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PubMed2006

Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?

Dietary flavonoids can improve endothelial function, but the response varies between individuals. Wide variability is also seen in flavonoid O-methylation, a major pathway of flavonoid metabolism. The O-methylation of flavonoids could alter activity, and thus influence any effect on endothelial function. The objective of the current analysis was to investigate whether variability in the endothelial function response to ingestion of tea, a rich source of flavonoids, is related to the degree of O-methylation of flavonoids. This relationship was investigated in two studies in which endothelium-dependent flow-mediated dilatation (FMD) of the brachial artery was assessed and urinary 4-O-methylgallic acid (4OMGA) excretion was used as a marker of the O-methylation of tea-derived flavonoids. In the first study, amongst participants consuming five cups of tea per day for 4 weeks, the degree of increase in 4OMGA excretion was inversely associated with the change in FMD responses (r -078, P=0.008). In the second study, there was a significant difference in the FMD responses to acute ingestion of three cups of tea between individuals with a low ( median) 4OMGA response (1.94 (sem 0.79) % and -0.25 (sem 0.53) %, respectively; P=0.03). That is, any improvement in FMD following ingestion of tea may be enhanced in individuals who O-methylate less of the absorbed flavonoids. The present results are consistent with the suggestion that differences in flavonoid metabolism may influence their effect on endothelial function. Thus, differences in flavonoid metabolism could be related to the level of benefit of dietary flavonoids on the risk of CVD.

Brachial Artery↗
PubMed1987

Extrahepatic bile duct cancer and smoking, beverage consumption, past medical history, and oral-contraceptive use.

Information on potential causal factors in 67 patients with histologically confirmed cancer of the extrahepatic bile ducts was compared with that from 273 patients with other cancers. The control group did not include subjects with tobacco- or alcohol-related cancers. The study subjects were interviewed at 11 large hospitals in eastern Massachusetts and Rhode Island between 1975 and 1979. Among the patients with extrahepatic bile duct cancer, the male-female ratio was 1.5. The use of cigarettes was associated with decreased risk of extrahepatic bile duct cancer. The use of alcohol and coffee was not related to risk of extrahepatic bile duct cancer. Fewer patients than controls reported tea consumption. A statistically significant association between the use of oral contraceptives and extrahepatic bile duct cancer was observed among women under 60 years of age. Patients reported significantly higher frequencies of history of ulcerative colitis or diseases of the gallbladder.

Aged↗
PubMed1993

Protection against N-nitrosodiethylamine and benzo[a]pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea.

In recent years we and others have shown the cancer chemopreventive effects of green tea in several animal tumor models. In this study we assessed the cancer chemopreventive effects of water extract of green tea (WEGT) and the polyphenolic fraction (GTP) isolated from WEGT against N-nitrosodiethylamine (DEN)- and benzo[a]pyrene (BP)-induced forestomach and lung tumorigenesis in A/J mice. The protective effects, both in forestomach and lungs, were evident by a decrease in number of tumors and the percentage of mice with tumors when WEGT and GTP were fed to animals during initiation, post-initiation and entire period of tumorigenesis protocols. Oral feeding of 0.2% GTP in drinking water to mice afforded 68-82 and 39-66% protection against DEN- and BP-induced forestomach tumorigenesis respectively. In case of pulmonary tumor multiplicity caused by DEN and BP, the protective effects of GTP were between 38-43 and 25-46% respectively. Similarly, oral feeding of 2.5% WEGT to mice also afforded 80-85 and 61-71% protection against DEN- and BP-induced forestomach tumorigenesis respectively. In case of lung tumorigenesis, the protective effects of WEGT were 43-62 and 25-51% respectively. Histological studies of forestomach tumors showed significantly lower squamous cell carcinoma counts in GTP- and WEGT-fed groups of mice compared to carcinogen alone treated control group of mice. When pulmonary tumors were examined histologically, no adenocarcinomas were observed in GTP- and WEGT-fed groups of mice compared to 20% mice with adenocarcinomas in carcinogen alone treated control group. Oral feeding of GTP and WEGT in drinking water also showed significant enhancement in the activities of glutathione S-transferase and NADP(H): quinone reductase in liver, small bowel, stomach and lung. The results of this study suggest that green tea possesses chemopreventive effects against carcinogen-induced tumorigenesis in internal body organs, and that the mechanism of such effects may involve the enhancement of phase II and anti-oxidant enzyme systems.

