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Risk factors for dislocation during the first 3 months after primary total hip replacement.

The prevalence of dislocation of a total hip replacement during the first 3 postoperative months was determined for a series of 315 patients who underwent a unilateral primary total hip operation. All operations were performed by 1 surgeon using a standardized posterior approach with a complete capsulectomy. All of the patients had a femoral component made by 1 manufacturer that had the same 28-mm modular head, the same femoral neck diameter, and the same offset for each size implant. One cementless acetabular component was used for all patients. All of the patients followed the same postoperative rehabilitation program. Of 315 patients, 14 sustained a dislocation, resulting in a prevalence of 4%. There were 13 posterior dislocations and 1 anterior dislocation. Because the surgeon, the surgical approach, the femoral component design, and the rehabilitation protocol were identical for all of these patients, the only variables that could affect the risk of dislocation were the size of the acetabular component and the femoral neck length, the type of fixation of the femoral component, the orientation of the acetabular component, and the characteristics of each patient. The patient characteristics that were studied included age; gender; height; weight; preoperative diagnosis; and a category termed cerebral dysfunction, which included a state of confusion during the hospital stay, a prior history of excessive alcohol consumption, or both of these conditions. Statistical analysis demonstrated 1 variable that was associated with a higher dislocation rate, the presence of cerebral dysfunction. There was a trend toward increased age as a risk factor. None of the other patient or component variables were found to be significant risk factors.

Adult↗

Developing a culturally and ecologically sound intervention program for youth exposed to war and terrorism.

This article describes the public mental health approach used to develop and implement a school-based postwar trauma/grief intervention program for adolescents in Bosnia-Herzegovina. This approach includes development of multilateral partnerships with local and ministerial stakeholders, systematic assessment that yields a detailed understanding of the specific range and severity of trauma and loss experiences, current adversities and trauma reminders among the affected population, and a training program aimed at developing the capacities of local service providers and an indigenous support infrastructure so that the intervention program may be directed and sustained by people within the communities served. Concluding comments detail an expanded conceptual framework for public mental health interventions that may be appropriate for terrorist and mass-casualty events.

Adolescent↗

RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

Two important Ras-guanyl nucleotide exchange factors, Sos and RasGRP1, control Ras activation in thymocytes. However, the relative contribution of these two exchange factors to Ras/ERK activation and their resulting impact on positive and negative selection is unclear. We have produced two lines of RasGRP1(-/-) TCR transgenic mice to determine the effect of RasGRP1 in T cell development under conditions of defined TCR signaling. Our results demonstrate that RasGRP1 is crucial for thymocytes expressing weakly selecting TCRs whereas those that express stronger selecting TCRs are more effective at utilizing RasGRP1-independent mechanisms for ERK activation and positive selection. Analysis of RasGRP1(-/-) peripheral T cells also revealed hitherto unidentified functions of RasGRP1 in regulating T cell homeostasis and sustaining antigen-induced developmental programming.

Animals↗

Results of and comments on the 2000 survey of the American Association of Academic Chief Residents in Radiology.

RATIONALE AND OBJECTIVES: The American Association of Academic Chief Residents in Radiology (A3CR2) annually surveys radiology residency programs on issues related to training. The objective is to highlight national similarities, differences, and trends to help programs establish standards and improve residency training. MATERIALS AND METHODS: Questionnaires were mailed to 180 accredited diagnostic radiology residency training programs in the United States. The survey covered the usual general topics and more specific topics considered every 4 years; for 2000 the latter were on-call issues and the chief residency year. RESULTS: Completed surveys were returned from 63 programs (35%). Important findings included increased caseload and call commitments, especially for smaller programs. Resident salaries appear to have increased more than the consumer price index. Nonemergent after-hour coverage and teleradiology are now a large part of the resident work practice. Women continue to be underrepresented, with a trend downward. Chief residents are more involved in organizing preparation for board examinations and have greater office facilities and more administrative duties. CONCLUSION: This survey provided useful insights. All levels of residency face increased workloads. On-call hours have not changed, but the work has intensified and the use of teleradiology has increased. Many programs have adopted a "night-float" system, and nonemergent after-hours coverage should be considered in any program evaluation. Continued vigilance and sustained efforts are required to ensure that radiology is considered as a specialty by both men and women. With increased demands on attending physicians' time, chief residents may need to take on more administrative responsibilities.

Curriculum↗

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos signaling pathways both play important roles downstream of RANKL. We show here that RANKL selectively induces NFATc1 expression via these two pathways. RANKL also evokes Ca(2+) oscillations that lead to calcineurin-mediated activation of NFATc1, and therefore triggers a sustained NFATc1-dependent transcriptional program during osteoclast differentiation. We also show that NFATc1-deficient embryonic stem cells fail to differentiate into osteoclasts in response to RANKL stimulation, and that ectopic expression of NFATc1 causes precursor cells to undergo efficient differentiation without RANKL signaling. Thus, NFATc1 may represent a master switch for regulating terminal differentiation of osteoclasts, functioning downstream of RANKL.

