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Metastases to parotid gland from cancers of the upper airway and digestive tract.

Forty-four cases of parotid metastases were diagnosed and treated in the period 1968-1994. In 10 patients (23%), the primary tumour was sited in the mucosal layer of the upper airway or digestive tract: oropharynx (n=3), larynx (n=3), nasopharynx (n=2), hypopharynx (n=1) and the maxillary sinus (n=1). Histologically, the primary tumour was squamous cell carcinoma in 9 cases and adenocarcinoma in one. One patient received surgical treatment only, two patients surgery and postoperative radiotherapy, one radiotherapy only, four chemotherapy and two symptomatic treatment only. Only one patient is alive, disease-free, 5 years after treatment. The other patients died: six within 1 year, two within 2 years and one within 3 years of diagnosis.

Adenocarcinoma↗

Obstructive sialadenitis.

The value of all the procedures which have been described for the investigation of disorders of the major salivary glands is discussed in so far as they aided the management of one bizarre case of obstructive submandibular sialadenitis. In particular an unusual indication for salivary gland scanning is also suggested.

Humans↗

Synthetic diagnosis of parotid tumor.

Computed tomography (CT), ultrasounds, and radioisotope scintigraphy (RI scinti) were applied before operation to 156 patients with parotid tumor, and the result of each test and/or the synthetic study of them were compared with the findings during operation and the pathological diagnosis of isolated tissue. CT was found to be a very effective diagnostic aid in determining the location of the tumor. CT and ultrasounds both provided adequately reliable information regarding the tumor content. For diagnosing the malignancy of the tumor, synthetic diagnosis using CT, ultrasounds and RI scinti had a high diagnostic accuracy. By using the above mentioned methods of diagnosis, an accurate preoperative diagnosis of the tumor could be obtained.

Diagnostic Errors↗

Primary squamous cell carcinoma of the parotid gland: a case report with electron microscopic findings.

Primary squamous cell carcinoma of the parotid gland is a rare tumor. Histological and ultrastructural features of a primary squamous cell carcinoma arising in the right parotid gland is presented. Light microscopically the tumor consisted of poorly differentiated squamous cell nests. PAS reaction was negative. Ultrastructurally the tumor cells were oval or spindle shaped and the cytoplasmic processes were frequently found. The majority of the tumor cells contained numerous intermediate filaments in their cytoplasm. No secretory granule was found. The desmosomes were well developed. It is known that mucoepidermoid carcinoma may be often misdiagnosed as squamous cell carcinoma. These findings can enable us to distinguish primary squamous cell carcinoma from mucoepidermoid carcinoma of the parotid gland.

Carcinoma, Squamous Cell↗

Recurrent swelling of parotid glands and Sjögren's syndrome.

This study included 125 patients with chronic parotitis, and it presents in particular, a long-term clinical, laboratory, and sialographic study of 22 patients who were diagnosed as having adult recurrent sialadenitis of the parotid glands (ARSPG). Twelve of the 22 patients with ARSPG were shown to have Sjögren's syndrome (SS). These patients had recurrent parotid gland swelling for 1.5-14 years (mean, 5.2 years) before xerostomia and keratoconjunctivitis sicca occurred. Ten of the 22 patients with ARSPG did not develop SS, but did experience recurrent parotitis which extended from childhood into adulthood. The ARSPG underwent remission in seven of these patients. It is suggested that patients with ARSPG, but without a history of parotid gland swellings in childhood, should be diagnosed provisionally as having subclinical SS (SCSS).

Adolescent↗

Mucus escape reaction that involves the mandible: a case report and diagnostic imaging considerations.

We present a case of mucus escape reaction in which we encountered difficulty in interpreting the images acquired by plain radiography, computed tomography, and magnetic resonance imaging. The 48-year-old male Japanese patient was referred for evaluation of a gradual swelling subjacent to the inferior border of the left mandible. At the early imaging examinations, magnetic resonance imaging provided information crucial to resolving the issue of whether the lesion consisted of a central malignant disease process or a malignant disease in the submandibular space or both of these two separate disease entities. Magnetic resonance imaging demonstrated no evidence of tumorous lesion, but rather showed a fluid-containing cavity that was also confirmed by the subsequent intrasurgical inspection. On further consideration of these imaging findings, we concluded that the entity was mucus escape reaction with simultaneous occurrence of an intraconnective tissue hemorrhage adjacent to the left submandibular gland, concomitant extensive bony defect of the left mandible and lingual cortical defect, and chronic sialoadenitis of the left submandibular gland.

Diagnosis, Differential↗

Sialographic changes in Sjögren's and SOX syndromes.

OBJECTIVES: The purpose of this study was to examine the sialographic presentations of Sjögren's syndrome and SOX (sialadenitis, osteoarthritis, and xerostomia) syndrome and to establish whether changes in duct dimensions were a feature of these conditions. STUDY DESIGN: The sialograms of 17 patients with Sjögren's syndrome, 18 patients with SOX syndrome, and 19 patients with no salivary gland disease were examined. Through the use of an A010 Solitaire Image Analysis System, ductal diameters were measured. The films were then assessed subjectively. RESULTS: There was more sialectasis seen in the patients with Sjögren's syndrome than in the SOX group (chi-squared test: p < 0.01). There were no differences in duct diameter between the three groups. Control subjects with normal glands were shown to have narrower main ducts than has been previously reported, with an age-related widening of 1 degree and 2 degrees ducts. CONCLUSIONS: Sialectasis is not a feature of SOX syndrome. Ductal narrowing should not be thought of as a feature of either SOX or Sjögren's syndrome.

Adult↗

Agreement of aspiration tests using barium videofluoroscopy, salivagram, and milk scan in children with cerebral palsy.

To study the agreement between three tests for aspiration, barium videofluoroscopy, salivagram, and milk scan we studied 63 children with severe non-ambulant spastic quadriplegic cerebral palsy (CP) aged 14 months to 16 years (32 males, 31 females). The salivagram was most frequently positive (56%, 95% confidence interval 43 to 68%); the next most frequently positive was barium videofluoroscopy when aspiration was defined as the presence of either laryngeal penetration of material or frank aspiration (39%, 95% confidence interval 26 to 53%). The milk scan was rarely positive (6%, 95% confidence interval 2 to 16%). Agreement between the tests of aspiration was poor. The maximum agreement (kappa=0.20) was between aspiration as diagnosed with the salivagram and by barium videofluoroscopy. Positive tests for aspiration are frequent in children with severe CP. Frequency varies widely depending on the investigation used. There is poor agreement between tests used for the diagnosis of aspiration. This information is of importance in assessing the significance of test results.

Adolescent↗

Tumours of the parotid region.

Fifty-eight operatively treated tumours of the parotid region are presented. Of the tumours 85 per cent were benign and 15 per cent malignant. The percentage of pleomorphic adenomas was 36 per cent. During five years of observation there were no recurrences of benign tumours. Operative complications consisted of one paresis of the mandibular branch of the facial nerve and one death due to bleeding and aspiration during the first postoperative day. Frey's syndrome occurred postoperatively in 26 per cent of the cases. It is emphasized that parotid tumours should be concentrated to centres where surgeons have sufficient experience with these cases.

Adenoma, Pleomorphic↗