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PubMedDate not supplied

Outcomes of transmetatarsal amputations in patients with diabetes mellitus.

The purpose of this study was to report on the long-term outcomes of transmetatarsal amputations secondary to sequelae of diabetes mellitus. We abstracted data from 35 diabetic patients receiving a transmetatarsal amputation over a 6-month period in 1992. Patients were followed for a mean 15.1 +/- 10.1 months. The results indicated that the most predictive factor determining higher level amputation (transfemoral or transtibial) appeared to be the actual indication for surgery (90.0% ischemia versus 4.0% infection, chi 2 = 21.7, odds ratio = 220, 95% confidence interval = 12.5-3885.0, p < 0.05). Those with a diagnosis of infection without underlying critical ischemia were significantly more likely to heal at the level of the foot. While all patients presenting for care had dramatically impaired nutritional values and elevated glucose, albumin was significantly lower in subjects receiving a transfemoral or transtibial revision. High-level amputees were also significantly less likely to have been prescribed depth-inlay shoe gear prior to their amputation (48.0% vs. 10.0%, chi 2 = 4.4, odds ratio = 8.3, 95% confidence interval = 1.0-75.7, p < 0.05). Those with a diagnosis of infection without underlying critical ischemia were significantly more likely to heal at the level of the foot. Though revision rates are high, the success rates are also high if that is defined as retaining the foot and providing a prosthesis-free normal gait.

Adult↗
PubMed1996

Amputation risk and survival after embolectomy for acute arterial ischaemia. Time trends in a defined Swedish population.

OBJECTIVES: To assess the outcome of embolectomy over an 19 year period. METHODS: Time trends in the outcome of acute arterial thrombo-embolectomy of the extremities were analysed in a population-based cohort of 1190 patients operated on between 1965-83. RESULTS: A total of 262 (22%) initial amputations were performed. The limb salvage rates at 5 years postoperatively were lower between 1975-79 (61%) than between 1965-69 (81%). A proportional hazards model revealed a relative hazard (RH) of amputation of 2.2 (95% confidence interval (CI) 1.3-3.3) for 1975-79 compared with 1965-69. Operation at any district hospital entailed a 70% higher risk of amputation (RH 1.7; 95% CI 1.3-2.5) compared with the University hospital. The relative survival rate at 5 years postoperatively decreased towards the end of the study period (33% between 1975-79 compared with 43% between 1965-69). Younger age-groups had a considerably lower risk of death in the University hospital compared with the county and district hospitals. CONCLUSIONS: Contrary to the results in other hospital based reports no improvement in amputation or survival rates since 1965 could be demonstrated in this large series with no patient selection.

Acute Disease↗
PubMed1997

Indications for arterial reconstruction and major amputation in the management of chronic critical lower limb ischaemia. The Scottish and Northern Vascular Audit Groups.

OBJECTIVES: The aim of this study was to derive specific clinical indications for surgery in patients with chronic critical lower limb ischaemia and to determine the extent to which practice in Scotland conformed to these indications. DESIGN, MATERIALS AND METHODS: Consensus on indications was achieved using a modified Delphi method in which a postal questionnaire was completed by 29 vascular surgeons on two occasions, with feedback between the rounds. Respondents indicated the appropriateness of arterial reconstruction and primary major amputation for 218 case scenarios comprising all possible combinations of clinical and angiographic findings. RESULTS: Agreement was reached on 31 appropriate indications for major amputation and 65 for arterial reconstruction. In 10 hospitals in Scotland, 400 primary amputation and arterial reconstruction operations were reviewed retrospectively and compared with the indications. The clinical findings for 7 (4%) arterial reconstructions and 48 (24%) major amputations did not conform to the indications agreed by the Delphi method. The proportion of operations conforming to the agreed indications differed significantly by size of unit (p < 0.025). CONCLUSIONS: This study shows that consensus can be reached on indications for surgery. However, in practice some operations performed do not conform with these indications. This discrepancy may be due to inappropriate practice.

Amputation, Surgical↗
PubMed2001

Amputation. Preoperative assessment and lower extremity surgical techniques.

Amputation surgery is an important part of the treatment for severe limb disorders. The decision-making process must be done thoughtfully, remembering that blood flow is not the only issue. Many factors enter into the decision to perform a partial foot amputation or to perform a more proximal level amputation. Adherence to good surgical principles, proven techniques, and gentle soft tissue handling can make the difference between a successful and durable amputation or continued complications and frustrations.

