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At least 955 records · Page 53Linked to original sources
PubMed2000

Vestibular and visual contribution to fish behavior under microgravity.

Vestibular and visual information are two major factors fish use for controlling their posture under 1 G conditions. Parabolic flight experiments were carried out to observe the fish behavior under microgravity for several different strains of Medaka fish (Oryzias latipes). There existed a clear strain-difference in the behavioral response of the fish under microgravity: Some strains looped, while other strains did not loop at all. However, even the latter strains looped under microgravity conditions when kept in complete darkness, suggesting the contribution of visual information to the posture control under microgravity. In the laboratory, eyesight (visual acuity) was checked for each strain, using a rotating striped-drum apparatus. The results also showed a strain-difference, which gave a clue to the different degree of adaptability to microgravity among different strains. Beside loopings, some fish exhibited rolling movement around their body axis. Tracing each fish during and between parabolas, it was shown that to which side each fish rolls was determined specifically to each individual fish, and not to each strain. Thus, rolling direction is not genetically determined. This may support the otolith asymmetry hypothesis. Fish of a mutant strain (ha strain, having homozygous recessive of one gene ha) have some malfunction in otolith-vestibular system, and their behavior showed they are not dependent on gravity. Morphological abnormalities of their ear vesicles during the embryonic and baby stages were noted. Their eyesight and dorsal light responses were also studied. Progress in the project of establishing a new strain which has good eyesight and, at the same time, being deficient in otolith-vestibular system was reported. Crosses between the strain of good eyesight and ha strain were made, and to some extent, F2 fish have already shown such characteristics suited for living under microgravity conditions.

Animals↗
PubMed1999

Sediment deposition rates on the continental margins of the eastern Arabian Sea using 210Pb, 137Cs and 14C.

Eight gravity cores from the active eastern continental margins of the Arabian Sea were dated using 210Pbxs, 137Cs and 14C. The short-term (< or = 100 years) sedimentation rates range from 0.06 to 0.66 cm/year where as the long-term (> or = 1000 years) ones using AMS 14C on planktonic foraminifera varied from 0.004 to 0.13 cm/year. For long-term chronology (< or = 50,000 years) AMS dating of well-cleaned planktonic foraminifera is most suited.

Animals↗
PubMed1974

Continuous distributions of ventilation-perfusion ratios in normal subjects breathing air and 100 per cent O2.

A new method has been developed for measuring virtually continuous distributions of ventilation-perfusion ratios (V(A)/Q) based on the steadystate elimination of six gases of different solubilities. The method is applied here to 12 normal subjects, aged 21-60. In nine, the distributions were compared breathing air and 100% oxygen, while in the remaining three, effects of changes in posture were examined. In four young semirecumbent subjects (ages 21-24) the distributions of blood flow and ventilation with respect to V(A)/Q were virtually log-normal with little dispersion (mean log standard deviations 0.43 and 0.35, respectively). The 95.5% range of both blood flow and ventilation was from V(A)/Q ratios of 0.3-2.1, and there was no intrapulmonary shunt (V(A)/Q of 0). On breathing oxygen, a shunt developed in three of these subjects, the mean value being 0.5% of the cardiac output. The five older subjects (ages 39-60) had broader distributions (mean log standard deviations, 0.76 and 0.44) containing areas with V(A)/Q ratios in the range 0.01-0.1 in three subjects. As for the young subjects, there was no shunt breathing air, but all five developed a shunt breathing oxygen (mean value 3.2%), and in one the value was 10.7%. Postural changes were generally those expected from the known effects of gravity, with more ventilation to high V(A)/Q areas when the subjects were erect than supine. Measurements of the shunt while breathing oxygen, the Bohr CO(2) dead space, and the alveolar-arterial oxygen difference were all consistent with the observed distributions. Since the method involves only a short infusion of dissolved inert gases, sampling of arterial blood and expired gas, and measurement of cardiac output and minute ventilation, we conclude that it is well suited to the investigation of pulmonary gas exchange in man.

Acetone↗
PubMed1992

Congenital hip dislocation: the importance of early detection and comprehensive treatment.

