The discovery of marine natural products with therapeutic potential.
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The research project CADISO (Cardiovascular Diseases and Stability of the Organism--Phytotherapeutical Possibilities) is an alliance board associating approximately 20 professional institutions, its centre and coordinating laboratory being the Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Králové. It aims at the prevention (additives in food industry) and therapy of diseases of the circulatory apparatus using phytotherapeutic agents and substances isolated from higher plants and fungi. The project is divided into three systems of investigation: ADAPRETE, i.e. the substances increasing the nonspecific resistance of the organism (adaptogenes of plant origin, immunostimulants), DIACORD, dealing with the substances acting on the cardiovascular system in a mediated way, i.e. treating the diseases the eventual action of which alters the heart and vessels (antihypercholesterolemics, antihyperlipidemics, antidiabetics, anti-oxidants and quenchers of free radicals, hepatoprotectives, anti-aggregating agents), and CORCORAN studying the taxons and substances isolated from them which act directly on the circulatory system (cardiotonic, anti-arrhythmic and vasodilating agents). To achieve a real purpose of the project, the linking-up of the phytochemical, pharmacological-toxicological, pharmaceutical-technological fields, production of raw materials and legislation is ensured.
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The resin of Dracaena cochinchinensis has been used as the substitute for Chinese drug Xuejie (Sanguis Draconis) for 20 years in China. The pharmacological, toxicological and clinical studies have shown that the former is similar to the latter in effects, and can be used as a substitute for the latter. This paper deals with the resources, morphological and histological characters, chemical and physical analysis of Sanguis Lignum Dracaenae Cochinchinensis.
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The characteristics of Dioscorea spongiosa, or in Chinese Mianbixie, are clearly different from those of D. septemloba in morphology, histology, pollen etc. The establishment of the position of the new species of D. spongiosa is well grounded.
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Through a critical study of ancient Chinese herbals, it is concluded that the botanical origin of Guijiu should be Dysosma versipellis or D. pleiantha instead of Sinopodophyllum emodi, and that Xiaoyelian was originated from the latter. In Chinese Pharmacopoeia and many other books, the botanical origin of Xiaoyelian was erroneously referred to as Podophyllum emodi.
Through many years' research, a set of cultivation techniques for Rehmannia glutinosa in summer has been found out as "selecting necks in autumn; growing seedlings with plastic films in early spring; culturing around summer solstice and reaping after autumn". A Study has also been made on the scope feasible for spreading the application of these techniques.
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An original error on Huzhang and Tiannanxing in Li Shizhen's "Bencao Gangmu" (Compendium of Materia Medica, 1596) is corrected in this paper. The conclusion is that Huzhang in "Shen Nong's Materia" (around 200) should be the tuber of Pinellia pedatisecta and Tiannanxing in "Kaibao Bencao" (974) the tuber of Arisaema heterophyllum but they were merged or confused by Li Shizhen. The former, in fact, has been cultivated, marketed, exported and used medically for its high quality, but it has disappeared from herbal literatures owing to Li's error. Therefore, the above-mentioned correction should be accepted in the next edition of Pharmacopoea of the people's Republic of China.