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PubMed1998

[The use of biological monitoring in the assessment of occupational exposure to styrene in fiberglass-reinforced plastics industry].

A field study was carried out in order to investigate the effect of occupational exposure to styrene on the urinary excretion of mandelic and phenylglyoxylic acids (MA and PGA). Over a period of three years, 210 periodical, prophylactic examinations were performed on 66 fiberglass-reinforced plastics workers. The examinations embraced environmental and biological monitoring, which involved the measurement of styrene concentration in the air and the excretion rate of urinary MA and PGA. An eight-hour time-weighed average (MAC) exposure values ranged from 16.1 to 246 mg/m3 (mean: 76.1 mg/m3). The average urinary excretion rates of MA and PGA were 17.7 (1-202) and 28.8 (2-267) mg/h, respectively. The measurements of MA excretion rate were compared with the measurements of styrene concentration in the air. It seems advisable to investigate whether the recommended biological limits value of 16 mg/h for mandelic acid is not too high in view of the binding OEL value of 50 mg/m3 for styrene.

Adult↗
PubMed1965

INDUCTION AND MULTI-SENSITIVE END-PRODUCT REPRESSION IN THE ENZYMIC PATHWAY DEGRADING MANDELATE IN PSEUDOMONAS FLUORESCENS.

1. The first five enzymes involved in the degradation of mandelate in Pseudomonas fluorescens have been examined. 2. Induction is not significantly affected by glucose. 3. The first three enzymes form a group inducible by mandelate and repressible by benzoate, catechol and succinate. 4. The possibility that benzoate and catechol act as repressors only after they have been degraded to succinate is unlikely since mutants blocked at suitable points in the pathway have the same repression pattern as the wild type. 5. It is concluded that synthesis of the enzymes is subject to a multi-sensitive repression mechanism that can be independently activated by benzoate or catechol or succinate. 6. In each case the repression can be largely overcome by increasing the concentration of the inducer. 7. The enzymes of the first group are thus controlled by a dual system in which induction by the first substrate is opposed by repression exerted by the end product of the first group and by the products of succeeding groups.

Benzoates↗