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PubMed1952

The half-life on homologous gamma globulin (antibody) in several species.

1. The half-lives of homologous gamma globulins labelled with I(131) agree well with the half-lives of passively administered homologous antibodies and provide a simple, quantitative tool for the determination of antibody half-life when immunochemical techniques are difficult to apply. 2. The half-lives of gamma globulin or antibody vary markedly from species to species and apparently even among age groups within a species. 3. The half-lives of gamma globulin or antibody seem to be dependent, at least in part, on the metabolic rate of the host.

Antibodies↗
PubMed1953

Gamma globulin; status of availability for prevention of poliomyelitis.

A limited and temporary preventive effect has been noted for gamma globulin used under certain conditions. There is available a supply of gamma globulin which is inadequate to meet the demand with the methods of use indicated in the light of present knowledge. All supplies of gamma globulin have been placed under the responsibility of the Office of Defense Mobilization. Supplies allocated to the state of California are being made available to physicians through their local health departments on the basis of past and current incidence of poliomyelitis for use in protecting persons in household contact with patients with diagnosed cases. The most effective use of California's allocation of this material can be expected to prevent or modify approximately 40 cases on the basis of the past five-year experience (1947-1951). Parents, physicians and health officials must know the facts and cooperate to make the best of a difficult situation.

Biomedical Research↗
PubMed1987

Refractory aplastic anemia: concomitant therapy with antithymocyte globulin and high-dose corticosteroids.

Bone marrow transplantation is possible for only a minority of patients with severe aplastic anemia. There has been successful treatment in some patients with immunosuppressive agents: high-dose 6-methylprednisolone, antilymphocyte globulin, and antithymocyte globulin. We report the successful treatment of two patients with severe aplastic anemia with the simultaneous administration of antithymocyte globulin and high-dose 6-methylprednisolone after failure with antithymocyte globulin and low-dose corticosteroids.

Adolescent↗
PubMed1991

Impaired binding properties of thyroxine-binding globulin in hepatocellular carcinoma and chronic liver disease.

To determine the factors underlying the apparent reduction in binding ability of thyroxine-binding globulin in hepatocellular carcinoma, hormone-binding characteristics were further examined in patients with this disease and in control subjects. No differences in affinity constants with respect to triodothyronine or serum thyroxine-binding globulin from hepatocellular carcinoma, cirrhotic and normal subjects were found. The affinity for thyroxine was significantly reduced in hepatocellular carcinoma (0.41 +/- 0.13 x 10(10) mol-1) and cirrhotic (0.65 +/- 0.1 x 10(10) mol-1) patients compared with normal subjects (0.94 +/- 0.7 x 10(10) mol-1). Investigations carried out on liver tissue obtained from patients with hepatocellular carcinoma and chronic liver disease showed that thyroxine-binding globulin within tumor tissue was elevated and bound less exogenous tracer hormone compared with that obtained from nontumor tissue. Tumor-derived thyroxine-binding globulin with altered binding properties is, at least partly, responsible for the abnormal behavior of the serum protein in patients with hepatocellular carcinoma.

Adult↗
PubMed1983

Serial analysis of circulating immune complexes, complement, and antithymocyte globulin antibodies in heart transplant recipients.

Thirteen heart transplant patients receiving heterologous antithymocyte globulin were examined serially for the presence of circulating immune complexes, activation of complement, and antibodies to antithymocyte globulin. Using three independent assays, all patients were found to develop immune complexes at some time following transplantation, mostly as a consequence of antithymocyte globulin administration and infection. Simultaneous analysis of endogenous complement levels revealed C3 and C4 hypocomplementaemia in 28 and 44% of the samples, respectively. However, no correlation was evident between immune complex or complement levels and cardiac rejection assessed histologically in 64 endomyocardial biopsies. Serial analysis of antibodies to equine and rabbit antithymocyte globulin by solid-phase radioimmunoassay showed that 8 of 10 patients had significantly elevated values. Evidence was also obtained which indicated a substantial degree of cross-reactivity between the antibodies to these heterologous proteins. The results demonstrate a complex interplay of immune reactants relating to transplantation, infection, and immunosuppression therapy.

Adult↗
PubMed1995

Inflammatory neuropathies--pathogenesis and the role of intravenous immune globulin.