Hip dislocation is the musculoskeletal condition most commonly missed during neonatal examinations. Failure to diagnose the condition can lead to long-term disability and is a common target in pediatric legal suits concerning damage to the musculoskeletal system. Early neonatal assessment for hip dislocation includes an examination using the Barlow and Ortolani tests. Later examinations include assessment of gluteal folds, knee height and the degree of hip abduction. The preferred treatment is use of the Pavlik harness, an outpatient treatment regime that provides effective reduction in 90 percent of the cases. The harness uses flexion and free abduction to direct the femoral head into the acetabulum; it uses time, gravity and motion to position the hip in a reduced position. The harness requires three to six months of continuous wear for the hip to become radiographically stable. Health care providers are instrumental in diagnosing congenital hip dislocation and teaching families how to promote the infant's physical and psychosocial well-being. If this condition is not detected until after the infant is 6 weeks old, or the harness is ineffective after three weeks, skin traction, closed reduction and spica-cast application may be needed. Open reduction and recasting are also options. In rare cases, total hip replacement is necessary in later life.

Caregivers↗
PubMed2003

The simultaneous in vivo perilymphatic perfusion of avian auditory and vestibular end organs.

Perilymphatic perfusion is a method that allows the control of fluid parameters throughout the perilymphatic space of the inner ear. We have evaluated a new method for continuous perilymphatic perfusion of the auditory and vestibular end organs with artificial perilymph (APL) in chickens. Perfusate temperature (39.0 degrees C), pH (7.4), osmolarity (328 +/- 2 mosm), and flow rate (2 microl/min) were carefully controlled. Independent functional tests of vestibular and auditory sensory systems were made throughout perfusion periods by recording peripheral compound action potentials (CAPs). The recordings provided a means of monitoring the status of hair cell transduction, synaptic transmission and collective primary afferent activation in response to auditory or vestibular gravity receptor stimuli. Auditory and vestibular responses were stable during perfusion. No significant changes occurred in vestibular or auditory CAP amplitudes during long-term perfusion (50-80 min, n=7) and responses remained stable in one animal perfused for over 3 h. To our knowledge, there have been no reports evaluating vestibular function under these conditions. This technique enables us to systematically study receptor pharmacology in the peripheral vestibular and auditory systems virtually simultaneously in vivo. The model is well suited for use in the study of the pharmacology and toxicology of inner ear sensory systems.

6-Cyano-7-nitroquinoxaline-2,3-dione↗
PubMedDate not supplied

[Fetal lesions due to the bistoury during cesarean section: a study of 58 cases. The 5-year case records of 3117 cesarean sections at the Institutes of Clinical Obstetrics and Gynecology of the University of Rome La Sapienza].

In the present article the authors have carried out a statistical investigation on data relative to the caesarean sections performed in the Departments of Obstetrics and Gynaecology of the University of Rome "La Sapienza" since 1986 to 1990. Particular object of this study is to evaluate data regarding fetal bistoury lesions incidentally caused while performing the incision of the uterine wall during a caesarean section. To our knowledge, this topic has never been taken into account by the world's literature, nevertheless it is important also for its legal and insurance implications. Throughout the mentioned period 13787 deliveries occurred, 3117 of which were caesarean sections: this is equal to a frequency of 22.6%, with an increase rate of 37.5% during the whole 5 years time. 58 cases of fetal bistoury lesions have been found to occur since 1986 to 1990: this equal to 1.8% of all the performed caesarean sections. Even if their gravity was usually scarce, and only 7 cases needed a specific treatment, 25.8% of these lesions involved areas such as forehead, cheek bone, cheek, mostly related to possible aesthetic damages with their connected legal consequences. In order to evaluate what factors can contribute to the occurrence of these lesions and taking account of the large number of factors that may be involved (such as conditions at which the operation is performed, skill and experience of the surgeon etc.), the authors focus their attention to those which, for their clinical significance and possibility of detection, suit more than others such a statistical investigation.(ABSTRACT TRUNCATED AT 250 WORDS)

Birth Injuries↗
PubMed1997

Space Station Biological Research Project.

To meet NASA's objective of using the unique aspects of the space environment to expand fundamental knowledge in the biological sciences, the Space Station Biological Research Project at Ames Research Center is developing, or providing oversight, for two major suites of hardware which will be installed on the International Space Station (ISS). The first, the Gravitational Biology Facility, consists of Habitats to support plants, rodents, cells, aquatic specimens, avian and reptilian eggs, and insects and the Habitat Holding Rack in which to house them at microgravity; the second, the Centrifuge Facility, consists of a 2.5 m diameter centrifuge that will provide acceleration levels between 0.01 g and 2.0 g and a Life Sciences Glovebox. These two facilities will support the conduct of experiments to: 1) investigate the effect of microgravity on living systems; 2) what level of gravity is required to maintain normal form and function, and 3) study the use of artificial gravity as a countermeasure to the deleterious effects of microgravity observed in the crew. Upon completion, the ISS will have three complementary laboratory modules provided by NASA, the European Space Agency and the Japanese space agency, NASDA. Use of all facilities in each of the modules will be available to investigators from participating space agencies. With the advent of the ISS, space-based gravitational biology research will transition from 10-16 day short-duration Space Shuttle flights to 90-day-or-longer ISS increments.

