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PubMed2005

[2-year clinic effect of fluoride drop on dental caries prevention of primary teeth].

OBJECTIVE: To study the preventive effects of fluoride drop on dental caries for children. METHODS: The comparative method was carried out in 1 200 children aged from 3 to 4. The subjects were divided into three groups: fluoride drop group, fluoride toothpaste group and control group. The research period was 2 years. RESULTS: The results demonstrated that new dfs was 1.35 +/- 0.57 in the fluoride drop group after one year, 1.85 +/- 0.57 after two years. The new dfs was 1.53 +/- 1.09 in the fluoride toothpaste group after one year and 2.75 +/- 1.33 after two years. There was no significant difference of the dfs reduction between fluoride drop and toothpaste group. CONCLUSION: Fluoride drop is effective in the prevention of dental caries in Chinese kindergarten and primary school children.

Ambulatory Care Facilities↗
PubMed2005

The inhibitory effect of an arginine bicarbonate/calcium carbonate CaviStat-containing dentifrice on the development of dental caries in Venezuelan school children.

OBJECTIVE: This study assessed the effect of an arginine bicarbonate/calcium carbonate (CaviStat)-containing dentifrice on caries development, mainly in 11- to 12-year-old Venezuelan children over a two-year period. METHODOLOGY: Children (726) with a DMFT between 3 and 6 were examined at baseline, six months, and one and two years using a mirror, probe, and DMFS scoring. Subjects who completed the study consisted of two groups; 304 test and 297 control. The test group received a CaviStat-containing dentifrice, and the controls used a commercially available 1100 ppm fluoride toothpaste. All subjects were instructed to brush three times a day for 1 minute followed by swishing for 30 seconds. RESULTS: After six months, the mean DMFS scores increased only slightly from baseline in both groups, 6.93 +/- 0.22 in the control and 6.59 +/- 0.22 in the test subjects. After one year, the mean DMFS score in the control group rose to 8.00 +/- 0.24 and leveled off at 7.92 +/- 0.30 at two years. In contrast, the mean DMFS score in the test group decreased to 5.50 +/- 0.24 after one year before rising to 6.99 +/- 0.28 at two years. DMFS difference between the two groups was highly significant (p < 0.001), but mainly due to the large difference seen at one year. Dissection of the data showed that the erupted first molars dominated the overall DMFS changes. At the beginning of this study, first molar scores started at high values and showed a pattern thereafter like that seen for the total data. In contrast, premolars/molars, which erupt 4-6 years later (and at the start of the study had a mean DMFS score slightly above zero), showed a clear rise in the DMFS score in the control group during the first year of the study, which continued to rise until the end of the investigation. In contrast, the CaviStat group showed no change in the premolar/second molar DMFS score from baseline during the first year (giving the impression of 100% inhibition at one year), but showed a delayed rise thereafter that paralleled that seen in the controls between one and two years (58.3% inhibition at two years). Reversal of the development of early dental caries lesions in the CaviStat subjects and limitations of the diagnosis of very early caries lesions with standard dental explorers was suggested for the interesting first molar, first year data. Inhibition of caries initiation and caries progression in the CaviStat group was also observed and easier to see in the premolar/second molar, second year data where the DMFS scores were very low at baseline and reversals are not a significant issue. The results were subjected to statistical analysis including analysis of covariance. Largely because of the first year and first molar data, the difference between control and experimental groups was highly significant (p < 0.001). Similar comparison with the later-erupting premolar/molar teeth showed the CaviStat effect was also significant but at a lower level (p < 0.05). The differences could not be due to examiner error since the Kappa for 10% of the subjects randomly selected and re-examined was 0.898 overall and 0.914 for the first molar data. The data also suggested CaviStat inhibition of caries progression because of a slower rate of rise of missing+filled teeth in the CaviStat vs. the control group (p < 0.05). CONCLUSION: A CaviStat-containing toothpaste was more effective both clinically and statistically in inhibiting caries initiation and progression than the fluoride toothpaste control, and manifested its effects differently in the already-erupted first molars than in the later-erupting premolars and second molars.