Amputation, Surgical↗
PubMed2002

Socio-economic outcome of paraplegia compared to lower limb amputation.

STUDY DESIGN: The socio-economic outcome was retrospectively compared between patients with traumatic lower limb amputation and those with paraplegia due to a spinal cord injury (SCI). OBJECTIVE: To evaluate the effect of specific rehabilitative procedures on the socio-economic outcome. SETTING: Paraplegic Centre at the University Hospital in Zurich, Switzerland. METHODS: Accidents occurring in a collective of 1.9 million persons in Switzerland over 3 years were included in the study. Fifty-six persons with unilateral amputation of lower limbs were compared with 54 persons with paraplegia. The follow-up was assessed over 5 years. RESULTS: The following data was obtained in patients with amputations compared to those with SCI (median values): (1) hospital stay: 150 versus 164 days; (2) the work was taken up after 689 versus 616 days; (3) the global average case costs amounted to SFr. 491.000 versus SFr. 606.000 during the first 5 years after injury; (4) the permanent degree of disability was determined to 40% versus 42%. Except for the global costs, all differences were not significant. CONCLUSIONS: There are only a few differences between the socio-economic outcomes between patients with lower limb amputations and those with paraplegia. It remains unclear if the highly specialised rehabilitation services provided for patients with SCI accounts for the similarity since individuals with SCI have additional neurogenic dysfunction of the bladder and bowel. Alternatively, the data may suggest a need for greater rehabilitation services for amputees or may reflect a threshold effect in rehabilitation outcomes.

Adolescent↗
PubMed2001

Back pain as a secondary disability in persons with lower limb amputations.

OBJECTIVE: To evaluate the frequency, duration, intensity, and interference of back pain in a sample of persons with lower limb amputations. DESIGN: Retrospective, cross-sectional survey. SETTING: Community-based survey from clinical databases. PARTICIPANTS: Participants who were 6 or more months post lower limb amputation (n = 255). INTERVENTION: An amputation pain survey that included several standardized pain measures. MAIN OUTCOME MEASURES: Frequency, duration, intensity, and interference of back pain. RESULTS: Of the participants who completed the survey (return rate, 56%), 52% reported experiencing persistent, bothersome back pain. Of these, 43% reported average back pain intensity in the mild range (1-4 on 0-10 rating scale) and 25% reported pain of moderate intensity (5-6 on 0-10 scale). Most respondents with back pain rated the interference of their pain on function as none to minimal. However, nearly 25% of those with back pain described it as frequent, of severe intensity (>or=7 on 0-10 scale), and as severely interfering with daily activities including social, recreational, family, and work activities. CONCLUSIONS: Back pain may be surprisingly common in persons with lower limb amputations, and, for some who experience it, may greatly interfere with function.

Activities of Daily Living↗
PubMed2002

Goal attainment scaling in the rehabilitation of patients with lower-extremity amputations: a pilot study.

OBJECTIVE: To assess the interrater reliability, construct validity, and responsiveness of Goal Attainment Scaling (GAS) among patients who have had lower-extremity amputations. DESIGN: Pilot study comparing GAS with 2 functional measures with established reliability, validity, and responsiveness values. SETTING: Regional amputee program in southwestern Ontario. PARTICIPANTS: Ten patients (6 women, 4 men; mean age +/- standard deviation, 72.3+/-10.7 y) with unilateral lower-extremity amputations who were consecutively admitted to a regional amputee program. The ratio of transtibial to transfemoral amputations was 6:4. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Subjects were assessed by using GAS, the Barthel Index, and the Locomotor Capabilities Index (LCI) of the Prosthetic Profile of the Amputee. RESULTS: The interrater reliability of GAS was r=.67, and 63% of goals developed were identified independently by both investigators. The construct validity between GAS and the Barthel Index and the LCI was r=.44 and r=.35, respectively. GAS was more responsive than both the Barthel Index and the LCI, as indicated by the calculation of effect sizes and relative efficiencies. CONCLUSION: This pilot study suggests that GAS is a promising outcome measure for the rehabilitation of patients with lower-extremity amputations.

