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At least 955 records · Page 53Linked to original sources
PubMed1991

Eccrine syringofibroadenomatous hyperplasia in a patient with bullous pemphigoid: a case report and review of the literature.

A 76-year-old man with multiple erythematous lesions on his palms and soles which appeared following bullous pemphigoid (BP) is the subject of this case report. The lesions were not raised above the normal skin level, and there were no nodules on the erythematous lesions. The lesions had the histologic appearance of eccrine syringofibroadenoma. This condition is considered to be not a true tumor but a hyperplasia of eccrine sweat ducts following recurrent subepidermal blister formation in BP.

Adenofibroma↗
PubMed1976

[The distribution of isoenzymes of lactate dehydrogenase in benign and malignant neoplasms of the human prostate (author's transl)].

The distribution of LDH isoenzymes from homogenate supernatant of bioptically obtained benign and malignant tumours of the human prostate was investigated by agar gel electrophoresis and correlated with the degree of histological differentiation of these tumours. In comparison to the benign adenomas (52.6% H subunits), the values of H subunits declined (adenocarcinomas 47.3% H subunits) in dedifferentiated carcinomas to 37.1% on the average which demonstrate a tendency of increased malignancy. The LDH isoenzyme distribution of malignant tumours is correlated with the degree of histological differentiation of these tumours, which is important for the clinical prognosis.

Adenocarcinoma↗
PubMed1990

Association of microscopic gonadoblastoma and contralateral ovarian fibroadenoma in patients with gonadal dysgenesis and Turner phenotype.

A rare case of microscopic gonadoblastoma associated with gonadal fibroadenoma in a patient with gonadal dysgenesis and Turner phenotype is reported. The higher incidence of tumor pathologies in patients with gonadal dysgenesis presenting a Y chromosome in their karyotype is discussed, and the need for judicious microscopic analysis of the gonadal streaks of these patients for the detection of possible incipient tumors is emphasized.

Adenofibroma↗
PubMedDate not supplied

Aspiration cytology of 147 adnexal cysts with histologic correlation.

OBJECTIVE: To assess the usefulness of cytology in the diagnosis of 147 histologically established adnexal cysts. STUDY DESIGN: Retrospective, macro-microscopic study based on fluid aspirated from 132 ovarian and 15 extraovarian cysts and projected as a cytohistologic correlation. RESULTS: Typical macroscopic features were identified in 76% of endometriotic cysts, in 53% of mucinous neoplasms and in 67% of dermoid cysts. Cytology helped to identify 67% of nonneoplastic and 56% of neoplastic cysts. The lowest diagnostic sensitivities were observed in functional cysts and benign serous neoplasms (50%), while the highest were shown by endometriotic cysts (76%) and malignant epithelial neoplasms (71%). Inadequate samples were obtained from all types of cysts, even malignant ones (two mucinous cystadenocarcinomas). Diagnostic cytology was useless in extraovarian cysts (33% sensitivity). An adult granulosa cell tumor was erroneously diagnosed as a follicular cyst by cytologic examination. CONCLUSION: Examination of the cyst fluids obtained by aspiration demonstrated low sensitivity, with 43% of inadequate samples obtained from all types of cysts. Malignant cystic neoplasms may be overlooked in inadequate samples. Our study also revealed that specificity in this type of analysis is high in inadequate samples, provided that the technique is carried out correctly.

Adenofibroma↗
PubMed1982

Breast masses in adolescent females.

The clinical records of 51 female patients between the ages of 8 and 20 years who underwent excision of breast masses at Boston's Children's Hospital Medical Center were reviewed. In most instances excisional biopsy using local or general anesthesia was performed on an ambulatory basis. Fibroadenomas account for the majority of breast masses (81.4%). There were no malignancies. Breast tumors in pediatric and adolescent populations are best managed by careful physical examination, careful follow-up, needle aspiration when feasible, observation and surgical excision of persistent, enlarging or symptomatic masses. Patient education and breast self-examination teaching are highly recommended. Excisional biopsy of unilateral subareolar masses in the early pubertal female should be avoided, since these usually represent a physiologically enlarged breast bud.

Adenofibroma↗
PubMed1999

Expression of the extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase-2 in bronchopulmonary and breast lesions.

Tumor cells interact with stromal cells via soluble or cell-bound factors stimulating the production of matrix metalloproteinases (MMPs), a group of enzymes largely involved in the extracellular matrix (ECM) remodeling in tumor invasion. Among these factors, extracellular matrix metalloproteinase inducer (EMMPRIN) has been shown to stimulate in vitro the fibroblast production of various MMPs such as interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), and gelatinase A (MMP-2). In this study, the EMMPRIN protein was detected by immunohistochemistry prominently in malignant proliferations of the breast and the lung. It was present at the surface of both tumor epithelial and peritumor stromal cells. Because previous studies have reported that stromal cells do not express EMMPRIN mRNAs, it is very likely that EMMPRIN is bound to stromal cells via a specific receptor. Moreover, our observations also demonstrated that the same peritumor stromal cells strongly express MMP-2. Our results show that EMMPRIN is an important factor in tumor progression by causing tumor-associated stromal cells to increase their MMP-2 production, thus facilitating tumor invasion and neoangiogenesis. (J Histochem Cytochem 47: 1575-1580, 1999)

Adenocarcinoma↗
PubMed1991

Ultrasound tissue characterization of breast biopsy specimens.