Animals↗
PubMed1992

Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives.

Green tea, next to water, is the most popular and commonly consumed beverage in the world, especially in eastern countries. In prior studies we have shown that the polyphenolic fraction isolated from green tea (GTP) exerts antigenotoxic effects in various mutagenicity test systems (Mutat. Res., 223: 273-285, 1989) and that its topical application or oral feeding in drinking water protects against polycyclic aromatic hydrocarbon-induced skin tumor initiation and complete carcinogenesis in SENCAR and BALB/c mice [Cancer Lett., 42: 7-12, 1988; Carcinogenesis (Lond.), 10: 411-415, 1989] and UV B radiation-induced photocarcinogenesis in SKH-1 hairless mice [Carcinogenesis (Lond.), 12: 1527-1530, 1991]. In the present study we assessed the effect of skin application of GTP to SENCAR mice on 12-O-tetradecanoylphorbol-13-acetate (TPA) and other skin tumor promoter-caused induction of epidermal ornithine decarboxylase (ODC) activity. Topical application of GTP to mouse skin inhibited TPA-induced epidermal ODC activity in a dose-dependent manner. The inhibitory effect of GTP was also dependent on the time of its application relative to TPA treatment. Maximum inhibitory effect was observed when GTP was applied 30 min prior to topical application of TPA. GTP application to animals also inhibited the induction of epidermal ODC activity caused by several structurally different mouse skin tumor promoters. In order to identify which of the specific epicatechin derivatives present in GTP is responsible for these inhibitory effects, they were isolated from GTP and evaluated for their inhibitory effects against TPA-caused induction of epidermal ODC activity. Among these, (-)epigallocatechin-3-gallate (EGCG), which was the major constituent present in GTP by weight, exerted the maximum inhibition. EGCG also showed greater inhibitory effects against TPA-caused induction of epidermal ODC activity when compared with several other naturally occurring polyphenols. The results of this study suggest that GTP, specifically its epicatechin derivative EGCG, could provide anti-tumor-promoting effects against a wide spectrum of skin tumor promoters.

Animals↗
PubMed1988

Pancreatic cancer, blood glucose and beverage consumption.

We studied the incidence of pancreatic cancer in 122,894 men and women who had previously reported amount and frequency of coffee, tea, and alcohol consumption; reporting was done at a multi-phasic health check-up (MHC) taken while subjects were members of a large prepaid health plan. We also tested the hypothesis that a pre-clinical effect of pancreatic cancer on glucose homeostasis leads to mild hyperglycemia and a generally increased thirst. If true, this could partially explain the increased consumption of beverages (particularly coffee) reported in association with pancreatic cancer in some case-control studies. However, in the 49 pancreatic cancer cases diagnosed during 6 years of follow-up, we found no evidence of increased risk associated with coffee, tea, or alcoholic beverages. We also found no evidence to support the increased-thirst hypothesis when we examined the 19 cases diagnosed within 12 months of having MHC. We did confirm a significantly increased risk among cigarette smokers (relative risk, 2.5; 95% confidence interval, 1.3-4.7) which was progressive with increasing levels of cigarette use. In addition, risk of pancreatic cancer was greater for persons previously under treatment for diabetes mellitus (relative risk, 4.5; 95% confidence interval, 1.2-16.7). Our results add to the growing body of evidence against a causal role of coffee in pancreatic cancer.

Aged↗
PubMed1998

[A case-control study on diet and gastric cancer].

