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At least 955 records · Page 53Linked to original sources
PubMed2001

The influence of the viewing angle on neck-load during work with video display units.

Ergonomic measures have been found to reduce load-related trouble from the neck-and-shoulders during visual display unit (VDU) work. An important question is the height at which the screen should be placed to give the lowest possible load. Should it be placed at eye-level or below? The aim of the present study was to investigate whether there was any difference in external loading moments of force about the C7-T1 segment when the VDU-operators had a viewing angle of 20 degrees below the horizontal plane as compared to 3 degrees above the horizontal. Eight secretaries were videofilmed in the sagittal plane in the two work postures during simulated work. The loading moment was calculated from the film. It was significantly lower at viewing angle 3 degrees above the horizontal than at 20 degrees below the horizontal, both at the beginning (1.3 vs 2.2 nm) and at the end (1.4 vs 2.1 nm) of the film sequences (p < 0.05).

Adult↗
PubMed1998

The effects of intermittent illumination on a visual inspection task.

Two experiments are described in which eye movements were monitored as subjects performed a simple target-spotting task under conditions of intermittent illumination produced by varying the display-screen frame rate on a computer VDU. In Experiment 1, subjects executed a saccade from a fixation point to a target which appeared randomly at a fixed eccentricity of 14 character positions to the left or right. Saccade latency did not differ reliably as a function of screen refresh rate, but average saccade extent at 70 Hz and 110 Hz was reliably shorter than at 90 Hz and 100 Hz. Experiment 2 examined the same task using a range of target eccentricities (7, 14, and 28 character positions to the left and right) and across a wider range of screen refresh rates. The results confirmed the curvilinear relationship obtained in Experiment 1, with average saccade extent reliably shorter at refresh rates of 50 Hz and 125 Hz than at 75 Hz and 100 Hz. While the effect was greater for remote targets, analyses of the proportional target error failed to show a reliable interaction between target eccentricity and display refresh rate. In contrast to Experiment 1, there was a pronounced effect of refresh rate on saccade latency (corrected for time to write the screen frame), with shorter latencies at higher refresh rates. It may be concluded that pulsation at frequencies above fusion disrupts saccade control. However, the curvilinear functional relationship between screen refresh rate and saccade extent obtained in these studies differs from previously reported effects of intermittent illumination on the average size of "entry saccades" (the first saccade to enter a given word) in a task involving word identification (Kennedy & Murray, 1993a, 1996). This conflict of data may arise in part because within-word adjustments in viewing position, which are typical of normal reading, influence measures of average saccade extent.

Adult↗
PubMed2004

Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3).

Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, pleiotropic human disorder characterized by obesity, retinopathy, polydactyly, renal and cardiac malformations, learning disabilities, and hypogenitalism. Eight BBS loci have been mapped, and seven genes have been identified. BBS3 was previously mapped to chromosome 3 by linkage analysis in a large Israeli Bedouin kindred. The rarity of other families mapping to the BBS3 locus has made it difficult to narrow the disease interval sufficiently to identify the gene by positional cloning. We hypothesized that the genomes of model organisms that contained the orthologues to known BBS genes would also likely contain a BBS3 orthologue. Therefore, comparative genomic analysis was performed to prioritize BBS candidate genes for mutation screening. Known BBS proteins were compared with the translated genomes of model organisms to identify a subset of organisms in which these proteins were conserved. By including multiple organisms that have relatively small genome sizes in the analysis, the number of candidate genes was reduced, and a few genes mapping to the BBS3 interval emerged as the best candidates for this disorder. One of these genes, ADP-ribosylation factor-like 6 (ARL6), contains a homozygous stop mutation that segregates completely with the disease in the Bedouin kindred originally used to map the BBS3 locus, identifying this gene as the BBS3 gene. These data illustrate the power of comparative genomic analysis for the study of human disease and identifies a novel BBS gene.

ADP-Ribosylation Factors↗
PubMed1999

Developing a video-mediated communication system for hospitalized children.

