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At least 955 records · Page 53Linked to original sources
PubMed1991

Radiographic fallopian tube recanalization: absorbed ovarian radiation dose.

Absorbed radiation dose to the ovaries during radiographic fallopian tube recanalization was estimated in 29 patients with use of thermoluminescent dosimeters placed in the vaginal fornix. With an average fluoroscopic time of 8.5 minutes +/- 5.5 and an average of 14 +/- 5 105-mm spot radiographs obtained, the average absorbed dose to the ovaries was 8.5 mGy +/- 5.6 (0.85 rad +/- 0.56). Technical guidelines for keeping patient radiation exposure to a minimum during this new interventional procedure are suggested.

Adult↗
PubMed1996

[Primary fallopian tube carcinoma. Analysis of 32 cases].

A retrospective analysis of 32 patients with primary fallopian tube carcinoma treated at Center of Oncology in Kraków is presented. In all cases therapy consisted of primary total abdominal hysterectomy with bilateral salpingo-oophorectomy followed by adjunctive radiotherapy. Five year without evidence of disease survived 53.1% of the patients. Stage of disease was the only prognostic factor: survival at 5 years was 76.9% for stage Io, 55.6% for stage IIo, and 20% for stage III.

Adult↗
PubMed1987

Levels of CA 125 in patients with recurrent carcinoma of the fallopian tube: two case histories.

Our study reports 6 patients with advanced adenocarcinoma of the fallopian tube, with elevated levels of serum CA 125 (greater than 35 U/ml). In two patients the serum CA 125 values were followed during treatment. In one of them the CA 125 values decreased during clinical remission and increased at the time of tumor progression. In the second patient we observed increasing levels of CA 125 preceding clinical evidence of recurrent disease. The possible usefulness of CA 125 for monitoring patients with tubal cancer is discussed.

Adenocarcinoma↗
PubMed1994

Primary carcinoma of the fallopian tube: a study of 8 cases.

Eight patients with primary tubal carcinoma of the fallopian tube are presented. These patients constituted 0.3% of all gynecological malignancies encountered during the period the study was conducted. The most common symptom was abnormal vaginal bleeding (4 patients). All patients but one had extra tubal disease at the time of surgery. No patient was operated with a preoperative diagnosis of tubal cancer. All patients were subjected to primary surgical therapy. As adjuvant therapy, radiotherapy (3 patients) and chemotherapy (5 patients) were given. Only three patients are living with a mean survival of 30 months.

Adult↗
PubMed1989

Carcinoma of the fallopian tube: clinical management.

From 1970 to 1986, 36 women were diagnosed to have primary fallopian tube cancer. Fifty-three percent of the patients were Stage III with a median adjusted survival of 27 months. Although varied adjunctive therapies were employed, none provided a clear survival benefit. Five "second-look" procedures were performed. Only one was negative, occurring in a Stage IIIC patient treated with combination chemotherapy. She has continued without evidence of disease 26 months following diagnosis. Recurrent disease was uniformly fatal, despite efforts at salvage therapy. Disease biology and response to therapy parallels that of similar stage epithelial carcinoma of the ovary.

Adult↗
PubMed1997

Neoglycoprotein-binding sites (endogenous lectins) in the Fallopian tube, uterus and blastocyst of the rabbit during the preimplantation phase and implantation.

