS: Among 19,194 patients with troponin ≤ 18 ng/L, 117 (0.6%) experienced the composite outcome. Higher troponin levels were associated with increased event rates in unadjusted analyses. Adjusted analyses showed no independent associations overall, though patients whose highest troponin values fell within the ≥ 11- ≤ 18 ng/L range continued to demonstrate significantly worse outcomes than those with lower peak levels. Elevated troponin values correlated with older age, male sex, and greater comorbidity burden. CONCLUSION: In this post-hoc analysis of patients with troponin values below the 99th percentile URL, absolute levels and temporal changes were not independently associated with 30-day adverse outcomes. These findings support the use of subthreshold troponin values in rapid rule-out protocols, emphasizing the need to consider clinical context and comorbidities in risk assessment.

Humans↗
PubMed2005

'Like a baby with a box of matches': British scientists and the concept of 'race' in the inter-war period.

Historians of science have often presented the inter-war period as a time when British scientific communities radically questioned existing scholarship on 'race'. The ascendancy of genetics, and the perceived need to challenge Nazi 'racial' theory have ben highlighted as pivotal issues in shaping this British revision of 'racial' ideas. This article offers a detailed analysis of British scientific thinking in the inter-war period. It questions whether historians have exaggerated or oversimplified the prevalence of anti-'racial' reform. It uses a wide range of scientific writings to consider issues of continuity and change in 'racial' thinking in mainstream British scientific communities. The article probes the relationship between science and politics, focusing on the extent to which ideological factors affected both the scientific agenda and conclusions as regards 'racial' issues. Far from dismissing the idea that events in the inter-war period triggered changes in the way in which British scientists dealt with 'race', the article argues that the seeds of the post-Second World War international scientific rejection of 'race' were sown in inter-war Britain amid considerable ambivalence and discord.

History, 20th Century↗
PubMed2005

An fMRI investigation of race-related amygdala activity in African-American and Caucasian-American individuals.

Functional magnetic resonance imaging (fMRI) was used to examine the nature of amygdala sensitivity to race. Both African-American and Caucasian-American individuals showed greater amygdala activity to African-American targets than to Caucasian-American targets, suggesting that race-related amygdala activity may result from cultural learning rather than from the novelty of other races. Additionally, verbal encoding of African-American targets produced significantly less amygdala activity than perceptual encoding of African-American targets.

Amygdala↗
PubMed1990

The impact of race on volunteer helping relationships among the elderly.

As programs solicit their help in providing transportation, shopping assistance, telephone reassurance, counseling, and information and referral to needy elderly people, older adults are going to fill increasingly important roles as volunteers in the social service system for this aging society. Little empirical work has been done on effective volunteer behavior. This article aims to increase understanding of this topic by exploring how race influences relationships between volunteers and the people they serve. This analysis reveals that race by itself does not affect volunteer helping behavior; black and white older adults perform similarly in volunteer roles on measures of time committed to service and satisfaction levels of clients. However, the racial composition of the dyad does have significant effects on the helping relationship; higher levels of contact and client satisfaction are reported when the volunteer and the client are of the same race. Professional training and support are necessary to overcome problems associated with racial differences between volunteers and their clients.

Black or African American↗
PubMed1995

Kawasaki syndrome in Washington State. Race-specific incidence rates and residential proximity to water.

