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At least 955 records · Page 53Linked to original sources
PubMed1991

Natural killer cells in meningiomas.

A monoclonal antibody against the surface marker IOT-10 of natural killer (NK) cells was used to investigate the presence of these cells in a series of twenty intracranial meningiomas. In all of these tumours, IOT-10 positive NK cells were found in small numbers, mainly distributed among the tumor cells. Two recurrent tumors showed a relatively high number of immunostained cells. The data obtained in the present study suggest that a NK-cell-mediated immunological response can occur in meningioma tissue.

Adult↗
PubMed1991

Therapeutic response may be predicted by some clinical parameters in essential hypertensive patients.

Several clinical parameters have been studied in a sample of 211 essential hypertensives in order to determine their usefulness as predictors of therapeutic response. One hundred and twenty-four patients (58.8%) achieved normotension with monotherapy, whereas 87 hypertensives (41.2%) needed two or more drugs to control their BP values. Patients who required a combination of drugs exhibited higher levels of systolic and diastolic BP, higher frequency of acute severe hypertension before the beginning of treatment, a more advanced stage of hypertension, and higher plasma aldosterone levels when they were compared with those controlled with a single drug. Likewise, previous cardiovascular complications related to hypertension, enlargement of cardiac silhouette on chest x-ray films and left ventricular hypertrophy were more frequent in the former. By means of a logistic regression analysis, these last three parameters showed a significant relationship with the number of required drugs. We conclude that hypertensives exhibiting this clinical profile have a higher probability of requiring a combination of drugs in the pharmacological treatment of essential hypertension.

Adult↗
PubMed1991

[Differential expression of HLA DR, DP and DQ in cultivated, human ciliary body epithelial cells].

The antigen-specific activation of T-helper lymphocytes is dependent on the presentation of antigen in context with the gene products of major histocompatibility complex class II (MHC II). Aberrant expression of MHC II on the ciliary epithelium has been observed in uveitic eyes, which may enable these cells to interact specifically with lymphocytes and may play a role in ocular autoimmunity. Human MHC II consists of three subclasses, termed HLA DR, DP and DQ, which seem to be differentially regulated and may have different functions. The present study was initiated to investigate the dynamics of the differential MHC II expression on cultured human non-pigmented ciliary epithelial cells (NPE cells) in response to gamma-interferon by means of immunohistochemistry. NPE were isolated by a technique of selective adhesion to tissue culture substrate, and growth was induced after transfection with an origin-defective mutant of SV-40 virus DNA. NPE grown in control tissue culture medium did not express MHC class II. HLA DR and DP could be induced by incubation with low concentrations of gamma-IFN for short periods. HLA DQ was expressed only weakly even with higher doses of gamma-IFN and longer incubation periods. The differential expression of HLA DR and DP, compared to HLA DQ in response to gamma-IFN in the ciliary epithelium, is similar to observations in other non-lymphoid ocular cells, but appears to be different from the regulation of MHC II on lymphoid cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Cell Line, Transformed↗
PubMed1990

[Do clinical parameters exist that permit predicting the need to combine a diuretic with captopril in the initial treatment of essential arterial hypertension?].

In the present work the clinical, biological, radiological, electrocardiographic and hormonal characteristics are analyzed in 51 patients suffering mild essential hypertension, in whom treatment with captopril in monotherapy or associated to chlortalidone managed to normalize arterial pressure and maintained the pressure control during a period of one year. Captopril in monotherapy at a dose of 50 to 150 mg/day normalized blood pressure in 34 patients (66.7%) while in the remaining 17 patients (33.3%) the association of 25 mg of Chlortalidone was required. When comparing the subgroup of patients whose blood pressure levels were controlled with captopril as the only used drug (Group A) against those who required the association with diuretics (Group B), we could only observe significant differences regarding the blood pressure level and cardiothoracic index, being these higher in the group of patients who required pharmacologic association. We conclude that only the severity of hypertension allows to predict the necessity of associating a diuretic to captopril in order to obtain the control of blood pressure levels.

Adult↗
PubMedDate not supplied

[Traumatic tear of the diaphragm].

