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At least 955 records · Page 53Linked to original sources
PubMed1989

[Long-term effects of partial splenic embolization (PSE) for hypersplenism].

24 cases of hypersplenism were treated by PSE using Gelfoam particles. In cases with 90% embolized, the mean WBC and platelet counts were improved for 5.0 and 3.4 months. In cases with over 60% embolized, those were improved for 19.6 and 19.3 months. 9 cases with over 60% embolized remain in good condition more than 2 years, especially 2 cases of them remain more than 3 years. One patient with total embolized developed a splenic abscess and died after one month from PSE. But another severe complications were not shown.

Adult↗
PubMed1989

[A case of calvarial metastasis of thyroid carcinoma with intraorbital extension].

A 63-year-old man came to our hospital with complaints of exophthalmos and a tumor in the right temporal region. Physical examination revealed not only these findings but also a tumor in the right lateral side of the neck. Plain skull X-ray showed radiolucent area with irregular non-sclerotic margin in the right temporal region of the skull and erosion of the lateral half of the right minor sphenoid wing. Post-contrast CT demonstrated a homogeneously enhanced tumor in the right temporal region with extracranial and intracranial extension, partly invading the right orbita, which compressed the eyeball anterioinferiorly. On MRI (TR 500msec, TE 30msec), the tumor showed an isointensity area with a thin rim of low intensity. Right external carotid angiography revealed the numerous tumor vessels fed by the middle meningeal artery, the accessory meningeal artery and the anterior branch of the superficial temporal artery. On right internal carotid angiography, it was shown that the branches of the right ophthalmic artery were also feeding the tumor. 99Tc scintigraphy demonstrated the areas of increased radionuclide concentration in the skull and neck lesion. Preoperative embolization of the tumor vessels fed by the external carotid artery system was performed. Chopped gelfoam serving as embolization material were injected through a transfemoral catheter, selectively placed into the external carotid artery. Following this procedure, the numerous tumor vessels disappeared completely.

Adenocarcinoma↗
PubMed1989

Therapeutic embolization of pulmonary arteriovenous malformation.

A 49-year old man presented with recurrent transient ischaemic attacks and a pulmonary arteriovenous malformation (PAM) was found in his lower left lobe. Left lower lobectomy was performed, and the attacks ceased. However, 18 months later, a fresh PAM was detected in the right lower lobe. In order to avoid further lung resection, therapeutic embolization with metal-dacron coils and gelfoam was performed, resulting in complete occlusion of the PAM. The patient remained well at follow-up 6 months later. Therapeutic embolization is an effective alternative to surgery in the treatment of PAM, especially in the presence of multiple lesions when it is important to conserve functional lung tissue.

Arteriovenous Malformations↗
PubMed1989

[Percutaneous catheter embolization of the of the internal iliac artery in life-threatening gynecological bleeding].

16 patients with life-endangering hemorrhages caused by gynecologic malignancies have been treated with the percutaneous transcatheter embolisation. In general for embolisation of the internal iliac artery gelfoam was used. Life-endangering bleeding could be stopped in all cases, only 3 mild persistent bleedings and another recurrence of hemorrhage could be controlled conservatively. Major-complications did not occur. The significant advantage of catheter embolisation in controversy to surgical treatment is discussed.

Adult↗
PubMed1989

[Experimental canine hepatic artery embolization with polyvinyl alcohol microspheres].

Polyvinyl alcohol microsphere impregnated with barium sulfate was found to be a good embolizing agent in regard to shape, suspension and distribution in the arteries. Different-phase hepatic artery embolization with microspheres (50 approximately 100 microns, 100 approximately 300 microns) was performed in 20 dogs to evaluate the angiographic and histopathologic changes and hepatic function alterations. Permanent occlusion of the peripheral arterioles was observed on follow-up angiograms one week to six months after embolization. Shrinkage of the embolized segment and focal infarct of the liver were noticed in nearly half of the specimens both grossly and microscopically. The shape and structure of the microspheres were seen unchanged on different-phase specimens, and microspheres as small as 50 microns could reach the corresponding small peripheral arterioles. The liver function alterations were comparable with gelfoam embolization. This study suggested that permanent embolization of small arterioles was possible with such microspheres.

