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Results for “Self Stimulation”

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At least 937 records · Page 52Linked to original sources
PubMed2000

Chronic corticosterone enhances the rewarding effect of hypothalamic self-stimulation in rats.

Excessive levels of glucocorticoids have been implicated in the etiology of affective disorders in humans, and in a range of behavioral deficits in animals. In the present study, we used an established regimen of corticosterone administration (40 mg/kg, for 21 days) to determine its effects upon responding for rewarding brain stimulation in rats. After chronic treatment, subjects exhibited an unexpected but significantly increased sensitivity to the rewarding effects of brain stimulation. These results suggest that chronic, high levels of corticosterone are unlikely to cause anhedonia in rodents.

Animals↗
PubMed1985

Preference paradigm: provides better self-stimulation reward discrimination than a rate-dependent paradigm.

To obtain a better understanding of how well the Y-maze preference test paradigm indexes electrical brain stimulation reward, the present experiment compared the abilities of this rate-independent paradigm and a rate-dependent paradigm to assess the rewarding effectiveness of brain stimulation. The rate-dependent paradigm used was an operant chamber. The results showed that over a wide range of stimulation parameters the rate-independent paradigm provided a better assessment of the rewarding effectiveness of the brain stimulation than did the rate-dependent paradigm.

Animals↗
PubMed1981

[Cortisol weakening of hippocampal neuron response during self stimulation].

In unrestrained rabbits, the majority of dorsal hippocampus' neurons changed their firing rate immediately after cessation of electrical stimulation of the lateral hypothalamus. Microionophoretic application of cortisol inhibited the excitatory responses selectively and intensified the inhibitory responses unspecifically. Cortisol seems to affect the hippocampal neurons via different mechanisms depending on the level of their excitability and the transmitters involving them into the integrative function of the positive reinforcement.

Animals↗