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DPOAE-patterns in different types of autosomal-dominant nonsyndromal hearing impairment.

Twelve families with autosomal-dominant nonsyndromal hearing impairment (ADNSHI) were examined. The mode of inheritance was determined by pedigree and at least three generations with affected persons had to be found. Pure tone audiogram (PTA), DP-gram and caloric vestibular test (CVT) were performed on 30 affected persons. By PTA we could find eight families with mild to moderate mid-frequency U-shaped ADNSHI, three families with moderate to severe gently sloping high tone ADNSHI and one family with variable ADNSHI. The corresponding DP-grams showed a family-specific DP-gram in 20 (66%) of the examined persons. Seven (23%) showed no distortion-product otoacoustic emissions (DPOAE). In three (10%) persons the DP-grams varied but were also abnormal. The CVT was normal in all cases. Obviously it is possible to find out typical DP-grams in families with ADNSHI. This could be used for early diagnosis of hearing disorders in newborns of such families. Problems could only occur in progredient cases.

Audiometry, Pure-Tone↗

Auditory brain stem responses in patients with human immunotropic virus infection of different stages.

Thirty patients (26 men, 4 women) with human immunotropic virus infection of different stages were examined. Eleven patients had a history of i.v. drug abuse, nine patients had a history of treated lues infection, and one patient suffered from Kaposi's sarcoma. At the time of the examination, opportunistic infections or acute encephalitis were not apparent in any patient. All patients underwent otoneurological examinations, including pure-tone audiometry, caloric vestibular testing, and recording of the auditory brain stem responses (ABR). Six patients reported onset of hearing impairment during the last 3 yr. Two of them had flat sensorineural hearing loss; in the other cases, pure-tone audiometry showed high tone hearing loss with negative recruitment. ABRs were normal in 19 cases, with the latencies for waves III and V and for the I-V interpeak latency significantly delayed when compared to the values of the control group. The frequency of abnormal ABR findings did not correlate to the stage of the disease. The results of the study indicate that auditory and, more specifically, ABR abnormalities commonly occur in human immunotropic virus disease. More studies are necessary to prove whether the ABR is suitable to monitor therapeutic effects.

Acquired Immunodeficiency Syndrome↗

[Caloric stimulation of the vestibular organ after cochlear implant surgery].

BACKGROUND: Alterations of the vestibular organ after intracochlear insertion of the electrode array in cochlear implant (CI) surgery are estimated in the literature to be more than 30 % . By performing a most atraumatic electrode insertion following the "soft surgery technique" as described by Lehnhardt , the risk of postoperative vestibular dysfunction should be minimised. METHODS: In the present study we compared pre- and postoperative results of the caloric stimulation test in cochlear implant patients and analysed the influence of untimely opening of the perilymphatic space under cochleostomy. In addition we used a non-validated questionnaire, asking for continuous postoperative vertigo after cochlear implant surgery. RESULTS: From patients with preoperative normal or hyperfunction on the implanted ear (n = 32) approximately 16 % showed a hypofunction or nonfunction on the implanted side postoperatively, independent of the technique of the cochleostomy. Only 12 % (n = 98) of the patients who were without vestibular problems preoperatively described postoperative vertigo longer than two days in the questionnaires. CONCLUSIONS: Although we found no significant difference regarding the influence of the technique of the cochleostomy on the preservation of vestibular function, we conclude that the concept of an atraumatic electrode insertion reduces the risk of vestibular dysfunction after CI-surgery.

Adolescent↗

The caloric vestibular reaction in space. Physiological considerations.

Caloric stimulus testing was performed as part of the vestibular research program during the European Spacelab 1 mission in Nov/Dec 1983. Contrary to prediction according to the classical endolymph flow theory originally forwarded by Bárány, caloric nystagmus was elicited in both tested astronauts. The intensity of the response was found comparable to that measured on earth. The theoretical consequences of these findings are discussed and possible mechanisms are considered. The direct volume displacement hypothesis is favoured as the primary effect responsible for the observed vestibulo-ocular nystagmus. Estimated differential pressure conditions resulting in the endolymph canal support this hypothesis and are in agreement with the observed response intensity. It is further speculated that interaction in the central vestibular system between canal and otolith signals be responsible for the well-known body position modulation of the observed nystagmus.

Biomechanical Phenomena↗

Vestibular function tests in children.