Analysis of Variance↗
PubMed2005

Advanced oral antibacterial/anti-inflammatory technology: A comprehensive review of the clinical benefits of a triclosan/copolymer/fluoride dentifrice.

INTRODUCTION: Triclosan is a broad-spectrum antibacterial agent, marketed for use in oral products. It is effective against both gram-positive and gram-negative bacteria. PVM/MA is the non-proprietary designation for a polyvinylmethyl ether maleic acid copolymer. It has been demonstrated that there is a greater uptake of triclosan to enamel and buccal epithelial cells from the use of a fluoride dentifrice containing triclosan and the PVM/MA copolymer than from a dentifrice containing triclosan alone. This Supplement details the results of antibacterial, anti-inflammatory, and short- and long-term plaque and gingivitis studies with a triclosan/copolymer/ fluoride dentifrice. Additionally, the Supplement reviews studies on the effect of a triclosan/copolymer/fluoride dentifrice on periodontitis, calculus, caries, whitening and stain removal, oral malodor, and on the microflora. CONCLUSION: Clinical studies indicate that the use of a triclosan/copolymer/fluoride dentifrice (Colgate Total Toothpaste) may provide oral health benefits beyond those associated with "traditional" toothpaste use, in a manner that is safe and effective. Studies presented in this Supplement demonstrate that Colgate Total Toothpaste provides superior protection against plaque and gingivitis, caries, oral malodor, exhibits superior stain removal, and provides protection against the progression of periodontal disease.

Anti-Infective Agents, Local↗
PubMed1991

[The effect of mouthwashes containing amino-fluoride and stannous fluoride on plaque formation and gingivitis in adults].

UNLABELLED: The aim of the study was to assess the effect of amine fluoride (AmF)--stannous fluoride (SnF2) containing toothpaste and mouthrinsing on dental plaque accumulation and gingivitis. The examinations were performed on two groups of 20 (using AmF/SnF2)-, resp. 24 (using NaF) participants. The mean age was 45.6-, resp. 48.8 years. The duration of the study was five months. Toothbrushing was performed with standardized (multi-effect) toothbrushes, and after it mouthrinsing twice a day. Dental plaque was scored with the Plaque Index of Silness and Löe (1964) and gingivitis was assessed by the modified Sulcus Bleeding Index (Mühlemann and Son 1971) Plaque Index mean values showed a significant decreased in both groups (p less than 0.01). The reduction in the AmF/SnF2 group was more pronounced (63.7%) than in the NaF group (39.3%). The Sulcus-Bleeding Index mean values decreased also significantly in both groups (p less than 0.01). The decrease in the AmF/SnF2 group was 56.5% and in the NaF group 39.0%. CONCLUSION: in the course of a five-month's period AmF/SnF2 containing toothpaste and mouthrinsing had better clinical effect on plaque accumulation and gingivitis than NaF containing toothpaste and mouthrinsing.

Adult↗
PubMed1990

Fluoride in dental plaque after a single toothbrushing with monofluorophosphate dentifrice.

Many studies have shown that topical fluoride applications can produce a fluoride reservoir in dental plaque. Since the most common topical fluoride application is via toothbrushing with fluoridated dentifrices, the aim of this study was to measure fluoride uptake by dental plaque after a single toothbrushing with monofluorophosphate (MFP) toothpaste and to follow the plaque until its fluoride concentration returned to the prebrushing levels. In a fluoridated area, plaque samples were collected from 26 children who brushed with MFP toothpaste, 22 children who brushed with a fluoride-free control toothpaste, before brushing and at intervals of 10 minutes, 1 hour and 2 hours after brushing. A combination fluoride electrode was used to determine the fluoride content of the samples. In conclusion, our study has shown that brushing with fluoridated water has a positive effect on the fluoride level of the plaque and the addition of MFP did not make a significant change, although it had a short term effect. A negative correlation was established between plaque wet weight and its fluoride content whenever the plaque equilibrated.