OBJECTIVE: To study the relationship between consumption of fish sauce, diet, living-habit and risk of gastric cancer. METHODS: A population-based 1:2 matched case-control study was conducted in Changle and Fuqing Cities of Fujian Province during May 1994 to July 1995. Totally, 272 matched pairs were investigated. RESULTS: Risk state single-factor analysis indicated that there were significant associations between occurrence of gastric cancer and over consumption of fish sauce (OR = 2.57), pickled vegetables (OR = 1.41) and sea food (OR = 1.57), low consumption of fresh vegetables (OR = 1.95), citrus fruits (OR = 1.41), other fruits (OR = 1.31) and green tea (OR = 1.72), exposure to moldy cereals (OR = 2.32), taking meals at irregular times (OR = 5.47) and familial history of malignancy (OR = 3.27). No associations between risk of gastric cancer and smoking, alcohol drinking, amount of salft consumption, use of refrigerator were found. Analysis of risk state conditional logistic regression showed that fish sauce, pickled sea food, irregularly taking meals and familial history of malignancy were included in a set of risk factors for gastric cancer, with a summary attributable risk percentage of 75.49%. CONCLUSION: Over consumption of fish sauce, pickled food, moldy cereals, irregularly taking meals and familial history of malignancy may be the local risk factors for high occurrence of gastric cancer, and fresh vegetables and fruits, green tea may have protective effects on it.

Adult↗
PubMed2003

Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils.

Since urease of Helicobacter pylori is essential for its colonization, we focused attention on foodstuffs which inhibit the activity of this enzyme. Among plant-derived 77 foodstuff samples tested, some tea and rosemary extracts were found to clearly inhibit H. pylori urease in vitro. In particular, green tea extract (GTE) showed the strongest inhibition of H. pylori urease, with an IC(50) value of 13 microg/ml. Active principles were identified to be catechins, the hydroxyl group of 5(')-position appearing important for urease inhibition. Furthermore, when H. pylori-inoculated Mongolian gerbils were given GTE in drinking water at the concentrations of 500, 1000, and 2000 ppm for 6 weeks, gastritis and the prevalence of H. pylori-infected animals were suppressed in a dose-dependent manner. Since the acquisition by H. pylori of resistance to antibiotics has become a serious problem, tea and tea catechins may be very safe resources to control H. pylori-associated gastroduodenal diseases.

Animals↗
PubMed1994

Alcohol in human history.

The role of ethanol in the history of human development is here summarized under seven topics: I. Alcohol: the substitute for water as the major human beverage; II. Alcohol as a component of the diet and source of calories; III. Alcohol, concentration by distillation; IV. The Reformation, Temperance and Prohibition; V. Potable nonalcoholic beverages: Boiled water (coffee, tea); VI. Purification and sanitation of water; VII. The present and future.

Alcohol Drinking↗
PubMed1980

Voluntary dehydration in men working in heat.

An investigation was carried out on 77 steelworkers, divided into two groups, at their work places. Group I (30 subjects) drank ad lib. a special tea containing (17.1 mmol/l NaCl, 1.34 mmol/l KCl, 0.14 mmol/l Na2HPO4, and 0.57 mmol/l vitamin C). Group II (47 subjects) drank ad lib. ordinary drinks (water, mineral water, and soda-water). Determination of water balance was performed seven times in all within 3 weeks. In groups I and II sweat losses were 5.1 +/- 1.2 kg and 5.0 +/- 1.3 kg, and intakes were 4.1 +/- 1.1 kg and 3.4 +/- 1.1 kg, respectively. When the intake period of the drinks with salts was extended it was found that voluntary dehydration decreased and amounted to 10% of sweat rate on the last day of the study. The voluntary dehydration in group I was lower by 40%, the difference being highly significant in comparison with group II (P < 0.001). Data obtained from anamnesis and a questionnaire results showed smaller fatigue, higher work capability and better subjective feelings in group I. Five subjects who previously had complained of recurrent pain and muscle spasm experienced disappearance of these symptoms. The importance of intake of water containing salts in hot working conditions and their role in maintaining the water-electrolyte balance for normal physiological functions and subjective feelings were discussed.

