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PubMed2003

Computer-assisted orthopedic surgery.

Computer-assisted surgery (CAS) utilizing robotic or image-guided technologies has been introduced into various orthopedic fields. Navigation and robotic systems are the most advanced parts of CAS, and their range of functions and applications is increasing. Surgical navigation is a visualization system that gives positional information about surgical tools or implants relative to a target organ (bone) on a computer display. There are three types of surgical planning that involve navigation systems. One makes use of volumetric images, such as computed tomography, magnetic resonance imaging, or ultrasound echograms. Another makes use of intraoperative fluoroscopic images. The last type makes use of kinetic information about joints or morphometric information about the target bones obtained intraoperatively. Systems that involve these planning methods are called volumetric image-based navigation, fluoroscopic navigation, and imageless navigation, respectively. To overcome the inaccuracy of hand-controlled positioning of surgical tools, three robotic systems have been developed. One type directs a cutting guide block or a drilling guide sleeve, with surgeons sliding a bone saw or a drill bit through the guide instrument to execute a surgical action. Another type constrains the range of movement of a surgical tool held by a robot arm such as ACROBOT. The last type is an active system, such as ROBODOC or CASPAR, which directs a milling device automatically according to preoperative planning. These CAS systems, their potential, and their limitations are reviewed here. Future technologies and future directions of CAS that will help provide improved patient outcomes in a cost-effective manner are also discussed.

Cost Savings↗
PubMed1982

Autologous blood retrieval in thoracic, cardiovascular, and orthopedic surgery.

A significant amount of red blood cells were conserved with use of the Cell Saver in cardiac surgery patients and in some orthopedic and vascular surgery patients. No major complications have been associated with its use in our cases. Our results are similar to those of others who have reported on the use of this device. In the cardiac surgery patients we observed significant serum protein losses which had to be replaced. We recommend the use of intraoperative albumin to help maintain adequate urinary output and hemodynamic stability.

Blood Proteins↗
PubMed2005

Orthopedic pitfalls: cauda equina syndrome.

Low back pain is an extremely common complaint encountered by emergency and primary care physicians. Although the majority of patients have uncomplicated benign presentations, there is a small subset who has a much more severe disease process called cauda equina syndrome, which entails acute compression of the nerve roots of the cauda equina. These patients usually present posttraumatically with the triad of saddle anesthesia, bowel or bladder dysfunction, and lower extremity weakness. Significant morbidity can result from delayed diagnosis and treatment; therefore, the emergency physician should remain aware of this potential orthopedic pitfall. This case report discusses the clinical presentation, diagnosis, and relevant treatment of cauda equina syndrome in the ED.

Abdominal Pain↗
PubMed2005

[Thromboprohylaxis in orthopedic surgery and traumatology].

Orthopaedic and trauma surgery are classified according 3 groups of venous thromboembolic risk. Elective total hip replacement (THR) or total knee replacement (TKR), hip fracture surgery or trauma patients are at high risk. Isolated lower extremity injury with fracture is at moderate risk whereas this risk is low without fracture as well as with knee arthroscopy. In THR and TKR, low molecular weight heparin (LMWH), fondaparinux or melagatran-ximelagatran are strongly recommended. The routine use of other anticoagulants, in particular vitamin K antagonist are not recommended. In patients at high risk of venous thromboembolism as for example trauma patients, optimal use of intermittent pneumatic compression is an alternative option in case of contra-indication to anticoagulant prophylaxis. Graduated compression stockings enhance the efficacy of pharmacological methods. In schedule surgery, initiation of prophylaxis with LMWH may be started postoperatively. To reduce the haemorrhagic risk of anticoagulants, timing of first postoperative dose is essential and is proper to each drug. Duration of prophylaxis depends on the surgical and the individual patients' risk. Extended prophylaxis in THR for up to 42 days with LMWH and up to 35 days with fondaparinux in hip fracture surgery is recommended. However extended prophylaxis after 14 days in TKR has not demonstrated a higher efficacy and should only be considered for patients with additional risk factors. In patients with isolated lower extremity injury or undergoing knee arthroscopy, LMWH should not be routinely used according to a low or a moderate risk and/or the duration of prophylaxis required. But LMWH has to be considered for patients with additional risk factors. Prophylaxis in other orthopedic procedures has not been assessed and will be extrapolated from the above recommendations.