Regulation of the initial phase of embryo implantation may involve the recognition interplay of glycoconjugates and respective receptors such as endogenous lectins on both cellular surfaces. Whereas changes in glycoconjugate composition have been detected in preparation for embryo implantation and described in detail, knowledge on endogenous lectins has remained scant. Affinity probes (carrier-immobilized carbohydrate structures as ligand part on a histochemically inert backbone) are used in the present investigation in order to gain further insights in this area. Cryostat sections of rabbit Fallopian tubes and uteri in nonpregnant and early pregnant [tubes: 3 days post coitum (d p.c.); uteri: 3, 5, 7 and 9 d p.c.] states were studied for binding patterns of a series of biotinylated (neo)glycoproteins. A high density of binding sites was detected with beta-galactosides (with decreasing intensity: beta-D-galactose-BSA, asialofetuin with its triantennary glycan chains, lactose-BSA). Considerably less binding (but with the same pattern) was obtained with beta-N-acetyl-D-glucosaminide-BSA and is interpreted to originate from a cross-reactivity of such sites which may bind physiologically to Gal-beta1,3/4-GlcNAc sequences. In contrast, no evidence for the presence of binding molecules with specificities for a-D-mannose-BSA, maltose-BSA, N-acetyl-galactosaminide-BSA and N-acetyl-D-neuraminic acid-BSA was obtained in these tissues under the same conditions. The epithelium of the Fallopian tube showed a high density of beta-galactoside-binding sites at the apical cell poles (including the cytoplasm and membrane region) already in the nonpregnant state. At 3 d p.c., a strong reaction in all epithelial cells of the isthmus and a marked decrease in the ampulla were noted. The putative lectin(s) appear(s) to be synthesized and secreted by the tubal epithelium. A physiological role in forming the mucoprotein layer of the blastocyst coverings by precipitating the appropriate mucin-type molecules can be considered. Within the endometrium, the beta-galactoside-binding molecules were almost exclusively localized at the apical cell pole of epithelial cells, whereas there was hardly any binding in the epithelial cytoplasm or in the endometrial stroma. The reaction was very weak in the non-pregnant state but increased considerably until 5 d p.c., starting in the luminal-most parts of the epithelium. While the reaction was rather homogeneous at the surface of the luminal epithelium at 5 d p.c., the degree of heterogeneity increased stepwise from 7 to 9 d p.c. In the implantation chamber, the density of these beta-galactoside-specific 'receptors' was further enhanced in particular at the epithelial surface of the placental folds. In contrast, the reaction was less intense at the antimesometrial uterine epithelium and in interblastocyst segments of the uterus, and it remained weak in the middle and deep crypts. The trophoblast showed a high density of galactoside-binding sites at its surface, and less in the cytoplasm. Neoglycoprotein binding to the blastocyst coverings observed at 7 d p.c. was strong in particular at the outer and inner surfaces. Physical factors (e.g. differential texture at surfaces) are discussed to influence the staining patterns of these extracellular coverings. Nevertheless, the observations made on the tubal and the uterine mucosa suggest that the putative lectin(s) detected here is (are) secreted by these epithelia and could be involved in the structural organization of the various layers of the blastocyst coverings with their remarkable content of oligosaccharide chains. This effect on topological aspects of the zona pellucida equivalents may be important for the interplay between trophoblast and uterine epithelium and the cascade leading to implantation initiation.

Animals↗
PubMed2005

Somatic cell amplification of early pregnancy factors in the fallopian tube.

This essay is concerned with the function of ovarian somatic cells, especially those of the cumulus oophorus, that are shed with the oocyte at the time of ovulation. Once dissociated from the surface of the oocyte(s), they remain in its close vicinity or that of the zygote(s) throughout the tubal sojourn. Most such follicular cells are not moribund or dead but continue to be synthetically active, although showing ultrastructural modification. Their secretions may include steroid hormones, prostaglandins and diverse peptides, molecules that would be presented locally to the endosalpinx. The cell suspension represents a potential route of amplification of early pregnancy signals from the embryo to influence the pattern of ovarian steroid secretion and perhaps that of folliculogenesis. Bearing in mind the relatively low concentration of hormones generated by the somatic cell suspension, vascular counter-current transfer of information is postulated from the Fallopian tube to the ipsilateral ovary. Molecular techniques are being applied as a means of examining endosalpingeal responses in four different experimental models in which the numbers and presumptive activity of suspended follicular cells are varied in pigs with spontaneous oestrous cycles. Because these animals ovulate on both ovaries, epithelial activity can be compared and contrasted between the two sides. In a final model, attempts are being made to generate early pregnancy responses in the absence of embryos by transplanting zygote-programmed cumulus cells from a mated donor into the Fallopian tube of an unmated recipient.