We have carried out a 9-month retrospective study in the Emergency Resuscitation Unit; 21 patients with abdominal trauma, 42 patients with chest trauma and 895 patients with multiple injuries were treated; 197 (22%) of the latter had also chest and/or abdomen involvement. Of the 260 patients with chest and/or abdomen involvement, six (2.3%) patients had traumatic tear of the diaphragm and four of them, presented thoracic herniation of abdominal content. Diagnostic suspicion was entertained in five patients by means of x-ray plain chest film; diagnosis was confirmed by a barium meal in two patients. In one patient, the diagnosis was established perioperatively. All patients had associated lesions. Four patients required mechanical ventilation after the operation. One patient died of cardiogenic shock on the fourth postoperative day. We emphasize the importance of the suspicion of such condition in patients with multiple injuries with chest and/or abdomen involvement.

Adult↗
PubMed1990

[The validation and usefulness of a questionnaire for evaluating the infrastructure of health centers].

A questionnaire was distributed in all the health centers of the Comunidad Valenciana to establish its validity and usefulness for the evaluation of the physical structure of the health centers. Subsequently, the results were validated by direct verification in 30% of centers. The results of the first part of the questionnaire, related to the type of premises that should be available, and of the second, about the characteristics of such premises, were significantly related with the satisfaction degree (r = -0.724, p less than 0.01), as well as with the criterion of previous planning (p less than 0.001) and the inclusion in structures of a traditional model (p less than 0.001). The 75th percentile of the results of the first and second part of the questionnaire are proposed to select those centers with an unacceptable structure, and, as a quick method, it is recommended to test the parameters of satisfaction degree, previous planning, and inclusion within traditional model structures.

Community Health Centers↗
PubMed1990

[Cardiac tamponade as the initial manifestation of a pulmonary neoplasm].

The development of cardiac tamponade as the presenting feature of neoplastic disease is extremely uncommon. We report three patients with lung adenocarcinoma clinically presenting as cardiac tamponade. The diagnosis was made by the cytological study of pericardial fluid in all three. To update the clinical aspects of this uncommon association we have reviewed the literature and we have found 52 additional patients with different types of neoplasia who presented as cardiac tamponade.

Adenocarcinoma↗
PubMed1990

[Use of a rapid method for detecting adenovirus in the feces of children].

Adenovirus (ADV) and rotavirus (RV) were screened by latex aglutination (LA) in 772 fecal samples from hospitalized and non hospitalized children under 7 years of age, those included 55 control samples. Reactive samples were confirmed by electron microscopy (ME) and enzimoimmunoassay (EIA). ADV were found in 20 (2.6%) samples and RV in 25 (3.2%). Coinfection by both viruses was not demonstrated. The greatest percentage of findings was observed in watery (23% ADV and 25% RV) and almost watery stools (8% ADV and 25% RV). We did not find any of those viruses in samples from control children. Concordance between LA and confirmation methods used was excellent. Thus the LA tests could provide a simple tool for the diagnosis of non hospitalized patients, increasing the possibilities of a rapid ethiological diagnostic in infectious diarrhoeas.

Adenoviridae↗
PubMed1990

[Malignant fibrous histiocytoma of the right ventricle and pulmonary artery. Apropos of a case. Review of the literature].

The authors report a case of malignant cardiac fibrohistiocytoma involving the right ventricular infundibulum and the pulmonary artery and responsible for a pseudo-thromboembolic right heart failure syndrome. Following discovery of the tumour mass on ultrasonography and catheterisation, wide excision of the pulmonary artery, pulmonary valve and the roof of the infundibulum as far as the middle part of the ventricle was performed under cardio-pulmonary by-pass. Reconstruction was performed with a valveless woven Dacron tube. The postoperative course was uncomplicated and the patient was still alive after 18 months. Histology revealed malignant fibrohistiocytoma. The authors also present a review of the literature of these rare tumours of the right-sided cavities (5 cases reported).

Aged↗
PubMed1979

[Acute abdomen due to hemoperitoneum as the first manifestation of a liver tumor. Report of four cases (author's transl)].