OBJECTIVES: To calculate race-specific incidence rates of Kawasaki syndrome (KS) and to assess the association of KS with residential proximity to water in Washington State. DESIGN: Incidence study over 4 1/2 years, using cases identified with a new statewide hospital data set and a case-control study. SETTING: King, Pierce, and Snohomish counties in Washington State. PATIENTS: One hundred twelve population-based incident cases meeting Centers for Disease Control and Prevention criteria for KS. MAIN OUTCOME MEASURES: Race-specific KS incidence rates and distance to permanent bodies of water among KS cases and matched controls. RESULTS: For the years 1985 through 1986 and 1987 through 1989, the annual KS incidence rates were 6.5 and 15.2 per 100,000 children younger than 5 years, respectively. Rates were highest among Asian Americans (33.3 per 100,000 children younger than 5 years in the 1987-1989 period), followed by blacks and whites (23.4 and 12.7 per 100,000 children younger than 5 years, respectively). The median distance to water did not differ between cases and controls and the proportion of cases living within 150 yd (135 m) of water was no greater than that of controls (odds ratio, 1.0; 95% confidence interval, 0.1 to 20.9). CONCLUSIONS: With complete ascertainment of incident-hospitalized cases of KS, the race-specific rates are among the highest documented in the United States. The rate among Asian Americans was less than that found in Japan, perhaps due to differences in environmental exposures or variations in susceptibility among different Asian ethnic groups. Although we found no association with permanent bodies of water, future studies of KS should include home inspection to assess exposure to temporary collections of standing water.

Black or African American↗
PubMed1981

Racing thoughts in psychiatric inpatients.

Racing thoughts, which have been previously described in schizophrenia and mania, were found to be equally prevalent in hospitalized depressed and manic patients. Racing thoughts are rare in schizophrenics who do not have an affective syndrome and more common in schizoaffective patients. The symptom is associated with disturbed concentration. It is experienced as pleasant by manic patients and as unpleasant by depressed patients. Racing thoughts may be important in the understanding of affective illness.

Adolescent↗
PubMed2000

Molecular analysis of racE function in Dictyostelium.

Dictyostelium has long proven to be a valuable system for studying various aspects of the cytoskeleton and cell motility. In this review we describe the isolation of a novel gene, racE, and how we have used multiple approaches to learn how the product of this gene is involved in cytokinesis. The racEgene was isolated in a screen designed to identify genes specifically required for cytokinesis. The use of GFP fusion proteins, coupled with mutational analysis, allowed us to determine that racE exerts its function at the plasma membrane throughout the entire cell cycle. Measurements of cortical tension and observations of live cells in suspension culture revealed that racE is involved in the regulation of cortical tension and actin organization at the cortex. We postulate that in the absence of proper cortical tension, cytokinesis cannot proceed normally.

Actins↗
PubMed1996

Prostate cancer, race, and socioeconomic status: inadequate adjustment for social factors in assessing racial differences.

BACKGROUND: This paper reviews the state of the art in analyzing race, social factors, and economic factors in cancer research, with an emphasis on prostate cancer and the role of socioeconomic status (SES) in racial differences in mortality. It analyzes the quality of articles in the literature that assess the role of SES in cancer mortality. METHODS: English-language titles were identified using MEDLINE with publication dates from mid-1985 through July 1994. Articles in the references of these articles were also included in the final selection, based originally on title and ultimately on content, dating back to 1978. Articles that included SES information and distinguished between whites and African-Americans were chosen, resulting in a final selection of 21 articles. Articles are summarized with consideration of five criteria considered minimal requirements of a well-designed study of the role of race in cancer mortality: (1) SES measure(s) should be on an individual level, not census level; (2) SES should be controlled for when making comparisons between whites and blacks; (3) SES should include at least (individual level) measures of income and education; (4) sample sizes are sufficient for the relevant populations; and (5) specific cancer sites should be studied separately. RESULTS: Of the articles reviewed, only two meet the minimum standards, neither of which studied prostate cancer. It is not clear whether observed racial differences in prostate cancer are directly attributable to race or reflect underlying social factor differences between whites and African-Americans. CONCLUSIONS: In the future, specific characteristics of SES should be measured at the individual level; there is a need for expansion and standardization of data in terms of social and economic content; other methodological advances are needed in modeling to take into consideration the influence of SES in outcome research related to cancer.

Humans↗
PubMed1998

Race, treatment, and survival among colorectal carcinoma patients in an equal-access medical system.