Activities of Daily Living↗
PubMedDate not supplied

The incidence and risks of failure to heal after lower extremity amputation for the treatment of diabetic neuropathic foot ulcer.

The primary goal of this retrospective cohort study was to determine the incidence of failure to heal after lower extremity amputation for the treatment of diabetic neuropathic foot ulcer, and the secondary goal was to identify risk factors associated with the outcome. We evaluated 1775 patients who underwent amputation for the treatment of 5314 neuropathic foot ulcers, and who were treated in a network of wound care centers. We calculated the incidence of failure to heal after the initial amputation, and used generalized estimation equations and generalized linear latent and mixed model regression to evaluate the association of failure to heal by the 20th week of care. The unadjusted incidence of failure to heal was 34.01%, and male sex, number of wounds, wound grade, and adjunct therapy were all significantly associated with failure to heal. With the exception of wound grade, the associations were not significantly affected by the treating wound care center, and a sensitivity analysis showed the results to be resistant to the theoretical influence of an unmeasured potential confounder. These findings should be useful to clinicians treating diabetic neuropathic foot ulcers, and should aid surgeons in the determination of the most appropriate level for lower extremity amputation.

Age Factors↗
PubMed2003

[Borderline amputations in diabetics--open questions and critical evaluation].

Minor amputations are frequently performed in neuroischemic or neuropathic lesions of the diabetic foot. In German-speaking countries, the term "Grenzzonenamputation" was created to describe the combination of minor amputation exactly in the border zone to vital tissues, necrosectomy and débridement. For early and optimal rehabilitation, as much vital tissue as possible should be conserved, especially the skeletal structures of the foot. "Grenzzonenamputationen" are of utmost importance for the prevention of ascending infections, and they reduce the duration of clinical and outpatient treatment. "Grenzzonenamputationen" should be performed only by experienced surgeons and if the arterial perfusion is sufficient. They should be as tissue-sparing as possible, and structured interdisciplinary postoperative care is mandatory. Controversial opinions exist with respect to the use of tourniquets, conservation or resection of cartilage and sesamoids, open amputation or primary closure of the wound, interdigital spacer function of toes, aseptic proximal transection of tendons, postoperative wound care, and antibiotic therapy. In view of these controversies, the most important distal minor amputations are described and discussed, with special regard to the habitual surgical way of thinking.

Aged↗
PubMed1987

Lower leg replantation in children: railroad amputation.

Replantation in the lower leg, although technically feasible, still remains a complicated clinical issue in terms of the decision-making process. In children, a limb salvage or replant procedure would seem preferable; however, in crush amputations from railroad injury, a very severe trauma, difficulties in treatment should be thoroughly weighed against prosthetic possibilities: for example, only a fair or good functional outcome would justify an attempt to replant a severed shin. Unfortunately, the outcome in most cases is unpredictable at the time of initial evaluation, and even during the replantation procedure itself. To facilitate prognosis, the authors determine four typical variants of replantation course and outcome, based on local patient conditions, although they stress that no clear indications for replantation vs. prosthesis can be derived from the variants listed. Rather, general guidelines for the surgeon's decision at a very early stage of treatment are presented. Choice of procedure and tactics cannot be determined once and for all, because the prognosis for functional outcome can change during the course of treatment. Among a few well-defined situations are clean amputations (replantation is indicated) and traumas with very extensive crushing of the whole lower leg (replantation is contraindicated). In the majority of cases, replantation is a worthwhile attempt, but this does not imply that a replanted extremity must be preserved at any cost. The surgeon must consider the possibility of re-amputation, in case of an unfavorable variant in the postoperative course. A successful case of replantation, involving two lower leg railroad amputations in a child, is presented.

Adolescent↗
PubMed2001

Postoperative and late survival outcomes after major amputation: findings from the Department of Veterans Affairs National Surgical Quality Improvement Program.