Active Transport, Cell Nucleus↗

Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment.

OBJECTIVE: To assess the effects of plant sterol or stanol ester consumption on their incorporation into erythrocytes and their effects on osmotic fragility of red blood cells. DESIGN: Double-blind, randomized, placebo-controlled intervention trial. SUBJECTS AND INTERVENTION: Forty-one subjects on stable statin treatment - who already have increased serum plant sterol and stanol concentrations - first received for 4 weeks a control margarine. For the next 16 weeks, subjects were randomly assigned to one of three possible interventions. Eleven subjects continued with control margarine, 15 subjects with plant sterol ester enriched and 15 subjects with plant stanol ester-enriched margarine. Daily plant sterol or stanol intake was 2.5 g. Erythrocyte haemolysis was measured spectrophotometrically at five different saline concentrations. RESULTS: Despite significant (P = 0.004) increases of, respectively, 42 and 59% in cholesterol-standardized serum sitosterol and campesterol concentrations in the plant sterol group as compared to the control group, campesterol levels in the red blood cells did not change (P = 0.196). Osmotic fragility did not change significantly (P = 0.757) in the plant sterol and plant stanol groups as compared to the control group. CONCLUSION: We conclude that plant sterol and stanol ester consumption for 16 weeks does not change osmotic fragility of erythrocytes in statin-treated patients. SPONSORSHIP: Netherlands Organisation for Health Research and Development (Program Nutrition: Health, Safety and Sustainability, Grant 014-12-010).

Anticholesteremic Agents↗

Cultural and noncultural predictors of health outcomes in Korean daughter and daughter-in-law caregivers.

In Western cultures, adverse health effects resulting from providing care for impaired elders is well documented for family caregivers, but little is known about the health of Korean caregivers. This study examined the level of depression and physical health of 120 daughter and daughter-in-law caregivers who cared for cognitively or functionally impaired elderly in Korea. It was hypothesized that cultural factors would have a greater effect on caregivers' health outcomes than noncultural factors, but, contrary to this expectation, the effects of noncultural factors were found to outweigh those of cultural factors. Moreover, the caregivers in this study reported a relatively high level of depression, and more caregivers rated their own health as "poor" than did Western caregivers in previous studies. Family caregiving for the impaired elderly is stressful and negatively affects Korean caregivers' health outcomes regardless of societal values such as filial piety and familism regarding parent care in Korea. Culturally acceptable and sensible support programs may be useful in sustaining long-term care at home by Korean daughter and daughter-in-law caregivers. Further family caregiving studies in the Korean sociocultural context are recommended.

Adult↗

Cancer curricula in U.S. dental schools.

The current cancer curricula of 52 U.S. dental schools were assessed using a survey similar to that conducted in 1981 by the American Association for Cancer Education. Data demonstrate significant declines in both cancer education representation on the curriculum committee and the existence of a cancer education committee. The percentage of schools with university general budget funding and NCI funding has also declined significantly. Despite recommendations from the 1981 AACE committee, deficits in oral oncology education at present include: 1) an active cancer education committee; 2) practical clinical oncology experience in diagnosis, the decision-making process, referral procedures, management of oral sequelae of cancer therapy, and maxillofacial rehabilitation; 3) psychosocial training in oncology; 4) community cancer activities; and 5) sustaining funds for oncology education programs.

Curriculum↗

The changing dynamics of Plasmodium vivax and P. falciparum in central India: trends over a 27-year period (1975--2002).

The changing epidemiology of malaria since 1975 was studied in a tribal forested belt of central India, Chhattisgarh state, which is the second most highly malarious state in India. Chhattisgarh, which accounts for 2% of the total population of the country, contributed >16% of the total malaria cases, 23% of Plasmodium falciparum, and 7% of deaths due to malaria in the country. Retrospective analysis further revealed that, in 1975--76, P. vivax was the predominant species (58%); however, since 1979, P. falciparum showed a steady upward trend (50%), and in 2002. P. vivax reduced to 28%. Between 1986 and 2000, P. falciparum cases reported by the National Anti Malaria Programme have increased 500%, and the number of deaths also showed a similar alarming increase. From 2000 to 2002, though the number of malaria infections and number of deaths declined sharply as a result of intensive intervention measures (30% and 95%, respectively), which included new drugs like Sulfadoxine Pyrimethamine and Arteether under Enhanced Malaria Control Programme, the proportion of P. falciparum has held steady without any decline. Moreover, along with Anopheles fluviatilis, the traditional vector in the forest, An. culicifacies has also established itself in the forest. The comeback of malaria and establishment of new vectors was largely due to the deterioration of health services along with emergence of resistance in P. falciparum to Chloroquine and in An. culicifacies to DDT. Therefore, a more diversified malaria control program might be needed for sustainable malaria control.