Animals↗
PubMed2005

[C-reactive protein, leukocyte count and D-dimer monitoring after orthopedic surgery: early diagnosis of infectious or thromboembolic complications. Part one: C-reactive protein and leukocyte count as an aid in diagnosing postoperative infection].

OBJECTIVES: To evaluate the usefulness of monitoring C-reactive protein (CRP) level and leukocyte count for early diagnosis of infection following orthopedic surgery. METHOD: A cohort of 179 patients was followed: group 1 comprised 128 patients undergoing lower limb arthroplasty, group 2 comprised 29 patients undergoing lower limb surgery without implant, and group 3 comprised 22 patients undergoing spinal or upper limb surgery. CRP level and leukocyte count were systematically measured on admission and then once a week for 4 weeks. Wound infections, other infections, wound disconnection without infection and hematoma were noted. CRP level and leukocyte count were monitored postoperatively in patients with and without complications. RESULTS: CRP level was 4- to 8-fold above the normal range at the first postoperative measurement but normalized within the next 3 weeks (reaching normal levels by the 30th postoperative day, on average). In the 7 cases of wound infection (WI), the CRP level rose to 28-fold above normal and was significantly different from that in without infection or with intercurrent infection (P<0.01). A receiver operating characteristic (ROC) curve was established for CRP level, and for a value of 60 (12-fold above the normal range) the sensitivity was 100%, the specificity 83.6% and the negative predictive value 100%. The variation in leukocyte count was minor, with a significant difference noted between only patients not infected or those with WI (P<0.05). DISCUSSION AND CONCLUSIONS: Measurement of CRP level can be used for early diagnosis of wound infection. In the case of strong clinical suspicion or in the presence of high risk factors, when the level is at 12-fold or more above the normal range, the diagnosis of infection is highly probable.

Adult↗
PubMed2005

Costs of a home-based rehabilitation program for older adults after lower limb orthopedic surgery: a pilot study.

Little is known about the cost of home-based rehabilitation programs in Quebec, Canada. The objective of this pilot project was to test a cost estimation methodology in the context of rehabilitation services delivered at home and to provide preliminary data on the costs for lower limb orthopedic surgery patients. This pilot study examined a short-term home care program for adults, aged 65 and over who returned home after lower limb surgery and required rehabilitation services. Efficacy was determined as the functional autonomy changes between admission and discharge from home rehabilitation program, as measured by the functional autonomy measurement system (SMAF). Costs of professionals, including direct and indirect time related to the intervention, were also determined in order to document cost-effectiveness of the program. Eighteen subjects were recruited. From those, 14 had complete data available for the analysis. The result shows that costs related to the combined natural improvement and the effect of the home-based rehabilitation program were CAN dollars 419 per unit of change of functional autonomy. The results of this pilot study confirm the feasibility of the cost estimation methodology for a home-based rehabilitation program.

Aged↗
PubMed2004

Guidelines and alternatives for neuraxial anesthesia and venous thromboembolism prophylaxis in major orthopedic surgery.

Neuraxial anesthesia during major orthopedic surgery, combined with venous thromboembolism prophylaxis, is generally safe and well tolerated, with potential benefits over general anesthesia. The risk of spinal/epidural hematoma, a rare but very serious complication, can be minimized by careful patient selection and attention to anesthetic technique. This risk is further reduced with the use of peripheral nerve blocks in place of neuraxial anesthesia.

Anesthesia, Conduction↗
PubMed2006

Medicare reimbursement: an orthopedic primer.