BACKGROUND: A surgical risk model is used to analyze postoperative mortality and late survival for older veterans who underwent above- or below-knee amputations in 119 Veterans Affairs (VA) hospitals from 1991 to 1995. METHODS: Preoperative medical conditions and laboratory values abstracted by the VA National Surgical Quality Improvement Program were linked to subsequent hospitalization and survival through 1999. Logistic regression and proportional hazards models were used to develop risk indexes for postoperative mortality and long-term survival. RESULTS: Thirty-day postoperative mortality was 6.3% for 1909 below-knee and 13.3% for 2152 above-knee amputees. Mortality varied greatly between the lowest-highest risk index quartiles (0.8%-18.4% for below-knee amputation and 2.3%-31.1% for above-knee amputation). Surviving patients had 10,827 subsequent VA hospitalizations during a median 32-month follow-up. Survival probabilities for below- and above-knee amputees were 77% and 59% at 1 year, 57% and 39% at 3 years, and 28% and 20% at 7.5 years. The lowest quartile of survival risk had a 61% five-year survival compared with 14% for the highest-risk quartile. CONCLUSION: A generic surgical risk model can be of use in stratifying prognosis after major amputation. The heavy burden of hospital use by these patients suggests the need for better disease management for this high-risk, high-cost patient population.

Adult↗
PubMed1988

Photoplethysmographic selection of amputation level in peripheral vascular disease.

In a prospective study 37 patients who required amputations of the leg were studied with a new technique: segmental photoplethysmographic skin perfusion pressures. The decision to amputate was made by a vascular surgeon in a traditional manner, with the aid of clinical criteria. The simple method of determining skin perfusion pressures with photoplethysmography is described; 273 measurements were performed. The technique proved to be highly correlated (r = 0.88) with wound healing after amputation, at a separating value of 21 mm Hg (p = 0.0001). The study suggests that the value of this noninvasive method will be to enable the surgeon to amputate at a lower level and to diminish complications and failure of rehabilitation.

Aged↗
PubMed1986

Effects of forelimb amputation and denervation on protein synthesis in spinal cord ganglia of the newt.

Analysis of the effects of forelimb amputation and denervation on [35S]methionine incorporation into the protein of newt brachial plexus nerve ganglia showed that amputation increases the level of protein synthesis about 4-fold as compared with that of control (nonamputated) animals. Denervation without amputation nearly doubles the level of protein synthesis as compared with controls. Analysis of labeled protein by means of two-dimensional gel electrophoresis and radioautogram revealed incorporation patterns that are similar to controls; this observation suggests that amputation affects nerve cells quantitatively rather than qualitatively, in influencing the production of putative neurotrophic agents. A group of basic proteins ranging in Mr from 15,000 to 31,000 are prominently expressed in these radioautograms from experimental ganglia and may be important in promoting forelimb regeneration in the newt.

Amputation, Surgical↗
PubMedDate not supplied

Surgical results of leg amputation according to Ghormley's technique in the treatment of chronic lower limb ischaemia.

The authors present their experience in the treatment of chronic lower limb ischaemia resulting from atherosclerosis by below knee amputation according to Ghormley's technique, with the immediate application of a semi-rigid plaster cast and early rehabilitation. From a group of 664 patients requiring major amputations, 61 patients (52 men) aged 64 +/- 11 fulfilled the criteria for unilateral below-knee amputation for critical limb ischaemia for atherosclerosis consequences. Peri-operative (30-days) mortality was of 3.28%. Stump healing was very good or good (no need for further surgery) in over 2/3 of patients, but in 20% the need for above-knee amputation developed. Postoperative knee contracture (defined as 15 degrees or more limitation to the movement range) was observed in 11.5% of patients.

Adult↗
PubMed1999

Prognostic factors for amputation in the case of envenoming by snakes of the Bothrops genus (Viperidae).

The prognostic factors for amputation following envenoming by snakes of the Bothrops genus were identified from the medical records of 3139 patients. Each of these patients had been bitten by Bothrops sp. and treated in the Hospital Vital Brazil, in São Paulo, Brazil, between 1981 and 1990. The 21 (0.67%) of the patients who had undergone amputation were compared with the 3118 who had not, with respect to the characteristics of the accident, the snake, the victim, the local and systemic manifestations of the envenoming and the treatment. There was an association between amputation and the month of the accident, the time of day when the accident happened, the length of the attacking snake, the anatomical region bitten, systemic bleeding and renal failure. Patients bitten in the fingers, during the cooler months, between 00.00 and 12.00 hours and/or by snakes > 60 cm in length, who developed blisters and abscesses at the site of the bite, systemic bleeding and/or renal failure underwent amputation more frequently than the others (P < 0.05 for each).

Adolescent↗
PubMed2003

Lower limb proximal amputation for a tumour: a retrospective study of 12 patients.