Animals↗

Altered growth control of rat hepatocytes after treatment with 3,4,3',4'-tetrachlorobiphenyl in vivo and in vitro.

Alterations of hepatocyte growth control by inducers of drug-metabolizing enzymes were investigated using 3,4,3',4'-tetrachlorobiphenyl (TCB) as the inducing agent. TCB was chosen as a selective 3-methylcholanthrene-type inducer and liver tumor promoter which probably exerts its biological actions through binding to the aryl hydrocarbon (Ah) receptor. In vivo treatment of rats with TCB (200 mg/kg) markedly stimulated growth of enzyme altered liver foci and [3H]-thymidine incorporation into nuclear DNA. Hepatocyte cultures from TCB-treated rats were more sensitive to exogenous growth factors such as EGF than those from untreated controls. In vitro TCB exposure of hepatocyte cultures also altered hepatocyte growth control in a dose-dependent manner and induced drug-metabolizing enzymes. TCB treatment in vivo enhanced EGF-stimulated autophosphorylation of the EGF receptor in liver plasma membranes. The results suggest that altered growth control is due to a direct effect of TCB on hepatocytes. The proposed model may be useful to elucidate a possible linkage between the functional stress imposed on hepatocytes by sustained overexpression of an adaptive program and modulation of hepatocyte growth control.

7-Alkoxycoumarin O-Dealkylase↗

Idiopathic left ventricular aneurysm and sudden cardiac death in young adults.

AIMS: We report three young patients presenting with life-threatening ventricular tachycardia (VT) or ventricular fibrillation (VF) and/or survived sudden cardiac arrest, who were admitted to our institution for further diagnostic evaluation. METHODS AND RESULTS: In all patients, idiopathic left ventricular (LV) aneurysms were identified after a detailed non-invasive and invasive evaluation. Sustained VT/VF was inducible during programmed ventricular stimulation in two of the three patients. Left ventricular aneurysms were depicted and characterized by various imaging modalities (echocardiography, magnetic resonance imaging, LV angiography). To elucidate the pathogenesis further, both myocardial viability and regional sympathetic innervation were assessed by radionuclide imaging techniques. Defects of innervation and metabolism were documented in the area of the aneurysm but distal to the aneurysm there were no signs of downstream denervation. CONCLUSION: Life-threatening arrhythmias may be the first manifestation of an idiopathic LV aneurysm, which can be reliably diagnosed with modern imaging techniques. Radionuclide imaging may yield additional information as to the involvement of the autonomic nervous system potentially associated with arrhythmogenesis. Management strategies in patients with an idiopathic LV aneurysm range from antiarrhythmic drug treatment, implantation of an automatic cardioverter-defibrillator to surgical aneurysmectomy.

Adult↗

Volunteerism by elders: past trends and future prospects.

A number of surveys indicate a rise in the percentage of elders involved in volunteer work over the past 25 years. This article identifies cultural, demographic, and programmatic factors that have contributed to this increase. After describing some current policies and programs, it identifies strategies for sustaining and expanding volunteerism by elders in the future.

Aged↗

Reality orientation for dementia: a systematic review of the evidence of effectiveness from randomized controlled trials.

The effectiveness of classroom reality orientation (RO) in dementia was evaluated by conducting a systematic literature review. This yielded 43 studies, of which 6 were randomized controlled trials meeting the inclusion criteria (containing 125 subjects.) Results were subjected to meta-analysis. Effects on cognition and behavior were significant in favor of treatment (cognition standardized mean difference [SMD] = -0.59; 95% confidence interval [CI] -0.95(-)-0.22; behavior SMD = -0.64, 95% CI = -1.20(-)-0.08). The evidence indicates that RO has benefits on both cognition and behavior for dementia sufferers. However, a continued program may be needed to sustain potential benefits. Future research should evaluate RO in well-designed multicenter trials.

Aged↗

Fatal crashes involving young male drivers: a continuous time Poisson change-point analysis.

BACKGROUND: In an effort to reduce road trauma, the New Zealand government implemented a series of intervention programs over the last decade, with young male drivers as the main target audience. Previous research, however, found little or no evidence that these programs had any impact on this group of drivers despite an apparent decrease in their crash involvement. OBJECTIVE: To determine the approximate time when the decrease in the number of fatal crashes involving young male drivers occurred. METHOD: A Poisson change-point estimator was used to locate the most likely point where a decrease in the average number of monthly crashes had occurred. RESULTS: The most likely time of change was found to coincide with the time when the Transport Act 1992 was debated and passed in Parliament. The publicity given to the issue and the Government's signal of impending actions were sufficient to induce a significant change in the behaviours of young male drivers. IMPLICATIONS: This result can partially reconcile the difference between the apparent reduction in the number of fatal crashes involving young male drivers and the inability of previous studies to find a significant impact of the various intervention programs since the change occurred prior to the actual implementation of the programs. Nevertheless, it was argued that the implementation of the programs subsequently was necessary in sustaining the reduction.