Adult↗
PubMed1985

Drug usage and outstanding performance among young adolescents.

In this study, 1,008 ninth grade boys and 1,040 ninth grade girls completed questionnaires concerning: (a) drug usage (alcohol, tobacco, marijuana, psychedelics, etc.) over the previous 6 months; and (b) outstanding performance in art, school subjects, music, leadership, performing arts, athletics, and writing. In general, the outstanding performer is rather more likely to be an abstainer and less likely to fall into the high-user category than is a nonoutstanding performer. The strongest support for this appears to come from use of tobacco. Differences between outstanding and nonoutstanding students are, however, often quite small.

Achievement↗
PubMed1985

Paracetamol metabolism in African villagers.

Paracetamol clearance has been measured from serial serum samples in 49 healthy black Africans from a village in Southern Africa. The subjects are minimally exposed to known environmental inducing or inhibiting agents and the staple diet consists of maize cereal and greens. The mean clearance (+/- SD) was 4.98 +/- 1.61 ml min-1 kg-1, which is significantly faster than the values found in previous investigations with paracetamol in whites and Asian immigrants in London. The mean half-lives were fairly similar but the apparent volumes of distribution were also found to be larger in the present study. The ethnic difference in paracetamol kinetics identified in this study is possibly genetically controlled.

Acetaminophen↗
PubMedDate not supplied

Prevalence of dental fluorosis and associated risk factors in Alappuzha district, Kerala.

BACKGROUND: Fluorosis is considered endemic in 15 states of India. Dental fluorosis is the most convenient biomarker of exposure to fluoride. In Kerala, although the condition is reported to be endemic in the districts of Alappuzha and Palakkad, there are no systematic epidemiological studies evaluating dental fluorosis. We studied the prevalence of dental fluorosis among school children in Ambalappuzha taluk, Alappuzha district, Kerala and evaluated the contribution of potential risk factors. METHODS: We conducted a community-based, cross-sectional survey of 1142 school children (630 girls, 512 boys) in the age group of 10-17 years, using a multistage random cluster sampling technique. A pre-tested structured questionnaire was used to assess exposure to various sources of fluoride. A dental specialist examined all the children to determine the presence or absence of dental fluorosis and graded the degree of dental fluorosis using Dean's Index. The water fluoride content in the study area was obtained from the district water authority department. Bivariate associations were examined using the Chi-square and Chi-square trend tests, while multiple logistic regression was used to evaluate the association of select risk factors with the presence or absence of dental fluorosis. RESULTS: The overall prevalence of dental fluorosis in our study sample was 35.6% and the community fluorosis index was 0.69. The prevalence of dental fluorosis was higher in the urban compared to the rural areas (55.3% v. 16.8%; p < 0.001), and in girls compared to boys (39.2% v. 31.3%; p < 0.01). The prevalence of dental fluorosis was higher among children who consumed pipe water as compared to children who consumed well water (44.8% v. 12.7%; p < 0.001). We noted a step-wise increase in the prevalence of dental fluorosis with a corresponding increase in water fluoride content in different panchayats (p = 0.024). The principal factor associated with the presence of dental fluorosis was a high fluoride content of drinking water (OR 1.85, 95% Cl: 1.17-2.92). We did not observe any significant association between dental fluorosis and the intake of brick-tea, consumption of fish or the use of toothpaste. CONCLUSION: Dental fluorosis is a public health problem in the Ambalappuzha taluk. Active steps must be taken to partially defluoridate the water before distribution to reduce the morbidity associated with dental fluorosis in this area. Similar surveys are required in other parts of India to identify areas with high water fluoride content and determine the extent and manner in which defluoridation can be carried out.