Since 1992, Medicare has paid physicians and other practitioners by using a resource-based relative value scale system (RBRVS). The Center for Medicare Services updates the RBRVS annually and reviews the work portion for each procedure every 5 years. The calculation of the work units is done by using a survey. This survey polls the average amount of time spent in each portion of the case. The survey process is quite complex. Some of the specific biases that can be found include rank lists, multidimensional, hypothetical items, and complexity and memory overload bias. Survey errors are easy to make over and above item bias. With this system, surgeons are encouraged to be slower to increase their compensation. Surveying methodology is not the most appropriate way to tabulate time and work. Unless this methodology changes, orthopedic surgeons will continue to be shortchanged.

Aged↗
PubMed2005

Perioperative assessment of the elective orthopedic surgery patient.

There are a number of safe and cost-effective therapeutic options for the potential management of all patients without allogeneic blood transfusion. Orthopedic surgeons should consider blood management using these options for all patients to provide them with safe and effective therapy, while minimizing the risks of allogeneic blood and preserving our decreasing blood resources.

Blood Transfusion↗
PubMed2005

Preoperative evaluation and methods to reduce blood use in orthopedic surgery.

Major elective orthopedic surgery may be associated with significant blood loss and allogeneic transfusion risk. Identifying patients at risk for allogeneic transfusion is best accomplished with a thorough preoperative evaluation of the patient's hematopoietic system, which, unfortunately, is not always carried out. An evaluation of the hematopoietic system begins with an evaluation of the patient's hemoglobin level a minimum of 30 days before the scheduled surgical procedure. This allows for expedited diagnosis and treatment of underlying comorbidities. An unexplained low level of hemoglobin or a hemoglobin level low enough to increase the patient's allogeneic risk should cause elective surgery to be deferred until an evaluation can be preformed and blood management strategies put in place.

Blood Transfusion↗
PubMed2004

Feasibility of knitted carbon/PEEK composites for orthopedic bone plates.

This paper focuses on fabrication and characterization of knitted carbon/PEEK fabric composites for orthopedic bone plate application. Bending performance of the knitted carbon/PEEK composite bone plates was investigated with respect to two principal knitting directions (wale- and course-directions). As a result, the wale-direction knitted composite bone plates had much scattering in bending stiffness and maximum bending moment although they exhibited the same bending behavior as that of the course-direction specimens. In comparison with our previously developed braided composite bone plates, the knitted composite bone plates had 55-59% bending stiffness, 40-63% yield bending moment, and 54-77% maximum bending moment. However, the knitted composite bone plates showed higher deformability. Based on the results of the braided composite bone plates, it is considered that the knitted composite plate with 3.2mm thickness can be suitable for forearm or humerus treatment especially when damaged bones need higher deformation to encourage bone ossification.

Benzophenones↗
PubMed2006

A citric acid-based hydroxyapatite composite for orthopedic implants.

We describe a novel approach to process bioceramic microparticles and poly(diol citrates) into bioceramic-elastomer composites for potential use in orthopedic surgery. The composite consists of the biodegradable elastomer poly(1,8-octanediol-citrate) (POC) and the bioceramic hydroxyapatite (HA). The objective of this work was to characterize POC-HA composites and assess the feasibility of fabricating tissue fixation devices using machining and molding techniques. The mechanical properties of POC-HA composites with HA (40, 50, 60, 65wt.%) were within the range of values reported for tissue fixation devices (for POC-HA 65wt.%, S(b)=41.4+/-3.1, E(b)=501.7+/-40.3, S(c)=74.6+/-9.0, E(c)=448.8+/-27.0, S(t)=9.7+/-2.3, E(t)=334.8+/-73.5, S(s)=27.7+/-2.4, T(s)=27.3+/-4.9, all values in MPa). At 20 weeks, the weight loss of POC-HA composites ranged between 8 and 12wt.%, with 65wt.% HA composites degrading the slowest. Exposure of POC-HA to simulated body fluid resulted in extensive mineralization in the form of calcium phosphate with Ca/P of 1.5-1.7 similar to bone. POC-HA supported osteoblast adhesion in vitro and histology results from POC-HA samples that were implanted in rabbit knees for 6 weeks suggest that the composite is biocompatible. Synthesis of POC-HA is easy and inexpensive, does not involve harsh solvents or initiators, and the mechanical properties of POC-HA with 65wt.% HA are suitable for the fabrication of potentially osteoconductive bone screws.