Aerospace Medicine↗
PubMed1996

A simple, differential extraction method for the simultaneous direct radioimmunoassay of androgens and androgen glucuronides in human serum.

A method is described for the differential extraction of unconjugated androgens (testosterone and dihydrotestosterone) and glucuronidated androgens (androstane-3 alpha,17 beta-diol glucuronide and androsterone glucuronide) from human serum using solid-phase, gravity-flow extraction columns. In this method, 100-microL aliquots of serum are loaded onto the normal-phase columns, unconjugated androgens are eluted with ethyl ether, and glucuronides are eluted with ethyl ether containing 2% acetic acid. Glucuronide eluates are washed with 1% aqueous acetic acid to remove cross-reacting steroid sulfates. Assays of sera for the four steroids were performed using standard radioimmunoassay methodology, except for androsterone glucuronide. This steroid was assayed with a novel radioimmunoassay method that employees a tritiated, unconjugated androsterone tracer and an anti-dehydroepiandrosterone sulfate antiserum. The new method is well suited for the assay of conjugated and unconjugated steroids in large numbers of specimens, particularly where the sample volume is limited.

Adult↗
PubMedDate not supplied

A 6 D.O.F. opto-inertial tracker for virtual reality experiments in microgravity.

Gravity plays a role in many different levels of human motor behavior. It dictates the laws of motion of our body and limbs, as well as of the objects in the external world with which we wish to interact. The dynamic interaction of our body with the world is molded within gravity's constraints. The role played by gravity in the perception of visual stimuli and the elaboration of human movement is an active research theme in the field of Neurophysiology. Conditions of microgravity, coupled with techniques from the world of virtual reality, provide a unique opportunity to address these questions concerning the function of the human sensorimotor system. The ability to measure movements of the head and to update in real time the visual scene presented to the subject based on these measurements is a key element in producing a realistic virtual environment. A variety of head-tracking hardware exists on the market today, but none seem particularly well suited to the constraints of working with a space station environment. Nor can any of the existing commercial systems meet the more stringent requirements for physiological experimentation (high accuracy, high resolution, low jitter, low lag) in a wireless configuration. To this end, we have developed and tested a hybrid opto-inertial 6 degree-of-freedom tracker based on existing inertial technology. To confirm that the inertial components and algorithms will function properly, this system was tested in the microgravity conditions of parabolic flight. Here we present the design goals of this tracker, the system configuration and the results of 0g and 1g testing.

Acceleration↗
PubMed1996

Duration threshold of induced hypertension on cerebral blood flow, energy metabolism, and edema after transient forebrain ischemia in gerbils.

We have investigated whether there is a duration threshold for the effects of phenylephrine-induced hypertension on CBF, brain energy metabolism, and cerebral parenchymal specific gravity (SG) following transient forebrain ischemia in gerbils. Sixty gerbils were randomly assigned to one of the four treatment groups: one control group and three groups subjected to an increase of 25 mm Hg in MABP induced by treatment, 30 min after reperfusion, with phenylephrine for 15 min, 30 min, or 60 min. The local CBF was measured continuously, and the SG was evaluated 120 min after reperfusion. Sequential changes in brain energy metabolism, as shown by the ratio of phosphocreatine to inorganic phosphate (Pi), the beta-ATP/Pi ratio, and intracellular pH, were also measured. The 15-min induced hypertension regimen was most suited to the recovery of brain energy metabolism, which was associated with an increase in local CBF and a decrease in cerebral edema. These results demonstrate that a suitable duration can be chosen to optimize the beneficial effects of phenylephrine-induced hypertension on ischemic brain injury following transient forebrain ischemia.

Animals↗
PubMed2005

What is the role of muscle receptors in proprioception?