OBJECTIVE: To analyse survival, prosthetic fitting and functional status after trans-femoral amputation or hip disarticulation for a primitive tumour. METHODS: Retrospective study of all patients admitted since 1985. RESULTS: Mean age at amputation was 55. Causes of amputation were osteosarcoma in 50%. Eight (8) patients had initial conservative surgery. Local recurrence was never observed. Nine (9) developed metastasis and required further hospitalisation. Fifty percent (50%) of patients died. Inpatient rehabilitation started 14 days after amputation (7-27), and was of a mean duration of 32 days. Prosthetic fitting was performed 13 days after admission (7 days when a liner was used). Further improvement of the prosthesis was performed in 10 patients. Among the patients who died, 5 had gone home, 4 were wearing their prosthesis all day long and 2 walked indoors with no additional support at discharge. Three (3) patients lived less than 2 months at home. Among the patients who did survive, all went home, 5 were wearing their prosthesis all day long and 2 walked indoors without aid at discharge. Two (2) patients practised sport and 4 drove. All the patients who were active have gone back to work. CONCLUSIONS: Gain due to prosthesis provision is undebatable. Good functional results can be obtained with adapted materials. Initial problems due to the synchronisation of treatments are resolved with multidisciplinary care. All patients should have a rapid and short hospitalisation in a rehabilitation unit and receive a first, simple prosthesis that can be further adapted.

Adult↗
PubMed1991

Motor reorganization after upper limb amputation in man. A study with focal magnetic stimulation.

To evaluate reorganization in motor pathways following amputation, we studied motor evoked potentials (MEPs) to transcranial magnetic stimulation in 7 patients with unilateral upper limb amputations, a patient with congenital absence of a hand, and 10 normal subjects. Electromyographic recordings were made from biceps and deltoid muscles immediately proximal to the stump and the same contralateral muscles. Magnetic stimulation was delivered by a Cadwell MES-10 magnetic stimulator through a 'figure eight' magnetic coil over scalp positions separated by 1-2.5 cm. Maximal M responses were elicited by peripheral nerve stimulation at Erb's point. The amplitude of MEPs was expressed both as absolute values and as a percentage of maximal responses to peripheral nerve stimulation. Threshold for activation of muscles ipsilateral and contralateral to the stump and the region of excitable scalp positions were also determined in 7 patients. Magnetic scalp stimulation induced a sensation of movement in the missing hand or fingers in the patients with acquired amputation, but failed to do so in the patient with congenital absence of a limb. It evoked larger MEPs, recruited a larger percentage of the motoneuron pool, and elicited MEPs at lower intensities of stimulation in muscles ipsilateral to the stump than in contralateral muscles. Muscles ipsilateral to the stump could be activated from a larger area than those contralateral to the stump. These results are compatible with cortical or spinal reorganization in adult human motor pathways targeting muscles proximal to the stump after amputations.

Adult↗
PubMed1996

The influence of lower-extremity muscle force on gait characteristics in individuals with below-knee amputations secondary to vascular disease.

BACKGROUND AND PURPOSE: The purpose of this study was to establish the relationship between isometric muscle force and temporal-spatial gait characteristics for individuals who have had a below-knee amputation secondary to vascular disease. SUBJECTS: Twenty-two individuals (15 male, 7 female) with dysvascular below-knee amputations participated. The male subjects were aged 35 to 72 years (x=59.6, SD=11.1), and the female subjects were aged 54 to 68 years (x=60.5, SD=5.1). Methods. The subjects underwent stride analysis during free-speed and fast walking, as well as bilateral isometric force testing of their remaining hip, knee, and ankle muscles. RESULTS: Stepwise regression analysis revealed that hip extensor force on the amputated side was the only predictor of both free speed (gamma=.50) and fast speed (gamma=.72). Hip abduction force of the sound++ limb was correlated with cadence for both free-speed trials (gamma=.57) and fast-speed trials (gamma=.57). Sound-side knee extensor force was related to free-speed stride length (gamma=.44), whereas residual-limb knee extensor force predicted stride length during fast walking (gamma=.67). CONCLUSION AND DISCUSSION: These results indicate that adequate force is necessary in both residual and sound limbs to improve functional gait ability and that ther hip extensors and abductors and the knee extensors should be emphasized in the rehabilitation of individuals with below-knee amputations.

Adult↗