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At least 955 records · Page 53Linked to original sources
PubMed2000

Survival from a lethal blood concentration of cyanide with associated alcohol intoxication.

We present a patient with a lethal blood concentration of cyanide. Additionally, he was found to have an alcohol blood level of 270 mg. dl-1, but made a complete recovery following administration of the antidotes dimethylaminophenol and thiosulphate. It is postulated that the patient may have been able to detoxify himself as a result of metabolism of cyanide to the non-toxic form, thiocyanate.

Adult↗
PubMed1981

Human body temperature and controlled cold exposure during moderate and severe experimental alcohol-intoxication.

In an attempt to obtain more conclusive data, especially concerning the condition in many cases of very high alcohol concentration, two groups of healthy volunteers were exposed to controlled cold surroundings in a climate chamber after i.v. infusion of 96% ethyl alcohol, 1-2 1/2 ml per kg bodyweight, supplemented with alcohol perorally; the maximum blood alcohol concentration measured was 57 mmol/l, corresponding to 2.62%. One group was not habituated to drinking; the other group was habituated to heavy drinking, but functioned well socially. During the stay in a neutral environment, the alcohol infusion caused a rapid elevation of skin temperature with a short, but significant delay in temperature elevation in the alcohol-habituated group. After controlled exposure to cold, a rapid fall in surface temperature back to pre-alcoholic infusion values was seen in both groups. During cold exposure, core temperature remained unchanged in both groups. No changes in plasma catecholamines were found. A 12-18% increase in metabolic rate was seen in both groups during cold exposure, probably as an expression of the specific dynamic effect of alcohol. That the observed vasoconstriction was sufficient to prevent an undue fall in core temperature is further supported by the fact that neither shivering, nor non-shivering thermogenesis was activated, as no visible shivering occurred and no rise in plasma catecholamines was seen.

Alcoholic Intoxication↗
PubMed1989

[Alcohol intoxicated female drivers in Schleswig-Holstein between 1977 and 1987].

This paper reports data on frequency of blood alcohol analyses of female drivers between the years 1977-1987 in Schleswig-Holstein, Germany, West. A comparison between the male and female drivers during the same period is made. Since the year 1980 the increase of traffic offences as well as general rise of other offences by alcoholized females was observed. Statistical data refering to day, hour, reason for the taking of blood sample, possible influence of taking medicaments and illness have been evaluated.

Accidents, Traffic↗
PubMed2003

Ethyl arachidonate is the predominant fatty acid ethyl ester in the brains of alcohol-intoxicated subjects at autopsy.

The role of fatty acid ethyl esters (FAEE), the nonoxidative ethanol metabolites, as mediators of alcohol-induced organ damage is increasingly being recognized. FAEE are detectable in the blood and in liver and adipose tissue after ethanol ingestion, and on that basis, FAEE can be used as markers of ethanol intake. In this study, 10 samples of human brain were collected at autopsy at the Massachusetts Medical Examiner's Office and analyzed for FAEE. FAEE were isolated and quantified as mass per gram of wet weight. The blood ethanol level was also obtained in each case along with the other drugs detected in routine postmortem toxicology screening tests. Ethyl arachidonate was the predominant FAEE species in the brain, representing up to 77.4% of total FAEE in the brain. The percent age of ethyl arachidonate of the total FAEE in the brain was significantly higher than what has been found in all other organs and tissues previously analyzed. Linoleate, the precursor of arachidonate, was a poor substrate for FAEE synthesis, as the percentage of ethyl linoleate of the total FAEE content was extremely low. Thus, this reflects preferred incorporation of arachidonate into newly synthesized FAEE in the brain. Since arachidonate is derived from linoleate, which is depleted in FAEE while arachidonate is enriched, the synthesis of FAEE may be linked to the desaturation and elongation of linoleate to arachidonate.

Adipose Tissue↗
PubMed1990

[Statistical study of alcohol intoxicated female victims of sex offenses].

Comparing 133 presumable rape victims who underwent blood sampling after the event with 2446 alcoholized female traffic offenders it was found that both groups had a delinquency maximum between midnight and 2 a. m. and a delinquency minimum between 6 a. m. and 6 p. m. Most of the rape victims, however, were approximately 5 years younger than the traffic offenders, most of whom were about 25 years old. The time intervals between blood sampling and the event were longer in the case of the rape victims (4 to 20 hours) whereas most traffic offenders underwent blood sampling 1 to 2 hours after the event. At comparable maxima of the distribution curves of blood alcohol concentration (between 1.5% and 2%) that of the rape victims showed a shift to higher values. This is also illustrated by the mean values of blood alcohol concentration at the time of the event: the blood alcohol concentration of the rape victims was 2.24% and thus 0.45% higher than that of the traffic offenders, who averaged only 1.97%. The reason for this is probably to be seen in the different modes of back computation. By assigning 38 offenders to 35 victims it was possible to set up and compare 35 pairs. Comparing the blood alcohol concentrations of all 35 pairs it was found that the blood of the victims contained on average 0.4% more ethanol than the blood of the offenders (1.41% vs. 1.01%).

Accidents, Traffic↗
PubMed1979

[Morphological and ultrastructural changes in the liver of rats on a low-protein diet regimen and in alcoholic intoxication].

The present study aims to clarify some discussion problems on the role of protein deficit in the diet during alcohol action. They carried out studies on rats, part of which received alcohol with whole protein diet, but other part -- low protein diet. The results from the morphological examination showed that lack of proteins in food was of substantial significance and increased pathological changes in liver, due to alcohol effect.

Alcoholic Intoxication↗