Animals↗
PubMed1983

Adenocarcinoma of the fallopian tubes: a clinicopathological study of eight cases.

Eight cases of clinically evident adenocarcinoma of fallopian tubes were encountered in King George V Memorial Hospital between Jan. 1950 and Dec. 1981. The tumours occurred predominantly in postmenopausal women and usually presented with vaginal bleeding and/or abdominal pain. A pelvic mass was invariably present. The tubal carcinomas were associated with peritoneal endosalpingiosis, ovarian serous neoplasms and epithelial lesions of the breast. Tumour spread was mainly by invasion of the tubal wall with direct involvement of adjacent organs and subsequent transcelomic dissemination. Prognostic factors are discussed. One patient presented with cerebellar disturbance which was considered to be a paraneoplastic syndrome. We believe this to be the first case of such a syndrome in association with tubal carcinoma and the case history is presented in detail.

Adenocarcinoma↗
PubMed2001

Polyp of the fallopian tube.

The case of a 34-year-old woman who had a radical hysterectomy for stage 1 b squamous cell carcinoma of the cervix and in whom an epithelial polyp was identified in the left fallopian tube is presented. The case is unusual in that the polyp developed in the absence of any evidence of tubal damage as demonstrated by a history of endometriosis or tubal sterilisation.

Adult↗
PubMed1987

Adenosquamous carcinoma of the fallopian tube. A clinicopathologic case report with verification of the diagnosis by immunohistochemical and ultrastructural studies.

A middle-aged woman presented with a pelvic mass. Pathologic examination of the resected specimen revealed a primary adenosquamous carcinoma of the left fallopian tube. Special studies supported the concept of the neoplastic cells differentiating along two major pathways, squamous cell carcinoma and mucin-producing adenocarcinoma.

Adenocarcinoma↗
PubMed1992

Prostaglandins in the ovary and fallopian tube.

More than 20 years following the recognition of a possible role for eicosanoids in ovarian function a physiological role for prostaglandins and/or leukotrienes in human ovulation, corpus luteum function and tubal motility remains to be demonstrated. With respect to ovarian function, the well-characterized preovulatory rise in eicosanoid production in animal species and humans, in conjunction with the large body of experimental evidence employing inhibitors of prostaglandin synthesis and replacement of individual prostaglandins, has provided strong evidence for a role in follicular rupture independent of other LH-mediated ovulatory events. The possible mechanism of prostaglandin-induced follicle rupture may involve stimulation of proteolytic activity via substances such as plasmin and PA; however, this is controversial. A role for prostaglandins in ovarian luteal function is well established in laboratory animals and large ruminant species, where PGF2 alpha derived from the uterus has been demonstrated to be the luteolytic factor. In humans, luteal function may be influenced by local intraovarian eicosanoid production, which has been suggested to involve the paracrine interaction of local ovarian hormones such as oxytocin, noradrenaline, insulin and IGFs, to name but a few. Several lines of evidence have also implicated prostaglandins as an aetiological factor in ovarian pathological states such as seen in the OHSS. However, the bulk of clinical experimental evidence to date has failed to support this contention. Prostaglandin production has likewise been well characterized in the fallopian tube in both humans and animal species. Whereas a role for prostaglandins in tubal transport has been demonstrated with animal species such as the rabbit, several studies have failed to define a similar function in humans. More recently, direct injections of prostaglandin analogues into the fallopian tube and the corpus luteum have been shown to be efficacious as a treatment for ectopic pregnancy. Whether the primary mechanism of action involves effects on tubal musculature or corpus luteum function, or is simply a local vascular effect, remains to be demonstrated. Therefore, although the physiological role for eicosanoids in ovarian and tubal function remains unclear, particularly in the human, an increasing body of recent evidence has suggested an important paracrine function for this class of cellular mediators whose interaction with other more recently characterized local ovarian factors has only begun to be recognized.