BACKGROUND: The aim of this study was to assess the influence of race on the treatment and survival of patients with colorectal carcinoma. METHODS: This retrospective cohort study included all white or black male veterans given a new diagnosis of colorectal carcinoma in 1989 at Veterans Affairs Medical Centers nationwide. After adjusting for patient demographics, comorbidity, distant metastases, and tumor location, the authors determined the likelihood of surgical resection, chemotherapy, radiation therapy, and death in each case. RESULTS: Of the 3176 veterans identified, 569 (17.9%) were black. Bivariate analyses and logistic regression revealed no significant differences in the proportions of patients undergoing surgical resection (70% vs. 73%, odds ratio 0.92, 95% confidence interval 0.74-1.15), chemotherapy (23% vs. 23%, odds ratio 0.99, 95% confidence interval 0.78-1.24), or radiation therapy (17% vs. 16%, odds ratio 1.10, 95% confidence interval 0.85-1.43) for black versus white patients. Five-year relative survival rates were similar for black and white patients (42% vs. 39%, respectively; P=0.16), though the adjusted mortality risk ratio was modestly increased (risk ratio 1.13, 95% confidence interval 1.01-1.28). CONCLUSIONS: Overall, race was not associated with the use of surgery, chemotherapy, or radiation therapy in the treatment of colorectal carcinoma among veterans seeking health care at Veterans Affairs Medical Centers. Although mortality from all causes was higher among black veterans with colorectal carcinoma, this finding may be attributed to underlying racial differences associated with survival. This study suggests that when there is equal access to care, there are no differences with regard to race.

Adult↗
PubMed1993

Race, income, and survival from breast cancer at two public hospitals.

BACKGROUND: Some studies have shown that adjustment for socioeconomic status reduces breast cancer survival differences between blacks and whites. The purpose of this study is to evaluate the effect of age, race, stage, treatment, and income status on breast cancer survival among women attending public hospitals in Chicago, Illinois. METHODS: Hospital Cancer Registry data on 887 black women and 265 white women with breast cancer onset between 1973-1985 were analyzed using Cox regression and Kaplan-Meier techniques. The purpose was to examine the effect of age, race, stage, treatment, and income on breast cancer survival. RESULTS: Black women with breast cancer were younger and poorer than white women with breast cancer. There were no significant differences between blacks and whites with regard to stage, estrogen receptor status, or type of treatment. Black women had lower 5-year breast cancer survival rates compared to white women (50.2% versus 60.2%; P = 0.05), and survival was lower when adjusted for stage and age. However, when adjusted for income in addition to stage and age, the effect of race on survival was reduced (from relative risk = 1.26; 95% confidence interval = 1.02, 1.57 to relative risk = 1.17%; 95% confidence interval = 0.95, 1.38). CONCLUSIONS: Income influences breast cancer survival differences between blacks and whites in this population.

Black or African American↗
PubMed2001

Subsite-specific incidence rate and stage of disease in colorectal cancer by race, gender, and age group in the United States, 1992-1997.

BACKGROUND: Subsite specific incidence rates of colorectal cancer vary considerably by age, gender, and race. This variation may be related not only to distinctions in exposure to genetic and environment factors but also to current strategies of early detection screening. Patterns of stage of disease in anatomic subsite may reflect the effect of screening. This study used the largest aggregation of cancer incidence data in the U.S. to examine subsite specific incidence rates of colorectal cancer and the relation of stage of disease to anatomic subsites by race, gender, and age group. METHODS: Data on the incidence of invasive colorectal cancer were obtained from 28 population-based central cancer registries. Age-specific and age-adjusted rates and stage distributions were analyzed by subsite, race, and gender. RESULTS: The impact of screening can be observed in the percentage of localized disease, which increased from 31.9% among cancers in the proximal colon to 37.0% in the descending colon to 41.5% in the distal colorectum. Within the same subsite, blacks were less likely than whites to receive a diagnosis of localized disease and more likely to receive a diagnosis of distant disease whereas stage distributions were approximately the same for males and females. Blacks were more likely than whites to receive a diagnosis of proximal colon cancer than distal colorectal cancer. The male-to-female rate ratios progressively increased from the proximal colon to the distal colorectum. The ratios of proximal-to-distal colorectal cancer gradually increased with advancing age. CONCLUSIONS: Differentials in stage of disease by subsites indicate a need for a targeted effort at early detection of cancer in the proximal colon. Risk factors and higher risk populations for colorectal cancers in each subsite need to be studied further to guide actions for improving the efficacy of screening.