Four cases of spontaneous acute hemoperitoneum due to rupture of a liver tumor are presented. The resulting acute abdomen was the first manifestation of the neoplasia. The four tumors corresponded histopathologically to a cavernous hemangioma, a bening adenoma related to anabolizing androgens, and two hepatocarcinomas in cirrhotic livers. All of the patients presented abdominal pain and shock, the characteristics of which are described in this report. One of the patients died due to cardiac arrest before surgical treatment. Emergency surgery was performed on the other three, consisting of left hepatic lobectomy and ligature of the hepatic artery for the hemengioma, and segmented hepatectomy for the adenoma and the hepatocarcinoma. Only the patient with benign tumor survived. Lastly, the authors review the literature, commenting on the clinical, physiopathologic, therapeutic, and prognostic aspects.

Abdomen, Acute↗
PubMed1990

[Toxic megacolon and intestinal perforation caused by Salmonella enteritidis].

Two cases of colitis due to Salmonella enteriditis which later developed a toxic megacolon with intestinal perforation are presented and the probable pathogenesis is discussed. This exceptional clinical course which has not been previously described forces to perform a differential diagnosis with chronic intestinal inflammatory disease which must be based on microbiologic, serologic and/or histologic criteria. Moreover, the authors warn about the unsuitability of using anticholigernic drugs in gastroenteritis since they could be related to the ethiopathogenical basis of the disease's unfavorable course in the described patients.

Adult↗
PubMed1990

Clinicopathological experience with pineocytomas: report of five surgically treated cases.

The clinicopathological experience associated with five cases of pineocytoma is presented. All patients were treated by surgical removal without postoperative radiotherapy. In three individuals, 2000 cGy was administered to the tumor as a presurgical diagnostic test, with no evidence of response. All cases demonstrated histological features of pineocytoma, according to the criteria of Borit et al., and of the so-called "pineocytoma with neuronal differentiation," according to the criteria of Rubinstein. The experience obtained from the present series reveals that these tumors can occur in the initial decades of life, that a cystic appearance and the presence of calcifications are distinctive features of their radiological evaluation, and that they have a good prognosis after surgical removal, even when the histological data indicate local invasion. The convenience of reserving the term "pineocytoma" for these tumors, and of including the so-called "pineocytomas without further differentiation" within the group of pineoblastomas, is suggested in order to achieve a practical clinicopathological assessment of parenchymatous pineal tumors.

Adolescent↗
PubMed1990

[Prevalence, forms of clinical presentation and treatment of arterial hypertension at an emergency unit].

In order to determine the prevalence of arterial hypertension and clinical presentation of the hypertensive crisis, as well as the need and efficacy of treatment, 3626 patients who were seen at an Emergency care Unit during a period of 37 randomly chosen days in a total time period of three months, have been studied. Two hundred and fifty one patients presented arterial hypertension, defined as a systolic arterial pressure above 160 mmHg and/or diastolic above 95 mmHG, which represents 6,92% of medical emergencies and 1.79% of total emergencies. Only 104 patients (2.86%) seeked help for some pathology related to hypertension, of whom 49 (19.5% of hypertense patients) presented as a hypertensive emergency, being the acute lung edema and unstable angina the most frequently encountered emergencies. Nifedipine was the most frequently used drug in both groups and managed to control pressure levels in almost 90% of patients with a hypertensive emergency in a mean time of less than one hour.

Adult↗
PubMed1990

[Inverted papilloma of the ureter. Review and treatment criteria].

We report a case of inverted papilloma of the ureter, a rare disease entity. To our knowledge, this makes the 22nd case reported in the literature. Patient anatomopathologic work up included electron microscopy and immunohistochemical methods. This condition is compared to urothelial tumours of the ureter and we discuss the therapeutic approach. Correct treatment is by tumor excision including its base by segmental resection of the ureter and end-to-end ureterorrhaphy or ureterocystoneostomy in tumors of the lower third. A case submitted to endoscopic resection with good clinical results has been recently described by Cabezas Zamora. Perioperative biopsy does not appear to provide more data relative to the surgical option. Like other authors, we believe that these warrant the same close follow-up as in urothelioma.

Aged↗