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At least 955 records · Page 53Linked to original sources
PubMed1979

The binding of diiodosalicylate and flufenamate to the plasma antiactivator: analysis of chemical fibrinolysis.

The fibrinolytic effect of diiodosalicylate was expressed as apparent units urokinase. The dissociation constant of the urokinase-inhibitor complex is increased 19 times in the presence of 10(-2) M diiodosalicylate. The binding of diiodosalicylate to the antiactivator was estimated and the increase in free urokinase in the presence of diiodosalicylate was calculated. With 10(-2) M diiodosalicylate present only 4% of the inhibitor remains free to bind urokinase. Therefore, the fibrinolytic action of diiodosalicylate can be explained on the basis of its binding to the inhibitor and the release of free urokinase.

Animals↗
PubMed1977

[Experience with etofenamate in sport injuries (author's transl)].

Experience with 2-(2-hydroxyethoxy)-ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate; active principle of Rheumon Gel) in the treatment of traumatic injury to the ankle joint is reported. In testing the effect of the product, volumetric measurements were carried out using an apparatus that permits highly accurate assessment by a simple and rapid method of measurement. The studies were carried out as a double blind trial. The result of the study shows that compared with placebo gel the increase in volume due to haematoma is reduced statistically significantly more rapidly under treatment with etofenamate. No localized or generalized side effects were observed.

Adolescent↗
PubMed1982

A study of the effects of indomethacin, flufenamate and salicylate on the localization of intracellular calcium in rabbit neutrophil polymorphs using an antimonate staining method.

An antimonate staining technique was used to localize intracellular calcium in rabbit peritoneal neutrophil polymorphs. When calcium was added to a previously calcium-free extracellular medium neutrophils showed a slight loss of intracellular stainable calcium after 1 h incubation. There was a significant increase in the number of damaged cells and a slight increase in degranulation. Indomethacin (5 X 10(-5)M and 8 X 10(-4)M), both in the absence and the presence of extracellular calcium, enhanced the loss of stainable calcium, and at 37 degrees, increased the amount of damage, but increased degranulation only at the higher concentration and in the presence of calcium. Indomethacin may act as a membrane labilizer. Salicylate (2.5 X 10(-3)M and 1 x 10(-2)M at 37 degrees) slightly decreased the loss of intracellular calcium in the presence of extracellular calcium and, in the absence and presence of calcium and at the higher concentration, decreased degranulation and decreased the amount of damage. Salicylate may act as a membrane stabilizer. Flufenamate (3 x 10(-5)M and 2.4 x 10(-4)M) showed variable effects.

Animals↗
PubMed1983

Dextran sulfate-dependent fibrinolysis in whole human plasma.

This study shows that Flu-beta-Ala can reduce the ability of human plasma to inhibit plasmin. This observation was utilized to develop a method for generating detectable fibrinolytic activity in whole human plasma as assessed on a radiolabeled fibrin plate. Plasma was pretreated with Flu-beta-Ala to remove inhibitors of fibrinolysis: then dextran sulfate was added and the mixture was further incubated at 4 degrees C. When normal plasma was treated in this manner, the rate of generation of fibrinolytic activity after 0.75 hr incubation with radiolabeled fibrin was equivalent to that of 35 ng/ml plasmin. The plasminogen dependence of this activity was tested by pretreating plasma with antibodies against plasminogen. The generation of fibrinolytic activity was totally blocked by this treatment, indicating that the observed fibrinolytic activity was plasminogen-dependent. When plasmas deficient in prekallikrein, factor XII, or high-molecular-weight kininogen were treated with Flu-beta-Ala and dextran sulfate, the initial rate of fibrinolytic activity was less than normal. But after 3 hr incubation with radiolabeled fibrin, the rate of fibrinolytic activity in these deficient plasmas approached that of normal plasma. Thus this dextran sulfate-dependent fibrinolytic activity is dependent on factor XII, prekallikrein, and high-molecular-weight kininogen, but the requirement is not absolute.

Dextran Sulfate↗
PubMed1983

Antiviral activity of Wratizolin.

Wratizolin, the new non-steroidal anti-inflammatory drug, was found to inhibit the replication of Herpes simplex, type 1 and 2, viruses (HSV-1, HSV-2) in vitro. The selectivity of the antiviral action is low because the drug disturbs cellular metabolism. Wratizolin at the relatively low concentration (37 micrograms/ml) inactivates partially purified HSV-2 after incubation for 30 min at 37 degrees. The addition of albumin to the reaction mixture inhibits the virucidal activity of the drug. Wratizolin has little if any effect on the production and action of interferon. The drug used topically as 2% solution in dimethylsulfoxide inhibits the evolution of lesions induced in the guinea pig skin by HSV-2. However, the drug did not prevent the replication of HSV-2 in the guinea pig skin.

Animals↗