Age Factors↗
PubMed1982

Race and socioeconomic status as confounding variables in the accurate diagnosis of alcoholism.

Utilized two psychologists as actors in making four videotapes to depict background information and verbal modes of communication for alcoholics according to black-white race differences and high-low socioeconomic status. Forty graduate psychology students (10 per group) then were shown randomly one of the four recordings and asked to make a diagnosis. A significant difference was found for the effects of race, socioeconomic status, and race X socioeconomic status interaction on the correct diagnosis of alcoholism. Results were interpreted as suggesting that a clinician's personal biases and/or prejudices might extend into the clinical diagnosis and treatment of clients.

Alcoholism↗
PubMed1989

Gifted and nongifted race and gender effects on item functioning on the Kaufman Assessment Battery for Children.

This study examined differential item function on the K-ABC for gifted and nongifted subjects on the basis of race and gender using the technique for partial correlation proposed by Stricker (1982) and Reynolds, Willson, and Chatman (1984). It was determined that there were no items biased against gifted Black children and that 8 items were biased against gifted White children. Three items were found to be biased against nongifted Black children, while 4 items were biased against nongifted White children. When gender was considered, 2 items were found to be biased against gifted males, and 2 items also were found to be biased against gifted females. There were 10 items that were biased against nongifted Black males and 6 items biased against nongifted females. Systematic bias against race or gender was not found. It appears that the K-ABC is a relatively nonbiased test suitable for the evaluation of both gifted and nongifted children regardless of race or gender.

Achievement↗
PubMed1976

Within and between race distances in population studies based on discrete traits of the human skull.

A battery of 24 discrete cranial traits has been tested for its power to discriminate within- and between-race distances for the two principal North American indigenous populations: Indian (7 samples, N = 366) and Eskimo (7 samples, N = 451). One of the Indian samples, Dakota Sioux, has been split according to tribal subdivisions, the intra-tribal mean distance providing a parameter of very close relationship. In addition, two Negro samples provide a parameter of relationship phylogenetically remote from the Amerinds. Separate male-female analysis of the three largest samples indicates that distances for pooled samples are not seriously affected by the sex component. Within-race distances (C. A. B. Smith's Measure of Divergence, MD), are smaller than between-race at the .00001 level of significance (Mann-Whitney U test) for both Indian-Eskimo and Amerind-Negro comparisons. The features most powerful for Indian-Eskimo and Amerind-Negro comparisons. The features most powerful for Indian-Eskimo discrimination are revealed by their percent contribution to the mean of 49 MD's. The African heritage of American Blacks is reflected in a characteristic Negro pattern of trait frequencies different from the Amerind. This battery of features yields valid taxonomical information useful in conjunction with other physical data to reconstruct affinities of extinct populations.

Black People↗
PubMed1978

Age, sex, and race effects on mortality from systemic lupus erythematosus in the United States.

Nationwide rates of death from systemic lupus erythematosus (SLE) were estimated from National Center for Health Statistics mortality data for 1968 to 1972 according to age, sex, and race. The overall rates for females, 6.3 per million person-years (whites 5.2, blacks 14.8), were about four times that for males, 1.6 per million person-years (whites 1.5, blacks 2.2). The overall rate for blacks, 8.8, was 2.6 times that for whites, 3.4. An earlier rise in age-specific mortality rates for females than males produced higher age-specific female-to male sex ratios in the early adult years than in later years. Mortality generally increased with age in whites whereas the phenomenon of an accentuation and decline during the early and middle adult ages was seen in blacks, particularly females. Analysis of age-, sex-, race-specific rates using one measure of synergistic interaction, S, revealed substantial synergy between the effects of sex and race on mortality during the childbearing ages (S = 3.2, 95% confidence interval = 2.3--4.4).