Accidents, Traffic↗

Sudden cardiac death in a southeast Asian immigrant: clinical, electrophysiologic, and biopsy characteristics.

The syndrome of sudden cardiac death in southeast Asians has only recently been given attention in the American medical literature. This case report describes a patient who presented with this rare syndrome. The physical examination, Holter monitor, 2-D echocardiogram, exercise treadmill test, radionuclide ventriculogram, coronary angiography, and endomyocardial biopsy were all normal. Programmed ventricular stimulation reproducibly induced sustained polymorphic ventricular tachycardia. Oral procainamide, oral quinidine and oral quinidine plus propranolol were not successful in suppressing inducible polymorphic ventricular tachycardia. The arrhythmia remained inducible after six weeks of oral amiodarone therapy. However, he has no clinical recurrences while on amiodarone after one year of follow-up.

Adult↗

Entrainment of ventricular tachycardia in postoperative tetralogy of Fallot.

The mechanism of ventricular tachycardia (VT) in postoperative tetralogy of Fallot has been ascribed to both reentry and triggered automaticity. We performed electrophysiologic studies on a patient with this condition and induced sustained uniform ventricular tachycardia by programmed extrastimulation. Pacing during the tachycardia at multiple cycle lengths from the right ventricular apex (RVA) and outflow tract (RVOT) produced constant but progressive fusion between the paced and tachycardia QRS. With termination of pacing, the last captured complex was unfused but coupled at the paced cycle length and then the tachycardia resumed at its intrinsic rate. Therefore, the VT was entrained. In addition, an area of slow conduction between the RVOT and RVA was demonstrated. These findings support a reentrant mechanism of this arrhythmia.

Adult↗

The efficacy, electrophysiologic and electrocardiographic effects of intravenous pirmenol, a new class I antiarrhythmic agent, in patients with ventricular tachycardia: comparison with procainamide.

UNLABELLED: The electrophysiologic and electrocardiographic effects of intravenous pirmenol were compared with intravenous procainamide in 17 patients with symptomatic ventricular tachycardia. Pirmenol was found to prolong the PR interval, the QRS duration, the QTc interval, the HV interval, the atrial effective refractory period, and the ventricular effective refractory period. The sinus cycle length decreased following pirmenol administration. The sinus node recovery time, the PA interval, the AH interval, the Wenckebach cycle length, and the AV nodal ERP were unchanged. In patients whose ventricular tachycardias remained inducible on pirmenol, the cycle length was significantly prolonged compared to baseline. These changes were similar to those seen following the administration of procainamide. All 17 patients had sustained ventricular tachycardia inducible during programmed ventricular stimulation in the baseline state. In four patients the ventricular tachycardia was suppressed with both primenol and procainamide. In the remaining 13 patients ventricular tachycardia remained inducible on procainamide. Of these 13 patients, an additional two patients had their ventricular tachycardias rendered noninducible on pirmenol. IN CONCLUSION: (1) the electrophysiologic and electrocardiographic effects of pirmenol are similar to those of procainamide; (2) although ventricular tachycardia inducibility following procainamide was similar to that of pirmenol, an occasional patient with ventricular tachycardia inducible on procainamide had ventricular tachycardias suppressed on pirmenol.

Administration, Oral↗

Device interaction--antitachycardia pacemakers and defibrillators for sustained ventricular tachycardia.

We evaluated the combined use of permanent automatic antitachycardia pacemakers and implanted defibrillators in ten patients with recurrent monomorphic sustained ventricular tachycardia (VT). Pacemaker programming was VVI-T automatic burst in eight patients, VVI-T magnet mode in one patient, and VVI in one patient. Device interactions occurred in four patients, requiring changes in pacemaker programming. These included defibrillator multiple counting during pacing, inappropriate pacemaker bursts initiating VT, inappropriate reset of the pacemaker antitachycardia mode by defibrillation, defibrillator discharge after pacemaker VT termination, and defibrillator VT reinitiation. Two patients required pacemaker programming out of the antitachycardia mode, and two required a change in antitachycardia pacing parameters. Seven patients remain in automatic VVI-T and three in VVI modes. Mean follow-up is 13 months and all patients are alive. Thus, although pacemaker/defibrillator combinations function well for patients with more than one VT rate, device interactions occur frequently and may require pacemaker reprogramming or elimination of the overdrive mode. Combined use of these devices should be cautiously considered when single device therapy is unsatisfactory. Devices that combine both pacing and defibrillation features may reduce adverse interaction.

Algorithms↗