Adolescent↗
PubMed1994

Effect of selenium on mercury vapour released from dental amalgams: an in vitro study.

Wet corroded and air oxidized surfaces from different types of dental amalgams were used in this in vitro study. The mercury vapour released before and after standardized brushing with a conventional (ACTA) and an experimental selenium-containing toothpaste was examined. The results showed differences between the wet corroded and the air oxidized surfaces. High copper, non- gamma 2- amalgams, released more mercury vapour than the conventional one throughout the experiment. When the amalgam surfaces were brushed with the conventional toothpaste, an increase of the released vapour was noted. The use of the selenium containing toothpaste resulted in all cases, in significantly lower amounts of mercury vapour.

Analysis of Variance↗
PubMed1994

Tooth brushing behaviour in twelve year old children and dental enamel.

This paper examines the association between the use of fluoride toothpastes by 12-year-old children and enamel opacities. Some problems inherent in measuring the effect of fluoride toothpaste on developing enamel are discussed. Data are shown that consider the association between tooth brushing behaviour and dental enamel defects in 1,934 children from areas in North Wales with low levels of fluoride in the drinking water (< 0.1 ppm F). Children who brushed more frequently were at greater risk of having diffuse types of enamel opacity present. No associations were identified between the amount of toothpaste used by the 12 year old subjects or the rinsing method used when brushing and enamel opacities.

Chi-Square Distribution↗
PubMed2000

A phase II study of Biotene in the treatment of postradiation xerostomia in patients with head and neck cancer.

One of the major side effects of radical radiation therapy for head and neck malignancies is xerostomia, or dryness of the mouth. There is no clearly effective treatment for this condition, but we have observed that patients in our practice believe that their symptoms improve significantly when using two "over-the-counter" oral comfort products - Biotene (toothpaste, mouthwash and chewing gum) and Oralbalance gel. We decided to study these agents in a formal phase II study to evaluate their usefulness in patients with postirradiation xerostomia. Twenty-eight patients with post-irradiation xerostomia were entered on the study. All had biopsy-proven carcinoma of the nasopharynx, oropharynx, oral cavity, hypopharynx or larynx, and had received primary radiotherapy with curative intent (> or =50 Gy in 20 fractions) more than 4 months before study entry. More than 75% of both parotid glands were included in the primary radiation field. There was no clinical evidence of recurrent disease. Patients were provided with a 2-month supply of Biotene mouthwash, toothpaste, chewing gum and Oralbalance gel. Response was evaluated 1 and 2 months after study entry using a patient-completed visual analogue scale to assess the severity of xerostomia and its effects on quality of life. For analysis, the scored baseline was subtracted from the later scores to assess change. Patients with an increase of 10 mm from their baseline score on the visual analogue scale were classified as having responded to the treatment intervention, and those with an increase of > or =25 mm from their baseline score were classified as having experienced a major improvement in their symptoms. After 2 months of treatment, 15 patients (54%) reported an improvement in intraoral dryness and 10 of these patients (36%) reported a major improvement. Similar proportions of patients (46% some improvement, 25% major improvement) reported an improvement in their ability to eat normally. Seventeen patients (61%) reported an improvement in oral discomfort, and 12 of these (43%) had a major improvement in their symptoms. The results of this study suggest that the use of Biotene (mouthwash, toothpaste and chewing gum) and Oralbalance gel can improve many of the symptoms of radiation-induced xerostomia. A placebo effect could account for many of the observed improvements in symptoms, and in order to assess the role of these agents in the management of patients with postirradiation xerostomia a randomised phase III study is needed.

Administration, Oral↗
PubMed1980

Plaque-inhibiting effect in orthodontic patients of a dentifrice containing stannous fluoride.

