Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Critical Pathways”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 955 records · Page 53Linked to original sources
PubMedDate not supplied

Pathways to care.

Explore the source record for details and available documents.

Australia↗
PubMed1998

Forms of better care.

The introduction of forms called critical care pathways into the paediatric unit of a hospital in Malawi has strengthened teamwork and helped to increase the efficiency with which resources are employed. They serve the dual function of indicating good management and providing an opportunity to note actions and potential progress.

Child↗
PubMed2003

Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition.

Cytotoxic lymphocytes employ Granzyme B as a potent initiator of apoptosis to cleave and activate effector caspases. Unexpectedly, cells transfected with Bcl-2 were resistant to granzyme B-induced killing, suggesting that a mitochondrial pathway was critical. Utilizing cells expressing a dominant-negative caspase 9, the current study demonstrated that caspase activation via the apoptosome was not required. Indeed, cleavage of caspase 3 to p20 still occurred in Bcl-2-transfectants but processing to p17 was blocked. This blockade was recapitulated by the Inhibitor-of-Apoptosis-Protein XIAP and relieved by Smac/DIABLO. Thus granzyme B mediates direct cleavage of caspase 3 and also activates mitochondrial disruption, resulting in the release of proapoptotic proteins that suppress caspase inhibition. Engagement of both pathways is critical for granzyme-induced killing.

Apoptosis↗
PubMed2005

Mechanisms of nitric oxide-mediated intestinal barrier failure in necrotizing enterocolitis.

Necrotizing enterocolitis (NEC) is the leading intestinal emergency in premature infants. The underlying etiology of NEC remains elusive, but hypoxic conditions and early enteral feeding are consistently implicated as the main risk factors in the pathogenesis of NEC. We postulate that nitric oxide (NO) plays a key role as a molecular signaling "hub" in the generation of gut barrier failure in NEC. Clinical studies suggest that inflammatory cytokines and excessive NO production may contribute to the pathogenesis of NEC. One of the major challenges in defining the critical signaling pathways that lead to the development of NEC is the lack of specific biochemical markers that consistently delineate the early stages of NEC. Intestinal pathology and molecular markers derived from late-stage NEC represent end-stage findings and thus provide little insight into the early events that led to intestinal inflammation. Such markers may not represent viable therapeutic targets for the treatment or prevention of NEC. Therefore, novel strategies are needed to identify the patients at risk for NEC and define the clinically relevant molecules that characterize the early stages of NEC. This review will examine the mechanisms of NO-mediated gut barrier failure and propose novel genetic-based approaches for elucidating the critical molecular pathways in NEC.

Enterocolitis, Necrotizing↗
PubMedDate not supplied

Learning is fundamental: the impact of education on successful clinical pathway implementation.

Successful implementation of a clinical pathway program is a complex, multifaceted task. Medical and hospital staff education is often overlooked or minimized during the implementation process. Even with a clinically sound pathway and a state-of-the-art variance-tracking system, implementation can fail miserably if the medical and hospital staff do not completely understand and support the pathway initiative. A well-developed plan for education provides staff members with the foundation they need to be successful within the pathway program.

Critical Pathways↗
PubMed1996

Supportive management of the patient with pancreatic cancer: role of the oncology nurse.

The oncology nurse attends not only to the physiologic needs of the patient with pancreatic cancer but also to the educational, economic, logistic, and psychosocial factors that impact on quality of care. Managing patient care from admission through discharge in today's short hospitalization periods, the oncology nurse's vigilant attention to "patient care maps" helps keep the multidisciplinary healthcare team on schedule, contain costs, and maximize hospital resources. Patient and family education provided by the oncology nurse, along with take-home reference materials, facilitates adjustment to the cancer diagnosis, encourages patient compliance with treatment procedures and pain management, and can cut health-care costs by eliminating unnecessary post-discharge trips to the doctor's office or emergency room. Oncology nursing assists patients with pancreatic cancer along the continuum of care via whatever pathway is chosen.

Critical Pathways↗
PubMed1996

The role of the anesthesia care coordinator in preadmission testing.

Surgery delays and cancellations are costly to hospitals and emotionally distressful to patients. At Sarasota (Fla) Memorial Hospital, staff members developed a critical pathway-the preanesthesia collaborative care track, called "the Track," to address problems associated with preparing patients for surgery. The track is designed to facilitate preoperative patient assessments and nursing interventions that achieve desirable patient outcomes and to enhance the delivery of quality health care to surgical patients. The RN anesthesia care coordinator of the Track assists in early patient-problem identification and ensures that appropriate clinical data are available for perioperative nurses, anesthesiologists, and surgeons to avoid last-minute delays and cancellations of scheduled surgical procedures.

Aged↗