Animals↗
PubMed1989

[Transcatheter arterial embolization in patients with renal arteriovenous malformation: a report of two cases].

We report two cases of renal arteriovenous malformation (AVM) with chief complaints of macroscopic hematuria, and treated with transcatheter arterial embolization (TAE) using Gelfoam. Although hematuria disappeared after TAE in both cases, recanalization of AVM was revealed by follow-up renal arteriography one and three months later respectively. TAE were repeatedly performed at the same time. At the follow-up, the partial infarction in the normal parenchyma of the treated kidney was demonstrated on CT scanning in one case. We suggest that if the residual or recanalization of AVM after the initial TAE is observed, careful follow-up should be preferred without repeated TAE unless some deriving symptoms have appeared.

Adult↗
PubMed1989

[Successful management of massive hemoptysis, following pulmonary mycosis by bronchial artery embolization in a patient with acute lymphoblastic leukemia].

In June 1987, a 20-year-old man was diagnosed as T-cell acute lymphoblastic leukemia. In August, at a nadir period of the remission induction chemotherapy, he complained of high fever and dry cough. A chest roentgenogram also showed a nodular area of increased density in the left upper lobe. Since his clinical state deteriorated progressively despite the administration of broad-spectrum antibiotics, amphotericin B was administered intravenously (with an initial dose of 5 mg/day, increased up to 25 mg/day). Concomitant with bone marrow recovery and continued antifungal therapy, he became soon afebrile and improved over the next 2 months. The infiltrates also began to resolve. Then he abruptly coughed up about 800 ml of blood and suffered from acute respiratory failure. Bronchial arteriographic studies demonstrated active extravasation of contrast medium in the region of the cavity. After therapeutic embolization with Gelfoam, the extravasation was no longer observed. Active bleeding abruptly ceased and had not recurred until the left upper lobectomy which was performed 10 days after the embolization. This case typically demonstrates the value of bronchial arterial embolization in treating massive hemoptysis.

Adult↗
PubMed1988

[Cytofluorometric and histopathological studies on non-cancerous liver lesions after lipiodol-transcatheter arterial embolization].

We have investigated the effects of preoperative Lipiodol-Transcatheter arterial embolization (Lp-TAE) on both the nuclear DNA content of noncancerous liver cells by DNA-cytofluorometry (using NIKON SPM-RF1-D), and the histopathological findings of liver lesions. Lp-TAE through the hepatic artery was performed on ten primary hepatocellular carcinoma patients using Gelfoam in combination with adriamycin (40 mg) or mitomycin C (20 mg), emulsified in Lipiodol (10 ml) and 60% Urografin (2 ml). And hepatic resection was carried out after one or two months later in each case. Histologically, primary hepatocellular carcinoma lesions showed various patterns of necrosis, while the non-cancerous liver cells did not show hepatocellular infarction in the liver cirrhosis. The results of the nuclear DNA content showed an increase in the fractions of poliploid cells in the non-cancerous lesions treated with Lp-TAE compared with that in the normal age-matched controls. But we found no remarkable differences in the ploidy patterns between Lp-TAE treated patients and untreated patients with liver cirrhosis. In conclusion, preoperative Lp-TAE does not induce any remarkable histological hepatocellular damage of non-cancerous lesion and does not affect nuclear DNA content of non-cancerous liver cells.

Adult↗
PubMed1988

[Transarterial segmental hepatic chemo-embolization in patients with hepatocellular carcinoma].