The present investigation was undertaken to study the plaque-inhibiting effect of a dentifrice containing stannous fluoride/stannous pyrophosphate during treatment with fixed orthodontic appliances. The test toothpaste was compared with sodium monofluorophosphate toothpaste and paste without fluoride and tin. When applied directly on the teeth, the test paste was found to reduce plaque growth significantly for 24 hours (P < 0.001). A double-blind cross-over designed study with twenty-one subjects showed statistically significant plaque inhibition after a 3-week test period on subjects showed statistically significant plaque inhibition after a 3-week test period on subjects showed statistically significant plaque inhibition after a 3-week test period on teeth with the appliances placed more than 1.5 mm. from the gingival margin (P < 0.01). Plaque reduction on teeth with the appliances placed close to the gingival margin was not statistically significant (P > 0.05). No statistically significant improvement in the gingival condition and no side effects were observed. It is concluded that because of its dual action on plaque and teeth stannous fluoride/stannous pyrophosphate toothpaste may be recommended as supplement to and not substitute for other forms of fluoride supplementation in this category of patients.

Dental Plaque↗
PubMed1991

The effect of toothbrushing on a hybrid composite resin.

This study observed the effect of various toothpastes on a hybrid composite resin to determine the difference in surface roughness as measured by a profilometer. Slurries (100 gm dentifrice/100 gm H2O) of eight toothpastes were tested by brushing composite resin samples 20,000 times and recording changes in surface smoothness with a profile meter. The surface topography of a hybrid composite resin was altered by routine toothbrushing; the effect of Colgate toothpaste was a statistically smoother surface than found with the other dentifrices; and the surface topography of acrylic resin was altered less by Colgate, Crest, Viadent, and Supersmile than the more abrasive Shane, Sensodyne, Rembrandt, and Topol dentifrices.

Acrylic Resins↗
PubMed1990

Circumoral dermatitis and cheilitis caused by tartar control dentifrices.

Twenty women had similar symptoms and clinical findings related to the use of tartar control toothpaste. Each had burning and itching around the corners of the mouth, followed by pruritic perioral patches of erythema 4 to 14 days later. All patients had begun using tartar control toothpaste 1 to 2 weeks before onset and had brushed their teeth at least three times per day. The typical findings included a moderately severe perioral erythema with fissuring of the angles of the mouth; scaling erythematous patches, separated by normal skin lateral to the initial erythema, were also present. No vesiculation or crusting was noted, and involvement of the gingiva and buccal mucosa was noted in only one case. On discontinuation of the tartar control toothpaste, marked improvement was seen within 1 to 6 weeks with, in most instances, either no treatment or 1% hydrocortisone cream.

Adult↗
PubMed2004

Effect of brushing on fluoride release from 3 bracket adhesives.

The purpose of this in vitro study was to compare fluoride ion release from 3 orthodontic bracket adhesives with and without brushing the bracketed teeth with a fluoridated dentifrice. The bracket adhesives included a light-cured composite resin (Transbond; 3M Unitek, Monrovia, Calif), a fluoride-releasing composite resin (Advance; L D Caulk Division, Dentsply International, Milford, Del), and a resin-modified glass ionomer (Fuji Ortho LC; GC America, Alsip, Ill). The teeth in the control group were not bonded with brackets. Sixty extracted human teeth were randomly assigned to 6 groups of 10 each: (1) Transbond, brushed; (2) Advance, brushed; (3) Advance, not brushed; (4) Fuji, brushed; (5) Fuji, not brushed; and (6) control, brushed. After bonding, each tooth was placed in a sealed plastic test tube containing 4 ml of deionized water. The toothpaste used in brushing contained 0.15% weight per volume sodium fluoride, 1500 parts per million parts fluoride (Winter-fresh gel; Colgate-Palmolive Co., New York, NY). Brushing began 24 hours after the teeth were bonded and placed in deionized water. After brushing, the teeth were thoroughly rinsed with deionized water and returned to a sealed test tube. Fluoride measurements were taken before brushing began, at intervals of 72 hours for 22 days, and 90 and 93 days after bonding. Findings included: (1) brushing significantly increased the release of fluoride ions from the teeth in the composite resin and control groups, (2) the enamel crowns of the unbonded control teeth absorbed and re-released a substantial amount of fluoride ions obtained from the toothpaste, (3) the brushed group of teeth bonded with the fluoride-releasing composite resin released significantly more fluoride on the last 4 days that measurements were taken after brushing than the nonbrushed group bonded with the same adhesive, (4) the brushed group of teeth bonded with the resin-modified glass ionomer released significantly more fluoride on the last 4 days that measurements were taken after brushing than the nonbrushed group bonded with the same adhesive, and (5) all groups released small amounts of fluoride ions 90 and 93 days after bonding (68.5 and 71.5 days after brushing ended); the resin-modified glass ionomer groups released significantly more fluoride than the other groups. Brushing with fluoridated toothpaste produced significantly greater fluoride release from teeth bonded with all 3 adhesives, and from the unbonded control teeth.