Animals↗
PubMed2004

Pilot study of outpatient paclitaxel, carboplatin and gemcitabine for advanced stage epithelial ovarian, peritoneal, and fallopian tube cancer.

OBJECTIVE: The purpose of this study was to determine the feasibility, response rate, and toxicity of paclitaxel, carboplatin, and gemcitabine as an outpatient regimen in the treatment of ovarian/non-ovarian and tubal adenocarcinoma. This is the largest completed study using this regimen as first-line treatment of these patients. METHODS: Following cytoreductive surgery, eligible patients were initially treated with paclitaxel (175 mg/m(2) via 1 h infusion), carboplatin (AUC = 5), and gemcitabine (800 mg/m(2)) as an outpatient every 21 days. Gemcitabine (800 mg/m(2)) was repeated on day 8. After six cycles of treatment, responders were eligible for an additional three cycles of paclitaxel and gemcitabine. Colony-stimulating factors were used at the discretion of the treating physician. RESULTS: Fifty-seven patients (median age = 58; range 41-81) with stage III/IV epithelial carcinoma of the ovary, fallopian tube, and peritoneum received a total of 476 cycles of chemotherapy. Grades 3 and 4 neutropenia developed in 19.7% and 9% of cycles while grades 3 and 4 thrombocytopenia developed in 4.2% and 1.3% of the cycles. One hundred thirty-seven (28.8%) cycles of a possible 476 cycles of gemcitabine were delayed primarily due to grades 3 and 4 neutropenia. Forty-five (84.9%) patients exhibited a complete response and three (5.7%) patients demonstrated a partial response, for a total response rate of 90.4%. Twenty-two patients developed some degree of neuropathy, although there was no reported interference with activities of daily living. The patients' median progression-free interval and median overall survival was 15.5 and 40.8 months, respectively. Forty-one of the original 57 patients were alive at the conclusion of data collection. CONCLUSIONS: This report represents the largest completed study in the world employing this triplet regimen in the first-line treatment of advanced stage epithelial ovarian, fallopian tube, or peritoneal cancer patients. Although the study exhibited a high response rate, the neuropathy encountered in the study, and the need to eliminate gemcitabine in 54% of the patients due to bone marrow suppression merits further investigation of the dosing schedule. More recent gemcitabine data suggest that lower doses and a 2-week regimen may be as effective with less toxicity. A comparison of our results with the GOG-0182 study, that utilizes the same regimen, should be informative.

Adenocarcinoma↗
PubMed1988

Metaplastic papillary tumor of the fallopian tube: a case report with ultrastructure.

This is the fifth metaplastic papillary tumor of the fallopian tube identified in a postpartum tubal ligation. Light microscopic studies demonstrate a mucinous metaplasia. The ultrastructure of this unusual papillary epithelial proliferation reveals abundant filaments with condensations. The tumor has not recurred during 4 years of follow-up.

Adult↗
PubMed1989

Carcinoma of the fallopian tube presenting as renal failure: case report.

We describe a patient with carcinoma of a fallopian tube initially presenting with oliguric renal failure. Urinary tract symptoms are uncommon as a result of this rare tumor, and renal failure due to bilateral ureteral obstruction by nodal metastases has not been reported previously as a complication.

Acute Kidney Injury↗
PubMed1988

Primary adenocarcinoma localized to the fallopian tubes: report on 33 cases.

Thirty-three cases of primary adenocarcinoma localized to the fallopian tubes were analyzed according to prognostic factors such as depth of infiltration, tumor differentiation, and lymph vessel invasion. Fifteen patients (45, 5%) died of recurrence within 5 years. Only for positive vessel invasion was the survival significance worse. Combination chemotherapy seems promising compared to radiotherapy in these early stages.

Adenocarcinoma↗