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A case of a vaginal fibroma in a 50-year-old woman is presented. The tumor presented as a solid mass in the upper third of the anterior vaginal wall. Intravenous pyelography (IVP) and cystoscopy excluded any association of the mass with the urinary tract. Surgical excision of the tumor was easily accomplished and histopathological examination established the diagnosis of a fibroid tumor of the vagina.
A typical peripheral ossifying fibroma in the anterior maxilla of an 11-year-old boy is presented. The importance of differential diagnosis and proper treatment for prevention of recurrence is discussed.
We present a 16 year-old girl who suffered since one year of a painless slow growing mass on the left medial orbital rim causing globe displacement. CT-scan and MRI of the orbit with T1 and T2 weighted images showed the presence of a large mucocoele in the frontal sinus. This occurred secondary to the obstruction of the sinonasal tract by a bony tumour. Histopathology showed a lesion consisting of fibrous tissue and ossicles or psammomatoid bodies. The diagnosis of a psammomatoid ossifying fibroma (POF) was made.
The authors report two cases of Demons-Meigs' syndrome, one following an ovarian fibrothecoma and the other an ovarian fibroma. There was a striking rise in the serum CA 125 level which was higher than 200 UI/ml, suggestive of cancer of the ovary in both cases. With the help of the literature data, the clinicopathological features of this rare condition and the different hypotheses concerning its aetiology are commented.
Thirty-four cases of ovarian fibroma are reported. The early symptoms were pelvic pain and abnormal uterine bleeding. All patients were in advanced menopause, mean age 63, except for one that was normally menstruatuating and was 23 years old. In all cases an ultrasound scan TV/TA and CA 125 tests were performed, and afterwards all patients were treated with either conservative or radical surgery. In addition to the above examinations, color Doppler tests on pelvic vessels were performed in 18 cases.
We present two clinical cases of radiolucent mandibular lesions in young women that simulated chronic periapical infectious pathology. The detection of both cases was fortuitous since they were totally asymptomatic. Diagnosis was reached in one case (upon periapical surgery and anatomo-pathologic study) after endodontic treatment and after verifying non-resolution of affected periapical area. The other case was an extensive lesion, which involved the periapices of the four inferior incisors in which surgery was directly performed upon verifying pulp vitality of these teeth. After surgery endodontic treatment was performed on the teeth that had lost their vitality. In both cases the histopathologic tests revealed the presence of a cemento-ossifying fibroma, the initial clinical and radiographic diagnosis of which could easily be overlooked.
Psammomatoid ossifying fibroma (POF) represents a unique subtype of fibro-osseous lesions. We describe a case of POF involving the orbit and the sinonasal tract, in a 13-year-old white female. Diagnosis depends on the histological, radiological and clinical features. Complete excision by endoscopic nasal surgery was the treatment of choice. Five years later the patient was free from symptoms and tumour recurrence. Differential diagnoses are discussed.
Successful removal of tumours of the heart involving the ventricular septum is uncommon. Review shows that of thirty endocardial fibromata reported, only six involved the septum. We wish to report another case, in which a large endocardial fibroma had replaced the ventricula septum and was removed, necessitating the reconstruction of this septum.
The authors have treated nineteen cases of desmoid fibroma of the limbs of which two were intraosseous. The severity of the lesion was greater when sited proximally in the limbs. In many patients, the tumours grew slowly and gave little incapacity. A large number of recurrences were found after surgical excision. The treatment, however, must be based on surgical excision which should be as extensive as possible. Radiotherapy should only be used after the tumour has recurred several times. In view of reports of spontaneous healing, hormone therapy was tried but no conclusions could be drawn from these trials.
Laser wavelengths are available that offer dentists treatment options for both hard and soft oral tissues. This article discusses the benefits of removing hypertrophic soft tissue by using an all-tissue laser. A clinical case is presented involving the use of both an 810 nm diode laser and a 2,780 nm Er,Cr:YSGG laser to remove two irritation fibromas, both located on the left cheek of the same patient. This unique perspective was ideal for comparing the healing of each wound. The Er,Cr:YSGG appeared to have a less traumatic effect on target tissue and offered improved postoperative healing, faster recovery time, and less trauma than traditional surgical modalities.