Adolescent↗
PubMed1985

Dietary habits and dental health in 6-year-old Finnish immigrant children in Sweden.

A survey, including a clinical and radiographic examination for dental health, was carried out on 19 6-year-old Finnish immigrant children and 24 Swedish children in a Stockholm suburb. The parents were interviewed about their children's and their own dietary habits. The study showed generally worse dietary habits in the Finnish than in Swedish group. Both the children and the parents in the Finnish group had more food intakes per day than the Swedes. The Finnish children had a significantly more frequent consumption of cariologically unsuitable products such as soft-drinks, sweets, lozenges and chewing-gum than the Swedish children and a majority of the Finnish parents took sugar in their coffee and/or tea. The Finnish children had also more filled and carious teeth. The study revealed a great need for both general dietary and dental health information in the studied group of Finnish immigrant families with pre-schoolchildren.

Child↗
PubMed2006

Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study.

CONTEXT: Green tea polyphenols have been extensively studied as cardiovascular disease and cancer chemopreventive agents in vitro and in animal studies. However, the effects of green tea consumption in humans remain unclear. OBJECTIVE: To investigate the associations between green tea consumption and all-cause and cause-specific mortality. DESIGN, SETTING, AND PARTICIPANTS: The Ohsaki National Health Insurance Cohort Study, a population-based, prospective cohort study initiated in 1994 among 40,530 Japanese adults aged 40 to 79 years without history of stroke, coronary heart disease, or cancer at baseline. Participants were followed up for up to 11 years (1995-2005) for all-cause mortality and for up to 7 years (1995-2001) for cause-specific mortality. MAIN OUTCOME MEASURES: Mortality due to cardiovascular disease, cancer, and all causes. RESULTS: Over 11 years of follow-up (follow-up rate, 86.1%), 4209 participants died, and over 7 years of follow-up (follow-up rate, 89.6%), 892 participants died of cardiovascular disease and 1134 participants died of cancer. Green tea consumption was inversely associated with mortality due to all causes and due to cardiovascular disease. The inverse association with all-cause mortality was stronger in women (P = .03 for interaction with sex). In men, the multivariate hazard ratios of mortality due to all causes associated with different green tea consumption frequencies were 1.00 (reference) for less than 1 cup/d, 0.93 (95% confidence interval [CI], 0.83-1.05) for 1 to 2 cups/d, 0.95 (95% CI, 0.85-1.06) for 3 to 4 cups/d, and 0.88 (95% CI, 0.79-0.98) for 5 or more cups/d, respectively (P = .03 for trend). The corresponding data for women were 1.00, 0.98 (95% CI, 0.84-1.15), 0.82 (95% CI, 0.70-0.95), and 0.77 (95% CI, 0.67-0.89), respectively (P<.001 for trend). The inverse association with cardiovascular disease mortality was stronger than that with all-cause mortality. This inverse association was also stronger in women (P = .08 for interaction with sex). In women, the multivariate hazard ratios of cardiovascular disease mortality across increasing green tea consumption categories were 1.00, 0.84 (95% CI, 0.63-1.12), 0.69 (95% CI, 0.52-0.93), and 0.69 (95% CI, 0.53-0.90), respectively (P = .004 for trend). Among the types of cardiovascular disease mortality, the strongest inverse association was observed for stroke mortality. In contrast, the hazard ratios of cancer mortality were not significantly different from 1.00 in all green tea categories compared with the lowest-consumption category. CONCLUSION: Green tea consumption is associated with reduced mortality due to all causes and due to cardiovascular disease but not with reduced mortality due to cancer.

Adult↗
PubMed1978

Cancer and total mortality among active Mormons.