The role of muscle afferents is discussed in terms of their contribution to kinesthesia, the senses of position and movement of the limbs. It is argued that muscle spindles are not well suited as position sensors, on several grounds. Yet we know from muscle vibration experiments that they do contribute to kinesthesia. A number of recent experiments have shown that positional information is of particular significance to the central nervous system. In other experiments it has been demonstrated that a disturbance to kinesthesia follows fatigue from exercise. Fatigue of elbow flexor muscles led subjects to make significant positional errors in a forearm matching task. The size of the errors correlated with the fall in force from fatigue. These data suggest that we derive a positional cue from the effort required to hold a limb against the force of gravity. A challenge for the future will be to reveal how the centrally derived sense of effort and peripherally derived afferent information interact to give us our kinesthetic sense.

Animals↗
PubMed1998

A new technique for morphologic measurement of the femur. Its application for Japanese patients with osteoarthrosis of the hip.

The cementless femoral prostheses developed in Western countries have commonly been used for Japanese patients, but it has been noted that it is difficult to achieve a good fit between the cementless femoral prostheses and some femora. In Japan, there are many patients with secondary osteoarthrosis (OA) of the hip, but Western designed femoral prostheses seem to be mainly for use with primary OA of the hip. To design femoral prostheses better suited to Japanese patients, a new method to study the morphometry of the femur is required--one which can determine the particular features of the femur in Japanese patients. In this study, a new morphologic measurement technique of the femur is proposed and applied to a number of Japanese OA patients in order to demonstrate its efficacy. In this technique, a three-dimensional solid model based on the outer and inner borders of the femoral cortex is constructed from 3-D CT images and computer-aided design (CAD) software. The bone axis is defined as the line of best fit to the centers of gravity of the femur cross sections in each CT plane by using the least square method. A new femur coordinate system is considered based on this bone axis. The corrected outer borders of the cortex are reconstructed in sections perpendicular to the bone axis. The angle between the principal axis of inertia of the sections and a plane defined by the femur coordinate system is selected as providing a good measurement of the torsion value to characterize the femur morphology. The angles of principal axis were measured in 110 OA and 36 normal hips, and then compared with each other. A significant difference between the OA and normal group was observed especially in the proximal region above the section 6 mm below the level of the lesser trochanter. It is suggested that the anteversion of the femoral neck influences the torsion of the parts below the lesser trochanter. From the results, it is demonstrated that the proposed measurement technique is a reliable and efficient means of determining femur morphology.

Adult↗
PubMed1994

Human cardiovascular and vestibular responses in long minutes and low +Gz loading by short arm centrifuge.

1.4 G, 1.7 G, and 2.0 G of +Gz and 60 minutes centrifugation was adopted to 20 healthy male subjects using 1.8 m radius centrifuge equipped to Nihon University School of Medicine. G was applied from lower G, considering G training effect for the subjects. Effects on performance decline and side effects of such a short-arm centrifugation were especially observed in the experiments, because this size of centrifuge could be used in space station in future for a strong countermeasure of cardiovascular deconditioning, demineralization from bone, etc. G training effect was observed same as higher and rapid G acceleration in fighter pilot. Subjects suffered from many types of discomfort; such as sensation of heaviness of diaphragm, cold sweat, nausea, irritable feeling, arrhythmia, tachycardia, rapid decrease of blood pressure, which sometimes caused interruption of G load. As 2.0 G and 60 minutes centrifugation seemed very tough load to the subjects, there should be necessary some G suit or other countermeasure, if we apply a higher G and/or longer G duration. Performance decline due to the load commonly continued for 1 hour or so. Side effects were observed in relation to neuro-vestibular, cardio-vascular, and autonomic nervous system.

Adult↗
PubMed1988

Sympathetic innervation of the cardiovascular system in the giraffe.

The extreme blood pressure gradients in the giraffe, produced by gravity and behaviour, present a special challenge to blood flow and vascular capacity regulation, e.g. via sympathetic nerves. We report the distribution of nerves in vascular tissue from giraffe extremities and neck based on immunofluorescence against specific antisera to dopamine-beta-hydroxylase, neuropeptide Y, neurofilament, and synapsin I. Sympathetic innervation of gravitation-dependent arteries in the limbs was restricted to the adventitia-media border, while in carotid arteries fibers penetrated deep into the media. Surprisingly, limb veins appeared to be devoid of sympathetic innervation, while jugular veins had a sparse innervation. The morphological response, medial hypertrophy, that parallels the hydrostatic pressure gradients in the circulation combines with the thick skin and tight underlying fascia, the 'g-suit', and an exquisitely distributed sympathetic innervation pattern to provide an effective array of mechanisms for cardiovascular regulation in the adult giraffe.