Adolescent↗
PubMed2003

Patterns of self-harm and attempted suicide among white and black/mixed race female prisoners.

AIM: The aim was to investigate ethnic differences in lifetime self-harm and attempted suicide in women prisoners, and to examine relationships between self-harm, suicide and substance use on dependence. BACKGROUND: Previous studies have suggested that there may be ethnic differences in the proportion of prisoners reporting substance misuse, self-harm and attempted suicide, although relatively few minority ethnic women have been studied in the UK. This study examines drug and alcohol dependence in white and black British women in prison, and explores possible associations with self-harm, suicide attempts, and family violence. METHODS: 301 women (190 white, 111 black or mixed race) were interviewed in ten prisons from different parts of England. Measures included the Alcohol Use Disorders Identification test (AUDIT), the severity of Dependence Scale (SDS), and section C (suicidality) of the MINI International Neuropsychiatric Interview. RESULTS: Half of the women in the sample reported at least one act of self-harm in their life and 46% reported making a suicide attempt at some time. Lifetime self-harm was associated with a history of harmful drinking and with being a victim of violence, including physical assault, sexual assault and violence from family and friends. Lifetime suicide attempts were associated with reported violence from family or friends. Current high suicide risk was most common among women on remand. Drug dependence and reported violence from family or friends were both more common amongst white women than black/mixed race women. Self-harm and attempted suicide were generally more common among white women, but black/mixed race women dependent on drugs had the highest proportion of women reporting self-harm. There was tentative support for a three-way association between ethnicity, dependence and self-harm; this raises the possibility that drug dependence may be a predictor of self-harm in the black female prison population.

Black People↗
PubMed2005

The impact of socioeconomic status and race on trial participation for older women with breast cancer.

BACKGROUND: Older women, and older minorities in particular, are under represented in breast cancer trials. Although socioeconomic status (SES) is associated with both race and age, to the authors' knowledge little is known regarding the impact of SES on trial enrollment among older women with breast cancer. METHODS: The authors performed a case-control study comparing women who were participants in National Cancer Institute cooperative group breast cancer trials (cases) with a population-based sample of breast cancer patients (controls) obtained from the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare data base. The sample was restricted to women age >/= 65 years who were living in SEER areas. Proxies for SES included the proportion of the population below poverty level (by zip code) and unemployed (by county) as well those with Medicaid insurance coverage. A multivariable logistic regression model was used to test the association of SES with trial participation after accounting for other patient and county characteristics. RESULTS: In bivariate analysis, trial participants were significantly less likely than community cancer patients to reside in high-poverty zip codes (20.9% vs. 24.9%, respectively; P < 0.001) or to have Medicaid insurance (2.0% vs. 10.0%; P < 0.0001). After adjusting for race, age, and county, trial participation remained inversely related to residing in areas with high poverty (odds ratio [OR] vs. residents of remaining counties, 0.78; 95% confidence interval [95% CI], 0.62-0.98), high unemployment rates (OR vs. residents of residents of counties in the lowest quartile, 0.50; 95% CI, 0.35-0.71), and having Medicaid insurance (OR vs. women without Medicaid, 0.22; 95% CI, 0.13-0.37); black race was not found to be related to trial participation (OR for black vs. white, 1.0; 95% CI, 0.67-1.47). CONCLUSIONS: Low SES was associated inversely with trial enrollment for older women with breast cancer and appeared to account for the enrollment disparities between black patients and white patients. Future efforts to enhance enrollment of elderly women in cancer research should identify specific barriers related to SES that may be amenable to intervention.

Black or African American↗