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PubMed1976

Secondary surgical treatment of the masculinized external genitalia of patients with virilizing adrenal hyperplasia.

Among 84 patients with virilizing adrenal hyperplasia operated on for deformed genitalia and followed for 7 to 22 years (mean 12 9/12 yr), 25 (30%) required secondary operations. For the most part, the secondary procedures were to provide a vaginal orifice adequate for coitus. The difficulties were due either to failure to adequately exteriorize the orifice at the first operation or to contraction of the outlet due to scar formation. Simple operative procedures to correct these difficulties are described.

Adrenal Hyperplasia, Congenital↗
PubMed1998

Masculinizing sclerosing stromal cell tumor in pregnancy: report of a case and review of the literature.

PURPOSE: To report a case of sclerosing stromal cell tumor of the ovary in pregnancy and to review the literature of this rare ovarian tumor. METHODS: The patient's office record and hospital record were reviewed. Gross and microscopic pathology were reviewed by one gynecologic pathologist. A Medline literature search and literature review were performed. RESULTS: Over eighty cases of sclerosing stromal cell tumor of the ovary have been reported in the literature since the definition of this pathologic condition in 1973. Only five cases have been reported during pregnancy and only two of these resulted in maternal virilization. This report describes severe maternal virilization with birth of a non-virilized female infant. CONCLUSION: Sclerosing stromal cell tumor of the ovary can result in severe virilization via androgen production. Surgery with removal of the involved ovary is required for diagnosis and cure. Prognosis is excellent.

Adult↗
PubMed2002

The use of flexion and extension MR in the evaluation of cervical spine trauma: initial experience in 100 trauma patients compared with 100 normal subjects.

The purpose of this study was to determine the value of flexion and extension MR in traumatized cervical spines following rear low-impact acceleration-deceleration injury. The cervical spines of 100 consecutive uninjured normal asymptomatic adults and 100 adult accident victims following rear low-impact motor vehicle accidents were evaluated using rapid T2-weighted MRI. Subjects were matched for age but not gender. The age range was 18 to 53 years, with a mean of 35 years. Injured subjects were evaluated during the subacute period, at 12 to 14 weeks after injury, following clinically resolved muscle spasm. Imaging findings were compared between normal and injured subjects. The normal subjects showed a stepwise segmental motion pattern that started at C1-C2 and transmitted to the lower cervical segments. Loss of normal cervical lordosis (hypolordosis) was observed in 4% (4 of 100) patients. Normal range of motion (rounded to the nearest 5 masculine ) was quantified as 50 masculine flexion (range, 45-65 masculine; standard deviation, 6.5 masculine ) and 60 masculine extension (range, 50-70 masculine; standard deviation, 6.5 masculine ). Asymptomatic disk herniations were observed in 2% (2 of 100) patients. In the subacute post-traumatic subjects, there was a loss of the normal segmental motion pattern, with hypolordosis in 98% (98 of 100) patients. Range of motion (rounded to the nearest 5 masculine ) was restricted, quantified as 25 masculine flexion (range, 5-40 masculine; standard deviation, 15 masculine ) and 35 masculine extension (range, 20-50 masculine; standard deviation, 10 masculine ). Disk herniations were observed in 28% (28 of 100) patients. Biomechanical changes in the herniated disk were noted, with mildly increased spinal stenosis following flexion. The authors conclude that flexion and extension MR can be a valuable adjunct examination in the evaluation of patients in the clinical setting of subacute cervical spine trauma.

Journal Article↗
PubMed2006

Determination of the androgenic potency of whole effluents using mosquitofish and trout bioassays.

