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PubMedDate not supplied

Zymographic characteristics of soluble and bound esterases in nervous tissues and brain tumors.

The Authors describe zymographic characteristics of non specific esterases in human and rat brain and in tumors of the nervous system. Bound and soluble esterases were evidenced using substrate and inhibitor systems in association with detergent extraction. In normal nervous tissues the results confirmed previous observations on the identity of the gray and white matter esterases, except for minor quantitative differences. In brain tumors some peculiar pattern was particularly useful for biological interpretation of tissue differentiation and cell metabolism. The Authors show that the use of Triton X-100 extraction associated with suitable effectors allows a more correct classification of non specific esterases.

Animals↗
PubMed1984

[Clinical aspects of intracranial epidermoids and dermoids].

The authors discuss 21 epidermoids and 6 dermoids of the craniocerebral region, which occurred in patients of the Leipzig Neurosurgical Clinic within a period of ten years. Main localisation was the sellar region. The clinical symptoms (frequently with lacking signs of brain pressure), the diagnosis and prognosis of the malformation tumours are dealt with.

Adolescent↗
PubMed1998

Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity.

Fotemustine is a chloroethylnitrosourea with antitumor activity in disseminated melanoma and adult primary brain tumors. Because new drugs are required for the treatment of medulloblastoma in children, we evaluated the preclinical antitumor activity of fotemustine in four s.c. medulloblastoma xenografts, in comparison with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Both drugs were administered as a single i.p. injection to nude mice bearing advanced-stage tumor. Fotemustine displayed significant antitumor activity in three of four medulloblastoma xenografts; two, IGRM34 and IGRM57, were highly sensitive, with 37 and 100% tumor-free survivors, respectively, more than 120 days after treatment at the highest nontoxic dose (50 mg/kg). Fotemustine was also highly active in a malignant glioma xenograft (IGRG88; five of six tumor-free survivors on day 177). Fotemustine proved to be significantly more active than BCNU in IGRM34 and the glioma xenograft IGRG88. The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase) was detected in all tumor xenografts, ranging in activity from 6 to 892 fmol/mg protein. The high in vivo sensitivity to fotemustine and BCNU observed in three xenografts was clearly associated with a low ATase activity (> 20 fmol/mg), whereas the two poorly sensitive or refractory medulloblastoma xenografts showed high ATase activity (> 500 fmol/mg). Alkylpurine-DNA N-glycosylase activity was detected in all tumor xenografts but at levels ranging only from 513 to 1105 fmol/mg/h; no consistent relationship was found between alkylpurine-DNA N-glycosylase activity and the in vivo sensitivity to the two chloroethylnitrosoureas. The improved activity and tolerance of fotemustine in comparison with BCNU in pediatric medulloblastoma xenografts strongly support the clinical development of this agent in children with brain tumors, in which ATase should be examined as a potential prognostic indicator.

Animals↗