Animals↗
PubMedDate not supplied

Iatrogenic vascular injuries. A review of 125 cases (excluding angiographic injuries).

From the files of an insurance company and from a number of our own files as expert medical witness to the court we have been able to collect 125 cases of malpractice suits following a iatrogenic vascular injury. An analytic study has revealed the following: --12 vascular injuries occurred after stripping of varicose veins of the lower extremities; --4 accidents occurred during arterial surgery; --35 lesions followed orthopedic surgery; and --2 general surgery. Besides these 53 injuries following surgical procedures, 72 injuries are described following non-surgical diagnostic or therapeutic procedures: --sclerotherapy of varicose veins or angiomas: 34 cases; --injection of anesthesic agents: 20 cases; --injections, infusions, catheterisms: 16 cases; and --endoscopic procedures: 2 cases. Vascular risk exists in almost all medico-surgical procedures and requires constant and careful attention since professional responsibility is easily involved. Early recognition and early correction of the vascular lesion reduce the incidence and the gravity of the complications.

Anesthetics↗
PubMed1995

[Senegal: installation of a microcomputer in the emergency admission service of the Ziguinchor Regional Hospital].

An Emergency Department was opened at the Regional Hospital of Ziguinchor in August 1993. Although adapted to local conditions, facilities are state-of-the-art and allow 24-hour reception of patients regardless of the gravity of their condition. There are many people involved: family, police, firemen, administration ... and there are also many questions. Records must be efficiently and accurately managed and the computer is the ideal tool for this purpose. The department was able to install a system at a particularly low cost since the PC computer and Epi-Info software were provided at no charge by the World Health Organization. To ensure consistent data entry, a coding system was used with some codes being specific to the department. Thanks to this system the department now has a 24 hour source of information for day-to-day management, statistical reporting, regional morbidity assessment, comparison of performance with similar facilities, and patient follow-up. Our experience shows that this type of low-cost computer system and simple processing techniques are perfectly suited to the special requirements of medical practice in Black Africa.

Abstracting and Indexing↗
PubMedDate not supplied

Tolerance of snakes to hypergravity.

Sensitivity of carotid blood flow to increased gravitational force acting in the head-to-tail direction(+Gz) was studied in diverse species of snakes hypothesized to show adaptive variation of response. Tolerance to increased gravity was measured red as the maximum graded acceleration force at which carotid blood flow ceased and was shown to vary according to gravitational adaptation of species defined by their ecology and behavior. Multiple regression analysis showed that gravitational habitat, but not body length, had a significant effect on Gz tolerance. At the extremes, carotid blood flow decreased in response to increasing G force and approached zero near +1 Gz in aquatic and ground-dwelling species, whereas in climbing species carotid flow was maintained at forces in excess of +2 Gz. Tolerant (arboreal) species were able to withstand hypergravic forces of +2 to +3 Gz for periods up to 1 h without cessation of carotid blood flow or loss of body movement and tongue flicking. Data suggest that the relatively tight skin characteristic of tolerant species provides a natural antigravity suit and is of prime importance in counteracting Gz stress on blood circulation.

Acceleration↗
PubMed2005

Characterization of very high gravity ethanol fermentation of corn mash. Effect of glucoamylase dosage, pre-saccharification and yeast strain.

Ethanol was produced from very high gravity mashes of dry milled corn (35% w/w total dry matter) under simultaneous saccharification and fermentation conditions. The effects of glucoamylase dosage, pre-saccharification and Saccharomyces cerevisiae strain on the growth characteristics such as the ethanol yield and volumetric and specific productivity were determined. It was shown that higher glucoamylase doses and/or pre-saccharification accelerated the simultaneous saccharification and fermentation process and increased the final ethanol concentration from 106 to 126 g/kg although the maximal specific growth rate was decreased. Ethanol production was not only growth related, as more than half of the total saccharides were consumed and more than half of the ethanol was produced during the stationary phase. Furthermore, a high stress tolerance of the applied yeast strain was found to be crucial for the outcome of the fermentation process, both with regard to residual saccharides and final ethanol concentration. The increased formation of cell mass when a well-suited strain was applied increased the final ethanol concentration, since a more complete fermentation was achieved.

Cell Culture Techniques↗