When a student is away from school for an extended time due to illness, he/she is provided with a tutor or access to in-hospital classrooms to keep up with his/her studies. This isolates the child from normal classroom experiences. A remote-control videoconferencing system (VCS), P.E.B.B.L.E.S.trade mark (Providing Education by Bringing Learning Environments to Students), was developed to allow a student access to his/her regular classroom from the hospital. Remote control is provided by a game pad, which allows the student to direct the system. The first iteration, P.E.B. B.L.E.S. I, tested feasibility. The design of P.E.B.B.L.E.S. II provides an integrated version of the system with user interface aimed at children. Four studies examined its efficacy in allowing a student to participate in typical classroom activities and in providing him/her a sense of presence in the classroom. Results indicate that the system can be used with relatively few errors when set to perform the majority of required activities. The study-participants reported positive experiences using the system, and remote users appeared to have a sense of presence in the classroom.

Attitude↗
PubMed2001

Impact of varying transmission bandwidth on image quality.

The objective of this paper is to determine the effect of varying transmission bandwidth on image quality in laparoscopic surgery. Surgeons located in remote operating rooms connected through a telemedicine link must be able to transmit medical images for interaction. Image clarity and color fidelity are of critical importance in telementoring laparoscopic procedures. The clarity of laparoscopic images was measured by assessing visual acuity using a video image of a Snellen eye chart obtained with standard diameter laparoscopes (2, 5, and 10 mm). The clarity of the local image was then compared to that of remote images transmitted using various bandwidths and connection protocols [33.6 Kbps POTS (IP), 128 Kbps ISDN, 384 Kbps ISDN, 10 Mbps LAN (IP)]. The laparoscopes were subsequently used to view standard color placards. These color images were sent via similar transmission bandwidths and connection protocols. The local and remote images of the color placards were compared to determine the effect of the transmission protocols on color fidelity. Use of laparoscopes of different diameter does not significantly affect image clarity or color fidelity as long as the laparoscopes are positioned at their optimal working distance. Decreasing transmission bandwidth does not significantly affect image clarity or color fidelity when sufficient time is allowed for the algorithms to redraw the remote image. Remote telementoring of laparoscopic procedures is feasible. However, low bandwidth connections require slow and/or temporarily stopped camera movements for the quality of the remote video image to approximate that of the local video image.

Color↗
PubMed2004

Delivering cognitive-behavior therapy for panic disorder with agoraphobia in videoconference.

Delivering psychotherapy by videoconference could significantly increase the accessibility of empirically validated treatments. The aim of this study was to compare the effectiveness of cognitive-behavior therapy (CBT) for panic disorder with agoraphobia (PDA) when the therapy is delivered either face-to-face or by videoconference. A sample of 21 participants was treated either face-to-face or by videoconference. Results showed that CBT delivered by videoconference was as effective as CBT delivered face-to-face. There was a statistically significant reduction in all measures, and the number of panic-free participants among those receiving CBT by videoconference was 81% at post-treatment and 91% at the 6-month follow-up. None of the comparisons with face-to-face psychotherapy suggested that CBT delivered by videoconference was less effective. These results were confirmed by analyses of effect size. The participants reported the development of an excellent therapeutic alliance in videoconference as early as the first therapy session. The importance of these results for treatment accessibility is discussed. Hypotheses are proposed to explain the rapid creation of strong therapeutic alliances in videoconferencing.

Adult↗
PubMed2006

HTLV-1 p12I protein sequences from South America: truncated proteins and common genetic signatures.

p12 pX ORF-I (p12I) of simian T cell lymphotropic virus 1 from Central and West Africa is a 91-amino acid (aa) protein, contrasting with the known p12 sequences from human T cell lymphotropic virus type 1, which are 99 aa in length. An in silico sequence analysis shows a premature termination codon in HTLV-1 p12I sequences from South American and Japanese strains. A translation analysis indicated the presence of 86-aa and 81-aa p12I proteins, shorter than the 99-aa protein found in the majority of HTLV-1 strains around the world. This report shows one more common feature between these two viruses. Additionally, the HTLV-1 p12 signature reported as a genetic marker of Brazilian sequences (p12I P63 and P91) is also highly prevalent in p12 Argentinean sequences. Because p12I may confer a proliferative advantage on HTLV-1-infected cells the existence of naturally truncated proteins might supply insights into its pathogenic mechanisms.