Osteofibrous dysplasia (ossifying fibroma of long bones) is a rare fibroosseous lesion. Only about 64 cases have been reported in the English literature. It is most commonly found in the tibia and fibula of a child ten years of age or younger. Of the four cases reported in this study, however, only one patient was younger than ten years of age. In two cases, the lesions were unusually located in the radius and ulna respectively. The other two cases had the usual tibial involvement. The last case had two recurrences after curettage before the patient was ten years of age. The other three patients who were treated after the age of 18 years had uneventful healing, one after wide resection and two after curettage. Extensive histologic examination and immunostaining for keratin were performed in all cases. No epithelioid cells were found. Because of a high recurrence rate after curettage, the treatment of this disease in a child should be conservative if the diagnosis is confirmed by biopsy. Only curettage with bone grafting is necessary for those patients older than 15 years of age with symptomatic lesions.
Fibroma of the tunica albuginea is a rare, benign lesion. Only twenty cases have been published. We have observed one case a solitary testis of a 40 years old patient. The treatment performed was enucleation. The interest of this case consists in the rarity of the case and the operative solution proposed. After a review of the literature, we summarise the characteristics of this disease.
A case of grossly disfiguring ossifying fibroma of the left maxilla is presented. The lesion expanded the left maxilla, the left zygomatic bone and it filled the left maxillary antrum to the partial obstruction of the nares. The lesion was completely excised under general anesthesia. About a year post-operatively, patient was fitted with a denture obturator. Further cosmetic osteotomy contemplated on the zyomatic bone which was flayered out could not be carried out because the patient was lost to follow-up.
A 34-year-old woman complained of a swelling in the midline of the mandible, present for about six months and diagnosed as ossifying fibroma. Because of the rapid development and the extent of the tumour, treatment consisted of a partial mandibulectomy, followed by immediate reconstruction with a free vascularized fibula transplant.
Psammomatoid ossifying fibroma of the orbit is a distinctive solitary fibro-osseous lesion of the orbital bones that histologically has characteristic small, round structures resembling psammoma bodies within a benign spindle cell stroma. We describe a 19-year-old woman with this uncommon orbital tumour.
Authors describe the case of a 56 year old man who was admitted because of soft tissue tumour on the end phalanx of his right second toe, growing since one year. The histological examination revealed a fibroma which made the wear of shoe preoperatively impossible. The case was interesting for its unusual localization and magnitude.
RNA-fragments rich in purine nucleotides and resulting from degradation of ribosomal RNA from E. coli M 500 Sho-R with pancreatic RNase exhibit only in vivo an inhibitory effect on Shope fibroma and vaccinia virus multiplication.
PURPOSE: The superoxide dismutase (SOD) like proteins encoded by Leporipoxviruses play a role in regulating the redox status of infected cells. The biological function of these proteins is unclear. Why poxviruses encode these proteins are still unknown. Exploiting standard hybridoma techniques, we developed a monoclonal antibody (MAb) against shope fibroma virus superoxide dismutase (sfvSOD) to be used in diagnostics and as tools to understand the role of SOD-like proteins in pathogenesis. METHODS: Hybridoma cell fusion technology was used for production of MAbs. Balb/c mice were immunized with sfvSOD-GST fusion protein. Hybridoma clones were screened using indirect enzyme linked immunosorbent assay (ELISA). Specificity and reactivity of the MAbs were determined by Western blot analysis (WBA) and indirect ELISA. Protein G affinity chromatography was used for the purification of MAbs. RESULTS: Two stable hybridoma clones producing MAbs against the two domains of the fusion protein were obtained. The anti-GST (glutathione-s-transferase) and anti-sfvSOD MAbs were found to react specifically with GST and sfvSOD proteins respectively, in addition to the sfvSOD-GST fusion protein. Isotypes of these MAbs were identified as IgG2b heavy chain and k light chain. CONCLUSION: The anti-sfvSOD MAb (P115.SOD MAb) has been successfully used in studying the enzymatic and biochemical properties of a SOD homolog encoded by sfv. We also developed a strong anti-GST MAb which was also cloned and characterized P115.GST MAb. The anti-GST MAb might be useful in analyzing GST fusion proteins and in immunoaffinity chromatography purification of GST fusion proteins.