The inflammatory neuropathies may be subdivided into an acute form, Guillain-Barré syndrome, and a chronic form referred to as chronic inflammatory demyelinating polyneuropathy. More recently a chronic, asymmetrical pure motor neuropathy with multifocal conduction blocks has been described. All three neuropathies are considered to be immune-mediated. Their response to therapy is discussed, with special emphasis on high-dose intravenous immune globulin. For Guillain-Barré syndrome the efficacy of intravenous immune globulin has been proven in a randomized clinical trial. In chronic inflammatory demyelinating polyneuropathy a response rate of over 60% in newly diagnosed patients is suggested. Clinical prognostic criteria, however, seem to be very important to predict the effect of intravenous immune globulin. In multifocal motor neuropathy intravenous immune globulin is at present the only alternative to cyclophosphamide.

Campylobacter jejuni↗
PubMed1984

Adverse reactions in selected patients following intravenous infusions of gamma globulin.

Fifteen patients with hypogammaglobulinemia or agammaglobulinemia were treated with intravenous gamma globulin preparation over a 17-month period. The patients were selected for treatment if they had chronic antibody deficiency syndromes associated with increased susceptibility to infections. Levels of circulating immune complexes, C1q, C3, and C3d were determined in serum samples obtained before treatment and immediately following treatment with the gamma globulin. In every patient studied, circulating immune complexes were detectable in the postinfusion samples. Two patients had adverse reactions to the intravenous gamma globulin therapy. Analysis of the serum samples of both of these patients showed that one patient had an autoantibody to IgA and the other had an autoantibody to beta-lipoprotein. Both IgA and beta-lipoprotein were present in the intravenous gamma globulin preparations. Therefore, reaction with each of the autoantibodies by the antigens activated the complement system in vivo with production of split products of C3.

Adult↗
PubMed1984

Use of intravenous immune globulin in pregnant women with common variable hypogammaglobulinemia.

Two patients with common variable hypogammaglobulinemia were treated with immune serum globulin during pregnancy. An intravenous immune serum globulin preparation was used in the last trimester of pregnancy. Both patients tolerated this preparation well and had an uneventful pregnancy. The two term newborns were healthy and had cord blood IgG levels likely to be the result of transplacental transfer of the intravenous immune serum globulin preparation. During pregnancy there is an increase in the IgG distribution space due to plasma volume expansion. Therefore, pregnancy is an indication for these immune serum globulin preparations that can be administered at high doses intravenously in order to confer adequate protection to the mother and the newborn.

Adolescent↗
PubMed1995

Antithymocyte globulin and methotrexate therapy of severe or persistent cardiac allograft rejection.

BACKGROUND: The treatment of severe or persistent acute rejection remains difficult despite newer immunosuppressive agents available. METHODS: To evaluate the effectiveness of rabbit antithymocyte globulin and methotrexate as therapy for severe or persistent acute cardiac allograft rejection, we conducted a retrospective analysis of clinical and laboratory data from 150 consecutive heart transplant recipients between 1983 and 1994. RESULTS: Thirteen episodes of severe or refractory acute rejection were treated with rabbit antithymocyte globulin in 10 patients. Rabbit antithymocyte globulin (125 mg/day for 3 consecutive days) was effective in 90% of patients. Therapy was well tolerated, and contributed to one infectious complication, no malignancy, and long-term survival in 8 of 10 patients. Recurrent rejection developed in 60% of patients. Methotrexate (7.5 to 15 mg/wk for 16 weeks) was administered to 8 patients with persistent rejection documented on three consecutive endomyocardial biopsies. Therapy was effective in 6 of the 8 patients, with one infectious complication and no malignancy on follow-up. White blood cell count decreased significantly during therapy (p = 0.008). Seven of the 8 patients in the methotrexate group are long-term survivors. CONCLUSIONS: Rabbit antithymocyte globulin is a valuable alternative in patients with severe or refractory acute rejection. Methotrexate is an important adjunct in patients with persistent rejection unresponsive to conventional immunosuppressive regimens.

Adult↗
PubMed1983

The microheterogeneities of thyroxine-binding globulin and alpha 1 protease inhibitor (alpha 1-antitrypsin) are interrelated.

Addition of 125I-thyroxine to serum allows autoradiography for thyroxine-binding globulin microheterogeneity to be carried out after isoelectric focusing has been performed to display (by protein stain) the heterogeneous bands of the alpha 1-antitrypsin (PI) system. Comparison of the protein stain for PI with the autoradiograph for thyroxine-binding globulin indicates that these two systems are interrelated with the major bands of the PI system corresponding to the bands on the autoradiograph. This correspondence holds for PI variants other than the common M type and in particular it holds for the deficient Z type in which the autoradiograph for thyroxine-binding globulin is strikingly different from normal. We conclude that the major cause of microheterogeneity of TBG is due to an association with the PI system under the conditions of isoelectric focusing as normally performed. Precipitation experiments with antisera to PI and TBG suggest that the complex between these biologically important globulins may occur under conditions other than isoelectric focusing, but further work will be needed to examine this possibility.