Acrylic Resins↗
PubMed2004

On the wettability of soft tissues in the human oral cavity.

In this study, the wettability of gingival surfaces in the human oral cavity was assessed by the measurement of intra-oral water contact angles. Intra-oral water contacts angles were measured in the morning prior to tooth brushing, immediately after tooth brushing and prior to and after lunch in order to reveal the influences of toothpaste and dietary components on the wettability of the gingiva. Within a group of 10 volunteers, gingival surfaces were hydrophobic, with water contact angles ranging from 72 to 79 degrees, which is high as compared with other soft tissues in the human body. Gingival contact angles were not affected by most commercial toothpastes involved in this study, but decreased slightly to 65 degrees after brushing with a hexametaphosphate containing toothpaste. During the day, however, the hydrophobicity readily recovered and after lunch contact angles on the gingival surfaces were higher than early in the morning, now ranging from 76 to 83 degrees. It is generally known that soft tissues in the human body involved in adsorptive and exchange functions and requiring lubrication are more hydrophilic than tissues with more protective functions. This study shows that gingival surfaces classify as the most hydrophobic soft tissue in the human body, attesting to their important protective role in the oral cavity.

Dentifrices↗
PubMed2002

Effect of contact media on the diagnostic quality of electrical resistance measurements for occlusal caries.

BACKGROUND: Electrical resistance measurements have been used for the diagnosis of occlusal caries. Both site and surface-specific techniques have been described, the latter more suited to clinical trials or epidemiological surveys. For surface-specific measurements the tooth is dried and a contact medium drawn along the fissure pattern to provide an electrical contact between a probe tip and the tooth surface. OBJECTIVES: Different contact media have been used and it was the aim of this study to investigate whether different contact media could influence the diagnostic accuracy and repeatability of surface-specific electrical resistance measurements. METHODS: Electrical resistance readings were taken on 99 molar teeth using saline, KY jelly, toothpaste or dental prophylaxis paste. Readings were repeated on 44 randomly selected teeth. The teeth were serially sectioned and visually examined to establish the deepest lesion if present. RESULTS: The Student t-test showed that there were statistically significant differences between readings taken with different contact media, with the exception of toothpaste and prophylaxis paste, where no difference was found. The strongest relationship between histology and resistance reading was achieved with KY jelly (r = 0.559). The optimum sensitivity and specificity achieved was 0.59 and 0.86, respectively (resistance cut-off 0.1 M(Omega)). ROC analysis showed that the diagnostic performance of saline was significantly inferior to the other contact media (P < 0.05). Limits of agreement were used to assess repeatability which were acceptable for all media except toothpaste. CONCLUSIONS: Differences were found between electronic resistance readings taken with different contact media. KY jelly was found to produce the best overall diagnostic performance and should be the standard material used for surface-specific measurements.

Dental Caries↗
PubMed2002

Esthetically objectionable fluorosis attributable to water fluoridation.