Results of measurements of ultrasound speed and absorption coefficients in the range 3 to 8 MHz in breast tissues at 37 C are reported and analyzed in attempts to identify a set of ultrasound parameters capable of discriminating normal, benign, and malignant tissues. We analyzed 118 tissue regions, comprising 47 normal, 55 benign, and 16 malignant by straight-line fitting of frequency dependence of attenuation. Data for ten additional regions, for a total of 128, became available and were added to the cohort when we subsequently fitted quadratic curves. Sound speed consistently emerged as the variable with greatest discriminating power, particularly for separating normal from benign and malignant tissue. Great difficulty was encountered in discriminating benign from malignant, even when the jackknife technique was used. More success was found with classification and regression trees (CART), although results were sensitive to assigned misclassification costs. Best results from straight-line fits were obtained when discriminating malignant from combined normal/benign data after randomly assigning 75 percent of the data to the learning set and 25 percent to the test set. Then, 23 out of 25 normal/benign and 4 out of 4 malignant cases in the test set were correctly classified. With quadratic fitting, best results were obtained in the three-class case--the false positive rate for malignancy was reduced to zero in the learning (0/31) and test (0/10) sets. Nevertheless, the false negative rate increased to 13 out of 31 (42 percent) in the learning set, while attaining zero (0/4) in the test set.

Adenofibroma↗
PubMedDate not supplied

Diaphanography in benign breast disorders. Correlation with clinical examination, mammography, cytology and histology.

Histologically classified benign breast disorder was present in 163 breast of 158 symptomatic women. The results of diaphanography (DPG) were correlated with those obtained by clinical examination (CE), mammography (M) and cytology (C). A tumour was palpable in 108 cases (66.3%). A false positive diagnosis, i.e. possibly malignant, probably malignant or malignant was made in 15 cases (9.2%) with DPG, and in 33 cases (20.2%) with M. Use of both M and DPG reduced the number of false positives to 1.8 per cent. In 8 cases (4.9%) false positive diagnosis was made with C. During a mean observation time of 58.5 months (range 44-72 months, one case of breast carcinoma was diagnosed.

Adenofibroma↗
PubMedDate not supplied

A biochemical characterization of human breast tumors.

The activities of PHI, LDH and LDH isoenzymes were examined in 45 samples of human breast tissue. There were 25 carcinomas, 10 fibroadenomas and 10 nontumor tissue samples. In the group of nontumor breast tissue, values were as follows: PHI (X = 574 SD = 69), LDH (X = 634 SD = 91), LDH5/LDH1 (X = 0.42 SD = 0.23); in the benign group, PHI (X = 425 SD = 95), LDH (X = 59 SD = 188), LDH5/LDH1 (X = 0.55 SD = 0.38); and in the malignant tumor group, PHI (X = 2871 SD = 1350), LDH (X = 3108 SD = 1417), LDH5/LDH1 (X = 3.33 SD = 0.95). The enzyme activities of nontumor and benign tissue were statistically similar, but when these parameters were compared with the enzyme values of malignant tissue, there was a significant statistical difference. Based on these results, it is possible to establish a biochemical criterion for malignancy with the PHI and LDH activity levels greater than 720 U/g and the LDH5/LDH1 ration greater than 1.3. By using this criterion, the examined specimens can be categorized as nontumor or benign in one group and malignant in another group. This corresponds to the histiopathologic system of classification.

Adenofibroma↗
PubMed1980

Subgross physiopathology of the breast associated with clinical cancer.

Fifty human breasts removed for cancer by radical mastectomy were submitted to subgross analysis of the glandular tree as a whole, stained thin sections (2 mm) under a dissection microscope, followed by histologic study of the lesions found. The glandular tree was more often atrophic (70%) than hyperplastic (30%). The frequencies of physiopathologic changes were as follows: ductal papilloma (4%), ductal hyperplasia (6%), fibroadenoma (16%), sclerosing adenosis (24%), cysts (28%), apocrine cysts (18%), cystic ducts (40%), blind terminal ducts (60%), atrophic lobules (88%), sclerotic lobules (34%), hyperplastic lobules (28%), cystic lobules (52%), persistent lobules in otherwise atrophic breasts (30%), lobules with aporcine metaplasia (30%), atypical lobules with proliferative changes (38%), and independent foci of microscopic cancer (20%). The data indicate: 1) a frequent lack of correlation between ovarian function (menstrual cycles, menopause) and type of mammary glandular tree (hyperplastic, atrophic); 2) a rarity of ductal lesions compared with the frequency of lobular lesions; 3) a ubiquitous distribution of the lesions either near or far from clinical cancer; 4) a significant association of atypical lobules with lobular sclerosis (p < 0.001) and apocrine metaplasia (p < 0.05). The frequency and ubiquity of lobular changes suggest further investigation among them to search for suitable candidates as preneoplastic or predictive lesions.

Adenofibroma↗
PubMed1980

Benign smooth muscle cell metaplasia in breast.

Three different benign breast lesions showing smooth muscle cells in the stroma are reported. Benign smooth muscle cells are rarely found in the breast, and it is likely that they originate from metaplastic changes of the stroma itself.

Adenofibroma↗