This study combined bioassay-derived and direct chemical analysis of steroidal compounds in pulp and paper and municipal sewage effluent in order to determine the cause of masculinization of female mosquitofish. The bioassays used in this study consisted of androgen and estrogen receptor binding, and aromatase inhibition using tissues from rainbow trout. This study observed no masculinization of female mosquitofish from a pulp and paper mill effluent that was previously observed to cause this effect. Mosquitofish sampled from the receiving environment of the same mill verified that masculinization was not occurring in the wild. The municipal sewage effluent also had no masculinizing effect. In vitro bioassays indicated significant sources of both androgens and estrogens in the effluents tested with sewage effluent having both the highest estradiol (41 ng/L) and testosterone (182 ng/L) equivalent concentration. These results could not be attributed to any particular compounds measured in the effluents. Two compounds implicated in the masculinization of mosquitofish by pulp and paper effluent, androstenedione and androstadienedione required relatively large (10-100 microg/L) waterborne concentrations to elicit a masculinizing effect and neither of these compounds are likely to occur at levels this high in the natural environment. The potent aromatase inhibitor, 4-hydroxyandrostenedione also did not cause masculinization at 100 microg/L indicating that masculinization did not occur through this mechanism. The mammalian anti-androgen, cyproterone acetate was only partially effective in mosquitofish and reduced the severity of masculinization in the presence of methyl testosterone. While neither effluent masculinized mosquitofish, there was a significant reduction of in vitro ovarian steroid production with the most severe effects observed with the sewage effluent. Overall, this study found the disappearance of a masculinizing effect that had been previously observed; concluded that based on 21 days aqueous exposures androstenedione and androstadienedione are not likely candidates for mosquitofish masculinization, and showed that masculinization and in vitro steroid production are unrelated biological endpoints.

Androgens↗
PubMed1980

Gender typing of game choices and qualities of boys' play behavior.

Relationships between gender choices and both movement patterns and social behavior were studied in first- and second-grade boys. Three-child, structured play groups were each composed of a boy whose mother saw him as high masculine in play preference on the Games Inventory, one seen as average, and one low masculine. Behaviors rated from videotapes included gender presentation variables, (e.g., leg separation), indicators of dominance and personal comfort (e.g., range of movements), and indicators of social skill and peer response (e.g., interaction initiations). The low masculine boys were found to be the most feminine in their gender presentation, least dominant and aggressive, and the lest socially successful of the boys. The greatest difference was between the low and the high masculine boys. The average masculine boys' scores were generally intermediate, but more similar to the low masculine boys on some variables and more similar to the high masculine boys on others. These conclusions apply to a grou interaction play task, but not to an initial noninteractive play task. A secondary study in which girls played with low and average masculine boys is also reported. Here it was found that low masculine boys were generally intermediate between average boys and girls on gender presentation and dominance variables, but lowest of the groups on social interaction variables.

Child Behavior↗
PubMed2003

Second to fourth digit ratio, testosterone and perceived male dominance.

Previous studies have shown that male faces with extreme features associated with testosterone are perceived as dominant and masculine. Women have been reported to prefer more masculinized male faces as they may consider testosterone markers to be an 'honest' indication of good health, and such considerations may underlie their aesthetic preferences. However, pronounced testosterone facial markers are also associated with dominance, and several negative personality traits. This suggests that female aesthetic preferences may be an adaptive compromise between positive attributes associated with higher than average testosterone, and negative attributes associated with more extreme masculinization. This current study attempts to clarify the role of hormone markers in female perceptions of dominance, masculinity and attractiveness, in male facial images. Recent evidence suggests that the relative length of the 2nd to 4th finger (2D : 4D ratio) is a pointer to prenatal testosterone levels and may thus serve as a window to the prenatal hormonal environment. We measured 2D : 4D in a sample of male college students and took salivary samples to analyse circulating levels of testosterone. Women rated facial images of these males for dominance, masculinity and attractiveness. Our results show that male 2D : 4D was significantly negatively related to perceived dominance and masculinity but not attractiveness. Circulating testosterone levels were not related to dominance, masculinity or attractiveness. These findings suggest that: (i) high prenatal levels of testosterone serve to 'organize' male facial features to subsequently reflect dominance and masculine characteristics presumably activated during puberty; and (ii) attractiveness is not directly related to testosterone levels. We conclude that facial dominance and masculinity reflect a male's perceived status rather than his physical attraction to women.

Adolescent↗
PubMed2002

Preferred partner characteristics in homosexual men in relation to speculated patterns of brain differentiation.