Vestibular function tests were performed on a series of 57 children between the ages of 1 and 16 years. Inattention and immaturity of eye movement control created difficulties in the analysis of the electronystagmography traces in some instances. With the eyes closed, spontaneous and positional nystagmus occurred in 20% of asymptomatic children and this was thought to be physiological. Changes in external ear pressure (fistula test) enhanced this spontaneous nystagmus. Smooth pursuit ataxia and optokinetic abnormalities were common in the children with reading disabilities and those with congenital deafness, and were thought to be soft neurological signs of brainstem dysfunction. The torsion swing chair test was acceptable and gave easily readable responses. Caloric abnormalities were very common in children with reading disabilities and provided useful information in those with congenital and acquired disorders of hearing and balance. It was concluded that normal data were required for children of all ages in order to improve our understanding of electronystagmography in children.

Adolescent↗

Influence of the multichannel cochlear implant on vestibular function.

Vestibular function was examined in 55 adult patients who underwent cochlear implant surgery. The percentages of the patients with normal results on an optokinetic nystagmus test and eye-tracking test before surgery were 85% and 82%, respectively. A caloric stimulation test was performed before surgery, and 67% of patients showed hypofunction or afunction. This same test was performed approximately 1 month after surgery, and 38% of patients showed functional deterioration. After surgery 47% of the patients reported some kind of subjective dizziness. The characteristics of dizziness were divided into three types: early, prolonged, and delayed. Fifty-eight percent of the patients had early type, 34% had prolonged type, and 8% had the delayed type. Eighteen percent of the patients felt dizziness when they used the implant device, indicating that electrical current spread from the implant device to the vestibular nerve. The other 82% of the patients did not report any relationship between the use of their cochlear implants and dizziness.

Adult↗

Hearing loss and vestibular dysfunction in childhood from the use of streptomycin in Albania.

With the entry of a large number of Albanians in the area of Epirus over the past 8 months, a significant number of children with hearing problems or deafness has been examined in the out patient ward of the University Hospital of Ioannina. From the Pediatric-Neurologic-Psychiatric and Otorhinolaryngologic examination of these children, 18 cases with hearing problems and vestibular dysfunction due to administration of streptomycin sulfate have been defined. This article reports the ototoxic drug which has been used and is still being used in Albania, the procedure of audiological and vestibular investigation, and the damage which has been evoked in the auditory and vestibular pathway of the children in whom it has been administered.

Acoustic Impedance Tests↗

Posture control in Pusher syndrome: influence of lateral semicircular canals.

UNLABELLED: Pusher syndrome is an interesting disorder of balance in patients with encephalic lesions characterized by the peculiar behavior of actively pushing away from the non-hemiparetic side and resisting against passive correction, with a tendency to fall toward the paralyzed side. The role of vestibular system on the pushing behavior is not clear. AIM: To evaluate horizontal semicircular canal function in patients with Pusher syndrome, using caloric and rotation tests. STUDY DESIGN: Observational prospective. MATERIAL AND METHOD: We evaluated 9 inpatients with stroke and Pusher syndrome at the neurological unit of HCFMRP-USP. We applied neurological and neuropsychological exams, NIHSS, Scale for contraversive pushing (SCP), caloric and rotation tests. RESULTS: We evaluated 9 patients (5 men) with mean age of 71.8 +/- 5.9 and mean NIHSS of 18.33. Three patients presented contralateral directional preponderance on caloric test and we found four patients with directional preponderance on analysis of the slow phase velocity of rotation test response. CONCLUSION: Our findings indicate that a dysfunction of semicircular canals does not seem to be relevant for the clinical manifestations of the Pusher syndrome.

Aged↗

[The validity of absolute "standard values" for the evaluation of the thermic vestibular test--results from electronystagmographic investigations with critical comment on the frequency nystagmogram (butterfly scheme) (author's transl)].

The findings presented here on the thermic examination of 100 healthy test persons and the statistical analysis lead up to the conclusion that the single standard deviation from the statistical mean value of a parameter (Claussen) describing the intensity of a thermic nystagmus reaction does not seem suitable to be assumed as normal range. This is true, too, if these values were achieved from a larger number of healthy persons. On application of the "butterfly scheme" (Claussen) a non-tolerable number of false positive findings resulted. The cause for this is the fact that extravestibular factors, particularly the degree of consciousness, but also the age, influence considerably the absolute value of nystagmus parameters. Furthermore, since the numerical values are not distributed normally, the statement of a standard deviation is not applicable. As an alternative, a procedure is being demonstrated which according to our knowledge was first mentioned by Jongkees. We are suggesting to base the evaluation of the thermic test on the comparison with so-called interquantile ranges of healthy persons. These are percentage ranges within the values of e.g. 80, 90 and 94% of healthy persons are found. In our opinion, in combination with the Jongkees-formula this procedure represents a more favourable criterion for the evaluation of a thermic test.

Adolescent↗