We can administer a Lipiodol-adriamycin emulsion transarterially into the portal vein, because more than a certain amount of Lipiodol injected into the hepatic artery enters the portal vein through arterioportal communications without arterioportal shunting. When Gelfoam embolization is followed by portal venous administration of this emulsion, hepatic chemoembolization is performed from both artery and portal vein simultaneously. But this chemoembolization must be in a limited area of the liver, since such treatment of the whole liver is lethal. We encountered a segmental hepatic chemoembolization in four patients with hepatocellular carcinoma by the catheterization of a hepatic segmental artery. In two cases operated after segmental chemoembolization, complete necrosis was certified in the main tumor and daughter nodules. Hepatic segmental atrophy and infarctions were also noted in the treated segment. In two non-operated cases, hepatic segmental atrophy and excellent antitumor effects were demonstrated by CT and radioisotope liver scan. Thus, we call this treatment "transarterial partial hepatectomy".

Aged↗
PubMed1988

[Preoperative chemoembolization of iopamiron-solved adriamycin and lipiodol on hepatocellular carcinoma--clinicopathological study of ten surgical cases].

Preoperative chemoembolization was performed in 10 patients with hepatocellular carcinoma. The therapeutic regimen included Adriamycin (ADM) solved in nonionic contrast media, Iopamiron and Lipiodol (LP). Two to four ml of the solution, containing 20-40 mg of ADM, was mixed with 5-10 ml of LP by "pumping" method. This emulsion was infused superselectively into the hepatic artery by the balloon-occluded method. The regimen contained no permanent embolic material (e.g., Gelfoam or Ivaron). Dense deposition of LP in the tumor was seen on the CT scan 3-4 weeks after TAI. Surgical specimens, resected 3-12 weeks after TAI, revealed total necrosis of the tumor in 4 cases, subtotal necrosis (more than 80% on the cut surface) in 3 cases, and partial necrosis (less than 80%) in 3 cases. Tumor invasion in the fibrous capsules was necrosed in 4/7 of the cases. Tumor thrombi in the portal vein were also necrosed in 2/4. Our new method is more effective than the previous ones of LP and ADM without Iopamiron, and is equally effective as the regimen using LP, anticancer drugs, and permanent embolic materials.

Adult↗
PubMed1988

[Large-dose intra-arterial injection of lipiodol in liver cancer].

Effects of lipiodol (LPD) on liver functions were examined in 130 patients with primary and metastatic liver cancer who underwent TAE or intraarterial chemotherapy between May 1984 and March 1988 at our department and were available for follow-up studies. Effects of anticancer agents, particularly Adriamycin (ADM), were also evaluated. Large-dose intraarterial infusion of LPD had little effect on the liver functions of patients without liver cirrhosis but often caused a deterioration in liver functions of those with cirrhosis. A combination of this therapy with TAE using Gelfoam sponge caused only a temporary elevation in the transaminase level. The dose of ADM showed little association with the degree of liver disorders, unlike the case of cardiotoxicity or bone marrow suppression. Although the therapeutic effects of intraarterial infusion of ADM-LPD emulsion for advanced cancer (e.g., H4 and Vp3) such as improvements in the Vp factor are remarkable, the dose must be carefully determined, especially when liver cancer is complicated by liver cirrhosis.

Doxorubicin↗
PubMed1988

[Chemoembolization therapy of hepatocellular carcinoma-antitumor effect and side effect].

Chemoembolization therapy with arterial injection of a mixture of various anticancer agents (CDDP, ADR, MMC) and Lipiodol along with gelfoam particles was carried out on 158 cases of hepatocellular carcinoma between January 1985 and July 1987. In two groups using CDDP the tumor regressed 50% or more in higher percentage than in the groups without CDDP. The antitumor effect was more significant in the group using CDDP and ADR than in the group using CDDP alone. No significant side effect was noted in any case.

Carcinoma, Hepatocellular↗
PubMed1979

[Antigenicity and resorptive behavior of the usual gelatin preparations and of dry fibrin foam].