Based on Church records for 15,500 California Mormons during 1968 to 1975 and for 55,000 Utah Mormons during 1970 and 1975, the ratio of age-adjusted death rates for religiously active Mormon males compared with U.S. white males is 38% for ages 35 to 64 years and 50% for ages 35 years and above. The remaining life expectancy for active Mormon men at age 35 is about 44 years, over 7 years greater than for U.S. white males. Their standardized mortality ratio is 50% for all cancer, being 23% for smoking-related cancer sites and 68% for all other sites. Active Mormons, defined here to be High Priests and Seventies, abstain almost completely from the use of tobacco, alcohol, coffee, and tea, but appear to be fairly similar to other white males with regard to socioeconomic status, urbanization, and diet. Active Mormons are healthier than Mormons as a whole and rank among the lowest in mortality when compared with other groups of healthy males.

Adult↗
PubMed2006

Correlates of alcohol consumption and tobacco use among tea industry workers of Assam.

An epidemiological study on alcohol and tobacco (smoking and nonsmoked tobacco) use was carried out in tea garden population of Assam, one of the largest agroindustries of India. A total sample of 2,264 individuals (male, 1,033; female, 1,231) aged 15 years and older was interviewed in 2002-2003 to collect information about alcohol and tobacco use using a predesigned and pretested questionnaire. Age-adjusted prevalence of alcohol consumption was 59.2% (male, 69.3%; female, 54%). Smoking was more common among males (13.2%) than females (2%). However, use of nonsmoked tobacco was almost as popular among female (71.9%) as among males (75.3%). More than half of the respondents (54.7%) were multiple users of alcohol and tobacco. Prevalence of alcohol consumption, nonsmoked tobacco use, and smoking among the young age group (15-24 years) was 32.2%, 52.5%, and 2.2%, respectively. Prevalence of smoking increased with age, and more than a quarter of males above 54 years were smokers. Similar age trends in the prevalence of alcohol and nonsmoked tobacco was not observed. Sociodemographic correlates, like education, occupation, and marital status, emerged as important predictors of substance uses irrespective of sex. Association of income with substance use was weak in this study, perhaps due to homogeneity of income level. Users of alcohol and tobacco were mostly illiterate, manual workers, and widows/widowers. However, smokers were more common among sedentary worker. Not withstanding the limitations of the study, the findings of the study are useful for planning interventional strategy to control alcohol and tobacco use for better health outcome.

Adolescent↗
PubMed2001

Helicobacter pylori seropositivity among 963 Japanese Brazilians according to sex, age, generation, and lifestyle factors.

Seropositivity of anti-Helicobacter pylori antibody (HP + ) was examined among Japanese Brazilians. The study was announced through 18 Japanese community culture associations in São Paulo, Curitiba, Mogi das Cruzes, and Mirandopolis in 2001. Among 969 participants, 963 individuals aged 33 - 69 years were analyzed. The overall HP + % was 48.1% (95% confidence interval, 44.9 - 51.3%). There was no difference in HP + % between 399 males and 564 females (49.6% and 47.0%, respectively). The HP + % increased with age; 35.3% for those aged 33 - 39 years, 46.2% for those aged 40 - 49 years, 46.5% for those aged 50 - 59 years, and 56.9% for those aged 60 - 69 years, but no differences were observed among the generations (Issei, Nisei, and Sansei) for each 10-year age group. Mogi das Cruzes, a rural area, showed a higher HP + %. Length of education was inversely associated with the positivity; the odds ratio (OR) relative to those with eight years or less of schooling was 0.61 (0.42 - 0.89) for those with 12 years or more. The associations with smoking and alcohol drinking were not significant. Fruit intake was associated with the HP + %; the OR relative to everyday intake was 1.38 (1.05 - 1.83) for less frequent intake, while intake frequencies of green tea, miso soup, and pickled vegetables (tsukemono) were not. Multivariate analysis including sex, 10-year age group, residence, education, and fruit intake showed that all factors except sex were significant. This is the largest study of HP infection among Japanese Brazilians, and the results indicated a similar pattern of age-specific infection rate to that for Japanese in Japan.

Adult↗