OBJECTIVES: The current study was designed to test a neurohormonally based theory of sexual orientation and preferred partner characteristics in homosexual men. The theory holds that the brains of homosexual men are masculinized and feminized directing attraction to targets younger and more masculine than self, and the brains of homosexual adolescents are incompletely masculinized and feminized directing attraction to targets older and more masculine than self. METHODS: Ninety-six homosexual men completed questionnaires that asked them to rate morphological and behavioral characteristics associated with ethologically relevant indicators of masculinity. The participants made ratings for themselves as adolescents and adults, their current partners and idealized partners as adults, and their idealized partners as adolescents. RESULTS: Results of within-subjects multivariate analyses of variance supported most of the hypotheses. Participants as adults rated their idealized partners as more masculine than themselves and their real partners on five measures: height, weight, muscle development, facial hair, and sexuality. As adolescents they indicated a preference for males older and more masculine than self. The participants in adulthood did not show the predicted preference for partners younger than themselves. CONCLUSION: The increased ratings of sexuality for self from adolescence to adulthood support the contention that some additional masculinization of the brain may occur with aging. The increased ratings of body size for the idealized target from adolescence to adulthood keeps the target more masculine then self across developmental periods. This phenomenon is consistent with the speculated feminization of the brain at both periods and its effects on partner preferences.

Adult↗
PubMed1992

Timing and duration of dihydrotestosterone treatment affect the development of motoneuron number and morphology in a sexually dimorphic rat spinal nucleus.

The spinal nucleus of the bulbocavernosus (SNB) is a sexually dimorphic motor nucleus in the rat lumbar spinal cord. SNB motoneurons and their perineal target muscles are present in adult males, but reduced or absent in adult females. This dimorphism is due to the presence of androgens during development. Perinatal treatment of females with testosterone (T), or a combination of dihydrotestosterone (DHT) and estrogen (E+D females) from embryonic (E) day 16 through postnatal (P) day 5, results in a masculine number of SNB motoneurons and the retention of the target muscles. Perinatal treatment with estrogen alone does not masculinize the SNB; prenatal treatment with DHT alone from E17-E22 results in a feminine number of SNB motoneurons and a significantly altered motoneuron morphology and connectivity. To determine if masculinization of the SNB involves the interaction of estrogen and DHT or results from a longer exposure to DHT alone, the number, morphology, and connectivity of SNB motoneurons in females treated with DHT both pre- and post-natally (from E16-P5) were examined. At E22, DHTP (E16-P5) females have SNB motoneuron numbers identical to E+D and normal females, but far fewer than normal males, thus indicating that T is essential for prenatal masculinization. After E22, SNB motoneuron number declines precipitously in normal females but remains stable in DHTP (E16-P5) females and E+D females, which do not differ from normal males at P10. These results demonstrate that DHT can completely masculinize SNB motoneuron number without any synergistic actions with estrogen, and suggest that the development of SNB motoneuron number is strictly an androgen-mediated event. In adulthood, horseradish peroxidase histochemistry reveals that the connectivity, dendritic length, and soma size of SNB motoneurons in DHTP (E16-P5) females are identical to those of normal males but differ significantly from those of DHTP (E17-E22) females. These data suggest that the altered connectivity in DHTP (E17-E22) females is not simply a hormone-specific effect, but the result of a truncated hormone exposure. Thus, DHT can fully masculinize SNB morphology and connectivity if given during the appropriate period of development. It is suggested that while T may be required to masculinize the SNB prenatally, DHT may be involved in masculinizing postnatal aspects of SNB development.

Animals↗
PubMed1998

Sexual differentiation of the vertebrate brain: principles and mechanisms.

A wide variety of sexual dimorphisms, structural differences between the sexes, have been described in the brains of many vertebrate species, including humans. In animal models of neural sexual dimorphism, gonadal steroid hormones, specifically androgens, play a crucial role in engendering these differences by masculinizing the nervous system of males. Usually, the androgen must act early in life, often during the fetal period to masculinize the nervous system and behavior. However, there are a few examples of androgen, in adulthood, masculinizing both the structure of the nervous system and behavior. In the modal pattern, androgens are required both during development and adulthood to fully masculinize brain structure and behavior. In rodent models of neural sexual dimorphism, it is often the aromatized metabolites of androgen, i.e., estrogens, which interact with estrogen receptors to masculinize the brain, but there is little evidence that aromatized metabolites of androgen play this role in primates, including humans. There are other animal models where androgens themselves masculinize the nervous system through interaction with androgen receptors. In the course of masculinizing the nervous system, steroids can affect a wide variety of cellular mechanisms, including neurogenesis, cell death, cell migration, synapse formation, synapse elimination, and cell differentiation. In animal models, there are no known examples where only a single neural center displays sexual dimorphism. Rather, each case of sexual dimorphism seems to be part of a distributed network of sexually dimorphic neuronal populations which normally interact with each other. Finally, there is ample evidence of sexual dimorphism in the human brain, as sex differences in behavior would require, but there has not yet been any definitive proof that steroids acting early in development directly masculinize the human brain.