Immunofluorescence studies of Gelastypt, Gelfoam, and Fibrospum showed species-specific, protein-dependent antigen characteristics. Additional experimental studies using guinea pigs revealed that, after subcutaneous implantation, these materials do not lose their antigen characteristics during the resorptive process. Remnants of subcutaneously implanted material could be demonstrated intracellularly (macrophages) in the spleens of the experimental animals four weeks later.

Absorption↗
PubMed1989

Transhepatic embolization of superior mesenteric varices in portal hypertension.

A 49-year-old woman with a history of excessive consumption of alcohol experienced lower-intestinal bleeding 2 years after undergoing a total abdominal hysterectomy and salpingo-oophorectomy because of carcinoma of the cervix. Mesenteric arteriograms showed large, focal varices in the ileum, hepatofugal blood flow, and an abnormal communication between these varices and the right ovarian vein. Percutaneous transhepatic embolization of these varices with absorbable, gelatin sponge (Gelfoam) and coils was successful in stopping the intestinal bleeding.

Embolization, Therapeutic↗
PubMedDate not supplied

Transcatheter embolization for treatment of acute lower gastrointestinal bleeding.

Treatment of lower gastrointestinal bleeding was attempted in 13 patients by selective embolization of branches of the mesenteric arteries with Gelfoam. Bleeding was adequately controlled in 11 patients with active bleeding during the examination. One patient improved after embolization but bleeding recurred within 24 hours and in another patient the catheterization was unsuccessful. Five patients with diverticular hemorrhage were embolized in the right colic artery four times, and once in the middle colic artery. Three patients had embolization of the ileocolic artery because of hemorrhage from cecal angiodysplasia, post appendectomy, and leukemia infiltration. Three patients had the superior hemorrhoidal artery embolized because of bleeding from unspecific proctitis, infiltration of the rectum from a carcinoma of the bladder, and transendoscopic polypectomy. One patient was septic and bled from jejunal ulcers. Ischemic changes with infarction of the large bowel developed in two patients and were treated by partial semi-elective colectomy, three and four days after embolization. Four other patients developed pain and fever after embolization. Transcatheter embolization of branches of mesenteric arteries is an effective way to control acute lower gastrointestinal bleeding, but still has a significant rate of complications that must be seriously weighed against the advantages of operation.

Adult↗
PubMed1988

Transcatheter embolotherapy of massive bleeding after surgery for benign gynecologic disorders.

Transcatheter embolotherapy is a well-established technique for control of bleeding in patients with pelvic trauma and pelvic malignancies, but it has been rarely used in massive vaginal bleeding after surgery for benign gynecologic disorders. We report five patients with massive post-operative vaginal hemorrhage following total abdominal hysterectomy (n = 3), repeated dilatation and curettage (n = 1) and cesarean section (n = 1), all successfully controlled with transcatheter embolization after many operative procedures had failed to stop the hemorrhage. The age of the patients ranged from 21 to 36 years. All patients underwent embolization of both internal iliac arteries with Gelfoam alone or in combination with stainless steel coils. The bleeding stopped immediately in all patients. Four patients recovered completely and one patient died of disseminated intravascular coagulation and multi-organ failure.

Adult↗
PubMed1985

[Retrospective study of short survival cases in hepatocellular carcinoma after transcatheter arterial embolization therapy].

Twenty-two patients with hepatocellular carcinoma were treated with transcatheter arterial embolization therapy. In the six who died within about a month, serum albumin and Ch-E were lower, and total bilirubin and ICG R15 were higher than in the other cases. In four of them, more than 50% of the liver was occupied by tumor, and tumor thrombosis were found in the portal trunk or bilateral first portal branch. Five patients died of hepatic failure followed by upper gastrointestinal bleeding. One died of cachexia. The causes of short survival were 1) severe liver cirrhosis, 2) portal obstruction, 3) large tumor, 4) widespread TAE, 5) retrograde flow of gelfoam.

Adult↗