Chemical Phenomena↗
PubMed1987

Evidence for endotoxin binding capacity of human Gc-globulin and transferrin.

In the present paper the ability of Gc-globulin and transferrin to bind endotoxin of Escherichia coli 0 111: B 4 is demonstrated. This conclusion is based on four lines of evidence. By affinity chromatography using lipopolysaccharide of E. coli 0 111: B 4 two endotoxin-binding proteins of serum were identified, showing an apparent molecular weight of 77,000 and 51,000, respectively. If serum samples preincubated with the tritiated endotoxin form have undergone isoelectric focusing under non-denaturing conditions one radioactive peak appears which coincides with the precipitate obtained by immunoelectrophoresis against anti-human Gc-globulin and anti-human transferrin. Radioimmunoprecipitation experiments of serum showed that tritiated endotoxin of E. coli 0 111: B 4 was only found in the precipitate obtained with anti-Gc-globulin, antitransferrin, and polyvalent antiserum against human serum. By isoelectric focusing of purified proteins 3H-lipopolysaccharide of E. coli 0 111: B 4 was only found associated with human Gc-globulin and transferrin.

Chromatography, Affinity↗
PubMed1985

Prevention of hepatitis B infection by hepatitis B immune globulin in infants born to mothers with acute hepatitis during pregnancy.

Eleven infants born to mothers with acute hepatitis B during the third trimester of pregnancy who were hepatitis B surface antigen-positive at delivery were treated with hepatitis B immune globulin within 24-48 h of birth. Five infants received one dose of hepatitis B immune globulin and 6 infants received a second dose at 1 mo of age. During the average 12.5-mo follow-up period, only 1 of 11 (9%) treated infants became hepatitis B surface antigen-positive and this individual developed acute hepatitis B at 9.5 mo of age and recovered. Twenty-four infants born to mothers with acute hepatitis B during the third trimester of pregnancy who were untreated served as historical controls. Of these, 17 (71%) showed evidence for hepatitis B infection and 15 (62.5%) became chronic hepatitis B virus carriers. This study shows that administration of hepatitis B immune globulin to infants born to mothers with acute hepatitis B is effective in preventing perinatal transmission of the hepatitis B virus. With the availability of the hepatitis B virus vaccine, the current recommendation is to give hepatitis B immune globulin to such infants within 24 h of birth, followed by three doses of the hepatitis B virus vaccine beginning soon after birth, and again 1 and 6 mo later.

Adult↗
PubMed1978

The advantage of a build-up anti-globulin technique for the detection of immunoglobulin on the red cells of rabbits infected with trypanosomes. A preliminary report.

A build-up anti-globulin technique has been used to detect immunoglobulin on the red cells of rabbits infected with Trypanosoma brucei brucei S 42 and 427. The method, which is useful for the detection of immunoglobulin on sparsely coated red cells, involves treating the red cells of infected rabbits with antiglobulin followed by alternate globulin and antiglobulin layers until a lattice is built up which allows agglutination to occur. The red cells of five infected rabbits have been tested with anti-rabbit IgG,-IgM and broad spectrum anti-globulin reagents at intervals after infection and following the administration of Berenil, a drug which destroys trypanosomes. The positive anti-globulin reactions which developed following inoculation with trypanosomes were much reduced after giving Berenil. The tests became more strongly positive again in two rabbits after reinfection.

Animals↗
PubMedDate not supplied

Is injection of contaminated animal bite wounds with rabies immune globulin a safe practice?

In Asia, it is still controversial whether it is safe to inject a contaminated animal bite wound with a foreign protein such as equine or human rabies immune globulin, even though this is recommended by the World Health Organization. A prospective study of 114 severe animal bite wounds which were injected with equine or human rabies immune globulin revealed an overall incidence of gross infection of 11.4%. No matched control group of patients bitten by animals whose wounds were not injected with immune globulin could be studied in this environment with a high prevalence of canine rabies. The incidence of wound infection in lacerations inflicted by sharp objects and sutured under local anaesthesia was therefore studied prospectively in 100 Thai patients from a similar socio-economic milieu; it was found to be 13%. Wound infection was more common in animal bites and lacerations of the lower extremities. It is concluded that injecting a properly cleansed bite wound with equine or human rabies immune globulin is a safe practice and should be performed whenever there is a possibility that the biting animal might have rabies.

Animals↗
PubMed1989

The uses of intravenous immune globulin in collagen vascular disorders.