Animals↗
PubMed2005

Hormonal influences on sexually differentiated behavior in nonhuman primates.

Sexually dimorphic behavior in nonhuman primates results from behavioral predispositions organized by prenatal androgens. The rhesus monkey has been the primary primate model for understanding the hormonal organization of sexually dimorphic behavior. Historically, female fetuses have received high prenatal androgen doses to investigate the masculinizing and defeminizing effects of androgens. Such treatments masculinized juvenile and adult copulatory behavior and defeminized female-typical sexual initiation to adult estrogen treatment. Testosterone and the nonaromatizable androgen, 5alpha-dihydrotestosterone, produced similar effects suggesting that estrogenic metabolites of androgens are not critical for masculinization and defeminization in rhesus monkeys. Long duration androgen treatments masculinized both behavior and genitalia suggesting that socializing responses to the females' male-like appearance may have produced the behavioral changes. Treatments limited to 35 days early or late in gestation differentially affected behavioral and genital masculinization demonstrating direct organizing actions of prenatal androgens. Recent studies exposed fetal females to smaller doses of androgens and interfered with endogenous androgens using the anti-androgen flutamide. Low dose androgen treatment only significantly masculinized infant vocalizations and produced no behavioral defeminization. Females receiving late gestation flutamide showed masculinized infant vocalizations and defeminized interest in infants. Both late androgen and flutamide treatment hypermasculinized some male juvenile behaviors. Early flutamide treatment blocked full male genital masculinization, but did not alter their juvenile or adult behavior. The role of neuroendocrine feedback mechanisms in the flutamide effects is discussed. Sexually differentiated behavior ultimately reflects both hormonally organized behavioral predispositions and the social experience that converts these predispositions into behavior.

Androgen Antagonists↗
PubMed1978

An exploration of antecedents and attributes of androgynous and undifferentiated sex roles.

This study sought to clarify the nature of androgynous (both masculine and feminine) and undifferentiated (neither masculine nor feminine) sex-role outcomes. One inquiry concerned the parent identification patterms most likely associated with androgyny and undifferentiation. ANother inquiry considered differences between the masculinity or femininity of androgynous adolescents and these sex-role behaviors as represented in masculine and feminine adolescents, respectively. Similarly, the sex-role differences for masculine, feminine, and undifferentiated adolescents were investigated. The white, middle-class Ss included 142 male and 193 female college students (average age under 19 years). Parent and S sex-role scores, as well as identification scores, were based upon adjective check list self-descriptions and parent descriptions obtained from the S's. Androgynous males most frequently identified with a nonstereotypic mother combining masculine and feminine qualities, whereas undifferentiated males more often identified with a stereotypically feminine mother (p less than .01). No differences in female identification emerged. Both sexes of androgynous Ss revealed masculine attributes similar to those of masculine Ss but lacked many of the femine qualities of feminine Ss. A blending of sex-role dispositions in androgyny was inferred.

Adolescent↗
PubMed2000

Binocular summation in the fovea and peripheral field of anisometropic amblyopes.

PURPOSE: Binocular performance in the central and peripheral visual fields was compared for normal and anisometropic amblyopes. METHODS: Binocular and monocular thresholds to a light detection task were measured along the four principal meridia in 10 young normal subjects and 10 anisometropic amblyopes using the Humphrey's Visual Field Analyser. Thresholds were obtained at the fovea and at retinal eccentricities of 5 masculine, 10 masculine, 15 masculine, 25 masculine, 40 masculine and 55 masculine on the horizontal, vertical and oblique meridia of 45 masculine and 135 masculine. RESULTS: Binocular summation ratios (binocular sensitivity/ 'best' monocular sensitivity) were calculated for all the eccentricities. In the normal group, the mean binocular summation ratio for the fovea and the peripheral field was not significantly different. In the amblyopic group, subjects showed no or minimal binocular summation in the foveal region but reached normal ratios in the periphery. DISCUSSION: Results are discussed in terms of tolerance to interocular sensitivity differences in the periphery and selective losses in cortical cells.