OBJECTIVE: We compared estimates of fluorosis prevalence and risk attributable to fluoridation using an index applied to the entire dentition and to the maxillary anterior teeth. We also estimated the prevalence of perceived esthetic problems attributable to current fluoridation policy (Attributable Burden). METHODS: Fluorosis prevalence estimates were obtained from the National Survey of Oral Health in US School Children (1986-87) for the 1839 survey children aged 12 -14 years who were scored for fluorosis, had never received fluoride drops or tablets, and had lived in only one home. For each child we calculated Dean's fluorosis index, and an anterior fluorosis index (value of the highest scored maxillary anterior tooth). We used each index to calculate risk of fluorosis attributable to fluoridation by subtracting at each level of severity the prevalence of fluorosis among those living in low fluoride areas (F <or= 0.3 ppm) from the prevalence among those living in optimally fluoridated areas (0.7 ppm F <or=1.2 ppm). Findings from five published studies were used to calculate risk of perceived esthetic problem attributable to fluorosis, by severity, i.e. the difference in the mean percentage of respondents who were satisfied with the appearance of their teeth with and without fluorosis. Finally, Attributable Burden was estimated by summing the products of risk of perceived esthetic problems attributable to fluorosis and risk of fluorosis attributable to fluoridation for each level of fluorosis severity. RESULTS: Prevalence of fluorosis, very mild or greater, was 26% with Dean's Index, which was significantly higher than the 18% figure calculated with the anterior index. Using the anterior index, fluoridation was a risk factor for very mild (attributable risk = 15%) and mild fluorosis (attributable risk = 3%). Risk of fluorosis (very mild or greater) attributable to fluoridation was significantly higher when calculated from prevalence estimates using Dean's Index than estimates calculated with the anterior index (24% versus 18%). The mean values of risk of perceived esthetic problems attributable to very mild and mild fluorosis were 9% and 33%, respectively. CONCLUSION: We found that approximately 2% of US schoolchildren may experience perceived esthetic problems which could be attributed to the currently recommended levels of fluoride in drinking water. The findings further suggest that both estimates of fluorosis prevalence and risk of fluorosis attributable to fluoridation will be higher when calculated with an index applied to the entire dentition. Data were unavailable for fluoridated toothpaste and diluted formula consumption, thus the risk of fluorosis attributable to fluoridation may be overestimated if consumption was higher in fluoridated areas. The risk of perceived esthetic problems attributable to fluoridation must be weighed against its lifetime benefits and the associated costs of alternative solutions such as educating parents about appropriate toothpaste use and lowering the fluoride content of children's toothpaste.

Adolescent↗
PubMed2003

Fluoridated elastomers: in vivo versus in vitro fluoride release.

OBJECTIVES: To compare (i) the in vivo release of fluoride from fluoridated elastomers to the in vitro release, and (ii) the residual fluoride content of the elastomers after 1 week in the mouth with and without fluoride toothpaste and mouthrinse. DESIGN: A prospective, longitudinal, cross-over study. SUBJECTS AND METHOD: Six subjects were recruited by poster to take part in the study. Each subject had one premolar in each quadrant to which a bracket could be fixed and exemplary oral hygiene. Elastomers were then placed on these brackets. INTERVENTION: The study was divided into two parts: (i) subjects used oral hygiene products with fluoride and (ii) oral hygiene products with fluoride were excluded. Both groups of elastomers were left in the mouth for 1 week. After collection the elastomers were stored in distilled water. MAIN OUTCOME MEASURES: The amount of residual fluoride in the ligatures after they have been placed in the mouth for 1 week was compared with the cumulative fluoride release in vitro over 1 week and 6 months. RESULTS: Only 13 per cent of the total amount of fluoride in fluoridated elastomers was released during the first week in vitro, compared with 90 per cent in vivo. There was a significantly greater amount (P = 0.001) of residual fluoride when the elastomers were in the mouth for 1 week in the presence of fluoride toothpaste and mouthrinse, than when fluoride supplements were excluded. CONCLUSIONS: (1) Higher levels of fluoride are lost from the fluoride elastomers in vivo than in vitro during the first week. (2) A significantly greater amount of residual fluoride was released from the elastomers placed in the mouth when fluoride toothpaste and mouthrinse were used.