Animals↗
PubMed2004

Potential pitfalls of computer aided orthopedic surgery.

Computer aided orthopedic surgery (CAOS) systems are becoming more and more frequently used in operating rooms all over the world. While their clinical benefit is no longer doubted, there is considerable potential for using these devices incorrectly At best, mishandling of a CAOS system may lead to prolonged operating times. In the worst case scenario, incorrect navigational feedback is provided, which carries the potential risk of endangering the patient or resulting in an unacceptable surgical outcome. From an economical point of view only the optimal performance of a navigation system will probably justify its significant investment costs. This article summarizes some of the major pitfalls that may occur during surgical navigation. It is structured to reflect different types of CAOS systems, and it presents guidelines on how to avoid most of the problems. In general, a surgeon who wants to apply this technology needs to be very familiar with the system that is used. It is essential to know the basics and the limitations of the underlying technical principles. Otherwise, the large potential that modern CAOS systems make available cannot be exploited effectively for the benefit of the patient.

Fluoroscopy↗
PubMed2005

The combination of epidural clonidine and S(+)-ketamine did not enhance analgesic efficacy beyond that for each individual drug in adult orthopedic surgery.

STUDY OBJECTIVES: To evaluate the benefit of epidural clonidine and S(+)-ketamine combination through the epidural route in adult orthopedic surgery. DESIGN: Randomized double-blinded study. SETTING: Teaching hospital. PATIENTS: Scheduled to undergo knee surgery, 56 American Society of Anesthesiologists physical status 1 and 2 adult patients. INTERVENTIONS: Patients were randomized to 1 of 4 groups to receive the combined epidural-intrathecal technique. A 10-mL epidural injection of either study drug or normal saline was first administered to all patients. Intrathecal anesthesia was performed with 15 mg of bupivacaine. The control group (CG) received epidural saline. The 0.1-mg/kg S(+)-ketamine epidural group received 0.1 mg/kg epidural S(+)-ketamine. The 0.5-microg/kg clonidine epidural group received 0.5 microg/kg epidural clonidine. The S(+)-ketamine/clonidine group received 0.1 mg/kg epidural S(+)-ketamine plus 0.5 microg/kg epidural clonidine. MEASUREMENTS AND MAIN RESULTS: Pain and adverse effects were evaluated by visual analog scale. Rescue analgesics were available to patients. The groups were demographically similar. Sensory level to pinprick, surgical and anesthetic time, and visual analog scale scores for pain at first rescue medication were similar among the groups. The time to first rescue analgesic (minute) was lowest in CG (P < .005). The CG required more rescue analgesics in 24 hours than any of the other groups (P < .0005). Patients who received either epidural clonidine, S(+)-ketamine, or both displayed similar analgesia. The frequency of adverse effects was similar among groups (P > .05). CONCLUSIONS: The association of epidural clonidine or S(+)-ketamine did not result in a greater analgesic effect in the model of acute postoperative pain studied, although the interaction of epidural clonidine and S(+)-ketamine is not attributable to sharing of a common second messenger system.

Adult↗
PubMed2005

[Surgical wound infections due to Pseudomonas aeruginosa in orthopedic surgery].