Amino Acid Sequence↗
PubMed2004

True three-dimensional displays that allow viewers to dynamically shift accommodation, bringing objects displayed at different viewing distances into and out of focus.

Under natural viewing conditions, viewers do not just passively perceive. Instead, they dynamically scan the visual scene by shifting their eye fixation and focus between objects at different viewing distances. In doing so, the oculomotor processes of accommodation (eye focus) and vergence (angle between lines of sight of two eyes) must be shifted synchronously to place new objects in sharp focus in the center of each retina. Accordingly, nature has reflexively linked accommodation and vergence, such that a change in one process automatically drives a matching change in the other. Conventional stereoscopic displays force viewers to try to decouple these processes, because while they must dynamically vary vergence angle to view objects at different stereoscopic distances, they must keep accommodation at a fixed distance--or else the entire display will slip out of focus. This decoupling generates eye fatigue and compromises image quality when viewing such displays. In an effort to solve this accommodation/vergence mismatch problem, we have built various prototype displays that can vary the focus of objects at different distances in a displayed scene to match vergence and stereoscopic retinal disparity demands and better simulate natural viewing conditions. By adjusting the focus of individual objects in a scene to match their stereoscopic retinal disparity, the cues to ocular accommodation and vergence are brought into agreement. As in natural vision, the viewer brings different objects into focus by shifting accommodation. As the mismatch between accommodation and vergence is decreased, natural viewing conditions are better simulated and eye fatigue should decrease.

Accommodation, Ocular↗
PubMed2004

Minimalism context-aware displays.

Despite the rapid development of cyber technologies, today we still have very limited attention and communication bandwidth to process the increasing information flow. The goal of the study is to develop a context-aware filter to match the information load with particular needs and capacities. The functions include bandwidth-resolution trade-off and user context modeling. From the empirical lab studies, it is found that the resolution of images can be reduced in order of magnitude if the viewer knows that he/she is looking for particular features. The adaptive display queue is optimized with real-time operational conditions and user's inquiry history. Instead of measuring operator's behavior directly, ubiquitous computing models are developed to anticipate user's behavior from the operational environment data. A case study of the video stream monitoring for transit security is discussed in the paper. In addition, the author addresses the future direction of coherent human-machine vision systems.

Awareness↗
PubMed2004

Ethical evaluation of displays that adapt to affect.

We are developing new kinds of sensors and algorithms that can sense and begin to interpret information related to affect. Starting from the standpoint of value-sensitive design, which considers values such as calmness, autonomy, and informed consent, displays that adapt to affect can be ethically evaluated. The question of how adaptive technologies act on these values is of critical importance to the affective computing group. We are seeking to better understand ethical implications for designers through empirical experiments.

Affect↗
PubMed2001

Environmental tobacco smoke exposure and overtime work as risk factors for sick building syndrome in Japan.

Sick building syndrome (SBS) is an increasingly common health problem for workers in modern office buildings. It is characterized by irritation of mucous membranes and the skin and general malaise. The impact of environmental tobacco smoke (ETS) exposure and overtime work on these symptoms remains unclear. The authors examined these relations using data from a 1998 cross-sectional survey of 1,281 municipal employees who worked in a variety of buildings in a Japanese city. Logistic regression was used to estimate the odds ratio for symptoms typical of SBS while adjusting for potential confounders. Among nonsmokers, the odds ratio for the association between study-defined SBS and 4 hours of ETS exposure per day was 2.7 (95% confidence interval: 1.6, 4.8), and for most symptom categories, odds ratios increased with increasing hours of ETS exposure. Working overtime for 30 or more hours per month was also associated with SBS symptoms, but the crude odds ratio of 3.0 for SBS (95% confidence interval: 1.8, 5.0) was reduced by 21% after adjustment for variables associated with overtime work and by 49% after further adjustment for perceived work overload. These results suggest that both ETS exposure and extensive amounts of overtime work contribute to the development of SBS symptoms and that the association between overtime and SBS can be explained substantially by the work environment and personal lifestyle correlated with overtime.