Adolescent↗
PubMed1997

Experimental analysis of sexual differentiation of the zebra finch brain.

Classical theories of sexual differentiation of brain and behavior hold that sex differences in the brain arise because of the action of gonadal steroid hormones. In mammals, testosterone secretion by the testes stimulates a masculine pattern of neural differentiation, whereas feminine patterns of development occur in the absence of testicular secretions. In some bird species, estrogen secreted by the ovary is thought to trigger feminine patterns of neural development, whereas masculine development occurs in the absence of ovaries. Sexual differentiation of the neural circuit for song in zebra finches is not easily explained by these theories. Although female zebra finches can be masculinized by treatments with estrogen, it has proven difficult to prevent masculine neural development in genetic males by treating them with inhibitors of estrogen synthesis. Moreover, when genetic female embryos are treated with inhibitors of estrogen synthesis, they develop significant amounts of testicular tissue that causes little or no masculinization of the song system. Thus, testicular secretions alone appear to be insufficient to cause masculine neural differentiation, and other factors need to be invoked. These factors may include ovarian secretions that inhibit masculine development, or direct genetic (nonhormonal) effects on neural differentiation.

Animals↗
PubMed2001

Marginalization among the marginalized: gay men's anti-effeminacy attitudes.

Contemporary research has shown that a significant portion of gay men have traits, interests, occupations, and behaviors that are consistent with the stereotype of gay men as effeminate, androgynous, or unmasculine. A great number of gay men exhibit gender nonconformity during childhood; most, however, "defeminize" during adolescence, possibly in response to stigmatization and society's gender-role prescription. Only a relatively small percentage of gay men continue to be gender-nonconforming in their adulthood, often at a price, as they also tend to have lower psychological well-being. Although gay culture historically appreciated camp and drag, which subvert the gender-based power hierarchy and celebrate gender nonconformity, anti-effeminacy prejudice is widespread among gay men. Ironically, gender-nonconforming gay men may suffer from discrimination not only from society at large, but from other gay men, who are most likely to have experienced stigmatization and may have been effeminate earlier in their lives. Drawing from anecdotes and findings from various sources, this article suggests that beyond many gay men's erotic preference for masculinity lies contempt and hostility toward effeminacy and effeminate men on sociopolitical and personal levels. Two correlates of gay men's anti-effeminacy attitudes are proposed: (a) hegemonic masculinity ideology, or the degree to which one subscribes to the value system in which masculinity is an asset, and men and masculinity are considered superior to women and femininity; and (b) masculinity consciousness, or the saliency of masculinity in one's self-monitoring, public self-consciousness, and self-concept. These two variables are hypothesized to interact with gay men's self-perceived masculinity-femininity and their history of defeminization in predicting attitudes toward effeminacy. Research is underway to measure levels of anti-effeminacy attitudes and explore hypothesized correlates.

Gender Identity↗
PubMed2003

A connectionist account of Spanish determiner production.

Evidence from experimental studies of Spanish children's production of determiners reveals that they pay more attention to phonological cues present in nouns than to natural semantics when assigning gender to determiners (Pérez-Pereira, 1991). This experimental work also demonstrated that Spanish children are more likely to produce the correct determiner when given a noun with phonological cues which suggest it is masculine, and more likely to assign masculine gender to nouns with ambiguous cues. In this paper, we investigate the phonological cues available to children and seek to explore the possibility that differential frequency in the linguistic input explains the priority given to masculine forms when children are faced with ambiguous novel items. A connectionist model of determiner production was incrementally trained on a lexicon of determiner-noun phrases taken from parental speech in a longitudinal study of a child between the ages of 1;7 and 2;11 (López Ornat, Fernandez, Gallo & Mariscal, 1994) preserving the type and token frequency information. An analysis of the database of parental productions revealed that while regular feminine nouns were slightly more frequent than regular masculine nouns, irregular masculine nouns outnumbered irregular feminine nouns by roughly 2 to 1. On the basis of this, we made the prediction that as the training lexicon builds up, the network will perform better overall on masculine determiners than would be predicted from their forms alone and will tend to assign masculine gender to ambiguous novel nouns in a test set. The findings indicate that, at least in the case of Spanish gender agreement for determiners and nouns, a general associative learning mechanism can account for important characteristics of the acquisition process seen in children.

Child↗