OBJECTIVE: The department of infection control carried out an investigation to search for the origin of 4 surgical site infections and 1 wound colonization by Pseudomonas aeruginosa in patients having undergone orthopedic surgery. PATIENTS AND METHODS: The authors retrospectively reviewed the medical records, the clinical data of the operating units, as well as the bacteriological assessments of the infected patients. Multiple environmental samples were made to screen for P. aeruginosa and care giving was evaluated. RESULTS: The 5 patients underwent surgery between August and September 2001 with various surgeons and were followed-up by various paramedics. The surgical procedures were varied and performed in different operating rooms. Various P. aeruginosa serotypes were isolated. No specific event could be related to the infections concerning the surgical procedures. In 3 of the 5 patients, non-sterile cotton jersey had been used, either normally (plaster or plaster splint) or after sterilization (wrapping of wounded limbs before surgical procedure). The culture samplings of non-sterile jersey were always contaminated by Enterobacteriaceae or Pseudomonas sp., with 2 positives cultures of P. aeruginosa. Only one water sample was positive, whereas other environmental samples remained negative. The reorganization of jersey supply put an end to this epidemic phenomenon. CONCLUSION: The most probable hypothesis for surgical wound infection was the cotton jersey in 3 of the 5 cases.

Bandages↗
PubMed2005

The potential of tissue engineering in orthopedics.

This article presents models of human phalanges and small joints developed by tissue engineering. Biodegradable polymer scaffolds support growth of osteoblasts, chondrocytes, and tenocytes after implantation of the models in athymic mice. The cell-polymer constructs are vascularized by the host mice, form new bone, cartilage, and tendon with characteristic gene expression and protein synthesis and secretion, and maintain the shape of human phalanges with joints. The study demonstrates critical progress in the design and fabrication of bone, cartilage, and tendon by tissue engineering and the potential of this field for human clinical orthopedic applications.

Animals↗
PubMed2006

Massive allograft use in orthopedic oncology.

Allograft transplantation is a functional reconstructive option for large-extremity osseous defects. Improvements in anatomic matching, infection prevention, allograft fixation, soft tissue reconstructions, and rehabilitation protocols have greatly influenced predictability and longevity of massive allografts. These demanding reconstructions require time, an experienced group of orthopedic surgeons working at an institution with access to a large volume of patients, and a reliable, modern bone bank to select the appropriate graft for each individual under safe conditions. This article discusses the current use of total condylar osteoarticular allografts, hemicondylar allografts, allograft arthrodesis, intercalary segmental allografts, hemicylindric intercalary allografts, and allograft-prosthesis composites.

Adolescent↗
PubMed1999

Tumor necrosis factor-alpha mediates orthopedic implant osteolysis.

Osteolysis complicating arthroplasty reflects progressive generation of implant-derived wear particles, which prompt an inflammatory reaction attended by recruitment of osteoclasts to the prosthesis-bone interface. To identify a soluble mediator of periprosthetic osteolysis we first showed that implant particles induce c-src in murine bone marrow macrophages (BMMs), a protein specifically expressed when these cells commit to the osteoclast phenotype. The fact that tumor necrosis factor-alpha (TNF) is a potent osteoclastogenic agent while at the same time is the only soluble moiety known to be c-src inductive suggests that this cytokine may mediate implant particle-induced osteoclastogenesis. Consistent with this hypothesis, prosthesis-derived wear particles, recovered at revision arthroplasty, dose-dependently prompt TNF secretion by BMMs. Similarly, particulate polymemthylmethacrylate, the major component of orthopedic implant cement, induces BMM expression of TNF mRNA and protein in a time- and dose-dependent manner. Furthermore, failure of BMMs derived from mice deleted of both the p55 and p75 TNF receptors to express c-src in response to polymemthyl-methacrylate indicates TNF is an essential mediator of particle induction of this osteoclast specific protein. To test the hypothesis that TNF mediates implant osteolysis, we established an in vivo murine model of this condition that histologically mirrors that of man. Verifying that TNF is essential to development of particle osteolysis, mice failing to express both the p55 and p75 TNF receptors are protected from the profound bone resorption attending polymemthyl-methacrylate particle implantation on calvariae of wild-type animals. Finally, the protective effect of deletion of both TNF receptors is recapitulated in mice lacking only the p55 receptor. Thus, targeting TNF and/or its p55 receptor may arrest wear particle osteolysis.

Animals↗