Adult↗
PubMed2004

Photometry in the workplace: the rationale for a new method.

OBJECTIVES: The assessment of lighting conditions in workplaces has traditionally focused on the measurement of illuminance. The rationale for a new method for the detailed evaluation of natural and artificial light in 'near work' situations, involving the assessment of luminance, is described. METHODS: The procedure comprises four successive phases: (1) identify object/images observed during work tasks; (2) outline the area of the operator's visual field where gaze is predominantly directed; (3) measure luminances in the visual field, pin-pointing all sources of primary and secondary luminance, and constructing iso-luminance maps; and (4) compare luminance ratios. RESULTS: The procedure was illustrated using the common example of near work in an office environment. Illuminance was found to be inadequate to evaluate the effects of natural and artificial environmental light in the workplace. This is due to the fact that the luxmeter is designed to integrate the light detected over a large angle, whereas in near work the operator's retina is mainly stimulated by light originating from objects/images placed in the occupational visual field. CONCLUSIONS: A detailed measurement of luminance within the occupational visual field is consistent with ocular anatomy and physiology, and can be used as part of a risk assessment for visual disturbances and to rationalize lighting at workstations.

Asthenopia↗
PubMed1995

How do desk-top computers affect the doctor-patient interaction?

General practice consultations were video-recorded before and after the introduction of a desk-top computer system into the practice. The recordings were analysed by detailed qualitative scrutiny of tape and transcripts (conversation analysis) to discover regular patterns of interaction. This analysis confirmed that the introduction of computers into the consultation had a significant impact on the communication between patient and doctor. In particular, we found that computer technology has had an impact on the practitioners' conduct and on the disclosure of information by the patient. The analysis also points to some recommendations both for training general practitioners in the use of computerized systems in the consultation, and for the (re)design of the technologies themselves.

Computer Terminals↗
PubMed2002

Assessment of driving with the global positioning system and video technology in young, middle-aged, and older drivers.

BACKGROUND: Driving is a complex task that is difficult to fully characterize objectively or in a blinded fashion. The main objective of this study was to determine the usefulness of the global positioning system (GPS) and video technology for examining age-related differences in driving. In this study, GPS was used to determine the position, velocity, and acceleration of a vehicle, driven by subjects of different ages, while video footage was used to provide a detailed context of the drive. METHODS: Twenty-four subjects who were young (20 to 29; n = 6), middle-aged (30 to 64; n = 8), and older (65 years of age and older; n = 10) drove their own vehicles on a 30-km route of various types of roads, with a GPS receiver and video camera recording. RESULTS: The combination of GPS and video data allowed for the determination of many age-related driving differences. The young subjects drove faster, had a shorter deceleration distance and time, as well as a shorter acceleration time. Young subjects also had a substantially higher number of infraction demerit points primarily due to speeding, not stopping fully at stop signs, and following too closely. Although the older subjects had a smaller number of demerit points assessed, they tended to make different types of errors than the young subjects, including not stopping at all at a stop sign and turning errors. CONCLUSIONS: GPS and video technology offer new opportunities for the assessment of age-related driving performance.

Adult↗
PubMed2005

Using remote assessment to provide home modification services to underserved elders.