Studies in our laboratory demonstrated that the long-term administration of intravenous immune serum globulin in patients with common variable hypogammaglobulinemia produced increased suppressor activity, which resulted in diminished in vitro B cell immunoglobulin synthesis. These studies suggested that intravenous immune globulin therapy might be a useful modality in altering immunoregulation in patients with collagen vascular autoimmune disease. In the present preliminary study, two groups of patients with collagen vascular disease were chosen: systemic lupus erythematosus and primary Sjögren's syndrome. Patients with systemic lupus erythematosus with mild clinical disease were chosen to minimize the risk of adverse effects on the disease process, particularly specific organ involvement (e.g., lupus nephritis). Each patient was used as his or her own clinical and laboratory control. Patients received 300 mg/kg of intravenous immune globulin every 4 weeks. As a whole the patient group did not experience any adverse effects from the intravenous immune globulin therapy. No clinical or laboratory changes were observed in one patient with systemic lupus erythematosus and one patient with Sjögren's syndrome. In the other patient with Sjögren's syndrome, there were subjective changes of improved well-being and increased energy levels without any objective changes in the sicca syndrome. There was a slight steroid-sparing effect (10 to 3 mg/day) but no effects on the sedimentation rate, the antinuclear antibody, or rheumatoid factor serologic studies. In a patient with steroid-dependent systemic lupus erythematosus, there was marked clinical improvement of the cutaneous vasculitis after the third infusion, with reduction in her oral steroid requirements from 25 to 7.5 mg/day.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Intravenous immune globulin use in newborns.

Newborn infants, and especially premature ones, are uniquely susceptible to severe and overwhelming bacterial infections. The reasons for this are not completely understood. A number of defects in the neonate's host defense system have been described, including deficiency of opsonic antibodies, abnormalities in the number and function of polymorphonuclear leukocytes, and depressed levels of the major complement components. Experimental animal studies in our laboratory have indicated that many of these defects can be overcome through the administration of intravenous immune globulin. Recently several investigators have attempted to treat or prevent bacterial infections in human neonates with intravenous immune globulin. We have found that doses as high as 750 mg/kg can be administered to premature infants without detectable side effects. This results in IgG levels comparable with those in term infants and adults. Limited studies in the literature suggest that intravenous immune globulin therapy may decrease morbidity and mortality from infection in premature human infants. Furthermore, prophylactic treatment of preterm infants may serve to prevent the development of infection in some instances. Optimal management of preterm and some term human infants may involve immunotherapy with intravenous immune globulin.

Animals↗
PubMed1996

What is an acceptable delay in rabies immune globulin administration when vaccine alone had been given previously?

Rabies immune globulins (RIG) are not always available. Rabies-exposed patients often present to medical centers, particularly in canine rabies infested regions, after a vaccine series has been started without immune globulin administration. It is known that rabies immune globulin can result in suppression of the neutralizing antibody response which usually yields detectable antibodies by day 7. We have shown that it can be administered with a delay of up to 5 days after the start of vaccine treatment without significant antibody suppression within the first month. This study utilized the WHO approved multisite Thai Red Cross intradermal postexposure regimen. Effective use of rabies immune globulin in severe and multiple wounds, particularly in small children, may require dilution of the RIG in normal saline to provide a volume adequate for infiltration of all wounds.

Antibodies, Viral↗
PubMed1984

[Influence of the factors altering the electrophoretic migration of the alpha 2 Gc globulin in the diagram of iso-electric focusing of the Gc type].

In the present study, it is shown that the pattern of the isoelectric focusing with immunofixation changes markedly in the presence of substances such as platelet extract, trypsin, chymotrypsin, vitamin D3 and neuraminidase. It has been recently found that the factor of platelet extract is actin (K. Shinomiya et al., Jpn. J. Legal Med., 36 (1982) 542-549; J. Biochem., 92 (1982) 1163-1171), and Gc globulin is bound by actin (H. Van Baelen et al., J. Biol. Chem., 255 (1980) 2270-2272). The Gc-actin complex appeared as supplementary bands of Gc-globulin near by the anode band of Gc1F-1F or Gc1S-1S. As to the Gc2-2, the supplementary band of Gc-actin complex appeared on the cathode side of the original anode band of Gc1F-1F or Gc1S-1S. Concerning Gc1F-1F (or Gc1S-1S), two supplementary bands of Gc-actin complex appeared on the anode side of the original band. Each product originated from the digestion of Gc-globulins of common phenotypes by trypsin appeared as four characteristic bands on the anode side of the original band. On the other hand, each product obtained by treatment of Gc-globulins of common phenotypes with chymotrypsin appeared as two characteristic bands on the anode side near the anode band of Gc1F-1F. The results obtained in this study give useful information to distinguish the pattern between original and supplementary bands which were altered by the action of factors.

Actins↗