Cariostatic Agents↗
PubMed1991

Triclosan and sodium lauryl sulphate mouthrinses. (II). Effects of 4-day plaque regrowth.

Toothpastes have been shown to exert some plaque inhibitory effects probably due to the action of detergents such as sodium lauryl sulphate (SLS). Recently the antimicrobial, triclosan, has been added to experimental and commercial toothpaste products to enhance activity against plaque. There is, however, little information as to the plaque inhibitory effects alone of ingredients such as SLS and triclosan. This investigation compared the effects on 4-day plaque regrowth of a 1% SLS, 0.2% triclosan and 0.2% chlorhexidine rinse with a 0.9% saline rinse. The study was single blind, latin square, four-period crossover design, balanced for residual effects and employing 16 healthy dentate volunteers. During each period, normal oral hygiene ceased and plaque regrowth from a zero baseline was measured by score and area after 2 x daily rinses with 10 ml volumes of each rinse. Washout was a minimum of 60 h. Plaque scores and areas were significantly lower with chlorhexidine than the other preparations and significantly higher with saline. There were no significant differences between SLS and triclosan. The results were essentially consistent with the similar substantivity of SLS and triclosan demonstrated from the salivary bacterial count investigation. Taste acceptability may, however, explain the small reverse trends noted between the two studies. It is concluded that both SLS and triclosan would individually confer plaque inhibitory properties to toothpaste formulations. However, when combined in a single formulation, their effects may not be additive.

Adult↗
PubMed1998

The effects of a potassium citrate, cetylpyridinium chloride, sodium fluoride mouthrinse on dentine hypersensitivity, plaque and gingivitis. A placebo-controlled study.

Home-use studies on dentine hypersensitivity have most commonly involved toothpastes and rarely have mouthrinses been employed. Potassium and/or fluoride toothpastes have been shown effective in the treatment of dentine hypersensitivity. The aim of this study was to evaluate the effectiveness of a total formulation, containing potassium citrate, sodium fluoride, cetylpyridinium chloride mouthrinse compared to the base rinse minus actives in the reduction of dentine hypersensitivity. The study was a randomised placebo controlled, double blind parallel design. At a screening visit, 90 adult subjects were recruited who were suffering from dentine hypersensitivity from at least 1 tooth responding to tactile stimulation (45gm pressure) and had at least 2 teeth responding to evaporative stimulation (air blast). During a washout period of 28 days and throughout the 56-day study period, subjects used a soft filament toothbrush and standard fluoride toothpaste. At baseline (day 1), threshold sensitivities to incremental tactile (10 g to 70 g) and evaporative stimuli were determined. Gingival health was assessed by recording bleeding on probing at 25 g pressure at mesiobuccal and lingual sites. Plaque scores from buccal and lingual surfaces of disclosed teeth were also measured. Subjects then used the prescribed rinse, 10 ml for at least 30 s after brushing 2x per day returning on days 28 and 56 for rescoring of sensitivity, gingivitis and plaque. Data from 88 subjects were used with the intent to treat analyses and 83 in the completely evaluable analyses. Groups were well balanced for demographic data and product returns suggested good compliance. Both groups showed highly significant improvements in tooth sensitivity. The pattern was for greater improvement in the test compared to the control group (statistically significant for the plaque score), whereas bleeding scores, already low, showed no change in either group. By definition, the placebo rinse could not have exerted any therapeutic action; the study therefore provides clear direct evidence as to the magnitude (30%-40%) of the little studied, but assumed, placebo response in dentine hypersensitivity trials.

Adolescent↗