PURPOSE: Although remote home assessment would enable specialists to prescribe home modifications for anyone, anywhere, the strategy is dependent on the ability to provide specialists with the same information as an in-home assessment. The purpose of this paper is to document that remote assessment is feasible and concurs largely with traditional in-home assessment based on expert judgment. DESIGN AND METHODS: We compared two new remote assessments, a "zero-tech" paper-and-pencil protocol and a "high-tech" televideo protocol, to traditional in-home assessments to determine the equivalence of the remote and in-home assessments. We determined equivalence by comparing each of the remote assessments to a traditional in-home assessment in the same home. In-home assessments were conducted by home-modification specialists in all homes. Data collection for the remote protocols was conducted by individuals inexperienced in home modification. Assessment data from the remote protocols were analyzed by specialists to diagnose problems and prescribe solutions. RESULTS: The overall rates of correct problem identification (i.e., Sensitivity + Specificity) were significant (p =.000) for both the remote paper-and-pencil (96.4%) and remote televideo (87.1%) protocols. Similarly, rates of agreement in recommendations of solutions were significant (p =.000) for both remote assessments (78.8% and 77.4%, respectively). IMPLICATIONS: The need for home-modification services, particularly in rural areas, far exceeds the capacity of specialists to provide them. Our findings suggest that remote assessments can potentially be used to identify mobility and safety problems in the home as well as to recommend solutions to those problems. As a result, remote home assessment has the potential to provide underserved elders with access to home-modification services that have heretofore eluded them.

Aged↗
PubMed1984

A computer algorithm for testing potential prokaryotic terminators.

The nucleotide sequences of 30 factor-independent terminators of transcription with RNA polymerase from E. coli have been compiled and analyzed. The standard features - a stretch of thymine residues and a preceding dyad symmetry - are shared by most sequences, but there are striking exceptions which indicate that these features alone are not sufficient to describe these sites. In two thirds of the sequences the 3'-half of the dyad symmetry contains the pentanucleotide CGGG (G/C) or a close derivative; about one third have TCTG or a close derivative just downstream of the termination point. The TCTG -box might be implied in termination of stringently controlled operons of E. coli. An algorithm to locate terminators in templates of known nucleotide sequence has been constructed on the basis of correlation to the distribution of dinucleotides along the aligned signal sequences. The algorithm has been tested on natural sequences of a total length of about 11,500 N. It finds all known independent terminators and only a few other sites, including some of the rho-dependent and putative terminators.

Base Sequence↗
PubMed1996

TransTerm: a database of translational signals.

The TransTerm database of sequence contexts of stop and start codons has been expanded to include approximately 50% more species than last year's release. It now contains 148 organisms and >39 500 coding sequences; it is now available on the World Wide Web. The database includes: (i) initiation and termination sequence contexts organized by species; (ii) summary parameters about the individual sequences (sequence length, GC%, GC3, Nc, CAI) in addition to tables of base frequencies for each species' stop and start codon sequence context; (iii) species codon usage tables; and (iv) summary tables of stop signal frequency.

Animals↗
PubMed1998

Analysis of complete genomes suggests that many prokaryotes do not rely on hairpin formation in transcription termination.

Free energy values of mRNA tertiary structures around stop codons were systematically calculated to surmise the hairpin-forming potential for all genes in each of the 16 complete prokaryote genomes. Instead of trying to detect each individual hairpin, we averaged the free energy values around the stop codons over the entire genome to predict how extensively the organism relies on hairpin formation in the process of transcription termination. The free energy values of Escherichia coli K-12 shows a sharp drop, as expected, at 30 bp downstream of the stop codon, presumably due to hairpin-forming sequences. Similar drops are observed for Haemophilus influenzae Rd, Bacillus subtilis and Chlamydia trachomatis, suggesting that these organisms also form hairpins at their transcription termination sites. On the other hand, 12 other prokaryotes- Mycoplasma genitalium, Mycoplasma pneumoniae, Synechocystis PCC6803, Helicobacter pylori, Borrelia burgdorferi, Methanococcus jannaschii, Archaeoglobus fulgidus, Methanobacterium thermoautotrophicum, Aquifex aeolicus, Pyrococcus horikoshii, Mycobacterium tuberculosis and Treponema pallidum -show no apparent decrease in free energy value at the corresponding regions. This result suggests that these prokaryotes, or at least some of them, may never form hairpins at their transcription termination sites.

Base Composition↗