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Results for “ACIDOSIS, DIABETIC”

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At least 955 records · Page 53Linked to original sources
PubMed1991

Thyroid hormones changes in infants and children with metabolic acidosis.

The influence of the acidotic state on the thyroxine (T4) peripheral metabolism was studied in two different forms of metabolic acidosis, ie infantile diarrhea and diabetic ketoacidosis. The serum concentrations of T4, free T4 (FT4), triiodothyronine (T3), reverse T3 (rT3), thyrotropin (TSH) and thyroxine-binding globulin (TBG) were measured and compared to healthy control groups. Lower T4 and T3 and higher rT3 serum concentrations were found in both tested groups of patients in relation to the control groups. In infants with severe metabolic acidosis FT4 values were lower than those observed in the control group. In addition, serum TBG levels were lower in diabetic patients as compared to control subjects. Despite the reduced serum T3 and T4 concentrations in both groups of patients, TSH concentrations, were within the normal range. Therefore, we concluded that acidosis caused either by diarrhea (not so far described) or by diabetes mellitus (well documented up to now) affects the thyroid hormones metabolism in a similar way, at least as far as the thyroid hormones blood levels are concerned.

Acidosis↗
PubMed2001

Indication and perioperative management for cardiac surgery in patients with liver cirrhosis. Our experience with 3 patients.

Three patients with noncardiac Child A cirrhosis underwent cardiac surgery. All survived surgery, but 2 died during follow-up periods. A 61-year-old woman who underwent successful double valve replacement died of diabetic coma and severe acidosis due to intestinal necrosis 18 months later. A 57-year-old woman who underwent successful mitral valve replacement died of liver failure induced by heart failure 9 years later. A 45-year-old man who underwent coronary artery bypass grafting is doing well 18 months after discharge. Proper perioperative management, including high-flow cardiopulmonary bypass, pharmacological and mechanical circulatory support, and mechanical respiratory support prevented further, potentially lethal, hepatic dysfunction, leading to good early surgical results. We concluded that patients with Child A cirrhosis could tolerate cardiac surgery. Subsequent surgical results, however, were unsatisfactory, and more careful follow-up is necessary to obtain better late results.

Cardiac Surgical Procedures↗
PubMed1997

Differential acute effects of oxovanadiums and insulin on glucose and lactate metabolism under in vivo and in vitro conditions.

Oxovanadium compounds such as vanadate and peroxovanadiums have been shown to have insulin-mimetic effects on various metabolic pathways, including glucose metabolism. A differential effect of various oxovanadium species on glucose metabolism in different tissues has been reported. The results from our present in vivo studies using rats show that peroxovanadiums and insulin have similar acute effects on decreasing blood glucose levels, but dissimilar effects on blood lactate levels. Furthermore, when bisperoxovanadate (BPV) was administered acutely to intact animals immediately before a bolus insulin challenge, it blunted the effectiveness of insulin in decreasing the blood lactate level, but at the same time demonstrated a synergistic effect on the hypoglycemic action of insulin. It was also observed in in vitro studies using normal 3T3-L1 adipocytes (not serum-deprived) that 1,10-phenanthroline bisperoxovanadate (PHEN-BPV) attenuates the incorporation of carbon from lactate but not from glucose, into lipid in both the absence and presence of insulin. Additionally, it was observed that PHEN-BPV had no effect on lactate dehydrogenase (LDH) activity. Thus, one may speculate that PHEN-BPV interferes with carrier-mediated lactate transport. These observations demonstrate that insulin and oxovanadiums differ in the handling of different metabolic substrates. Thus, even though oxovanadiums mimic many of the metabolic actions of insulin, their metabolic effects are by no means identical. Moreover, since vanadate had no acute effect on glucose metabolism under in vivo conditions, this may suggest that to be effective as a hypoglycemic agent vanadate needs to be converted to some other biologically active oxovanadium species. Finally, the observed interference by PHEN-BPV in the metabolism of lactate may predispose subjects using oral vanadate, as a part of the therapeutic regimen for management of diabetic hyperglycemia, to lactic acidosis.

3T3 Cells↗
PubMed2002

Search for occult secondary osteoporosis: impact of identified possible risk factors on bone mineral density.

OBJECTIVES: To determine whether the use of more elaborate diagnostic tests can identify possible risk factors for secondary osteoporosis and to evaluate the impact of these possible risk factors on the severity of bone disease in the study population. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: We have investigated 377 subjects (285 females, 92 males) with osteoporosis (T-score less than -2.5 in dual energy X-ray absorption) or nontraumatic lumbar vertebral fractures; these patients were referred to our hospital, a secondary care centre, for evaluation and treatment of osteoporosis. RESULTS: Osteoporosis without attributable risk factor was diagnosed in 106 women (37%) and 30 men (33%). In 241 patients (179 women, 62 men) one or more possible risk factors for osteoporosis (in this paper also called subclinical disease) were revealed. The most common were lactose malabsorption, disturbed exocrine pancreatic function and renal tubular disturbances, including renal hypercalciuria, incomplete renal tubular acidosis and mild phosphate diabetes. The number of possible risk factors in the individual patient was significantly related to the severity of osteoporosis as assessed by Z-scores (Spearman correlation r = -0.43, P < 0.001, n = 172 for females; r = -0.28, P < 0.05, n = 65 for males). CONCLUSIONS: All the identified subclinical diseases would have remained undetected if the currently accepted guidelines for the investigation of patients with osteoporosis were applied. The statistically significant correlation between the number of identified possible risk factors and the severity of bone disease in the individual patient strongly suggests the pathogenetic significance of the identified subclinical diseases. It is yet to be shown, whether specific treatment of these subclinical diseases yields additional improvement of bone mass as compared with standard treatment of osteoporosis.

Absorptiometry, Photon↗
PubMed1996

Metformin.

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Acidosis, Lactic↗